Active Movement Tasks Research Articles

The Swedish National Facility for Magnetoencephalography Parkinson’s disease dataset

Parkinson’s disease (PD) is characterised by a loss of dopamine and dopaminergic cells. The consequences hereof are widespread network disturbances in brain function. It is an ongoing topic of investigation how the disease-related changes in brain function manifest in PD relate to clinical symptoms. We present The Swedish National Facility for Magnetoencephalography Parkinson’s Disease Dataset (NatMEG-PD) as an Open Science contribution to identify the functional neural signatures of Parkinson’s disease and contribute to diagnosis and treatment. The dataset contains whole-head magnetoencephalographic (MEG) recordings from 66 well-characterised PD patients on their regular dose of dopamine replacement therapy and 68 age- and sex-matched healthy controls. NatMEG-PD contains three-minute eyes-closed resting-state MEG, MEG during an active movement task, and MEG during passive movements. The data includes anonymised MRI for source analysis and clinical scores. MEG data is rich in nature and can be used to explore numerous functional features. By sharing these data, we hope other researchers will contribute to advancing our understanding of the relationship between brain activity and disease state or symptoms.

Observation of Achilles Tendon Collagen Fiber Reorientation in Elderly Persons

[Purpose] To quantitatively evaluate the Achilles tendon collagen fiber orientation of elderly people by measuring the luminance variation coefficient in ultrasound images of active and passive motion tasks of the ankle joints. [Participants and Methods] The subjects were 20 healthy adults aged 60 years or older. Two exercise tasks, one passive movement of the ankle joint and the other active movement of the ankle joint, were performed and measured by ultrasound echo. The luminance average value and the luminance variation coefficient were calculated from the luminance histogram. [Results] The luminance average value increased, and the luminance variation coefficient decreased. The change rate of the luminance variation coefficient was large in the final dorsiflexion position in the passive movement task and in the 0–30% maximal voluntary contraction interval in the active movement task. [Conclusion] The results suggest that collagen fibers in the Achilles tendon of elderly people may be reoriented during active and passive ankle joint movements.

An examination of active inference in autistic adults using immersive virtual reality

The integration of prior expectations, sensory information, and environmental volatility is proposed to be atypical in Autism Spectrum Disorder, yet few studies have tested these predictive processes in active movement tasks. To address this gap in the research, we used an immersive virtual-reality racquetball paradigm to explore how visual sampling behaviours and movement kinematics are adjusted in relation to unexpected, uncertain, and volatile changes in environmental statistics. We found that prior expectations concerning ball ‘bounciness’ affected sensorimotor control in both autistic and neurotypical participants, with all individuals using prediction-driven gaze strategies to track the virtual ball. However, autistic participants showed substantial differences in visuomotor behaviour when environmental conditions were more volatile. Specifically, uncertainty-related performance difficulties in these conditions were accompanied by atypical movement kinematics and visual sampling responses. Results support proposals that autistic people overestimate the volatility of sensory environments, and suggest that context-sensitive differences in active inference could explain a range of movement-related difficulties in autism.

Comparative Functional MRI Study to Assess Brain Activation Upon Active and Passive Finger Movements in Patients with Cerebral Infarction

Purpose: To compare the effects of active and passive movements on brain activation in patients with cerebral infarction using fMRI. Methods: Twenty-four hemiplegic patients with cerebral infarction were evaluated using fMRI. All patients performed active and passive finger opposition movements. Patients were instructed to perform the finger opposition movement for the active movement task. For the passive movement task, the subject's fingers were moved by the examiner to perform the finger opposition movement. Statistical parametric mapping software was used for statistical analyses and to process all data. Results: In the affected hemisphere, sensorimotor cortex (SMC) activation intensity and range were significantly stronger during the passive movement of the affected fingers compared to the active movement of the affected fingers (p < 0.05). However, there were no significant differences between active and passive movements of unaffected fingers in SMC activation intensity and range in the unaffected hemisphere (p > 0.05). In addition, the passive movement activated many other regions of the brain. The brain regions activated by passive movements of the affected fingers tended to center toward the contralateral SMC. Conclusion: Our findings suggest that passive movements induce cortical reorganization in patients with cerebral infarction. Therefore, passive movement is likely beneficial for motor function recovery in patients with cerebral infarction. i 2014 S. Karger AG, Basel

Afferent and Efferent Aspects of Mandibular Sensorimotor Control in Adults Who Stutter

Individuals who stutter show sensorimotor deficiencies in speech and nonspeech movements. For the mandibular system, the authors dissociated the sense of kinesthesia from the efferent control component to examine whether kinesthetic integrity itself is compromised in stuttering or whether deficiencies occur only when generating motor commands. The authors investigated 11 stuttering and 11 nonstuttering adults' kinesthetic sensitivity threshold and kinesthetic accuracy for passive jaw movements as well as their minimal displacement threshold and positioning accuracy for active jaw movements. They also investigated the correlation with an anatomical index of jaw size. The groups showed no statistically significant differences on sensory measures for passive jaw movements. Although some stuttering individuals performed more poorly than any nonstuttering participants on the active movement tasks, between-group differences for active movements were not statistically significant. Unlike fluent speakers, however, the stuttering group showed a statistically significant correlation between mandibular size and performance in the active and passive near-threshold tasks. Previously reported minimal-movement differences were not replicated. Instead, stuttering individuals' performance varied with anatomical properties. These correlational results are consistent with the hypothesis that stuttering participants generate and perceive movements on the basis of less accurate internal models of the involved neuromechanical systems.

Proprioceptive performance of bilateral upper and lower limb joints: side-general and site-specific effects

Superiority of the left upper limb in proprioception tasks performed by right-handed individuals has been attributed to better utilization of proprioceptive information by a non-preferred arm/hemisphere system. However, it is undetermined whether this holds for multiple upper and lower limb joints. Accordingly, the present study tested active movement proprioception at four pairs of upper and lower limb joints, after selecting twelve participants with both strong right arm and right leg preference. A battery of versions of the active movement extent discrimination apparatus were employed to generate the stimuli for movements of different extents at the ankle, knee, shoulder and fingers on the right and left sides of the body, and discrimination scores were derived from participants’ responses. Proprioceptive performance on the non-preferred left side was significantly better than the preferred right side at all four joints tested (overall F1, 11 = 36.36, p < 0.001, partial η2 = 0.77). In the 8 × 8 matrix formed by all joints, only correlations between the proprioceptive accuracy scores for the right and left sides at the same joint were significant (ankles 0.93, knees 0.89, shoulders 0.87, fingers 0.91, p ≤ 0.001; all others r ≤ 0.40, p ≥ 0.20). The results point to both a side-general effect and a site-specific effect in the integration of proprioceptive information during active movement tasks, whereby the non-preferred limb/hemisphere system is specialized in the utilization of the best proprioceptive sources available at each specific joint, but the combination of sources employed differs between body sites.

Motor Homunculus: Passive Mapping in Healthy Volunteers by Using Functional MR Imaging—Initial Results

To determine the concurrence of activation in the primary motor cortex, induced by paradigms of active and passive movement of extremities, by using blood oxygen level-dependent functional magnetic resonance (MR) imaging. The HIPAA-compliant study was approved by the institutional review board, and written informed consent was obtained from the participating volunteers. Functional MR imaging data were collected from 11 healthy volunteers (four women, seven men; age range, 24-42 years) during active and passive movements of hand, elbow, shoulder, ankle, knee, and hip. These data were then mapped onto three-dimensional anatomic images. Volumes of activation were determined by using cross-correlation analysis at a coefficient threshold of 0.4 (P < .01). Regions of interest were drawn in pre- and postcentral gyri based on anatomic criteria. The mean number of activated voxels in the pre- and postcentral gyri induced by active and passive movements was compared by using Wilcoxon analysis. Concurrence ratios and proportional ratios of activation between active and passive movements were calculated for each somatotopic location. Primary motor cortex activation tended to increase with active compared with passive movements, although in the precentral gyrus, hand, elbow, and shoulder movements showed no statistically significant difference in mean number of activated voxels. In the postcentral gyrus, only the shoulder revealed a significant difference (P < .05). Concurrence ratios (activation volume overlap of two tasks/combined activation area of both tasks) ranged from 0.44 to 0.57. Proportional ratios (activation volume overlap of passive task with active task/total activation volume of passive task) ranged from 0.64 to 0.82. Passive movement paradigms may be an alternative to or complement to active movement tasks in patient populations.

Functional MRI Correlates of Lower Limb Function in Stroke Victims With Gait Impairment

Although knowledge concerning cortical reorganization related to upper limb function after ischemic stroke is growing, similar data for lower limb movements are limited. Previous studies with hand movement suggested increasing recruitment of motor areas in the unlesioned hemisphere with increasing disability. We used ankle movement as a lower limb analog to test for similarities and differences in recovery patterns. Eighteen subjects were selected with chronic residual gait impairment due to a single subcortical ischemic stroke. Functional MRI scans were obtained at 3.0 T during active and passive ankle dorsiflexion in the patients (8 females, 10 males; mean age, 59.9+/-13.5 years; range, 32 to 74 years) and 18 age-matched healthy control subjects. We observed substantial neocortical activity associated with foot movement both in the patients with stroke and in the healthy control subjects. Our primary finding was increased cortical activation with increasing functional impairment. The extent of activation (particularly in the primary sensorimotor cortex and the supplementary motor area of the unlesioned hemisphere) increased with disability. The changes were most prominent with the active movement task. Using ankle movement, we observed increased activation in the unlesioned hemisphere associated with worse function of the paretic leg, consistent with studies on movement of paretic upper limbs. We interpret this finding as potentially adaptive recruitment of undamaged ipsilateral motor control pathways from the supplementary motor area and (possibly maladaptive) disinhibition of the ipsilateral sensorimotor cortex.

Detection of the neuronal activity occurring caudal to the site of spinal cord injury that is elicited during lower limb movement tasks

Functional magnetic resonance imaging (fMRI) of the spinal cord (spinal fMRI) was used to detect neuronal activity elicited by passive and active lower limb movement tasks, in regions caudal to the injury site in volunteers with spinal cord injury. The objectives of this project are: (1) to assess the use of spinal fMRI as a tool for detecting neuronal function in the spinal cord below an injury, and (2) to characterize the neuronal response to active and passive movement tasks. Institute for Biodiagnostics, National Research Council of Canada, Winnipeg, Manitoba, Canada. fMRI of the spinal cord was carried out in 12 volunteers with cervical or thoracic spinal cord injuries. Spinal fMRI was carried out in a 1.5 T clinical MR system using established methods. Active and passive lower limb movement tasks were performed, and sagittal images spanning the entire lumbar spinal cord were obtained. Activity was detected in all volunteers regardless of the extent of injury. During both active and passive participation, activity was seen caudal to the injury site, although the number of active voxels detected with passive movement was less than with the active movement task. Average percent signal change was 13.6% during active participation and 15.0% during passive participation. Spinal fMRI is able to detect a neuronal response during both active and passive lower limb movement tasks in the spinal cord caudal to the injury site.

The discharges during movement of cells in the ventrolateral thalamus of the conscious monkey.

1. Monkeys were trained to perform a stereotyped movement task in return for food rewards. On completion of training a headpiece which allowed microelectrode access to the thalamus for single cell recordings during performances of the task was attached at a surgical operation. The location of each cell studied was determined by histological examination of the fixed brain and precise identification of electrode tracks. 2. Ninety-three of ninety-seven cells discharging in association with arm movements but not responding to natural activation of peripheral receptors in the forelimb were located predominantly in the rostral part of nucleus VPLo and the caudo-ventral part of VLo. These cells appeared to be associated with active movement in one direction of a specific joint. 3. 52% of these 'motor' cells discharged in association with movements of either forelimb. The other 48% discharged in association with movement of the contralateral arm and hand only. 4. Sixty cells responded to stimulation of deep receptors or to passive limb manipulation in the relaxed and cooperative animal. These cells were predominantly located in the ventro-caudal part of VPLo and all the responses were obtained from contralateral receptors. Their discharges during performances of the motor task were indistinguishable from those of 'motor' cells. 5. Ninety-two cells were driven by limb manipulation and by natural activation of superficial cutaneous receptors and these were found predominantly in VPLo and VPLc. All responses were from contralateral receptors. These cells discharged during performance of the motor task; for some of them, their afferent input zones were not being stimulated by contact with the manipulandum when their 'motor' discharges commenced. 6. Although responses in each of the above groups of cells were sought by imposing a sudden perturbation of the limb during the performance of the active movement task, no responses were seen.