The sulfated polysaccharides obtained from algae may serve as potential antiviral components, which can fight against corona virus disease (COVID-19) in the present pandemic situation. Here, bioactivity of some important sulfated polysaccharides including carrageenan, galactans, laminaran, alginates, fucoidans, naviculan, calcium spirulan, p-KG03, nostoflan etc. found widely in red, brown and green seaweeds, diatoms, cyanobacteria and microalgae are discussed. Though the vaccines are yet to be released in the market, these sulfated polysaccharides can help to build a stronger immune system and help in minimizing the problem of pandemic 2020 caused by severe acute respiratory syndrome-novel corona virus (SARS-CoV-2) and can also lower the risk of viral infections in the post-COVID era.