Activation Parameters Research Articles

Preparation of Humic Acid from Weathered Coal by Mechanical Energy Activation and Its Properties

Humic acid (HA) is rich in functional groups with high activity, which can effectively improve the soil environment. The large reserves of weathered coal in China provide sufficient raw material guarantee for HA extraction and utilization. At present, the activation side of weathered coal is still the main technical difficulty that restricts HA extraction. In this study, the weathered coal from Inner Mongolia was used as the raw material, and the mechanical energy was used to activate the weathered coal through a planetary ball mill, which improved the extraction rate of HA and optimized the molecular structure and composition of HA. The effects of four parameters, namely, ball material ratio, ball milling time, ball milling speed, and ball size, on the free HA content of weathered coal were investigated, the HA was extracted by alkaline extraction method, and the activated weathered coal and the extracted HA were characterized. The results showed that a ball material ratio of 9:1, a ball milling speed of 200 r/min, a ball milling time of 200 min, a milling ball size of Ф5:Ф10:Ф15 = 48:42:45 and 56:42:37 are the optimal parameters for the mechanical energy activation, and the HA extraction rate of activated weathered coal under these conditions reached 82.3%, which was 15% higher than that of the unactivated one. Moreover, the aroma of the ball-milled weathered coal increased, the content of oxygenated functional groups increased, and the molecular weight and aroma of HA increased. This provides scientific theoretical guidance for the preparation of HA with high aromaticity and large molecular weight from weathered coal.

Field theory of active chiral hard disks: a first-principles approach to steric interactions

A first-principles approach for active chiral hard disks is presented, that explicitly accounts for steric interactions on the two-body level. We derive an effective one-body equation for the joint probability distribution of positions and angles of the particles. By projecting onto the angular modes, we write a hierarchy for the lowest hydrodynamic modes, i.e. particle density, polarisation, and nematic tensor. Introducing dimensionless variables in the equations, we highlight the assumptions, which—though inherent—are often included implicit in typical closure schemes of the hierarchy. By considering different regimes of the Péclet number, the well-known models in active matter can be obtained through our consideration. Explicitly, we derive an effective diffusive description and by going to higher orders in the closure scheme, we show that this first-principles approach results in the recently introduced Active Model B +, a natural extension of the Model B for active processes. Remarkably, here we find that chirality can change the sign of the phenomenological activity parameters.

Effect of Mineral Fertilizers on the Biological Activity of Soils using Direct Seeding Technology

In the field, the effect of liquid mineral fertilizers and carbamide ammonium nitrate (LMF and CAN) in the agrocenoses of peas, chickpeas, coriander and flax on the biological activity of chernozems treated for a long time using null technology was studied. Among the biological parameters, the activity of enzymes involved in the carbon cycle (invertases, dehydrogenases), the intensity of soil respiration, the number of microorganisms, and the content of active carbon were evaluated. There is a difference in the effects of fertilizers on crops and different parameters of biological activity. The biological activity of the studied soils varied depending on the type of mineral fertilizer, as well as the cultivated crop.

Activities and Kinetic Parameters of Carboxylesterases in Model Insects depending on a Substrate of the Enzyme

House flies Musca domestica L. (Diptera: Muscidae) serve as a common model organism for testing of insecticides and research of insecticidal resistance mechanisms in insects. One of important stages is to assess of detoxifying enzyme activities including carboxylesterase activities (CarE). In this study, we compared specific activities and kinetic parameters (Vmax and Km) of CarE in adults M. domestica of two laboratory strains (TY, UF) depending on the enzymatic substrate used. The specific CarE activities towards α- and β-naphthyl acetate (α-NA and β-NA) were similar in both males and females of the TY strain. In males of the UF strain, the value of the specific and the maximal velocity (Vmax) of β-NA hydrolysis was 1.90- and 1.57-fold respectively less than that of α-NA; this difference was not observed in females of the same strain. Some characteristics of CarE varied depending on sex of insects when p-nitrophenyl acetate was used as an enzymatic substrate. In particular, the specific activity was 1.62-fold less in males of the UF strain compared to this value in females. The activity and main kinetic parameters of CarE towards α-NA not differed statistically significant depending on sex and the strains. Based on the results obtained we suggest that α-naphthyl acetate is the preferred substrate to evaluate the CarE enzymatic activity in the model insect M. domestica of different strains.

The association between parameters of physical activity and olfactory function-the importance of frequency and moderate intensity.

Overall physical activity (PA) has been linked to decreased olfactory dysfunction and could improve olfactory function. Additionally, decreased olfactory function can contribute to reduced overall PA levels, given its association with neurodegenerative disorders. This study aims to examine the relationship between specific PA parameters (duration, frequency, intensity) and olfactory function in adults. A total of 3,527 participants from the National Health and Nutrition Examination Survey (NHANES) 2013-2014 underwent assessments for weekly PA duration, frequency, and intensity, alongside a smell test (including odors such as chocolate, strawberry, grape, onion, smoke, natural gas, leather, and soap). Correlation analyses and binary logistic regressions using SPSS were used to evaluate associations. The total smell score exhibited small yet significant positive correlations with the duration, frequency, and volume of moderate PA (correlation coefficients ranging between 0.05 and 0.08; all p ≤ 0.05) and frequency of vigorous PA (correlation coefficient of 0.05; p < 0.05). For moderate PA, the duration, frequency, and volume were significantly and positively associated with the ability to correctly detect the smell of grapes while the frequency was significantly and positively associated with the ability to identify smoke and leather odors (odds ratios ranging from 1.01 to 1.07; p < 0.05). For vigorous PA, the frequency of PA was positively associated with the detection of grape smell (odds ratio of 1.05; p < 0.05). Some parameters of an active lifestyle are associated with improved odds of accurately identifying odors by up to 7.4%. Moderate PA duration, frequency, and volume were linked to better olfactory scores, while high-intensity PA had limited associations.

Pulsar Glitch Activities: The Spin Parameters Approach

Glitch activity refers to the mean increase in pulsar spin frequency per year due to rotational glitches. It is an important tool for studying super-nuclear matter using neutron star interiors as templates. Glitch events are typically observed in the spin frequency (ν) and frequency derivative ( ν̇ ) of pulsars. The rate of glitch recurrence decreases as the pulsar ages, and the activity parameter is usually measured by linear regression of cumulative glitches over a given period. This method is effective for pulsars with multiple regular glitch events. However, due to the scarcity of glitch events and the difficulty of monitoring all known pulsars, only a few have multiple records of glitch events. This limits the use of the activity parameter in studying neutron star interiors with multiple pulsars. In this study, we examined the relationship between the activity parameters and pulsar spin parameters (spin frequency, frequency derivative, and pulsar characteristic age). We found that a quadratic function provides a better fit for the relationship between activity parameters and spin parameters than the commonly used linear functions. Using this information, we were able to estimate the activity parameters of other pulsars that do not have records of glitches. Our analysis shows that the relationship between the estimated activity parameters and pulsar spin parameters is consistent with that of the observed activity parameters in the ensemble of pulsars.

Correlation Cosmic Ray Intensity Based on Variation in Solar Activity and Interplanetary Plasma Parameters Using Principal Component Analysis (PCA)

Correlation Cosmic Ray Intensity Based on Variation in Solar Activity and Interplanetary Plasma Parameters Using Principal Component Analysis (PCA)

Substitution reactivity of [Mo3(µ3-O)(µ3-CCH3)(µ-O2CCHCl2)6(CH3OH)3]O2CCHCl2 (Mo3) and the crystallization of a deca-molybdenum cluster [Mo10O10(μ3-O)8(μ-O)8(py)8](py)2 from Mo3 in pyridine

By heating the trinuclear acetate-bridged molybdenum cluster, [Mo3(µ3-O)(µ3-CCH3)(µ-O2CCH3)6(H2O)3]+ in neat dichloroacetic acid for 4 h (T = 115 °C), a new trinuclear molybdenum cluster with chemical formula [Mo3(µ3-O)(µ3-CCH3)(µ-O2CCHCl2)6(CH3OH)3]+ (abbreviated as Mo3) was synthesized. After precipitation from solution with DI water and redissolution in methanol, red crystals formed after one week at 10 °C. To quantify the rate of substitution of the terminal methanol ligands, crystals of the trinuclear cluster were dissolved in 0.1 M pyridine‑d5 and monitored over time using 1H NMR (T = 297–310 K). The rate constant for substitution was found to be kobs298K = 1.87 × 10−4 s−1 and activation parameters equal toΔHobs‡ = 116 (±7) kJ/mol andΔSobs‡ = 74 (±23) J mol−1K−1. In an attempt to substitute the terminal methanol ligands using concentrated pyridine, a deca-molybdenum cluster with a cube-like polyoxomolybdate core was discovered ([Mo10O10(μ3-O)8(μ-O)8(py)8](py)2) (abbreviated as Mo10). Herein, we describe the synthesis, crystallographic data, and substitution reactivity of [Mo3(µ3-O)(µ3-CCH3)(µ-O2CCH2Cl2)6(CH3OH)3]O2CCHCl2 and report on the unexpected formation of [Mo10O10(μ3-O)8(μ-O)8(py)8](py)2 from neat pyridine.

Design and Implementation of Water PH Level and Turbidity Monitoring System

Abstract: Building collapses have become a distressing and recurring issue in Nigeria, necessitating urgent action to mitigate their occurrence. This paper introduces an innovative approach to address this challenge by developing an Automated Structural Health Monitoring System (ASHMS) utilizing a mobile app. Focusing on major cities like Lagos and Abuja, the proposed system employs strategically placed sensors to gather data from various structural elements of buildings. The collected information, encompassing seismic activity, vibrations, bending moments, shear forces, and other key parameters, is wirelessly transmitted to the cloud where it can then be accessed and visualized using mobile app. The system offers real-time insights into the structural integrity of buildings and provides early warnings, thereby contributing significantly to reducing the risk of building collapses. Key findings show that when incorporated into an automated Structural Health Monitoring (SHM) system, the user's mobile app offers essential structural insights, capturing values such as a 0.5-unit vibration level, 20 units of shear force, 50 units of bending moment, and an 89-degree vertical wall angle. The app's userfriendly interface improves the effectiveness of monitoring and overseeing structural health, in line with the overarching objective of promoting safety in construction practices

Automated Structural Health Monitoring System for Mitigating Building Collapse in Nigeria: A Mobile App Approach

Abstract: Building collapses have become a distressing and recurring issue in Nigeria, necessitating urgent action to mitigate their occurrence. This paper introduces an innovative approach to address this challenge by developing an Automated Structural Health Monitoring System (ASHMS) utilizing a mobile app. Focusing on major cities like Lagos and Abuja, the proposed system employs strategically placed sensors to gather data from various structural elements of buildings. The collected information, encompassing seismic activity, vibrations, bending moments, shear forces, and other key parameters, is wirelessly transmitted to the cloud where it can then be accessed and visualized using mobile app. The system offers real-time insights into the structural integrity of buildings and provides early warnings, thereby contributing significantly to reducing the risk of building collapses. Key findings show that when incorporated into an automated Structural Health Monitoring (SHM) system, the user's mobile app offers essential structural insights, capturing values such as a 0.5-unit vibration level, 20 units of shear force, 50 units of bending moment, and an 89-degree vertical wall angle. The app's userfriendly interface improves the effectiveness of monitoring and overseeing structural health, in line with the overarching objective of promoting safety in construction practices.

ОЦЕНКА ТЕПЛОВОГО КОМФОРТА ДЕТЕЙ В ЖИЛЫХ И ОБЩЕСТВЕННЫХ ЗДАНИЯХ

In calculating children's thermal comfort, it is important to consider internal heat emissions, one of the main sources of which are the children themselves (heat exchange with the body surface, breathing, sweating). The accuracy of the calculation is influenced by their number, nature and intensity of activity, age, gender, and other parameters. Most regulatory documents base heat input calculations on a person with the following parameters: male, 20-30 years old, 70 kg, living in a temperate climate. This approach does not account for the physiological and age-specific characteristics of different age groups. The paper examines and refines the physiological parameters of children and uses models to numerically reflect the level of thermal comfort in a room. A calculation method is proposed that uses refined physiological parameters of children and evaluates thermal sensation of the indoor microclimate through the determination of Predicted Mean Vote (PMV) and Predicted Percentage Dissatisfied (PPD). Calculations of several microclimatic regimes were carried out, assessing the state of children of different ages and physical activity levels within the considered microclimate parameters. Analyzing the obtained data led to the conclusion that assessing human comfort using refined energy expenditures allows for a more flexible consideration of the thermal states of children in specific age groups. This enables higher quality regulation of the indoor microclimate of a specific room considering the examined factors.

Effects of Hypoxia and Inflammation on Hepcidin Concentration in Non-Anaemic COVID-19 Patients.

Background/Objectives: This study aimed to explore the influence of hypoxia, inflammation, and erythropoiesis on hepcidin and other iron status parameters in non-anaemic COVID-19 patients admitted to the emergency unit before the introduction of therapeutic interventions. Methods: Ninety-six COVID-19 patients and 47 healthy subjects were recruited. Patients were subdivided into hypoxic or normoxic groups and, after follow-up, into mild and moderate, severe or critical disease severity groups. Iron, unsaturated iron-binding capacity (UIBC), ferritin, C-reactive protein (CRP), and interleukin 6 (IL-6) were measured on automatic analysers. ELISA kits were used for hepcidin and erythropoietin (EPO) determination. We calculated total iron-binding capacity (TIBC) and ratios of hepcidin with parameters of iron metabolism (ferritin/hepcidin, hepcidin/iron), inflammation (hepcidin/CRP, hepcidin/IL-6), and erythropoietic activity (hepcidin/EPO). Results: Hepcidin, ferritin, EPO, CRP, IL-6, ferritin/hepcidin, and hepcidin/iron were increased, while UIBC, TIBC, hepcidin/CRP, and hepcidin/IL-6 were decreased in hypoxic compared to normoxic patients as well as in patients with severe or critical disease compared to those with mild and moderate COVID-19. Regarding predictive parameters of critical COVID-19 occurrence, in multivariable logistic regression analysis, a combination of EPO and ferritin/hepcidin showed very good diagnostic performances and correctly classified 88% of cases, with an AUC of 0.838 (0.749-0.906). Conclusions: The hypoxic signal in our group of patients was not strong enough to overcome the stimulating effect of inflammation on hepcidin expression. EPO and ferritin/hepcidin might help to identify on-admission COVID-19 patients at risk of developing a critical form of the disease.

Walnut Seed Coat (Juglans regia L.), a Plant Effective in Human Health: Antioxidant Activity and in Rats Nephroprotective Effect

In the study, the seed coat (WSC) of Posof (Ardahan/Türkiye) walnuts was extracted to determine their phytochemical components and antioxidant capacities. The effects of bioactive components in the ethanol extract of WSC (E-WSC) on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors were investigated. Additionally, antioxidant enzyme activity parameters were measured in the kidney tissues of Triton WR-1339-induced hyperlipidemic rats. Bioactive compounds in WSC were identified by GC-MS system. The antioxidant properties of WSC were measured using Fe+3, Cu+2 and Fe+3-2,4,6-tripyridyl-s-triazine (TPTZ) reducing agent, 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'- azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) scavenging activities. In this analysis, using 30 male Wistar rats (300 ± 30 g) randomly divided into five groups were treated as follows; K1: Healthy control group, K2: E-WSC (150 mg) o.d., K3: E-WSC (300 mg) o.d., K4: Hyperlipidemic group i.p., K5: Hyperlipidemic group i.p. + E-WSC (300 mg) o.d. Superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) analyzes were performed in kidney tissues. Based on these results, it was clearly determined that E-WSC has significant antioxidant activity due to its bioactive components, has an inhibitory effect on AChE and BChE enzymes, and has a protective effect against oxidative stress by improving hyperlipidemia-related kidney damage.

Sagittal spinal curvatures of young adults in the context of their self-reported physical activity and somatic parameters

The objective of this study was to assess the thoracic kyphosis (ThKA) and lumbar lordosis (LLA) in healthy young adults and to investigate potential relationships between spinal curvatures, self-reported physical activity (PA), and somatic parameters. The study included 380 female students and 211 male students aged 20.7 ± 1.5 years. The ThKA and LLA were measured using a Plurimeter-V gravity inclinometer. The level of PA was estimated using the International Physical Activity Questionnaire. ThKA was lower in women compared to men, while LLA was higher in women than in men (p < 0.0001). Female students reported lower PA than male students (p < 0.001). Female students with ThKA within normal values reported a significantly higher amount of low-intensity PA compared to those with ThKA below or above the norm. A correlation was found between ThKA and body mass index (BMI), body adiposity index (BAI), WC, and fat percentage (rho < 0.2), whereas LLA showed correlations with BMI, BAI, waist circumference, and fat percentage (rho < 0.2). Among male students, a correlation was found between LLA and BMI as well as WC (rho < 0.2). Maintaining a healthy body composition may be instrumental in mitigating the risk of developing spinal curvature abnormalities.

Low concentration adsorption of ammonia using metal halide loaded biogas residue-based carbon materials

Treating wastewater with elevated ammonia nitrogen levels in garbage treatment plants is a global concern, with blow-off recognized as an efficient process for nitrogen removal. However, this method generates low-concentration ammonia, presenting a challenge for adequate recovery. This study addresses this issue by impregnating metal halides onto K2CO3-activated biogas residue to create composite materials tailored for adsorbing low-concentration ammonia. We systematically investigated the impact of activation parameters, metal halide type, loading capacity, and environmental conditions on the adsorption properties of the materials. Notably, at an activation temperature of 700 °C, utilizing copper chloride with a loading capacity of 30 %, the material exhibited a saturation adsorption capacity of 29.32 mg/g for 200 ppm NH3, with a breakthrough time of 45.6 min, significantly surpassing the untreated sample and demonstrated excellent regeneration performance. SEM, BET, and FTIR analyses revealed that the material provided dispersion sites for metal halides, promoted the complexation of metal halides and ammonia and retained pores for ammonia diffusion, thereby enhancing adsorption efficiency. This innovative approach contributes to waste utilization and ensures efficient ammonia recovery through metal halide-ammonia complexation.

A Kinetic and Mechanistic Study of Ir (III)-Catalyzed Oxidation of Methionine by HCF (III) in an Aqueous Alkaline Medium

Introduction: The kinetic study of Ir (III) chloride-catalyzed oxidation of methionine by hexacyanoferrate (abbreviated as HCF) III ions in aqueous alkaline medium was performed spectrophotometrically at constant ionic strength of 0.5 moldm-3 and temperature of 35±0.10C. Method: The progress of the reaction was found to be first-order rate dependence kinetics with respect to [HCF (III)], [OH-], and [IrCl3]. The rate of reaction was found to decrease with an increased concentration of methionine. The ionic strength of the reaction mixture showed a positive salt effect on the reaction rate. Different activation parameters were also evaluated by studying the reaction at four different temperatures. The stoichiometry of the reaction showed Methionine: HCF (III) = 1:4. Result: The oxidation product of the reaction was found to be methionine sulphone, which was identified by an organic solvent method and IR Spectroscopy. Further, a suitable mechanism was proposed to explain all the experimental results. Conclusion: It is assumed that the reaction proceeded through complex formation between substrate (abbreviated) and iridium trichloride. A rate law was derived, which verified the results. CH3-S-(CH2)2-CH (NH2)-COO- + 4HCF (III) Ir (III), H2O CH3-SO2-(CH2)2-CH- (NH2)-COO- + 4HCF (II) result: 1.Methionine sulphone was found to be the main product of oxidation was identified using an organic solvent method and IR Spectroscopy. A suitable mechanism has been proposed to explain all the experimental results. It is assumed that reaction proceeds through complex formation between substrate (abbreviated) and iridium trichloride. A rate law has been derived which verifies the results. CH3 –S-(CH2)2-CH (NH2) – COO- + 4HCF (III) □(→┴(Ir(III),H2O) ) CH3-SO2-(CH2)2-CH (NH2)-COO- + 4HCF (II) 2. Degradation kinetic is anticipated to follow the first order kinetics at lower concentration. 3. The catalytic system can be recycled and reused without loss of activity. 4. The anticipated easy recovery of catalyst from the reaction mixture shows another positive signigficance.

Esaxerenone: blood pressure reduction and cardiorenal protection without reflex sympathetic activation in salt-loaded stroke-prone spontaneously hypertensive rats.

Mineralocorticoid receptor (MR) is involved in the mechanisms of blood pressure elevation, organ fibrosis, and inflammation. MR antagonists have been used in patients with hypertension, heart failure, or chronic kidney disease. Esaxerenone, a recently approved MR blocker with a nonsteroidal structure, has demonstrated a strong blood pressure-lowering effect. However, blood pressure reduction may lead to sympathetic activation through the baroreflex. The effect of esaxerenone on the sympathetic nervous system remains unclear. We investigated the effect of esaxerenone on organ damage and the sympathetic nervous system in salt-loaded stroke-prone spontaneously hypertensive rats (SHRSP), a well-established model of essential hypertension with sympathoexcitation and organ damage. Three-week administration of esaxerenone or hydralazine successfully attenuated the blood pressure elevation. Both esaxerenone and hydralazine comparably suppressed left ventricular hypertrophy and urinary albumin excretion. However, renal fibrosis and glomerular sclerosis were suppressed by esaxerenone but not hydralazine. Furthermore, plasma norepinephrine level, a parameter of systemic sympathetic activity, was significantly increased by hydralazine but not by esaxerenone. Consistent with these findings, the activity of the control centers of sympathetic nervous system, the parvocellular region of the paraventricular nucleus in the hypothalamus and the rostral ventrolateral medulla, was enhanced by hydralazine but remained unaffected by esaxerenone. These results suggest that esaxerenone effectively lowers blood pressure without inducing reflex sympathetic nervous system activation. Moreover, the organ-protective effects of esaxerenone appear to be partially independent of its blood pressure-lowering effect. In conclusion, esaxerenone demonstrates a blood pressure-lowering effect without concurrent sympathetic activation and exerts organ-protective effects in salt-loaded SHRSP. Esaxerenone has antihypertensive and cardiorenal protective effects without reflex sympathetic activation in salt-loaded stroke-prone spontaneously hypertensive rats.

Variation in Activation Parameters for the Preparation of Cellulose-Based Porous Carbon Fibers Used for Electrochemical Applications

Variation in Activation Parameters for the Preparation of Cellulose-Based Porous Carbon Fibers Used for Electrochemical Applications

The impact of Activation on the Performance of Optical Oxygen Sensing with the Luminescent Metal–Organic Framework MOF‐76(Eu)

AbstractThe influence of activation as key parameter for oxygen sensing by luminescent metal–organic frameworks has been investigated and quantified for the archetype MOF‐76(Eu). Activation at different conditions (regarding temperature and solvent‐exchange for distinct vacuum pressure and heating time), shows an influence on the overall quenching, response time and cyclability due to different pore accessibility and surface area and therefore on the overall performance of the sensor. The optical sensing process is based on luminescence quenching, analyzed from high vacuum (10−7 bar) to ambient pressure by dosing oxygen from 0.01 bar to 1 bar. Strong influence of the different activation parameters is observed, as MOF‐76(Eu) activated at 50 °C shows limited quenching of the luminescence intensity within 30 min, while methanol‐exchange and subsequent activation at 250 °C leads to a quenching rate of 98.6 %. In addition, the sensor response occurs more than 1000 times faster within 0.2 s. These results correlate well with physisorption data, which reveal a significant change in porosity and surface area according to the degree of activation. For a better understanding of the involved processes, adsorption isotherms were recorded, surface areas determined and correlated to the photophysical parameters, including Stern‐Volmer kinetics and cycling experiments for the differently activated MOF sensors.

Possibilities of backward walking application in the rehabilitation of patients with gonarthrosis: review

INTRODUCTION. Osteoarthritis of the knee joint or gonarthrosis (GA) is one of the most common joint pathologies. The medical and social significance of GA is associated with its high prevalence and a significant percentage of premature disability and a significant deterioration in the quality of life due to persistent pain syndrome. Modern treatment of patients with GA includes a combination of pharmacological and non-pharmacological methods; physical therapy is the leading method of non-drug therapy. By now, a number of studies have been conducted to research the effectiveness of backward walking (BW) in people with GA. AIM. Analysis of scientific data on the possibilities of using BW in the rehabilitation of patients with GA. MATERIALS AND METHODS. A systematic search of literary sources by keywords was carried out: “backward walking”, “gonarthrosis”, “knee osteoarthritis”, “knee joint”, “rehabilitation”, “physical therapy”. DISCUSSION. Recently, backward locomotion is increasingly used in medicine. Kinetic and kinematic analysis during BW showed a number of advantages over the usual method of movement, which can be successfully used for rehabilitation of patients with GA. BW is associated with less overload on knee joints. It is also one of the few natural ways of strengthening the quadriceps. It prevents excessive stretching of the anterior cruciate ligament and improves the stability of the knee joint. BW leads to a more cardiovascular and respiratory load and a more significant aerobic and anaerobic capacity of the organism compared with forward walking at similar parameters of physical activity. CONCLUSION. There is evidence that adding BW to conventional physiotherapy treatment may further reduce pain, functional disability and improve the strength of the quadriceps muscles.