Radiotherapy is commonly used with or without concomitant chemotherapy to treat head and neck cancer [1]. Xerostomia, an adverse effect of radiotherapy, results from radiation damage to the salivary glands [2]. Associated problems may include difficulty speaking, eating, and swallowing and decreased sense of taste. Despite improvement in technologies that deliver doses of radiation, such as intensity modulated radiation treatment, which spares more than 50% of the parotid glands from high-dose radiation, development of xerostomia often is unavoidable and can become permanent and refractory to intervention [3]. Current standard treatment options are saliva substitutes and stimulating agents. Pilocarpine hydrochloride, a cholinergic agonist, is the prototypical stimulating agent for treatment of xerostomia. The reported response rate for pilocarpine is 31%-54% [4], and the duration of response is often short. In addition, pilocarpine can produce adverse effects such as sweating, rhinitis, chills, and nausea that lead some patients to discontinue the medication [4]. Results from previous studies demonstrate that acupuncture-like treatment is effective in stimulating saliva production and improves xerostomia and its associated quality of life in patients with head and neck cancer treated with radiation [5-7]. The techniques used in these studies were either manual acupuncture, auricular acupuncture, or electroacupuncture. Currently, the National Cancer Institute/Radiation Therapy Oncology Group is launching a phase II-III study to investigate the efficacy of acupuncture-like transcutaneous nerve stimulation compared with pilocarpine in the treatment of radiation-induced xerostomia for patients with head and neck cancer. To our knowledge, no one has previously reported using a combination of manual acupuncture, auricular acupuncture, and electro-acupuncture to treat radiation-induced xerostomia. In this case study, we report significant improvement of severe xerostomia related to radiotherapy in a patient treated with this combination of acupuncture treatments. This patient reported a 30% increase in salivation, which corresponded with a functional improvement in his daily life, with benefits from each session lasting 10 weeks.