ABSTRACT This paper suggests a new mechanism from deep learning concept for personalised therapy in Clinical Decision Support Systems (CDSS). Basically, the texts used for the observation are acquired from the standard data sources and then forwarded to the text preprocessing task. In the pre-processing phase, the punctuation and special character removal, stop word removal, and stemming process are applied to remove noise and help to eliminate the redundant information in order to improve the data quality. Further, the pre-processed text is applied to the Adaptive Transformer Net (ATN) for the feature extraction purpose, where the attributes in this task are optimally determined with the aid of the Adaptive Walrus Optimization Algorithm (AWOA). Finally, the resultant text is subjected to the Hybrid Deep Learning Network (HDLNet). The HDLNet model is implemented by integrating the ‘Residual Long Short-Term Memory (Residual LSTM) with Dilated Recurrent Neural Network (Dilated RNN)’. From the results, the sensitivity analysis performed in the implemented technique secured 3.7% more efficient than LSTM, 7.76% improved than MobileNet, 6.7% superior to residual LSTM, and 0.90% effective than dilated RNN in dataset 1. Throughout the validation, the conventional techniques are evaluated with the suggested personalised therapy in CDSS to prove its efficacy.