As the volume and complexity of data continue to grow, predictive analytics has emerged as a vital tool for extracting actionable insights from big data, driving decision-making across various domains such as healthcare, finance, and e-commerce. However, selecting an appropriate machine learning algorithm for predictive analytics applications is challenging due to differences in algorithmic performance, computational requirements, and scalability, especially in the context of big data. This paper provides a comprehensive comparative analysis of popular machine learning algorithms utilized in predictive analytics, specifically focusing on their effectiveness and feasibility in big data environments. The study categorizes algorithms based on learning types—supervised, unsupervised, and reinforcement learning—and evaluates their performance across multiple dimensions: prediction accuracy, computational efficiency, scalability, and suitability for real-time analytics. Through a detailed analysis of algorithms, including linear regression, decision trees, support vector machines, neural networks, and clustering techniques, we assess each method’s strengths and limitations in handling large datasets. Additionally, the study introduces a series of metrics, such as accuracy, F1-score, and training time, as benchmarks for assessing the algorithms’ predictive capabilities and computational viability. A hypothetical case study demonstrates the application of these algorithms on a sample big data set, providing insights into their real-world performance across different predictive analytics scenarios. Visual data representations, including comparative tables and performance graphs, offer a clearer perspective on the trade-offs among algorithm choices. The findings highlight that while certain algorithms like random forests and neural networks achieve higher accuracy in prediction tasks, they may also require substantial computational resources, posing limitations for real-time processing in big data applications. This paper concludes with recommendations for selecting machine learning algorithms based on specific predictive analytics objectives, data characteristics, and processing requirements. Furthermore, it discusses the challenges associated with implementing these algorithms in big data contexts and explores potential advancements, such as the integration of deep learning and the use of distributed computing, as promising directions for enhancing predictive analytics performance in future applications.