Action Research Effort Research Articles

T Cell-Engaging Bispecific Antibodies Targeting gp100 and PRAME: Expanding Application from Uveal Melanoma to Cutaneous Melanoma.

Uveal melanoma represents a rare and aggressive subtype of melanoma with limited treatment options and poor prognosis, especially in the metastatic setting. Tebentafusp, a bispecific fusion protein, offers a promising therapeutic approach by targeting gp100, an antigen highly expressed in uveal melanoma cells, and redirecting T cell-mediated cytotoxicity towards tumor cells. This review provides an overview of the preclinical and clinical data on tebentafusp in the management of metastatic uveal melanoma. We summarize the mechanism of action, clinical efficacy, safety profile, and ongoing research efforts surrounding this innovative immunotherapy. Preclinical studies have demonstrated the ability of tebentafusp to induce potent and specific anti-tumor immune responses against gp100-expressing uveal melanoma cells. Clinical trials have shown encouraging results, with tebentafusp exhibiting meaningful clinical activity in a subset of patients with metastatic uveal melanoma. Importantly, tebentafusp has also demonstrated a manageable safety profile. By specifically targeting tumor cells expressing gp100, tebentafusp offers a promising therapeutic avenue for individuals with metastatic uveal melanoma, meeting a significant clinical need in this context. Continued clinical trials will provide additional insights into the impact of tebentafusp on treatment-resistant metastatic cutaneous melanoma. Furthermore, we are exploring the potential of T cell engagers directed against the cancer testis antigen PRAME, which could have widespread utility in the treatment of cutaneous melanoma as well as other PRAME-expressing malignancies.

Participatory ex-ante impact assessment for interactive research and development in agriculture and food systems

ABSTRACT Drawing upon literature from both impact assessment of development projects and agricultural research, the aim of this article is to analyse the pilot testing of a new multi-dimensional assessment framework for defining and evaluating the societal impact of agricultural research and corresponding education. The research approach involves an action research effort of pilot testing in three case studies from three different countries. The framework assumes a systems view, understands impact as socially embedded, and adopts the concepts of contribution and productive interactions rather than cause-and-effect attribution. The emerging experiences include developing both project-specific and universal indicators; gauging impacts at different levels and sustainability dimensions; handling the issues of attribution and time frame; and the role of stakeholder involvement. The results have the potential to support the development of a new role for impact assessment, by enabling principal actors in research and higher education institutions to take responsibility for contributing to concrete and demonstrable sustainability changes in society.

After the Hurricane: Anti-COVID-19 Drugs Development, Molecular Mechanisms of Action and Future Perspectives.

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a new coronavirus in the Coronaviridae family. The COVID-19 pandemic, caused by SARS-CoV-2, has undoubtedly been the largest crisis of the twenty-first century, resulting in over 6.8 million deaths and 686 million confirmed cases, creating a global public health issue. Hundreds of notable articles have been published since the onset of this pandemic to justify the cause of viral spread, viable preventive measures, and future therapeutic approaches. As a result, this review was developed to provide a summary of the current anti-COVID-19 drugs, as well as their timeline, molecular mode of action, and efficacy. It also sheds light on potential future treatment options. Several medications, notably hydroxychloroquine and lopinavir/ritonavir, were initially claimed to be effective in the treatment of SARS-CoV-2 but eventually demonstrated inadequate activity, and the Food and Drug Administration (FDA) withdrew hydroxychloroquine. Clinical trials and investigations, on the other hand, have demonstrated the efficacy of remdesivir, convalescent plasma, and monoclonal antibodies, 6-Thioguanine, hepatitis C protease inhibitors, and molnupiravir. Other therapeutics, including inhaled medicines, flavonoids, and aptamers, could pave the way for the creation of novel anti-COVID-19 therapies. As future pandemics are unavoidable, this article urges immediate action and extensive research efforts to develop potent specialized anti-COVID-19 medications.

Organising for Resilience to Climate Change in Critical Infrastructures: The Application of Viable System Model in an Oil Refinery

Oil refineries are among industrial installations that are vulnerable to climate extreme events, whose frequency and intensity have been increasing over the last decades. Building resilience in resources to withstand climate-related hazards and to recover fast at low human and material cost, for changing climate conditions, is required. In this paper, we present an action research effort for the design of a viable decentralized climate-resilience-providing virtual organization in an oil refinery in Greece using the Viable System Model. The VIPLAN method was employed for the methodological design of a distributed Climate Resilience Providing Organisation for the case of a refinery facility in Greece. The paper presents the process and the results of this effort.

Embedding Life Design in Future Readiness Efforts to Promote Collective Impact and Economically Sustainable Communities: Conceptual Frameworks and Case Example

This is the first of two sequential papers describing the design and first-year implementation of a collaborative participatory action research effort between Sociedad Latina, a youth serving organization in Boston, Massachusetts, and Boston University. The collaboration aimed to develop and deliver a combined STEM and career development set of lessons for middle school Latinx youth. In the first paper, life design and the U.N. Sustainable Development Goals are described in relation to the rationale and the design of the career development intervention strategy that aims to help middle school youth discover the ways that learning advanced-STEM skills expand future decent work opportunities both within STEM and outside STEM, ultimately leading to an outcome of well-being and sustainable communities. In addition to providing evidence of career development intervention strategies, a qualitative analysis of the collaboration is described. The second paper will discuss two additional frameworks that guided the design and implementation of our work. As an example of translational research, the paper will provide larger national and regional contexts by describing system level career development interventions underway using Bronfenbrenner’s bioecological and person–process–context–time frameworks.

Incorporating Future Climate Scenarios in Oil Industry’s Risk Assessment: A Greek Refinery Case Study

The impacts of climate change are anticipated to become stronger in the future, leading to higher costs and more severe accidents in the oil industry’s facilities and surrounding communities. Motivated by this, the main objective of this paper is to develop, for the oil industry, a risk assessment methodology that considers future climate projections. In the context of an action research effort, carried out in a refinery in Greece, we adapted the organization’s extant risk management approach based on the Risk Assessment Matrix (RAM) and suggested a risk quantification process that incorporates future climate projections. The Climate Risk Assessment Matrix (CRAM) was developed to be used to assess the exposure of the facility’s assets, including human resources, to future climate risks. To evaluate CRAM, a comparison with RAM for the specific organization for the period 1980–2004 was made. Next, the application of CRAM for the period 2025–2049 indicated that, even though the resilience of the operations of the company to extreme conditions seems adequate at present, increased attention should be paid in the future to the resilience of refinery processes, the cooling system, and human resources. Beyond the specific case, the paper provides lessons for similar organizations and infrastructures located elsewhere.

Applying Participatory Action Research Methods in Community-Based Adaptation With Smallholders in Myanmar

The effects of climate change to agriculture being largely location specific, it is crucial that adaptation measures recognize the value of targeted, context-specific, community-based strategies and processes. This research deployed participatory action research relying on a diverse range of socio-technical methods for facilitating community-level adaptation in climate-smart villages. Smallholder farms in four unique agro-ecologies in Myanmar were targeted. Results and insights from the 3-year, participatory action research effort chronicle how the climate-smart village approach was implemented in the four targeted climate-smart villages (CSVs). The key support systems needed for effective community engagement in implementing the CSVs are discussed. Social learning helped nurture capacities of farmers to find solutions and test and improve adaptation options. Using a combination of socio-technical processes, smallholder farmers, researchers, and facilitators improved their understanding of climate change, drivers of vulnerability, and coping activities. With this knowledge and understanding, the farmers in the CSVs identified a menu of adaptation options that they would test and adopt (and scale). This “portfolio approach” to deriving adaptation options ensured that there were opportunities for men, women, and landless households to participate in the community adaptation process. This approach allowed farmers to determine what was their preferred entry point. Invariably, such approaches nurture incremental adaptation with associated incremental learning. The research suggests that land tenure regimes influence the nature of the adaptation options and their eventual uptake. In villages with high incidence of landlessness, the adaptation options were limited to homesteads, the small patch of land around the household dwelling. A more secure tenure status provided farmers with freedom to engage in diversified and long-term production systems. Poverty and wealth levels of households were other factors influencing the uptake of adaptation options, especially those aimed at diversifying production for reduced risks.

A Collective Impact Model Towards Increasing STEM Major Student Retention

This article presents the research findings of a multidisciplinary team's collective research effort at one university over a five-year period as funded by the National Science Foundation's Improving Undergraduate STEM Education (IUSE) program. A collaborative learning and retention action research effort at a large Hispanic Serving Institution is analyzed using mixed methods to document the power of collective impact as the foundation for a learning support model for students historically underrepresented majoring in science, technology, engineering and mathematics (STEM) academic programs. The actions of the team of researchers are presented to describe the Rising Stars Collective Impact model and the impacts achieved. This is a model that aligns objectives, intervention efforts, and reports collective results. The long-term goals of the Rising Stars Collective Impact multiple programs managed by the funded program team included the following: (a) to improve the campus sense of community for students historically under-represented in STEM, (b) to establish innovative and robust STEM education research-based practices to support critical skill attainment for students, and (c) to support faculty understanding of the funds of knowledge of diverse students. The positive student retention and success impacts of this research effort are measured through quantitative statistical analysis of the changes in second-year STEM undergraduate student retention rates and representation rates of women, Hispanics, and African American STEM majors.

Towards intelligent and sustainable production systems with a zero-defect manufacturing approach in an Industry4.0 context

The paper addresses intelligent and sustainable production achieved through combination and integration of online predictive maintenance, monitoring of process parameters and continuous quality control of both input materials and output from the process. This enables production systems, within both manufacturing and process industries, to move towards zero-defect manufacturing. Such a zero-defect manufacturing approach allows for earlier identification of problems or issues, which will or already negatively affect the output. The paper outlines the first part of the second cycle of an action research effort at Gestamp HardTech AB in Sweden, whose objective is to keep its position as a world-leading provider of press-hardened vehicle parts. In order to fully implement the zero-defect manufacturing approach, 4-6 action research cycles are expected to be needed in order to iteratively refine the approach. During the first cycle, various methods and solutions for some of the individual issues/problems have been conceptualized, realized and initially tested. The selected design criteria for the action research efforts were: simplicity, low cost, robustness, high-quality output and future-proofing. The result from the research in the second cycle so far is an action plan for the technical change and a set of challenges/problems which need additional investigation.

Towards a policy relevant neighborhoods and health agenda: engaging citizens, researchers, policy makers and public health professionals. SESPAS Report 2018

A large volume of public health literature has shown how the social and physical features of a neighbourhood affect residents’ health, and how they contribute to health inequalities. In this article, we argue that citizens, researchers, policy makers and health professionals should engage in creating a common, policy-relevant neighbourhood and health agenda to effectively improve population health and reduce health inequalities. We discuss four critical processes for advancing this neighbourhood and health agenda: 1) citizen participation and community empowerment; 2) policy making; 3) producing relevant research; and 4) how to best communicate between stakeholders. Various methodologies and experiences currently exist to secure and promote citizen participation. Sufficient funding of research projects and specific policies, as well as continued communication strategies among stakeholders, are necessary elements of this neighbourhood and health agenda. Establishing collaborative and sustained relationships between citizens, policy makers, health professionals and researchers at local and higher political levels is a challenging but necessary step. Developing participatory action research and local participatory policy efforts are important steps towards developing a policy- relevant neighbourhood and health agenda.

UPAYA MENINGKATKAN HASIL BELAJAR PKN DENGAN MENGGUNAKAN MODEL PEMBELAJARAN KOOPERATIF TIPE TGT (TEAMS GAMES TOURNAMENS)

Penelitian ini merupakan penelitian tindakan kelas yang bertajuk PKn meningkatkan hasil belajar dengan menggunakan model pembelajaran kooperatif permainan tim tournamens (TGT) kelas V SD 24 Negeri Betung. Tujuan penelitian ini adalah untuk meningkatkan hasil belajar siswa kelas V SD Negeri 24 Betung melalui model pembelajaran kooperatif TGT. Subyek penelitian adalah siswa kelas V Betung kelas V negeri yang memiliki 21 siswa, terdiri dari 11 laki-laki dan 10 perempuan. Keberhasilan penelitian dianalisis berdasarkan ketuntasan belajar siswa yang memperoleh nilai siklus. Jika tidak selesai dalam hasil belajar siswa ketika mencapai nilai 65 sedangkan kelas jika terdapar dinyatakan tuntas 75% siswa yang mendapat skor 65 atau lebih. Dapat disimpulkan bahwa hasil belajar PKn menggunakan model pembelajaran kooperatif TGT kelas V SD 24 Betung menyatakan negara meningkat. Oleh karena itu, guru disarankan untuk mengembangkan pembelajaran dengan menggunakan model kooperatif tipe TGT karena dapat meningkatkan hasil belajar siswa.

Prioritizing Possibilities for Child and Family Health: An Agenda to Address Adverse Childhood Experiences and Foster the Social and Emotional Roots of Well-being in Pediatrics

ObjectiveA convergence of theoretical and empirical evidence across many scientific disciplines reveals unprecedented possibilities to advance much needed improvements in child and family well-being by addressing adverse childhood experiences (ACEs), promoting resilience, and fostering nurturance and the social and emotional roots of healthy child development and lifelong health. In this article we synthesize recommendations from a structured, multiyear field-building and research, policy, and practice agenda setting process to address these issues in children's health services. MethodsBetween Spring of 2013 and Winter of 2017, the field-building and agenda-setting process directly engaged more than 500 individuals and comprised 79 distinct agenda-setting and field-building activities and processes, including: 4 in-person meetings; 4 online crowdsourcing rounds across 10 stakeholder groups; literature and environmental scans, publications documenting ACEs, resilience, and protective factors among US children, and commissioning of this special issue of Academic Pediatrics; 8 in-person listening forums and 31 educational sessions with stakeholders; and a range of action research efforts with emerging community efforts. Modified Delphi processes and grounded theory methods were used and iterative and structured synthesis of input was conducted to discern themes, priorities, and recommendations. ResultsParticipants discerned that sufficient scientific findings support the formation of an applied child health services research and policy agenda. Four overarching priorities for the agenda emerged: 1) translate the science of ACEs, resilience, and nurturing relationships into children's health services; 2) cultivate the conditions for cross-sector collaboration to incentivize action and address structural inequalities; 3) restore and reward for promoting safe and nurturing relationships and full engagement of individuals, families, and communities to heal trauma, promote resilience, and prevent ACEs; and 4) fuel “launch and learn” research, innovation, and implementation efforts. Four research areas arose as central to advancing these priorities in the short term. These are related to: 1) family-centered clinical protocols, 2) assessing effects on outcomes and costs, 3) capacity-building and accountability, and 4) role of provider self-care to quality of care. Finally, we identified 16 short-term actions to leverage existing policies, practices, and structures to advance agenda priorities and research priorities. ConclusionsEfforts to address the high prevalence and negative effects of ACEs on child health are needed, including widespread and concrete understanding and strategies to promote awareness, resilience, and safe, stable, nurturing relationships as foundational to healthy child development and sustainable well-being throughout life. A paradigm-shifting evolution in individual, organizational, and collective mindsets, policies, and practices is required. Shifts will emphasize the centrality of relationships and regulation of emotion and stress to brain development as well as overall health. They will elevate relationship-centered methods to engage individuals, families, and communities in self-care related to ACEs, stress, trauma, and building the resilience and nurturing relationships science has revealed to be at the root of well-being. Findings reflect a palpable hope for prevention, mitigation, and healing of individual, intergenerational, and community trauma associated with ACEs and provide a road map for doing so.

Partner development praxis: The use of transformative communication spaces in a community-academic participatory action research effort in a Mexican ethnic enclave in Chicago

Trusting, productive relationships between traditionally discordant stakeholders—community members and researchers—are critical for successful Community-Based Participatory Research. Practical guidance on processes allowing for partner trust-building and collaborative leadership development in Community-Based Participatory Research literature lacks specificity. In this paper, we introduce our praxis of Transformative Communication Spaces to facilitate purposeful, iterative discourse that occurs in, and fuels each research phase. We elaborate on the use of Transformative Communication Spaces through Pláticas de Salud, Oral History Listening Events, and Data Analysis Think Tanks within the framework of our Little Village Participatory Community Health Assessment. We believe the integrity and potential of Community-Based Participatory Research is contingent on the use of Transformative Communication Spaces strategies to foster trusting partnerships necessary for shared learning and co-leadership.

Towards Intelligent and Sustainable Production: Combining and Integrating Online Predictive Maintenance and Continuous Quality Control

The paper addresses intelligent and sustainable production in the sense of combining and integrating online predictive maintenance and continuous quality control. The rationale for combining and integrating them is that continuous quality control can provide input to the online predictive maintenance in cases where no signs of maintenance issues have been indicated and inadequate output is produced (and the process parameters cannot be adjusted in order to meet the output specifications). The paper outlines the first part of an action research effort at Gestamp HardTech AB in Sweden, whose objective is to keep its position as a world-leading provider of press-hardened vehicle parts. The first initial design criteria concerned with simplicity and low-cost was changed after learning more details and what can be accomplished, and the updated first design criteria focused instead on robustness, high-quality output and future-proofing. The intermediary result is an action plan for the technical change, whereas the organizational change will be addressed later during the action research effort.

Public Disclosure to Improve Physical Education in an Urban School District: Results From a 2-Year Quasi-Experimental Study.

Many elementary schools have policies requiring a minimum amount of physical education (PE). However, few schools comply with local/state PE policy and little is known about how to improve adherence. We evaluated changes in PE among fifth-grade classes, following participatory action research efforts to improve PE quantity and policy compliance that focused on publically disclosing PE data. Data were collected in 20 San Francisco public elementary schools in spring 2011 and 2013. PE schedules were collected and PE classes were directly observed (2011, N = 30 teachers; 2013, N = 33 teachers). Data on the proportion of schools meeting state PE mandates in 2011 were shared within the school district and disclosed to the general public in 2012. From 2011 to 2013, PE increased by 11 minutes/week based on teachers' schedules (95% CI: 3.0, 19.6) and by 14 minutes/week (95% CI: 1.9, 26.0) based on observations. The proportion of schools meeting the state PE mandate increased from 20% to 30% (p = .27). Positive changes in PE were seen over a 2-year period following the public disclosure of data that highlighted poor PE policy compliance. Public disclosure could be a method for ensuring greater PE policy adherence.

Role and nature of systemic innovations in construction and real estate sector

Purpose – The paper aims to clarify the role of systemic innovations and the subsequent profound change these can have on the construction and real estate sectors. Systemic innovation as a concept has an inherent capability for viewing factors, actors and conditions as a system or several systems. This has a direct relevance in construction and real estate sector where operations are composed of temporary and continual networks of stakeholders and where the end products can be understood as systems. Design/methodology/approach – The paper builds additional viewpoints and interpretations on some recently completed research where sector wide innovation aspects and challenges have been studied. Two doctoral dissertations supervised by the author and an action research effort where innovative cellular building products were developed and implemented are presented. Findings – The paper provides insights about systemic innovations in the construction and real estate sectors. It presents research topics that explain further what is required for having successful systemic innovations. Research limitations/implications – This is a synthesis paper. The presented viewpoints and interpretations can be used as starting points for research, development and innovation actions. Practical implications – The paper presents starting points for companies and other service providers targeting new innovative products which have systemic implications. Originality/value – This paper explains the need and challenges of systemic innovations in the construction and real estate sectors.

Lessons from collaborative governance and sociobiology theories for reinforcing sustained cooperation: a government food security case study

ObjectivesThis research aimed to understand how cooperation and collaboration work in interagency arrangements using a case study of the public management of food security and nutrition in Bogotá, Colombia. Study DesignThis study explored the available scientific literature on Collaborative Governance within the Public Management body of knowledge and the literature on Cooperation from the Sociobiology field. Then, proposals were developed for testing on the ground through an action-research effort that was documented as a case study. Finally, observations were used to test the proposals and some analytical generalizations were developed. MethodsTo document the case study, several personal interviews, file reviews and normative reviews were conducted to generate a case study database. ResultsCollaboration and cooperation concepts within the framework of interagency public management can be understood as a shared desirable outcome that unites different agencies in committing efforts and resources to the accomplishment of a common goal for society, as seen in obtaining food and nutrition security for a specific territory. Collaboration emerges when the following conditions exist and decreases when they are absent: (1) a strong sponsorship that may come from a central government policy or from a distributed interagency consensus; (2) a clear definition of the participating agencies; (3) stability of the staff assigned to the coordination system; and (4) a fitness function for the staff, some mechanism to reward or punish the collaboration level of each individual in the interagency effort. ConclusionsAs this research investigated only one case study, the findings must be taken with care and any generalization made from this study needs to be analytical in nature. Additionally, research must be done to accept these results universally. Food security and nutrition efforts are interagency in nature. For collaboration between agencies to emerge, a minimum set of characteristics that were established during the merging of the public management and sociobiology fields of knowledge and validated by means of a case study must be accomplished.

Gender Issues on Change Agenda – Practising Intersectionality in Action Research

This article investigates how intersectionalities are handled in the orientations and positions of organization members when conducting feminist action research in workplaces. The Finnish Defence Forces are used as an empirical example of a hierarchical and gendered organization. The article employs the work conference method based on democratic dialogue with the aim of bringing together the divergent experiences and perspectives of the organization's members. Our interpretation is that the intersectional application of the work conference method reveals issues that would not have otherwise arisen. The method helps to highlight the habits and routines that are taken for granted in organizations. We suggest the use of the method both for identifying patterns of inequalities and for seeking remedies for them. The experiences gained from the empirical study support a multi‐method approach to action research. A more theory‐based consciousness of social positions and their interconnections will serve the development process. As a result, action research efforts might also become better anchored in organizational structures and practices.

Strengthening strategic capacity for nutrition in four African countries (632.14)

Undernutrition has received significant attention at global and national levels in recent years, as evidenced by the Scaling Up Nutrition (SUN) movement with 43 participating countries and a G8 commitment of $4.2 billion to the Nutrition for Growth initiative, among others. The translation of this attention into effective action at the country level poses many challenges, as documented previously. Here we describe the results of an on‐going action research effort to address these challenges by strengthening strategic capacity in four Africa countries: Burkina Faso, Mali, Ethiopia and Uganda. All four of these countries have developed multisectoral national nutrition policies and/or plans of action, created coordinating committees and identified SUN focal points. Further multisectoral progress faces challenges seen elsewhere, such as the dominance of sectoral goals and incentives, uneven understanding of multisectoral roles, responsibilities and leadership; uneven participation and ownership; weak human and institutional capacities; lack of effective sub‐national multisectoral platforms; and the persistence of unaligned donor‐ and NGO‐driven approaches. Initial efforts to address these challenges by facilitating informal strategic and adaptive management approaches reveals second order constraints such as high turnover of key staff in and out of government, heavy workloads, rigidity and risk avoidance. Ongoing work focuses on formation of strategic alliances, leadership development, the strengthening of sub‐national experiences to inform the design of multisectoral strategies at the national level and strengthening linkages with global initiatives.Grant Funding Source: Supported by UNICEF

Construction Projects as Research Objects – Different Research Approaches and Possibilities

Research as an activity can mean wide variety of different approaches and their dimensions. Researchers can act as rather passive observers and analyzers by having the current working practices as their research objects. The action research efforts are the ultimate other end. In such efforts researchers act as active change makers by implementing novel trials such as new working practices and their tools. Such trials can fail or be successful but nevertheless the targeted research data is collected as an evidence of the completed effort. Such failures are a real threat for companies and their projects involved in this kind of research. However, more risky action research can be a source for new kind of benefits and competitiveness compared with the more traditional, and wider used, passive observational research. In particular, a sound action research strategy can combine research and development, can speed up targeted changes and can actually mitigate the overall risk of change making. This paper presents a framework of project research strategy and method selection where attention is on degrees of different alternatives and their characteristics. The construction projects and their management represent the industrial context of this paper.