Acupoint Sticking Therapy Research Articles

Nursing of a lung cancer patient with cough treated by Traditional Chinese Medicine ointment combined with acupoint sticking therapy

Nursing of a lung cancer patient with cough treated by Traditional Chinese Medicine ointment combined with acupoint sticking therapy

Review on the application of acupoint sticking therapy for constipation in adult patients

Review on the application of acupoint sticking therapy for constipation in adult patients

Clinical observation of acupuncture plus acupoint sticking therapy for insomnia and its influence on subjective and objective sleep indicators

Clinical observation of acupuncture plus acupoint sticking therapy for insomnia and its influence on subjective and objective sleep indicators

Components of drugs in acupoint sticking therapy and its mechanism of intervention on bronchial asthma based on UPLC-Q-TOF-MS combined with network pharmacology and experimental verification

UPLC-Q-TOF-MS combined with network pharmacology and experimental verification was used to explore the mechanism of acupoint sticking therapy(AST) in the intervention of bronchial asthma(BA). The chemical components of Sinapis Semen, Cory-dalis Rhizoma, Kansui Radix, Asari Radix et Rhizoma, and Zingiberis Rhizoma Recens were retrieved from TCMSP as self-built database. The active components in AST drugs were analyzed by UPLC-Q-TOF-MS, and the targets were screened out in TCMSP and Swiss-TargetPrediction. Targets of BA were collected from GeneCards, and the intersection of active components and targets was obtained by Venny 2.1.0. The potential targets were imported into STRING and DAVID for PPI, GO, and KEGG analyses. The asthma model induced by house dust mite(HDM) was established in mice. The mechanism of AST on asthmatic mice was explored by pulmonary function, Western blot, and flow cytometry. The results indicated that 54 active components were obtained by UPLC-Q-TOF-MS and 162 potential targets were obtained from the intersection. The first 53 targets were selected as key targets. PPI, GO, and KEGG analyses showed that AST presumedly acted on SRC, PIK3 CA, and other targets through active components such as sinoacutine, sinapic acid, dihydrocapsaicin, and 6-gingerol and regulated PI3 K-AKT, ErbB, chemokine, sphingolipid, and other signaling pathways to intervene in the pathological mechanism of BA. AST can improve lung function, down-regulate the expression of PI3 K and p-AKT proteins in lung tissues, enhance the expression of PETN protein, and reduce the level of type Ⅱ innate immune cells(ILC2 s) in lung tissues of asthmatic mice. In conclusion, AST may inhibit ILC2 s by down-regulating the PI3 K-AKT pathway to relieve asthmatic airway inflammation and reduce airway hyperresponsiveness.

Evaluation of Effect of Acupoint Sticking Therapy on Idiopathic Edema by Ultrasound Imaging Based on Deep Learning Algorithm

This study was aimed to evaluate the therapeutic effect of acupoint application therapy on specific edema by using denoising convolutional neural network (DnCNN) ultrasound images. 144 patients with idiopathic edema were selected as the research objects, and they were randomly divided into the conventional treatment group and the acupoint application group. Traditional Chinese medicine (TCM) symptom score, quality-of-life score, and adverse reactions were compared between the two groups before and after treatment. Ultrasound images based on the deep learning algorithm were used to evaluate the efficacy. The results showed that compared with conventional ultrasound, ultrasound based on DnCNN was more accurate in the diagnosis of idiopathic edema. The total effective rate of edema treatment in the acupoint application group was higher than that in the conventional treatment group (45% vs 93%, P < 0.01 ). After treatment, the scores of TCM symptoms in the acupoint application group were lower than those in the conventional treatment group, and the quality-of-life score in the acupoint application group was higher than that in the conventional treatment group P < 0.05 . There was no significant difference in the incidence of adverse reactions between the two groups P > 0.05 . In summary, ultrasound-assisted examination based on the algorithm is accurate in the diagnosis of idiopathic edema. Acupoint application therapy has a significant effect on idiopathic edema and does not increase the incidence of adverse reactions, which has a guiding role in clinical treatment.

A network pharmacology analysis to identify active components and targets of Moschus in treatment and rehabilitation of Bell's palsy

The traditional Chinese herb, Moschus (also called She Xiang in Chinese), is used to accelerate the rehabilitation of Bell's palsy (BP) through acupoint sticking therapy in China. However, the mechanism of its effect is not clear. In this study, we explored the pharmacological mechanism using bioinformatics analysis. We identified 59 active ingredients in Moschus using the Traditional Chinese Medicine Integrated Database, including 17-beta-estradiol, testosterone, and 2,6-decamethylene pyridine. In total, 837 differently expressed genes were identified in blood of BP patients by RNA sequencing. Finally, 33 proteins were identified with overlapping predictions by the Comparative Toxicogenomics Database and Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine. Proteins of interest were closely associated with 406 Gene Ontology biological processes and 4 pathways. The hub proteins in the protein–protein interaction network were FOS, JUN, proopiomelanocortin, and G protein-coupled estrogen receptor 1. A pharmacology network was constructed with 15 active components of Moschus, 33 protein targets and four pathways. The docking model of androst-4-ene-3,17-dione and FOS-JUN complexes was predicted and constructed. The results indicated testosterone as an effective component of Moschus that may enhance BP rehabilitation by targeting FUN and the mitogen-activated protein kinase and cyclic adenosine monophosphate signaling pathways, and that docking of androst-4-ene-3,17-dione and FOS-JUN complexes might play a critical role. The findings provide a direction for future research to verify the key targets of Moschus in the treatment of BP and an application prospect in the field of facial nerve rehabilitation.

Effects of Evodia rutaecarpa Acupoint Sticking Therapy on Rats with Insomnia Induced by Para-Chlorophenylalanine in 5-HT1Aand 5-HT2A Gene Expressions

Effects of Evodia rutaecarpa Acupoint Sticking Therapy on Rats with Insomnia Induced by Para-Chlorophenylalanine in 5-HT1Aand 5-HT2A Gene Expressions

Efficacy and effect on related brain-gut peptides of acupoint sticking therapy for functional dyspepsia

Efficacy and effect on related brain-gut peptides of acupoint sticking therapy for functional dyspepsia

Clinical observation on acupoint sticking therapy plus electroacupuncture for treating peripheral facial paralysis

To observe the clinical effect of acupoint sticking therapy with Mian Tan Gao (facial paralysis paste) plus electroacupuncture (EA) for treating peripheral facial paralysis and its influence on patients’ facial nerve functions, facial disability index and clinical symptoms and signs. A total of 96 peripheral facial paralysis patients were allocated into an observation group, a medicine group and an EA group by simple randomization, with 32 cases in each group. Patients in the medicine group were treated with oral mecobalamine and prednisone acetate; patients in the EA group were treated with EA on the basis of the medicine treatment; while patients in the observation group were treated with acupoint sticking therapy with Mian Tan Gao (facial paralysis paste) plus EA. After 4-week treatment, the clinical efficacy, the adverse events, and the scores of House-Brackmann (H-B) facial nerve function grading scale, visual analog scale (VAS), clinical symptoms and signs, and facial disability index (FDI) were compared. After 4-week treatment, the total effective rate was 96.9% in the observation group, higher than 68.7% in the medicine group and 75.0% in the EA group (both P 0.05). The between-group comparison of the adverse event across the three groups showed no statistical significance (P>0.05). Acupoint sticking therapy with Mian Tan Gao (facial paralysis paste) plus EA can decrease H-B grade, reduce pain severity and improve clinical symptoms and signs as well as the facial disability condition in peripheral facial paralysis patients. This method produced more significant efficacy compared with oral medicine and medicine plus EA.

Clinical observation on acupoint injection of Chuankezhi injection plus acupoint sticking in treating bronchial asthma

To observe the clinical efficacy of acupoint injection of Chuankezhi plus acupoint sticking treatment for bronchial asthma, and provide clinical evidence for the synergy of the two therapies, and explore their synergistic mechanism. A total of 70 patients were randomized into an acupoint injection plus sticking group and an acupiont sticking group by the random number table, with 35 cases in each group. The treatment took place in July and August. The acupoint injection plus sticking group was treated with acupoint injection and acupiont sticking, while the acupiont sticking group was treated only with acupiont sticking therapy. The treatment course was 4 weeks. After the treatment, the scores of symptom scale in the two groups before treatment, 3 months and 6 months after the treatment were observed. During the treatment, there were 5 dropouts in the acupoint injection plus sticking group with 30 cases remained, and 4 dropouts in the acupiont sticking group with 31 cases remained. Before the treatment, there was no significant difference in the total scores of symptom scale between the two groups. Three months after the treatment, the total scores of symptom scale of both groups were lower than those before treatment, and the intra-group differences were statistically significant (both P 0.05). Six months after the treatment, the total scores of symptom scale in both groups were lower than those before treatment, and the intra-group differences were statistically significant (both P<0.05), so were the differences in the difference values of the scores before treatment and 6 months after treatment (both P<0.05). Acupoint injection of Chuankezhi plus acupoint sticking or acupoint sticking alone both can improve the symptoms of patients with bronchial asthma. Acupoint injection of Chuankezhi plus acupoint sticking has a higher total effective rate than single acupoint sticking therapy.

Clinical observation on warm needling moxibustion plus acupoint sticking therapy for cervical radiculopathy

To observe the clinical effect of warm needling moxibustion plus acupoint sticking therapy for cervical radiculopathy. A total of 120 cases were allocated into an observation group, a warm needling group and an acupoint sticking group according to the random number table, with 40 cases in each group. Cases in the observation group received warm needling moxibustion plus acupoint sticking therapy; cases in the warm needling group received the same warm needling moxibustion in the observation group; cases in the acupoint sticking group received the same acupoint sticking therapy in the observation group. The scores of Japanese Orthopaedic Association (JOA) and visual analog scale (VAS) were recorded before and after treatment. The total effective rate was 95.0% in the observation group, versus 77.5% in the warm needling group and 75.0% in the acupoint sticking group (both P<0.05). Inter-group differences in JOA and VAS between the observation group and the other two groups were statistically significant (all P<0.05). Warm needling moxibustion plus acupoint sticking therapy is effective in treating cervical radiculopathy, and it can significantly alleviate pain and enhance clinical efficacy, and thus is worth clinical popularization.

Effect of acupoint massage plus acupoint sticking therapy for the stress reaction during postoperative anesthesia recovery period in patients undergoing nasal endoscopic surgery

To observe the effect of acupoint massage plus acupoint sticking therapy for the stress reaction during postoperative anesthesia recovery period in patients undergoing nasal endoscopic surgery. A total of 120 patients undergoing nasal endoscopic surgery were included, and all patients were under trachea intubation and general anesthesia. The patients were randomized into an observation group and a control group, with 60 patients in each group. Patients in the control group received conventional anesthesia resuscitation, while patients in the observation group received acupoint massage plus acupoint sticking therapy on the basis of conventional anesthesia resuscitation. Changes in the heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were observed at three time points including the end of the surgery (T0), the removal of the tracheal tube (T1) and 10 min after the removal of the tracheal tube (T2). The awakening and tube removal time, choking cough and restlessness, and adverse reactions (dizziness, nausea and vomiting) in 24 h post-surgery period were compared. At T1 and T2, the comparisons of HR, SBP and DBP between the two groups showed statistical significance (all P<0.05). Intra-group comparisons showed that the HR, SBP and DBP of the control group at T1 and T2 were significant different from those at T0 (all P<0.05). There were significant differences in the awakening time and tube removal time between the two groups (both P<0.05). The incidences of choking cough and restlessness were 8.3% and 3.3% respectively in the observation group, versus 53.3% and 30.0% in the control group, and the between-group comparisons showed statistical significance (both P<0.05). The incidences of dizziness, nausea and vomiting in 24 h post-surgery period were 3.3%, 5.0% and 0.0% respectively in the observation group, versus 43.3%, 33.3% and 25.0% in the control group, and the between-group comparisons showed statistical significance (all P<0.05). Acupoint massage plus acupoint sticking therapy can effectively regulate the stress reaction during postoperative anesthesia recovery period in patients undergoing nasal endoscopic surgery, and maintain a stable internal environment.

Altered metabolites in guinea pigs with allergic asthma after acupoint sticking therapy: New insights from a metabolomics approach

BackgroundClinical evidence gathered in Chinese communities suggested that acupoint sticking therapy could be an alternative treatment for asthma-related diseases. However, its underlying mechanism is still poorly understood. Aim/hypothesisIn this study, we aimed to investigate the mechanism of the anti-inflammatory effect of acupoint sticking application with ‘Treatment of Winter Disease in Summer’ (TWDS) prescription by using metabolomics. MethodsAllergic asthma in guinea pig was sensitized and challenged by ovalbumin (OVA). Histopathological evaluation of the lung tissue was performed by hematoxylin and eosin (H&E) staining and Masson's trichrome staining. The levels of Th2 cytokine and IgE level in serum were measured using enzyme-linked immunoassay (ELISA). The mRNA expression levels of IL-4, IL-5, IL-13 and orosomucoid-like 3 (ORMDL3) were measured using quantitative reverse transcription polymerase chain reaction (RT-qPCR). Proteins of NF-κB signaling pathway were measured using western blot. The serum metabolomics profiles were obtained by using ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOF-MS). ResultsThe overall results confirmed that AST with TWDS prescription had a significant protective effect against OVA-induced allergic asthma in guinea pig. This treatment not only attenuated airway inflammation and collagen deposition in the airway, but also decreased the levels of IL-4, IL-5, IL-13 and IgE in serum. In addition, metabolomics results indicated that metabolisms of phospholipid, sphingolipid, purine, amino acid and level of epinephrine were restored back to the normal control level. Moreover, results of the gene expression of ORMDL3 in lung tissues indicated that AST using TWDS could alter the sphingolipid metabolism. Further western blotting analysis also showed that its anti-inflammatory mechanism was by decreasing the phosphorylation of p65 and IκB. ConclusionThe study demonstrated that metabolomics provides a better understanding of the actions of TWDS acupoint sticking therapy on OVA-induced allergic asthma.

Effect and safety of stimulating acupoints in children with cough variant asthma: A Meta-analysis

OBJECTIVETo evaluate the efficacy and safety of stimulating acupoints in subjects with childhood cough variant asthma (CVA). METHODSA Meta-analysis of randomized controlled trials (RCTs) about the comparison between acupoint sticking therapy and non-acupoint sticking therapy for childhood CVA was conducted. The trials’ quality and risk bias were assessed using the Cochrane Handbook tool. Odds ratio (OR) or risk ratio (RR) with 95% confidence intervals (CIs), mean differences (MDs) or standardized mean differences (SMDs) of a random-effects model were calculated. Heterogeneity was assessed by P value and I2 statistics. RESULTSThirteen studies were included in our review, indicating that the total effective rate of stimulating-acupoint group is better than that of control group [RR 1.19, 95% CI (1.13-1.26), P < 0.000 01]. The recurrence rate in two years [RR 0.31, 95% CI (0.19-0.51), P < 0.000 01] and cough duration [MD = −2.42, 95% CI (–3.75, −1.09), P = 0.0004] of childhood CVA in stimulating-acupoint group were significantly lower than those in control group. Besides, stimulating acupoints can reduce the level of IgE [SMD = −0.75, 95% CI (–1.21, −0.30), P = 0.001] and EOS [SMD = −0.36, 95% CI (–0.92,0.21), P =0.22]. CONCLUSIONOur findings suggest that stimulating acupoints had positive effects on childhood CVA and was relatively safe treatment. However, more RCTs with more useful indicators are warrant to confirm the current findings.

Observation of curative effect of acupuncture combined with Anchang powder acupoint application in the treatment of irritable bowel syndrome with diarrhea

Objective To study the effects of acupuncture combined with Anchang powder acupoint application in the treatment of irritable bowel syndrome with diarrhea. Methods A total of 100 patients with irritable bowel syndrome with diarrhea in our hospital from July 2014 to July 2016 were enrolled.The subjects were randomly divided into the control group (n=50) and the treatment group (n=50). The control group were treated with trimebutine, while the treatment group were treated with acupuncture combined with Anchang powder acupoint application. The two groups were treated for 4 weeks. The clinical effects of the two groups after treatment were compared. The clinical symptom scale was used to evaluate the clinical symptoms, and the quality of life was evaluated by the quality of life scale (QOL) The recurrence rate after half a year heal of the two groups were compared. Results The total efficacy rate of the treatment group was 92.0% (46/50), significantly higher than 68.0% (34/50) of the control group (χ2=9.000, P=0.003). After treatment, the clinical symptom integral (1.89 ± 0.95 vs. 4.02 ± 1.13, t=10.202) of the treatment group were significantly lower than the control group (P<0.05). After treatment, the quality of life rating scores (34.15 ± 6.75 vs. 28.47 ± 5.01, t=4.803) of the treatment group were significantly higher than the control group (P<0.01). Half a year after treatment, the recurrence rate of the treatment group was 24.1% (7/29), significantly lower than 64.7% (11/17) of the control group (χ2=7.405, P=0.007). There was no significant difference of the two groups during the treatment. Conclusions Acupuncture combined with Anchang powder acupoint application showed a good efficacy for the patients with irritable bowel syndrome with diarrhea. And the treatment showed the low incidence of adverse reactions and low recurrence rate, can mprove the clinical symptom and quality of life. Key words: Irritable bowel syndrome; Acupuncture therapy; Acupoint sticking therapy; Clinical study

Effects of acupoint application combined with modified Xiaoqinglong decoction on airway remodeling and inflammatory factors levels in patients with bronchial asthma

Objective To explore the effects of acupoint application combined with modified Xiaoqinglong decoction on airway remodeling and serum C-reactive protein (CRP), interleukin-8 (IL-8) and eosinophil chemotactic factor (eotaxin) levels in patients with bronchial asthma. Methods A total of 78 patients with bronchial asthma were randomly divided into two groups, 39 cases each group. The control group was treated with conventional western medicine therapy, and the study group was treated with acupoints plus Xiaoqinglong decoction on the basis of the control group. The treatment effect, adverse reaction were observed, and airway remodeling associated indicators like Transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and serum CRP, IL-8, Eotaxin levels were detected as well. Results After treatment, the clinical asthma control rate was 87.18% (34/39) in the study group and 58.97% (23/39) in the control group, and the difference was statistically significant (χ2=7.885, P 0.05). Conclusions The acupoint application combined with modified Xiaoqinglong decoction can significantly improve the clinical effect, inhibit airway remodeling, decrease the level of serum CRP, IL-8 and Eotaxin in patients with bronchial asthma, and its safety is high. Key words: Asthma; Bronchi; Acute diseas; e Acupoint sticking therapy; Xiao Qing Long Tang; Airway remodeling; Inflammatory cytokines

Clinical study of abdominal acupoint massage combined with sticking therapy in the treatment of constipation after thoracolumbar fracture

Objective To investigate the clinical effect of massage combined with abdominal acupoint sticking therapy in the treatment of constipation after thoracolumbar fractures. Methods 50 thoracolumbar fracture patients with constipation were selected as the research subjects.According to the computer random grouping, all patients were divided into two groups, 25 cases in each group.The control group received phenolphthalein tablets.The observation group underwent abdominal acupoint massage and sticking therapy treatment.The two groups were treated for a course of 7 days.The clinical curative effect, defecation feeling, stool, defecation frequency and number of vector gas were compared between the two groups. Results After treatment, the proportions of defecation and carefree, laborious and soft, dry in the observation group were 76.00%, 24.00%, 88.00%, 12.00%, respectively, compared with the control group, there were statistically significant differences (χ2=6.65, 6.35, all P<0.01). The total improvement rate after treatment in the observation group was 96.00%, which was significantly higher than 72.00% in the control group(χ2=5.36, P=0.02). After treatment for 48 hours and 72 hours, the frequency of defecation and the number of vector gas times in the observation group were higher than the control group(t=6.22, 22.37, 10.29, 8.97, all P<0.05). Conclusion Abdominal acupoint massage combined with sticking therapy in the treatment of constipation after thoracolumbar fractures has significant clinical effect. Key words: Constipation; Phenolphthalein tablets; Acupoint sticking therapy; Massage; Lumbar vertebrae

The clinical effect of acupoint application for the patients with the chronic insomnia with liver-stagnation and Spleen-deficiency syndrome

Objective To observe the clinical effect on sleep improvement about acupoint application in treating the chronic insomnia of Liver-stagnation and Spleen-deficiency Syndrome. Methods A total of 68 patients with chronic insomnia with Liver-stagnation and Spleen-deficiency Syndrome were randomly and blindly divided into treatment group and control group by registration order. In the treatment process, 1 was eliminated and 33 were completed in the treatment group, 2 were eliminated and 32 were completed in the control group. The treatment group underwent An Mian Tie therapy half an hour before bed and the control group underwent placebo therapy in the same way of treatment group. Two groups were treated for 40 days and followed-up visit six months. The change of Pittsburgh Sleep Quality (PSQI), Index Insomnia Severity Index (ISI) and TCM Syndromes Scale were detected. Results The clinical total effective rate of treatment group was 72.7% and the control group was 9.4%, and the difference was statistically significant (χ2=46.977, P<0.01). The PSQI scores after treatment (7.55 ± 1.52 vs. 13.90 ± 2.44, t=148.165), and follow up 1 month (8.97 ± 2.51 vs. 13.17 ± 2.79, t=37.926) in the treatment group were significantly lower than those in the control group (P<0.01). The ISI scores after treatment (7.03 ± 3.37 vs. 20.89 ± 4.40, t=73.75), and follow up 1 month (9.81 ± 3.16 vs. 19.41 ± 3.66, t=40.79) in the observation group were significantly lower than those in the control group (P<0.01). The TCM Syndromes Scale scores after treatment (2.05 ± 1.09 vs. 6.98 ± 1.23, t=17.116), and follow up 1 month (4.06 ± 1.59 vs. 6.83 ± 0.91, t=68.055) and follow up 6 month (5.12 ± 1.84 vs. 7.19 ± 1.07, t=27.716) in the observation group were significantly lower than those in the control group (P<0.01). Conclusions Acupoint application could obviously change the sleep quality and Chinese medicine symptom in chronic insomnia of Liver-stagnation and Spleen-deficiency Syndrome. Key words: Insomnia; Liver-Qi stagnation and spleen deficiency; Acupoint sticking therapy; Clinical study

Clinical study on the effect of oral and acupoint application of traditional chinese medicine combined with azithromycin for the children with mycoplasma pneumonia

Objective To investigate the clinical curative effect of oral and acupoint application of traditional chinese medicine combined with Azithromycin for the children with Mycoplasma Pneumonia. Methods A total of 160 children with mycoplasma pneumonia were divided into two groups according to digital random table method, with 80 cases in each group. The patients of the two groups were given conventional treatment to relieve cough and reduce phlegm; On the basic treatment of conventional treatment, the control group were treated with azithromycin, wile the treatment group were treated with oral traditional chinese medicine Tinghuang runfei decotion and acupointion application of Tinglizi, Baijiezi, Shengnanxing, Dahuang, and Bingpian. The treatment of both groups last 3 weeks. The time of defervescence, the disappearance time of cough and pulmonaryrales of the two groups were compared, and the serum levels of inter leukin 8 (IL-8), tumor necrosis factor- (TNF-α), thrombin regulatory proteins (TM), D-dimer were compared before and after treatment. The total effect rate and the incidence of adverse events were compared. Results The defervesce time (3.79 ± 1.68 d vs. 4.88 ± 1.61 d, t=3.846), disappearance time of cough (8.21 ± 2.42 d vs. 10.35 ± 2.60 d, t=5.389) and disappearance time of pulmonary rales (6.21 ± 1.89 d vs. 7.78 ± 2.08 d, t=4.997) in the treatment group were significantly less than those in the control group (P<0.01). The levels of IL-8 (9.98 ± 4.26 ng/L vs. 14.18 ± 4.82 ng/L, t=5.840), TNF-α (20.78 ± 5.93ng/L vs. 26.07 ± 6.42 ng/L, t=5.414), TM (9.63 ± 2.88 μg/L vs. 13.08 ± 3.37 μg/L, t=6.961), D-dimer levels (0.09 ± 0.04 ng/L vs. 0.15 ± 0.06 ng/L, t=7.442) the treatment group were significantly better than those in the control group (P<0.01). The total effect rate in the treatment gruop was significantly higher than that of the control group (97.5% vs. 88.8%; χ2=4.783, P=0.029), but there was no significant difference in the incidence of adverse events between the two groups (16.3% vs. 10.0%; χ2=1.370, P=0.272). Conclusions Oral and acupointion of traditional chinese medicine Tinghuang runfei decotion combined with azithromycin could relieve the symptoms, improve the clincal effect and show its safety for the children with mycoplasma pneumonia. Key words: Mycoplasma pneumoniae; Tinghuang-Runfei decotion; Acupoint sticking therapy; Azithromycin

Bufei Yishen Granules Combined with Acupoint Sticking Therapy Suppress Inflammation in Chronic Obstructive Pulmonary Disease Rats: Via JNK/p38 Signaling Pathway.

The present study was initiated to explore the mechanism of the effects of Bufei Yishen granules combined with acupoint sticking therapy (Shu-Fei Tie) on inflammation regulated by c-Jun N-terminal kinase (JNK) and p38 MAPK signaling in COPD rats. Seventy-two rats were divided into healthy control (Control), Model, Bufei Yishen (BY), acupoint sticking (AS), Bufei Yishen + acupoint sticking (BY + AS), and aminophylline (APL) groups (n = 12 each). COPD rats were exposed to cigarette smoke and bacteria and were given the various treatments from weeks 9 through 20; all animals were sacrificed at the end of week 20. MCP-1, IL-2, IL-6, and IL-10 concentrations in BALF and lung tissue as well as JNK and p38 mRNA and protein levels in lung were measured. The results showed that all the four treatment protocols (BY, AS, BY + AS, and APL) markedly reduced the concentrations of IL-2, IL-6, and MCP-1 and levels of JNK and p38 MAPK mRNA, and the effects of Bufei Yishen granules combined with acupoint sticking therapy were better than acupoint sticking therapy only and aminophylline. In conclusion, the favorable effect of Bufei Yishen granules combined with Shu-Fei Tie may be due to decreased inflammation through regulation of the JNK/p38 signaling pathways.