Activity Of Dapsone Research Articles

Activity of dapsone versus community and hospital bacterial pathogens from the CANWARD study

Activity of dapsone versus community and hospital bacterial pathogens from the CANWARD study

Outcome of Dapsone in the Treatment of Ashy Dermatosis

Background: Ashy dermatosis or Erythema Dyschromicum Perstans is a rare disorder of unknown etiology characterized by asymptomatic,slowly progressive, ashen-gray macular pigmentation of the skin. Various therapies have been tried without any benefit. The anti-inflammatory activity of dapsone on Erythema Dyschromicum Perstans may be the first oral treatment option. Objective: The aim of the present study was to evaluate the efficacy of dapsone in the treatment of ashy dermatosis. Methodology: This study was carried out on total thirty (30) cases having ashy dermatosis & age group 20-60 years were selected for the study of which 16 females & 14 males during the period of January 2010 to December 2011 in the Department of Dermatology & Venereology of Shaheed Suhrawardy Medical College Hospital and Bangabandhu Sheikh Mujib Medical University at Dhaka city of Bangladesh. All the cases were diagnosed clinically & confirmed by histopathological examination. The patients were given Dapsone 100 mg daily for three months & follow up was done for the next 3 months. Results: 16(53.33%) females & 14(46.66%) males were included in the study. Out of thirty patients, two patients (6.66%) shown excellent response, seven patients (23.33%) shown good response, eight (26.66%) patients shown fair response, 8 patients (26.66%) shown poor response & remaining five patients (16.66%) did not show any response clinically. So improvement was shown in 25(83.33%) cases and 5(16.66%) cases show no improvement at all. Conclusion: This study suggests that dapsone has significant efficacy profile for treatment option of ashy dermatosis. DOI: http://dx.doi.org/10.3329/jssmc.v4i1.11998 J Shaheed Suhrawardy Med Coll, 2012;4(1):18-21

Activity of subinhibitory concentrations of dapsone alone and in combination with cell-wall inhibitors against Mycobacterium avium complex organisms.

MICs of dapsone (p-p'-diaminodiphenylsulfone) were determined radiometrically for ten strains each of the Mycobacterium avium complex (MAC) and Mycobacterium tuberculosis. MICs ranged from 50 to 250 micrograms/ml for Mycobacterium tuberculosis and from 2 to 100 micrograms/ml for MAC. However, at a concentration as low as 1.5 micrograms/ml dapsone significantly inhibited growth of MAC bacteria when used in combination with other drugs specifically acting at the mycobacterial cell-wall level. The latter drugs were used in subinhibitory concentrations, and included m-fluorophenylalanine (an inhibitor of mycoside-C biosynthesis), ethambutol (an inhibitor of arabinogalactan biosynthesis), and ethionamide (an inhibitor of mycolic acid biosynthesis). Using a radiometric method (Bactec 460-TB), the activity of dapsone was found to be enhanced for 2/10 strains in the presence of m-fluorophenylalanine, for 3/10 strains in the presence of ethambutol and for 5/10 strains in the presence of ethionamide. A satisfactory correlation between the radiometric data and bacterial viable counts was established.