Active Constituents Of Traditional Chinese Medicines Research Articles

Study on compatibility of traditional Chinese medicine active constituents with antioxidant activity

To find a research method suitable to multi-component multi-index composition-activity relationship of traditional Chinese medicines (TCMs) with the antioxidant activity of four compatible active constituents of TCMs as the subject. LARS-based regression algorithm and comprehensive weight coefficient method were adopted to study in vitro clearance of DPPH and polyaromatic hydrocarbon with different doses of four compatible active constituents--total flavonoids of Glycyrrhizae Radix et Rhizoma (TFG), Ginkgo Folium extract (GBE), total flavonoids of Epimedii Folium (TFE) and astragaloside (AST) according to the comprehensive efficacy assessment procedures, that is test design, efficacy test and mathematical modeling (model verification). LARS and comprehensive weight coefficient method was adopted to assess the optimal comprehensive efficacy of clearing DPPH and polyaromatic hydrocarbon. The results showed that the optimal dose combination of compatible constituents is TFG-GBE-TFE-AST 1: 0.2545: 0.007 6:0.011 5. The above compatibility of TCMs constituents can effectively clear polyaromatic hydrocarbon and DPPH with a good antioxidation. The uniform design adopted in this experiment, in combination of synthetic weight method, is suitable to the data analysis of "non-linear and small-sample" biotic experiment and the study on screening and assessment of compatibility of TCMs constituents.

Application of ADME process in vivo in combination with network pharmacology in study of traditional Chinese medicine

Application of network pharmacology in traditional Chinese medicine (TCM) will be benefit for clarifying active components and mechanism of action of TCM and increase the study level of new drug of Chinese medicine. ADME process can identify drug components from TCM and obtain the possible metabolites which can clarify active components in vivo. For the complexity of active constituents of TCM, it indicated that the ADME process will be the precondition for application of network pharmacology in TCM. This paper introduced the study ideas of the combination of ADME process in vivo and network pharmacology.

English

Applications of plant biotechnology play increasingly important role in solving food and energy crisis. As the world’s largest country by population, China pays special attention to the development of agricultural biotechnology and biomass energy technology. Several excellent review articles have introduced the research progress of China’s crop biotech and bioenergy. However, plant biotechnology in China has more diverse applications for non-food uses and environmental sustainability. This paper reviews the recent applications of plant biotechnology in bioenergy, biocontrol, traditional Chinese medicine (TCM), and phytoremediation of polluted environments. The emphasis is mainly focused on the bioconversion of biofuels especially bioethanol and the activated carbon, the survey of energy plants rich in hydrocarbons and carbohydrates, the biocontrol agents (plant epiphytic yeasts) and phytoremediation of heavy metal pollution and water eutrophication. Moreover, plant biotechnology shows very good efficacy in the identifications of confused medicinal plants, active constituents of TCM and the taxonomic identification of plant diseases and insects. The huge number of biomass residue and abundant plant resources provide vast application perspectives for China’s plant biotechnology.   Key words: Biomass energy, biocontrol agents, environmental pollution, phytoremediation, plant biotechnology, traditional Chinese medicine.