Acupoint Injection Therapy Research Articles

Clinical Analysis of Acupuncture Combined with Acupoint Injection for the Treatment of Chronic Nonbacterial Prostatitis

Objective: To evaluate the therapeutic effect of acupuncture combined with acupoint injection on chronic nonbacterial prostatitis (CNP). Methods: A total of 72 CNP patients admitted between March 2022 and October 2023 were selected. The patients were randomly divided into two groups using a random number table. The combined treatment group (36 cases) received acupuncture combined with acupoint injection therapy, while the control group (36 cases) received conventional Western medicine treatment. The overall efficacy rate, symptom severity, prostatic fluid indicators, incidence of adverse reactions, and recurrence rates were compared. Results: The overall efficacy rate of the combined treatment group was higher than that of the control group (P < 0.05). After 10 days of treatment, the symptom severity score of the combined treatment group was higher than that of the control group, and the prostatic fluid indicators were lower than those of the control group (P < 0.05). The incidence of adverse reactions in the combined treatment group was lower than in the control group (P < 0.05). During the follow-up period of 1–6 months, the recurrence rate in the combined treatment group was lower than that in the control group (P < 0.05). Conclusion: Acupuncture combined with acupoint injection can alleviate CNP disease symptoms, improve prostate function, and prevent post-treatment adverse reactions. It also has a lower recurrence risk and demonstrates excellent efficacy.

Nursing of acupoint injection therapy combined with intravenous administration of antiemetics in the treatment of nausea and vomiting in a patient with paclitaxel liposome chemotherapy

Nursing of acupoint injection therapy combined with intravenous administration of antiemetics in the treatment of nausea and vomiting in a patient with paclitaxel liposome chemotherapy

Diffusion Tensor Imaging Evaluates Effects of Acupoint Injection at Zusanli (ST36) for Type 2 Diabetic Peripheral Neuropathy.

BackgroundAcupoint injection is a therapeutic method that combines acupuncture and Western medicine and shows good curative effects for neuropathies. This study aimed to explore the efficacy of acupoint injection for treating diabetic peripheral neuropathy (DPN) by magnetic resonance neuroimaging (MRN).Material/MethodsForty patients with DPN were randomly divided into an acupoint injection group (AI; n=20) and intramuscular injection group (MI; n=20). The AI group received an acupoint injection of mecobalamin at acupoint Zusanli (S36); the MI group received intramuscular injection of mecobalamin. The curative effect was evaluated by the Toronto Clinical Neuropathy Score and diffusion tensor imaging (DTI).ResultThe neuropathy scores of both groups decreased from baseline (AI 9.31±2.36; MI 9.34±2.54) to after the 2-week treatment (AI 7.12±1.87; MI 7.86±2.11); the differences were not significant. The fractional anisotropy (FA) value showed significant differences on the common peroneal nerve (AI 0.36±0.04; MI 0.31±0.05; P<0.05) and tibial nerve (AI 0.38±0.07; MI 0.34±0.06; P<0.05) after treatment. Likewise, apparent diffusion coefficient (ADC) values between groups showed significant differences for the common peroneal nerve (AI 1.44±0.17×10−3 mm2/s; MI 1.61±0.20×10−3 mm2/s; P<0.05) and tibial nerve (AI 1.54±0.22×10−3 mm2/s; MI 1.60±0.17 10−3 mm2/s; P<0.05).ConclusionsPatients with DPN showed lower nerve FA and higher ADC in DTI-MRN. The acupoint injection of mecobalamin could treat DPN and repair the damaged nerves, which was shown by elevated FA and lowered ADC. Our study provides clinical evidence for the application of acupoint injection therapy and the evaluation of DPN by MRN.

Problems of acupoint injection therapy

There are a large number of clinical reports that acupoint injection therapy is effective, but there are still some basic problems that have not been effectively resolved, such as the type, dosage, concentration and compatibility of acupoint injection drugs. This article analyzes and discusses the problems of acupoint injection therapy in five aspects: the effect of acupoint injection on local tissues, the study of mechanism, the best treatment plan and advantages, and the similarities and differences with local injection therapy.

Acupoint injection therapy for diabetic retinopathy: A protocol for systematic review and meta-analysis.

Background:Diabetic retinopathy (DR) is a common diabetic microvascular complication, and it is also the main cause of blindness in adults. At present, some studies have reported acupoint injection for the treatment of DR. However, the effectiveness and safety are still uncertain. This study aims to evaluate the efficacy and safety of acupoint injection for the treatment of patients with DR.Methods:The databases of English databases (PubMed, Embase, Cochrane Library, Web of Science) and Chinese databases (China National Knowledge Infrastructure, Chinese Scientific Journal Database, Wanfang Database, and Chinese Biomedical Literatures Database) will be retrieved. Published randomized controlled trials and quasi-randomized controlled trials on the topic will be retrieved by 2 investigators independently. We will apply a fixed-effect model or random effect model basis on the heterogeneity test and employ with RevMan 5.3 software for data synthesis. The total effective rate will be selected as the primary outcome, visual acuity, hemorrhage areas, exudates, capillary nonperfusion areas, hemorheological indicators, mean defect of visual field, glycated hemoglobin, and adverse events as secondary outcomes.Results:This study will comprehensively summarize the high-quality trials to determine the effectiveness and safety of acupoint injection treatment for patients with DR.Conclusion:The systematic review of this study will summarize the currently published evidence of acupoint injection treatment for DR to further guide its promotion and application.Protocol registration number:INPLASY2020110026

Acupoint injection treatment for non-dialysis dependent chronic kidney disease: A meta-analysis of randomized controlled trials.

Aim:To analyze the effects of acupoint injection in the treatment of non-dialysis dependent chronic kidney disease through a systematic review with meta-analysis.Methods:This systematic review with meta-analysis was conducted following the recommendations of the declaration of PRISMA. Full-text literature of randomized controlled trial of acupoint injection therapy for non-dialysis chronic kidney disease was searched in PubMed, Embase, Cochrane Library, China National Knowledge Internet, the Chinese Scientific Journal Database, the Wanfang Database, China Biology Medicine database. The efficacy and safety of acupoint injection for non-dialysis chronic kidney disease were evaluated.Results:Seventeen studies containing 1414 patients met the criteria. The results shows that acupoint injection combined with basic treatment can significantly improve the levels of Ccr (WMD = 4.81; 95% CI:2.54 to 7.08) and Hb (WMD = 4.56; 95% CI:1.72 to 7.39), reduce the levels of BUN (WMD = −0.90; 95% CI: −1.26 to −0.54)and Scr (WMD = −7.66; 95% CI: −12.39 to −2.93), and improve the effective rate (OR = 3.12; 95% CI: 2.29 to 4.26).Conclusion:Our current analysis showed that combined acupoint injection therapy can reduce the levels of BUN and Scr, and increase Ccr and Hb in non-dialysis CKD patients. However, the existing evidence is still insufficient due to the high risk of included trial bias, and future research needs to improve methodological quality.Registration number: CRD42020168143.

Efficacy and safety of acupoint injection therapy for allergic rhinitis: A protocol for systematic review and meta-analysis.

Background:Allergic rhinitis (AR), characterized by nasal itching, sneezing, and congestion, is a common disorder of nose. In the United States, AR affects 10% to 20% of adults. The negative impact of the high prevalence of AR has caused a great economic burdens worldwide. Modern Western Medicine mainly treats AR with antihistamine drugs, glucocorticoids, allergic immunotherapy (AIT), but it seriously affects patients compliance because of its long course of treatment, high medical costs and side effect. And now, as an important mean of treating AR, acupoint injection has been widely used in clinics, and has achieved significant efficacy.Methods and analysis:The following databases will be searched for relevant information before July 2020: PubMed, Embase, Cochrane Library, Web of Science, and CNKI. Major results: scores of Rhinitis Quality of Life (RQLQ), Rhinitis Total Symptom Scores (RTSS). Secondary results: levels of antigen-specific serum immunoglobulin E (IgE), total effective rate, adverse event. Data will be collected independently by 2 researchers, and the risk of bias in meta-analysis will be evaluated according to “Cochrane Handbook for Systematic Reviews of Interventions”. All data analysis will be conducted using Review Manager V.5.3. and Stata V.12.0.Results:The curative effect and safety of acupoint injection treatment for AR patients will be evaluated systematically.Conclusion:The systematic review of this study will summarize the currently published evidence of acupoint injection treatment for AR to further guide its promotion and application.Ethics and dissemination:The private information from individuals will not be published. This systematic review also will not involve endangering participant rights. Ethical approval is not required. The results may be published in a peer-reviewed journal or disseminated in relevant conferences.Open Science Framework (OSF) registration number: https://osf.io/fa9dq.

Autologous blood or autologous serum acupoint injection therapy for psoriasis vulgaris

Background:Psoriasis vulgaris (PV) is a refractory and relapsing skin disease that affects the physical and mental health of patients and leads to poor quality of life. Current conventional systemic therapy shows a large side effect, which can not be used for a long time, easy to relapse after drug withdrawal, long-term efficacy is poor. At present, traditional Chinese medicine treatment of psoriasis vulgaris effective, can alleviate symptoms, improve the quality of life, stabilize the condition, prolong the remission period. Whereas, there is no related systematic review and meta-analysis. Thus, we intend to conduct a systematic review and meta-analysis to testify autologous blood or autologous serum acupoint injection therapy for Psoriasis Vulgaris.Methods:Our systematic review will search all randomized controlled trials for autologous blood therapy of PV, electronically and manually, regardless of publication status and language, until March 19, 2020. Databases include PubMed, EMBASE, Web of Science, Cochrane Controlled Trials Register, China National Knowledge Infrastructure, China Biomedical Literature Database, Chinese Science Journal Database, and Wanfang database. Other sources, including reference lists of identified publications and meeting minutes, will also be searched. Manually search for grey literature, including unpublished conference articles.Result:The main outcomes contain the variation of Psoriasis area and severity index, dermatology life quality index, itching score, the effective rate and adverse events from baseline to the end of studies. This study will provide a comprehensive review of the available evidence for the treatment of PV with this therapy.Conclusion:We will summarize sufficient evidence to confirm the therapeutic effect and safety of autologous blood or autologous serum acupoint injection therapy for PV. Due to the data is not individualized, formal ethical approval is not required.INPLASY registration number:INPLASY202040052.

Acupoint Injection for Nonspecific Chronic Low Back Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Studies.

Introduction Nonspecific chronic low back pain (NCLBP) became a public health and economic problem. Acupoint injection was used widely for patients with NCLBP. However, there were inconsistent results on the efficacy for these people. Therefore, this review was performed to systematically assess the efficacy and safety of acupoint injection. Materials and Methods The literature sources were collected via EMBASE, Medline, CENTRAL, CINAHL, CNKI, VIP, Wanfang, and Sino-Med Database from their inception to October 13, 2019. Endnote X7, widely used document management software, was used to manage and screen the literature sources. Each record was screened according to the predetermined inclusion criteria by two review authors independently. Quality assessment tool, “Risk of table,” was used to assess the quality of the included studies according to the recommendation of the Cochrane Handbook for Systematic Reviews of Interventions. Data extraction was performed by one reviewer and verified by another reviewer. Any disagreement was addressed via consulting with a third reviewer in the abovementioned processes. All procedures were performed according to the Cochrane Handbook for Systematic Reviews of Interventions. Results This review included 13 studies involving 1381 patients with NCLBP. Quantitative analysis results indicated that there is no sufficient evidence that acupoint injection can improve the pain of patients with low back pain based on two trails: Visual Analogue Scale (VAS: MD = −1.33, 95% confidence interval (95% CI) −3.30 to 0.64, P=0.18, random-effect model). When assessing the effectiveness of acupoint injection therapy, the results indicated that acupoint injection can improve the effective rate for nonspecific chronic low back pain (OR = 3.64, 95% CI 2.4 to 5.21, P < 0.0001, fixed-effect model). Conclusion There is insufficient evidence to indicate that acupoint injection therapy could improve the pain for patients with NCLBP. However, the level of evidence was downgraded to “very low quality” because of the poor methodological quality and clinical heterogeneity. The results should be interpreted with caution. Higher quality RCTs with more appropriate comparison, more objective outcome instruments, and adequate follow-up periods are necessary to assess the efficacy of acupoint injection for NCLBP. The PROSPERO Research registration identifying number is CRD42019119158.

Autologous whole-blood or autologous serum acupoint injection therapy for chronic urticaria: A systematic review protocol.

Background:Chronic urticaria (CU) is a common and easily recurring skin disease in the world. Many trials have shown that autologous whole-blood or autologous serum acupoint injection therapy is effective in treating CU. There is currently no systematic review of this therapy. The program aims to evaluate the effectiveness and safety of this therapy in patients with CU.Methods:Literature search will be conducted at Medline, PubMed, Excerpt Medica Database, Springer, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Chinese Scientific Journal Database, and other databases. The search date is until May 2019. We will search for popular terms including CU and this therapy. Import the literature electronically. Duplicate documents will be deleted. The primary outcome is the urticaria activity score or other validated scales. Secondary outcomes included response rate, quality of life scale, recurrence rate, and adverse events. A systematic review and search for a randomized controlled trial of this therapy for CU. Implement the Cochrane RevMan V5.3 bias assessment tool to assess bias assessment risk, data integration risk, meta-analysis risk, and subgroup analysis risk (if conditions are met). The mean difference, standard MD, and binary data will be used to represent continuous results.Results:This study will provide a comprehensive review of the available evidence for the treatment of CU with this therapy.Conclusion:This study will provide new evidence for assessing the effectiveness and side effects of this therapy for CU. Since the data is not individualized, there is no need for formal ethical approval.PROSPERO registration number:CRD42019128364.

Clinical study on the application of acupoint injection therapy with vitamin B1 in patients with diabetic peripheral neuropathy

Context: Acupoint injection therapy with Vitamin B1is very effective in the management of diabetic peripheral neuropathy (DPN), and there are few adverse side effects. Aims: The overall purposes of our study are to determine the specific methods of acupoint injection therapy with Vitamin B1for patients with DPN and to demonstrate the effectiveness of this therapy for DPN patients. Settings and Design: The enrolled patients were divided into two groups – the experimental group (75 patients) and the control group (51 patients). Subjects and Methods: We used four main acupoints in our study – EX-B3, ST36, GB39, and GB34. We compared the changes of DPN symptoms, days of pain loss, changes of tendon reflexes, and electromyographic (EMG) parameters between two groups after 15 days of treatment. Statistical Analysis Used: T-test was used to compare the characteristics between different treatments. Results: The best acupoint set for performing the acupoint injection therapy with 5% Vitamin B1, includes EX-B3, ST36, GB34, and GB39. The mean efficiency rate in terms of changes of DPN symptoms was 84.5% that is significantly lower compared with 61.9% of control group. Furthermore, the day of the pain loss of experimental group was significant lower than that of control group and the efficiency rates in terms of patellar reflex and Achilles tendon reflex were 90.0% and 89.1%, respectively (P &lt; 0.05). In the experimental group, EMG parameters were improved significantly. Conclusions: Our study suggests that the acupoint injection therapy with Vitamin B1is preferable, easier, and cost-effective approach in terms of DPN treatment.

Observation on therapeutic effect of electroacupuncture plus acupoint-injection for nerve root sciatica

To observe the clinical effects of electroacupuncture (EA) plus acuoint-injection for nerve root sciatica. A total of 114 cases were randomly divided into an observation group and a control group, 57 cases in each group. The observation group was given EA plus acupoint-injection therapy with Cobamamide. The control group was given oral administration of Diclofenac Sodium Sustained-release Tablets plus muscular injection of Cobamamide. After one-course treatment, the clinical effects were compared between the two groups. The total effective rate was 96.5% in the observation group and 91.2% in the control group, without a statistical significance in the difference between the two groups (P>0.05). The curative rate was 57.9% in the observation group and 21.1% in the control group, with a statistical significance in the difference between the two groups (P<0.05). In the follow-up on the fourth day after the treatment, the recurrence rate was 23.1% in the observation group and 47.9% in the control group, with statistical difference between the two groups (P<0.05). EA plus acupoint-injection therapy for sciatica of nerve roots is remarkable in the clinical effect and needs promotion in clinic.

Observation on the effect of acupoint injection plus massage therapy on primary dysmenorrhea

Objective To observe the clinical effects of acupoint injection therapy plus massage on primary dysmenorrhea (PD).

Clinical observation on treatment of chronic eczema with acupuncture plus acupoint injection therapy

To observe the clinical effects of acupuncture combined with acupoint injection therapy in treating chronic eczema. Seventy patients were randomly divided into two groups. Thirty-six cases in the treatment group were treated with acupuncture, acupoint injection therapy and tapping with plum-blossom needle, while 34 cases in the control group were treated with oral administration of Loratadine plus topical application of Halometasone Cream. After a three-week treatment, the curative and remarkable effective rate and the total effective rate were respectively 80.6% and 97.2% in the treatment group, versus 47.1% and 79.4% in the control group. The differences in the curative and remarkable effective rate and total effective rate between the two groups were statistically significant (all P<0.05). No obvious adverse reaction appeared in the two groups during the treatment. Acupuncture plus acupoint injection therapy is effective for chronic eczema with high in safety.

Clinical observation on the treatment of 69 patients with diabetic neurogenic bladder with acupoint injection therapy

Objective To investigate an effective therapy to cure Diabetic Neurogenic Bladder (DNB).Methods By adopting multi-center,random,comparative and single-blind clinical experiments,138 patients with DNB from three centers were divided equally into two groups,namely a control group and a therapy group.Patients in the therapy group were treated with acupoint injection therapy with Astragalus injection,while others were treated by western medical based therapy.After four weeks,the effectiveness was collected.Results After the treatment,the TCM syndrome integral of the treatment group and the control group was (18.47± 1.67) and (23.19±2.82) respectively,both reduced than that before the treatment[(29.25±2.12) and (29.13 ± 1.69) respectively]; the difference between the two groups after treatment was statistically significant (P＜0.05) ; bladder residual urine volume in the treatment group and the control group was (88.47± 16.7) ml and (143.19±28.2)ml respectively,both reduced than that before the therapy [(308.90±22.6)ml and (305.90± 20.8)ml respectively],the difference between the two groups after treatment was statistically significant (P＜0.05) ;The total effective rate was 88.4％ and 72.5％ in the treatment group and the control group respectively,showing statistical difference(P＜0.05).Conclusion It is confirmed that acupoint injection therapy with Astragalus injection is an effective curative method for DNB. Key words: Diabetic neurogenic bladder; Astragalus injection; Acupoint injection; A multicenter randomized controlled study

Multicenter randomly controlled trial on acupoint injection therapy with Chinese herbal medicines for oculomotor paralysis

ObjectiveTo evaluate the clinical effect of acupoint injection therapy for paralysis of oculomotor nerve with Chinese herbal medicines. MethodsA total number of 456 patients from 3 centers with paralysis of oculomotor nerve were randomly divided into an acupoint injection group and a control group with 228 cases each. Patients in the acupoint injection group were treated with injection of Chinese herbal medicines to Jīngmíng (▪ BL 1), Yángbái (▪ GB 14), Sìbái (▪ ST 2), Tóngziliáo (▪ GB 1) on the affected side, and Gĕnshū (▪ BL 18) on both sides, Compound Angelica Injection was the main drug, and the corresponding acupoints and other injection drugs were also used according to differentiation of syndrome. Patients in the control group were treated with common western medicine. The treatment was given once a day, 10 times constituted one course with 3 days of interval. After 3 courses, the effect was assessed. TCM syndrome score, eyeball movement degree, the sizes of oculi rimae and pupil of the two groups were recorded before and after treatment. ResultsThe effective rate of acupoint injection group was 91.7% (209/228), and that of the control group was 73.6% (168/228). There was statistical significance in comparing the difference between the two groups (P<0.05). TCM syndrome scores of the two groups after the treatment became less obviously than those before the treatment (P<0.01, P<0.05), the score of acupoint injection group was more reduced than that of the control group (P<0.05). Eyeball movement degree and oculi rimae were enlarged and the pupil reduced in the affected eye in both groups after the treatment (all P<0.05). The musculus rectus medialis for the eyeball movement in the acupoint injection group was more improved than that of the control group, and the oculi rimae was bigger in the acupoint injection group than that in the control group (both P<0.05). ConclusionAcupoint injection therapy with Chinese herbal medicines has assured effect on the treatment of oculomotor paralysis.

Applications of Nanomaterials in Acupuncture and Moxibustion Instrument and Materials

By analyzing the relationship between nanotechnology and medical science, especially nanotechnology and acupuncture, the application of nanomaterials for needling therapy, acupoint catgut embedding therapy, acupoint external application, acupoint injection therapy, and meridian point diagnosis were discussed. Nanomaterials will make the development of acupuncture possess an unprecedented domain. It’s pointed out that breakthrough will be achieved from the research of the application of nanomaterials on the development of nano-needles for needling therapy, nano-thread for acupoint catgut embedding therapy, nano-medicine for acupoint external application therapy, nano-drug carrier for acupoint injection therapy, nano-sensor for meridian and acupoint diagnosis.

Significant Neurological Improvement in Two Patients with Amyotrophic Lateral Sclerosis After 4 Weeks of Treatment with Acupuncture Injection Point Therapy Using Enercel

Amyotrophic lateral sclerosis (ALS) is a progressive, uniformly fatal, degenerative disorder of the upper motor neurons that does not currently have an effective treatment regimen. Here, we report two patients with ALS who were treated with 4 weeks of acupuncture injection point therapy using Enercel. These patients were administered 0.25–0.5 cc Enercel Plus IM to specific acupuncture points for 5 days per week for 4 weeks. Patient #1 presented with flaccid paralysis of all four extremities and impaired speech and swallowing. By Week 4, she demonstrated significant improvement in her motor strength in all four extremities (R > L) and improved speech and swallowing. However, she did not continue to receive the Enercel acupoint injections, and she subsequently demonstrated a slow, progressive loss of neurological function during the ensuing 3 months, as shown on follow-up examinations. Patient #2 had significantly impaired speech and mild motor loss in the upper extremities and the left leg. After 4 weeks of treatment, his voice had significantly improved to the point where his speech was understandable and his motor functions had returned to normal. He continued receiving Enercel acupoint injections during the 3-month follow-up period and his clinical improvements were maintained. Thus, these two patients with ALS showed clinical improvements after 4 weeks of Enercel acupoint injection therapy. Follow-up data suggests that ongoing therapy may be necessary in order to maintain these positive effects. This preliminary study merits further study and confirmation.

Research progress of acupuncture and moxibustion in treating diabetes mellitus

This article summarizes the commonly-used acupuncture and moxibustion therapies, such as acupuncture therapy, moxibustion therapy, auriculo-acupuncture therapy, acupoint-injection therapy, electro-acupuncture therapy, acupoint-application therapy and the comprehensive therapy, in the treatment of diabetes mellitus, and explores the possible mechanisms of acupuncture and moxibustion in treating diabetes mellitus from the influence of acupuncture and moxibustion on levels of the blood sugar level, insulin, blood lipid, blood rheology, anti-peroxide, the contents of cAMP and cGMP, and the activity of Na+−K+/ATPase.

Acupoint Injection Therapy for Terminal Cancer Pain

Acupoint Injection Therapy for Terminal Cancer Pain