Management Activities Research Articles

CellKine clinical trial: first report from a phase 1 trial of allogeneic bone marrow–derived mesenchymal stem cells in subjects with painful lumbar facet joint arthropathy

Abstract Background: Lumbar facet joint arthropathy (LFJA) is a major cause of low back pain (LBP), with current treatments offering limited long-term benefits. Bone marrow–derived mesenchymal stem cells (BM-MSCs) show promise due to their immunomodulatory and trophic effects, potentially addressing underlying degenerative processes in LFJA. Objectives: This initial report describes the outcomes of the first treated patient in an ongoing mutidisciplinary phase 1 clinical trial evaluating the safety and feasibility of intra-articular allogeneic BM-MSCs for painful LFJA. Methods: Following enrollment in our IRB-approved protocol, symptomatic LFJA was confirmed through double blocks on L4 and L5 medial branches. Two 1-mL syringes, each containing 10 million BM-MSCs, were prepared in the cGMP facility and administered bilaterally to the patient’s L4-L5 lumbar facet joints. The patient underwent standardized follow-ups, including clinical examinations and functional and imaging assessments for 2 years, utilizing patient-reported outcomes measurement information system—computer adaptive tests (PROMIS CATs), visual analogue scale, Oswestry disability index, work functional status and opioid pain medication use, and MR imaging Fenton–Czervionke score. Results: The patient tolerated the procedure well, with no drug-related adverse events during the study period. Pain, spine function, and work functional status improved at multiple follow-ups. This patient also reported improvements in mental and social health, along with a notable improvement in the grade of facet synovitis observed at the one-year follow-up MRI evaluation. Conclusions: This case report suggests the safety and feasibility of administering intra-articular allogeneic BM-MSCs, offering therapeutic benefits for pain management and functional activities.

Ship detection in reefs and deep-sea with medium-high resolution images

ABSTRACT Accurate and efficient ship detection is crucial for ocean monitoring and management, especially in reefs and deep-sea, where fishing and illegal activities threaten sustainability of ecosystems. Obtaining the size of ships in reefs and deep-sea helps to identify ship types and to assess the impact of ships on marine ecosystems quantitatively. Ship detections were mainly applied at coast or river of the inland region using high spatial resolution remote sensing data due to its rich details and frequent coverage. However, the ships located in reefs and deep-sea regions were rarely studied because of price, and availability of high spatial resolution remote sensing data. Global covered medium-high resolution (10–30 m) remote sensing data (such as Sentinel-2) makes it possible to obtain the spatial-temporal distribution of ships, especially small ships. This study developed a deep learning ship detection algorithm – an enhanced Rotated-Ship Detector (RShipDet) to detect ships in reefs and deep-sea regions. RShipDet was applied to Nansha Islands based on two medium-high resolution ship detection datasets (Sentinel2-Ship and SDGSAT-Ship). These two datasets include various backgrounds of reefs and deep-sea, and complex scenarios such as cloud cover and parallel ships, adapting RShipDet to ship detection under complex circumstances in reefs and deep-sea. The results showed that: (1) Small gains: gains of 3.3% and 8.7% Average-Precision (AP) compared to Rotation-equivariant Detector (ReDet) and Faster-RCNN on Sentinel2-Ship dataset; (2) Strong generalization capabilities: 77.4% AP on SDGSAT-Ship dataset; (3) Better performance under complex conditions: RShipDet obtained more accurate ship detection results over regions with cloud cover, islands and reefs, deep-sea, and ports compared to other classical detectors. Our algorithm could be applied for better management of ocean resources and activities in reefs and deep-sea.

Implementation of a New Classification and Stratification System for Solitary Bone Tumor: Osseous Tumor Radiological and Interpretation and Management System (OT-RIMS)

Abstract Objectives To propose a histological-grades-based Osseous Tumor Radiological Interpretation and Management System (OT-RIMS) that would simplify the radiological evaluation of bone tumors, categorize key radiological features into severity levels, and inform corresponding patient management actions. Methods This retrospective study between January 2015 and August 2022 evaluated patients with solitary bone tumors confirmed by pathology and imaging follow-up received two or three imaging modalities of radiographs, CT, or MRI. Three radiologists independently assessed radiological features, categorized bone lesions based on OT-RIMS criteria, and reached a consensus. Kappa statistics and observed agreement were calculated. Results A total of 341 patients (mean age, 26.0 years; 159 women) were included, with 102 malignant, 177 benign, and 62 intermediate or low-grade malignant bone lesions. Sensitivity and specificity of readers 1, 2, and 3, respectively, in the identification of malignant tumors into OT-RIMS 4 were 93.1% (95 of 102) and 93.3% (223 of 239), 96.1% (98 of 102) and 91.6% (219 of 239), 92.2% (94 of 102) and 89.5% (214 of 239). Inter-reader agreement of OT-RIMS category for three readers was considered excellent (Kendall’s W = 0.924, p < 0.001) with a kappa value of reproducibility in categories 1&2, 3, and 4 of 0.764, 0.528, and 0.930, respectively. Conclusion The OT-RIMS category demonstrated excellent reproducibility despite the reader’s expertise level in categorizing the risk stratification of bone tumors and informing patient management, with histological grades used as the reference standard. Advances in knowledge The OT-RIMS category reliably stratifies bone tumors into four categories corresponding to histological grades and standardized patient management.

Wild Boar Proves High Tolerance to Human-Caused Disruptions: Management Implications in African Swine Fever Outbreaks

Currently, African swine fever (ASF), a highly fatal disease has become pervasive, with outbreaks recorded across European countries, leading to preventative measures to restrict wild boar (Sus scrofa L.) movement, and, therefore, keep ASF from spreading. This study aims to detail how specific human activities—defined as “car”, “dog”, “chainsaw”, and “tourism”—affect wild boar behavior, considering the disturbance proximity, and evaluate possible implications for wild boar management in ASF-affected areas. Wild boar behavior was studied using advanced biologging technology. This study tracks and analyzes wild boar movements and behavioral responses to human disturbances. This study utilizes the dead reckoning method to precisely reconstruct the animal movements and evaluate behavioral changes based on proximity to disturbances. The sound of specific human activities was reproduced for telemetered animals from forest roads from different distances. Statistical analyses show that wild boars exhibit increased vigilance and altered movement patterns in response to closer human activity, but only in a small number of cases and with no significantly longer time scale. The relative representation of behaviors after disruption confirmed a high instance of resting behavior (83%). Running was the least observed reaction in only 0.9% of all cases. The remaining reactions were identified as foraging (5.1%), walking (5.0%), standing (2.2%), and other (3.8%). The findings suggest that while human presence and activities do influence wild boar behavior, adherence to movement restrictions and careful management of human activity in ASF-infected areas is not a necessary measure if human movement is limited to forest roads.

The Benefits of Cognitive Therapeutic Exercise in Symptomatic Arnold–Chiari Syndrome Type I: A Case Report on Gait, Balance, and Pain Management

Background: Chiari malformation is a rare congenital condition in which the cerebellar tonsils herniate through the foramen magnum, causing symptoms related to compression of the surrounding structures. Rehabilitation plays a key role in the pre- and post-operative management of the syndrome, as it can improve strength, range of motion, motor coordination, pain management, and performance of activities of daily living. Methods: This article presents the case of a 43-year-old woman with Chiari malformation 1B who underwent resection of the filum terminale. She presented as an outpatient at the University Hospital “G. Martino” in Messina, complaining of difficulty walking, balance problems, lumbar pain, and heaviness in the lower limbs. Following a multidisciplinary assessment, she underwent an 11-month rehabilitation protocol based on cognitive therapeutic exercise. Results: The patient achieved significant improvements in pain, mental confusion, and quality of life after treatment and at the 12-month follow-up. Conclusions: The results of this study highlight the significant benefits of cognitive therapeutic exercises in Chiari malformation, with improvements in several key areas, including quality of life, pain management, and ability to perform activities of daily living.

The Impact of Cross-Border Banking on Financial Stability

The globalization of financial markets has ushered in an era of interconnectedness, where financial institutions increasingly operate across national borders. This phenomenon, known as cross-border banking, has both potential benefits and risks for financial stability. While it can enhance risk diversification and promote economic growth, it also poses challenges such as contagion effects and regulatory coordination issues. This study aims to comprehensively investigate the impact of cross-border banking on financial stability, particularly within the European Union (EU). By examining the costs and benefits, developing metrics to measure optimal integration, and applying these metrics to EU countries, this research seeks to provide policymakers and regulators with valuable insights into the management of cross-border banking activities. The study begins by analysing the costs and benefits of cross-border banking. While it can offer advantages like risk spreading and increased credit stability, it also introduces risks such as contagion and regulatory challenges. The research explores the interplay between these factors and their implications for financial stability. To quantify the optimal level of cross-border banking integration, the study develops forward-looking indicators. These metrics aim to measure the extent to which a country's banking system is integrated into international markets while minimizing risks. By applying these indicators to EU countries, the research identifies which countries are more susceptible to systemic risks and which ones demonstrate optimal practices. Furthermore, the study investigates the systemic risks associated with cross-border banking, particularly the risk of financial contagion. It examines how the interconnectedness of financial institutions can facilitate the spread of shocks across borders and explores the role of regulatory coordination in mitigating these risks. The research also evaluates the trade-off between cross-border banking integration and local financial stability. While integration can provide diversification benefits, it can also increase vulnerability to external shocks. The study seeks to determine the optimal level of integration that allows countries to benefit from international markets without compromising domestic stability. Finally, the study provides policy recommendations based on its findings. By identifying countries with imbalances or low diversification, the research offers guidance on how to improve financial stability through targeted interventions. The recommendations aim to enhance the resilience of cross-border banking systems and contribute to a more stable and efficient global financial landscape.

Physical activity in the creative learning of adolescents

In the educational context, the use of physical activity as a teaching resource to generate creative learning in adolescents is commonly ignored by teachers, wasting the opportunity that, through body movement, the student can acquire significant knowledge for his life. In this context, the objective of the research was to analyze the incidence of physical activity on the creative learning of adolescents. The quantitative approach was used by collecting quantitative data and its analysis was carried out with the help of computer and statistical tools that showed the reality of the management of physical activities. A population of 129 students was considered the General Baccalaureate of the Gonzalo Abad Grijalva Educational Unit in the city of Chone, province of Manabí – Ecuador. The Results demonstrate a relevant connection between physical activity and the development of thinking skills, obtaining that the strengthening of interpersonal relationships between students, the relaxation of the body, and the promotion of health care, constitute a path for the development of creativity in the acquisition of interdisciplinary knowledge in the educational process.

A Sensor Probe with Active and Passive Humidity Management for In Situ Soil CO2 Monitoring

Soil CO2 concentration and flux measurements are important in diverse fields, including geoscience, climate science, soil ecology, and agriculture. However, practitioners in these fields face difficulties with existing soil CO2 gas probes, which have had problems with high costs and frequent failures when deployed. Confronted with a recent research project’s need for long-term in-soil CO2 monitoring at a large number of sites in harsh environmental conditions, we developed our own CO2 logging system to reduce expense and avoid the expected failures of commercial instruments. Our newly developed soil probes overcome the central challenge of soil gas probes—surviving continuous exposure to soil moisture while remaining open to soil gases—via three approaches: a 3D printed housing (economical for small-scale production) following design principles that correct the usual water permeability flaw of 3D printed materials; passive moisture protection via a hydrophobic, CO2-permeable PTFE membrane; and active moisture protection via a low-power micro-dehumidifier. Our CO2 instrumentation performed well and yielded a high-quality dataset that includes signals related to a prescribed fire as well as seasonal and diel cycles. We expect our technology to support underground CO2 monitoring in fields where it is already practiced and stimulate its expansion into diverse new fields.

Preventive Maintenance Planning for Machines Computer Numerical Control (CNC) Type Hurco Vmx24 to Improve Reliability Using the Reability Centered Maintenance (RCM) Method (Case Study)

Abstract: This paper presents the results of the analysis of Computer Numerical Control (CNC) machine components that result in decreased machine efficiency in the production system with the Reliability Centered Maintenance (RCM) approach. Utilized to improve the performance of machine components. The machine has not been maintained regularly so that at any time the machine can experience damage which results in losses to the company's income. so that an analysis is designed for maintenance planning management activities with the methodology of identifying and analyzing failure factors using the Failure Mode Effect Analysis (FMECA) worksheet, Logic Tree Analysis (LTA), and finally the Action Road Map. The results of the analysis carried out are divided into three categories of maintenance actions, namely, Condition Direction (CD) maintenance, Time Directed (TD) maintenance, Finding Failure (FF) maintenance with a periodic checking interval of 2 times within a period of 12 days.

Configurational risks and innovation performance of complex product systems development: A fsQCA lens

Complex products and systems (CoPS) development demands effective risk management, which is frequently impeded by a lack of clarity regarding the impact of risks on performance. This study aims to investigate how multiple risks jointly affect innovation performance in CoPS projects. Based on the configurational theory and WSR framework, we use fuzzy set qualitative comparative analysis (fsQCA) with data from 97 CoPS projects and examine the combined effects of risks on innovation performance. We identify two types leading to high innovation performance and four patterns causing low innovation performance. The results verify the asymmetrical causality of the influence of risks on innovation performance in CoPS projects. The findings contribute to broadening the relationship studies of risk and innovation performance by adopting an empirical method in the context of CoPS. Moreover, our study can help managers implement flexible risk management activities within CoPS projects, by addressing several equivalent and distinctive paths.

Buffer with N Policy and Active Management

The N policy is a buffer and transmission management scheme proposed for nodes in wireless sensor networks to save energy. It exploits the concept that the output radio of a node is initially switched off until a critical queue of packets is built up. Then, the output transmission begins and continues until the buffer is completely flushed. The cycle then repeats. In this study, we analyze a buffer with the N policy, equipped additionally with active queue management, which allows for dropping some packets depending on the current buffer occupancy. This extension enables controlling the performance of the node to a much greater extent than in the original N policy. The main contribution is the formulae for the key performance characteristics of the extended policy: the queue size distribution, throughput, and energy efficiency. These formulae are proven for a model with a general distribution of service time and general parameterizations of active management during the energy-saving and transmission phases. Theoretical results are followed by sample numerical calculations, demonstrating how the system’s performance can be controlled using active management in the transmission phase, the energy-saving phase, or both combined. The influence of the threshold value in an actively managed buffer is then shown and compared with its passive counterpart. Finally, solutions to some optimization problems, with the cost function based on the trade-off between the queue length and throughput, are presented.

A sustainable integration of mining activity in a tourist mountain territory: The case of GermanascaValley

Every mining activity shows a footprint on the territory. The signs left by mining operations are physical, such as tunnels, extractive waste facilities, dressing plants, but also economic and social, due to job placement, income and knowledge connected to mining activity sensu lato. In the extraordinary context of the Germanasca Valley, mining has coexisted for hundreds of years with the mountain environment of the Alps and with the local population, and has become a fundamental part of local development, intimately connected with the territory and the local economic and social fabrics.The progressive migration of mining crops at lower altitudes has left behind old mining structures that here, more than elsewhere, guaranteed new forms of industrial and geo-tourism. Similarly, the technological advance and the evolution of mining production, towards a higher quality product, with a consequent reduction in the quantities exploited, led over time to a progressive reduction in the number of employed miners. The resilience of the local population, however, balanced the contraction of work in the mine, transforming former miners in tourist guides and increasing the induced activities, passing from the previous “in house” model to an “outsourcing” model, characterized by external management of mine-related activities. The transformation of old mines into museums has certainly contributed to the development of the area, particularly considering a slow tourism that shows scarce attitude to a “fast and junk” tourism. The challenge is to understand if and how geotourism influence, in specific mining areas (such as Germanasca Valley), the attractiveness of a place.

Efforts To Improve Alpinia Galanga Production Capability In The Prosperous Plantation Group In Red Mata Village, Banyuasin I Sub-District, Banyuasin District

This study aims to determine and analyze the improvement of alpinia galanga production capabilities in the Makmur Sejahtera Plantation Group, Merah Mata Village, Banyuasin I District, Banyuasin Regency. This program is a flagship Corporate Social Responsibility (CSR) program of PT PLN Indonesia Power Merah Mata Generating Unit called Kampung Alpinia galanga, which raises the issue of community empowerment. This program aims to develop management activities, production, and distribution of Alpinia galanga agricultural products and support government programs regarding food security in the communities around PLTG Borang. The method used in this research is a qualitative approach with a descriptive method. The Alpinia galanga Village program has been running since 2021 by PT PLN Indonesia Power UP Merah Mata PLTG Borang. Initial planning was carried out to determine the program's roadmap to be implemented through collaboration between PLTG Borang and the alpinia galanga Village Group. The program scheme that is run together is a long-term empowerment program. After the development of alpinia galanga agricultural commodities and the manufacture of alpinia galanga derivative products, farmers are trained to market Alpinia galanga derivatives/product branding, one of the innovations of Alpinia galanga village. PT PLN Indonesia Power UP Merah Mata PLTG Borang runs the Kampung Alpinia galanga mentoring program for residents on an ongoing basis to encourage the economy of residents, as evidenced by the increase in average income from IDR 600,000 to IDR 3,438,679, which reduces poverty by 3.33% in Merah Mata Village in 2023.

Cardiovascular prevention in old age

The enormous potential of cardiovascular prevention in terms of expanding the life span and health span is presently nowhere near being realized. The five classical cardiovascular risk factors body mass index (BMI), systolic blood pressure, non-high-density lipoprotein (non-HDL) cholesterol, tobacco smoking, and diabetes mellitus account for more than half of the cases of incident cardiovascular diseases. Cardiovascular prevention is also effective and adequate in seemingly healthy individuals aged 70years or above, although the association of several cardiovascular risk factors with cardiovascular diseases is less pronounced in old age. The cardiovascular risk of seemingly healthy persons aged 70years or above can validly be determined using the Systematic COronary Risk Evaluation-Older Persons (SCORE2-OP), leading to risk-adjusted clear treatment recommendations. National and international guidelines advocate individualized cardiovascular prevention in several domains including diet, physical activity and risk factor management through to old age.

Optimalisasi Penggunaan Human Resource Information System (HRIS) pada Human Capital Administration of The Foundation

The Foundation is a non-profit organization that focuses on education and empowerment of women in micro-enterprises (MSMEs). The Foundation has several community activity programs such as scholarship programs, batik learning houses, learning house programs for underprivileged community groups, etc. Community Service Activities carried out by STIE Trisakti at The Foundation aim to help organizations improve the accuracy and completeness of data on the HRIS (Human Resource Information System) used by The Foundation so that the process of managing Human Resource (HR) management activities becomes more efficient and appropriate. The STIE Trisakti Community Service Team together with The Foundation team carry out activities to apply management science, especially human resource management, to optimize the use of HRIS as a solution for managing organizational HR by updating employee data through the process of collecting the latest employee data and filling out employee data update forms continuously. The use of HRIS in routine activities is the responsibility of the HC administration unit so that the available data is accurate and can minimize errors that generally occur in the process of organizational HR management activities. Accurate employee data information is an important part of the HR management process to achieve efficiency and effectiveness in achieving success goals.

Formulation and evaluation of herbal microsphere gel

Formulation and evaluation of herbal microsphere gel involves designing a gel-based delivery system for herbal active ingredients encapsulated within microspheres. The process typically includes selecting suitable herbal extracts, encapsulating them into microspheres using techniques like solvent evaporation or emulsion-solvent evaporation, and then incorporating these microspheres into a gel base. Evaluation criteria may include physical characteristics (particle size, morphology), drug release kinetics, rheological properties, stability, and efficacy of the herbal ingredients. This approach aims to enhance the stability, controlled release, and therapeutic efficacy of herbal compounds, offering potential applications in various fields including pharmaceuticals, cosmetics, and personal care products. This present study demonstrated the effectiveness of carbopol based herbal gel containing extracts of tamarind possessing antibacterial activity. Thus, the formulated herbal gel incorporated with tamarind extracts show great promises in the management of antibacterial activity. Gel loaded with microspheres of tamarind was prepared with aim to deliver the drug which passes through transdermal route as it provides quick onset of action when compared to oral route. This gel loaded with microspheres of tamarind was successfully prepared using solvent evaporation method.

Health-enhancing physical activity in obesity management: the need to (seriously) go beyond weight loss.

There are many false hopes around the impact of physical activity and exercise in obesity management, especially regarding weight loss. Narrowly focusing on weight loss only leads to disappointment for patients and practitioners. Indeed, in persons with overweight or obesity, exercise training, specifically aerobic (i.e. endurance) training, is associated with significant additional weight and fat loss compared to the absence of training. However the magnitude of this effect remains modest, amounting to only 2-3 kg additional weight or fat loss on average. We therefore argue that this conversation needs to be re-oriented towards the many potential health benefits of physical activity that can be seen beyond weight loss. Exercise training has been shown to improve the cardiometabolic risk profile by effects including decreasing abdominal visceral fat and improving insulin sensitivity. Aerobic, as well as combined aerobic and resistance (i.e. strength) training, increase cardiorespiratory fitness, a major risk factor for ill health. Resistance training improves muscle strength, another major component of physical fitness, even in the absence of a significant change in muscle mass. Beyond body mass loss, recognizing the broad value of physical activity/exercise in improving health and quality of life of people with obesity is a crucial perspective shift.

VARIAÇÃO BIOMÉTRICA E REPRODUÇÃO DO BIVALVE Anomalocardia flexuosa (BIVALVIA; VENERIDAE) EM DIFERENTES ÁREAS DE PESCA

The bivalve Anomalocardia flexuosa is one of the main fishing resources utilized in artisanal fishing in northeastern Brazil. The objective of the study was to identify the reproductive and biometric variations in the A. flexuosa shell across different fishing areas in the estuary of the Goiana and Megaó rivers in Northeast Brazil, generating information to support strategies for its conservation. Three bimonthly sampling points were used, with P1 being characterized by manual fishing; P2 by more intensive fishing than P1, with the use of less potent fishing gear; and P3 by high-intensity fishing with tools that enhance the collection capacity, such as long-handled nets. For each specimen collected, shell length, shell height, shell width, total weight wet weight, and meat yield were measured to assess size patterns of the organisms and meat yield. Histological analyses were also conducted to identify the reproductive stages. From the analysis of 5,188 captured specimens, it was observed that with P3 presented the lowest body sizes, possibly reflecting overfishing at the site. Growth models were isometric for shell measurements and negative allometric for the length-weight relationship in P1 and P2, and positive allometric in P3. Photomicrographs were taken of 32 specimens for P1, withe 45% males, 48% females and 7% unidentified; and 25 specimens in P3, 12% males, 52% females and 36% unidentified. Regarding reproductive stages, the most representative were the “maturation” and “mature” stages. Due to the evidence of overfishing in P3 and high potential yield in other points, we highlight the need for efficient management actions that mitigate the impacts of overfishing, such as rotation of fishing areas.

Occurrence of plastic additives in coral-reef invertebrates on natural and plastic substrates

Numerous studies have investigated the occurrence of plastic additives in marine biota. Yet, their main vector of transfer into organisms tissues remains unknown. We explored seven common additives in benthic coral reef invertebrates residing on natural/plastic substrates in a protected marine reserve versus an unprotected reef to ascertain whether additives transfer by substrate leaching. Samples of three coral-reef species were extracted and analyzed by GCMS and HPLC. Of the seven chemical additives investigated, dibenzylamine and bis(2-ethylhexyl) phthalate were detected. No significant association was found between additives and substrate type, possibly because these plastics have been submerged for years, and the majority of additives within them have leached. The marine reserve had fewer samples with additives, highlighting the importance of active management. Understanding the transfer vectors of plastic additives into biota is essential for assessing the risk they pose and devising effective management tools for protecting coral reefs.

Do managers have more incentives to hoard bad news during panic? A study of terrorist attacks and stock price crash risk

We identify a robust and significant relationship, both statistically and economically, between the rise in a firm's stock price crash risk and the occurrence of terrorist attacks in the vicinity of the firm's headquarters. The empirical findings support the idea that terrorist attacks often trigger increased performance pressures and elevated investor sensitivities, thereby initiating the information manipulation activities of firm managers. Additionally, we examine the heterogeneous effects of corporate governance quality and firm transparency, indicating that firms with superior corporate governance and transparency are less vulnerable to the impact of terrorist attacks. We offer insights into the economic consequences of managerial behavior responses because of the traumatic shock of terrorist attacks.