AbstractThe significance of the present article is to enhance the thermal management and energy efficiency of complex engineering infrastructures such as energy storage systems, modern electric vehicles, thermal insulations, heavy‐duty machinery, and production units. This research aims to understand the intricate relationship between the thermal conductivity performance of ternary () hybrid nanomaterial and entropy generation to optimize material design and efficacy. A synergetic combination of three distinct nanomaterials silicon dioxide, ferric oxide, and titanium oxide with ethylene glycol and water in the ratio 3:2 as a base solvent is comprised of contributing unique thermophysical properties. To elucidate the impact of this hybrid composition on thermal conductivity, various factors are analyzed. The advanced computational technique of Artificial intelligent feed‐forward neural network (AIFFNN) is utilized. The problem governed the system of PDEs, which is transformed into ODEs by dimensionless similarity. Adams method provided the dataset which is filtered and embedded into Marquardt–Levenberg Algorithm (LMA). The study examines the role of nanomaterial constituents, morphology, and boundary conditions on thermal performance and entropy generation. Graphical analysis of velocity, temperature, and entropy is provided with respect to varying parameters, including surface absorption (λ), magnetic strength (Tesla M), radiation parameter (Rd), Brownian motion (Br), and Eckert number (Ec). The findings have practical significance for optimizing material design in engineering and industrial applications.