Three radii from the surface of the Sun… more natural radiation around Jupiter than would be encountered immediately following a nuclear war… to the farthest planet and beyond… these challenges are faced by the three “Ice & Fire” missions: Solar Probe, Europa Orbiter, and PlutoKuiper Express. These three missions will be beneficiaries of the X2000 and related advanced technology development programs. Technology developments now in progress make these missions achievable at costs recently thought adequate only for missions of relatively short durations to “nearby” destinations. The next mission to Europa after Galileo will determine whether a global subsurface liquid water ocean is currently present, and will identify locations where the ocean, if it exists, may be most accessible to future missions. Pluto-Kuiper Express will complete the reconnaissance of the known planets in our Solar System with geological, compositional, and atmospheric mapping of Pluto and Charon while Pluto remains relatively near the Sun during its 248 year orbit. An extended mission to a Kuiper Disk object may be possible, depending on remaining sciencecraft resources. Using a unique combination of Sun shield/high gain antenna and quadrature encounter geometry, Solar Probe will deeply penetrate our nearest star's atmosphere to make local measurements of the birth of solar wind, and to remotely image features as small as 60 kilometers across on the Sun's surface. Avionics technology, leading to integration of functions among a set of multichip modules with standard interfaces, will enable lower production costs, lower power and mass, and the ability to package with modest shielding to enable survival in orbit around Europa inside Jupiter's intense radiation belts. The same avionics and software can be utilized on the other Ice & Fire missions. Each mission is characterized by a long cruise to its destination, facilitated by planetary flybys. The flight systems will represent a unique early integration of science “payload” and “spacecraft,” becoming a more integrated “sciencecraft.” To reduce operations and tracking costs, sciencecraft will be more autonomous. They will self-monitor and self-command, while sending a continuous beacon alerting ground receivers to general sciencecraft health and any need for immediate attention. Where solar power proves impractical for achieving mission goals, an advanced radioisotope power source may be utilized with a much smaller amount of fuel than on prior missions. The three missions described are to begin the Outer Planets/Solar Probe exploration program, as first proposed in the FY1998 Federal Budget. Sciencecraft, launch systems and mission operations must all fit within a single program, encouraging system- and program-wide tradeoffs to minimize costs. Some of the system and technological solutions utilized by these missions may find application in a variety of other science-driven missions.