Offshore oil field loose sandstone reservoirs have high permeability. However, during the water injection process, water injection blockage occurs, causing an increase in injection pressure, making it impossible to continue injecting water on site. Current research mainly focuses on the factors causing water injection blockage, with less attention given to the blockage locations and the pressure increase caused by water injection. There is a lack of research on the change in the law of injection capacity. This paper establishes a simulation experiment for water injection blockage that can accommodate both homogeneous and heterogeneous cores. The experimental core is 1 m long and capable of simulating the blockage conditions in the near-well zone during water injection, thereby analyzing the core blockage position and blockage pressure. The study clarifies the influence of water quality indicators, heterogeneity, and core length on the blockage patterns in reservoirs during water injection. The research findings are as follows: I. The reservoir blockage samples were characterized using scanning electron microscopy (SEM), casting thin sections, and X-ray diffraction (XRD) analysis. The results indicate that the main factors causing blockage are clay, silt, and fine particulate suspensions, with the fine particles mainly consisting of hydrated silicates and alkali metal oxides. The primary cause of blockage in loose sandstone is identified as the mechanism of migration and accumulation of clay, fine rock particles, and suspended matter in the injected water. II. By monitoring pressure and permeability changes in the core flooding experiments, the impact of reservoir heterogeneity on water injection capacity was evaluated. The evaluation results show that the blockage locations and lengths in heterogeneous cores are twice those in homogeneous cores. III. For heterogeneous reservoirs, if the initial permeability at the inlet is lower than in other segments of the core, significant blockage resistance occurs, with the final resistance being 1.27 times that of homogeneous cores. If the initial permeability at the inlet is higher than in other parts, the final blockage resistance is close to that of homogeneous cores. This study provides theoretical support for the analysis of blockage locations and pressures in loose sandstone water injection and offers technical support for the design of unplugging ranges and pressures after blockage in heterogeneous formations. At the same time, it provides a theoretical basis for selecting the direction of acidizing after blockage occurs in loose sandstone.