The reliable transmission of electrical signals through shielded cables in the presence of electromagnetic interference (EMI) remains a critical challenge for signal integrity. This paper presents a novel and comprehensive approach for measuring and reducing voltage coupling in shielded cables connected to a shielded room from a waveguide. Additionally, we introduce an innovative active EMI filter to effectively mitigate common-mode (CM) and differential-mode (DM) noises, thereby enhancing the overall signal quality. To address the issue of voltage coupling, an open circuit method with a transmission line is considered for the measurement of output voltage at the end of the shielded cable. In order to assess the impact of EMI on transmitted signals, we utilize a state-of-the-art noise separator that enables precise differentiation and characterization of CM and DM noise components. This analysis provides valuable insights into the overall noise profile, guiding the subsequent steps toward noise reduction. An active EMI filter was designed to effectively attenuate the unwanted noise. The filter intelligently targets and mitigates both CM and DM noises, resulting in improved signal integrity. The experimental setup encompasses a shielded room, shielded cables, a waveguide, and the equipment. The obtained output voltage from the shielded cable is 495 V. It is given as an input to the equipment (Cuk converter). The noises are generated when the input voltage is given; the noises are separated by using a noise separator. CM noise obtained at the output of an active noise separator is 118.8 dBµV. DM noise obtained at the output of a differential mode noise separator is 115.8 dBµV. With the active EMI filter, we achieve remarkable reductions in CM and DM noise levels. After adding a filter to the circuit, the noises are reduced below the limit line according to the International Special Committee on Radio Interference standard; the CM noise is 44.8 dBµV and the DM noise is 47.8 dBµV.