This study investigated the relationship between lifestyle and cognitive regulation of emotion and the risk of seeking cosmetic surgery in young women. The current study was a cross-sectional study. The outcome variable in this research was cosmetic surgery seeking. The association between sociodemographic and health behaviors with risk of cosmetic surgery seeking investigated. The multinomial logistic regression was used to examine the association between health promotion lifestyle and cognitive emotion regulation with cosmetic surgery seeking. Underweight was associated with cosmetic surgery seeking [5.50; 95% CI 1.90-15.92; P<0.005]. Other risk factors were former smoking, alcohol use, and poor sleep quality. An increase in poor lifestyle is associated with an increased risk of cosmetic surgery seeking [30.41; 95% CI 4.87-189.84; P<0.001]. Adaptive cognitive emotion regulation protects against cosmetic surgery seeking [0.36; 95% CI 0.15-0.84; P<0.001]. Lifestyle and adaptive cognitive emotion regulation played a significant role in people who were looking for cosmetic surgery, and therefore, like in other areas of disease and health, lifestyle and adaptive cognitive emotion regulation are important in cosmetic surgery, and it is necessary to pay attention to the effects of each of them. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.