Summary During the hydraulic fracturing process, an acidic hydraulic fracturing fluid (HFF) is injected at high flow rates to break the rock and enhance its flow potential. This rock-fluid interaction induces both physical and chemical alterations on the fracture surface, resulting in the formation of a “reaction-altered zone.” Recent research has revealed that the depth of reaction penetration is minimal, and most changes occur on the fracture surface. To gain a deeper understanding of how fracture roughness affects fracture aperture change, in this work we adopt an experimental approach. Two similar samples of carbonate-rich Wolfcamp shale with calcite-filled fractures are selected. One sample is cut through the center creating a smooth fracture (SF), while the other is fractured by parting along the calcite-filled fracture, generating a rough fracture (RF). The fracture surface topography, mineral distribution, fracture aperture, and rock hardness are characterized before a reactive coreflood using an equilibrated acidic brine is conducted. The pressure drop across the core is measured, and the effluent is periodically collected and analyzed using mass spectrometry. The temporal changes in the fracture surface are observed by conducting physicochemical surface characterization after the coreflood. The results indicate that calcite dissolution is the primary chemical reaction occurring on the fracture surface, weakening it. Furthermore, this dissolution decreases the fracture roughness, which results in fracture closure and ultimately a decrease in the fracture conductivity. The most significant change in the fracture aperture is observed near the inlet. These results highlight the potential impact of fracture roughness on the mechanism of fracture evolution during acidized core floods. Higher fracture roughness is associated with increased fines migration and a more significant overall change in fracture aperture during injection. This research provides valuable insights into the intricate processes at play during hydraulic fracturing and aids in understanding the dynamics of fracture growth in such conditions.