Background: Several studies have reported neurological manifestations and complications related to specific coronavirus genotypes, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this study, we examined one of the rare clinical manifestations of Coronavirus disease 2019 (COVID-19), which was one of the first cases of acute transverse myelitis in children in the world. Case presentation: This case report was dedicated to a little girl with COVID-19 admitted with weakness, lethargy, and constipation. Her magnetic resonance imaging (MRI) showed signal changes accompanied by edema. The patient did not show an optimal response to the methylprednisolone succinate and intravenous human immunoglobulins (IVIG) and experienced cardiorespiratory arrest. The patient was eventually discharged with partial recovery in limb power. Conclusions: his study demonstrates the importance of rapid diagnosis and treatment of the sequelae of COVID-19 infections.