This study was an experimental study conducted at the Poltiteknik Bina Husada Kendari registered in the academic year 2022/2023. The objective of this study was to find out whether the effect of the Anticipation Guide Strategy significantly affects students’ reading comprehension. The sample for this study was 2 classes (60 students) from 4 classes (110 students) in the Dental Health Study Program at the Poltiteknik Bina Husada Kendari. The instrument for collecting data was a reading comprehension narrative text in the form of a multiple-choice test, that consisted of 30 items. Pre-test and post-tests were conducted in both experimental and control classes. To analyze the data was used Independent Sample t-Test. After analyzing the data, the research got; (1) the students’ achievement in reading comprehension taught by conventional method had Mean = 61.333 and Standard Deviation = 9.1852. (2) the student’s achievement in reading comprehension taught by the anticipation guide strategy had a Mean = 85.167 and a Standard Deviation of 6.3631. It can be concluded that there is a difference in the average student learning outcomes between the control group and the experimental group. (3) The result of the Independent Sample t-test showed that the significance value (Sig.) was 0.000 smaller than the probability of 0.05. That shows if H0 is rejected and Ha is accepted. This means that there was a significant effect of using the anticipation guide strategy on students’ reading comprehension at Politeknik Bina Husada Kendari.
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