Acceptable Health Risk Research Articles

The fate of Alternaria toxin tenuazonic acid (TeA) during the processing chain of wheat flour products and risk control strategies for mycotoxins

The fate of Alternaria toxin tenuazonic acid (TeA) during the processing chain of wheat flour products was systemically evaluated. TeA was analyzed by liquid chromatography–mass spectrometry (LC–MS/MS) in wheat grains and the corresponding wheat flour products produced throughout the whole chain. The results indicated that TeA contamination in wheat grains largely determines the level of TeA toxin present in byproducts, semi-finished products, and finished products of the processing of four types of simulated processed wheat flour products (e.g., dry noodles, steamed breads, baked breads, and biscuits). The different food processing techniques had different effects on the fate of TeA. Wheat flour processing can reduce the TeA content in wheat grains by 58.7–83.2 %, indicating that wheat flour processing is a key step in reducing the TeA content in the food chain. Among the four types of wheat flour products, the decreases in TeA content in biscuits (69.8–76.7 %) were greater than those in dry noodles (15.5–22.3 %) and steamed breads (24.9–43.6 %). In addition, the decreasing effect of TeA was especially obvious in the wheat flour product chain with a high level of contamination. The processing factors (PFs) for TeA were as low as 0.20 for the four wheat processing methods and as high as 1.24 for the dry noodle processing method. At the average and 95th percentiles, dietary exposure to TeA in Chinese consumers including infants and young children did not exceed the relevant threshold value of toxicological concern (TTC) of TeA (1.5 µg/kg body weight per day), indicating an acceptable health risk for Chinese consumers via wheat flour products. These findings provide new insight into the fate of TeA in the food chain and mycotoxin control on the safety of wheat flour products and public health.

Pollution of four heavy metal elements in dried chili peppers in Guizhou Province and its health risk assessment

This study aimed to evaluate arsenic (As), cadmium (Cd), chromium (Cr), and lead (Pb) levels in dried chili peppers from nine districts in Guizhou Province. These heavy metals, widely dispersed and capable of transferring to crops, pose potential health risks to humans. The assessment included modeling daily intake (EDI), target hazard quotient (THQ), total target hazard index (TTHQ), and target carcinogenic risk (TCR) to assess health risks across different population groups. Results showed chromium (0.9540 ± 0.301 mg/kg) and lead (0.8949 ± 0.266 mg/kg) had the highest concentrations, followed by arsenic (0.3287 ± 0.093 mg/kg) and cadmium (0.0627 ± 0.017 mg/kg). Children exhibited higher EDI values than adults, indicating greater health risks from dried chili pepper consumption at equivalent levels. THQ and TTHQ values were below 1 across all regions, indicating no significant health risks associated with dried chili pepper consumption. Similarly, TCR values were below 10–4 for all nine regions, indicating an acceptable level of carcinogenic risk. Overall, consuming dried chili peppers in Guizhou Province poses an acceptable health risk, but caution is advised, especially for children, to limit heavy metal exposure.

A New Approach Refined Probabilistic Health Risk Assessment of Shaoguan Smelter Based on Microenvironment - Guangdong Province, China, 2021.

This study introduces a novel method for developing an advanced exposure conceptual model tailored for health risk assessment, focusing on microenvironments. The research was conducted at a major smelter in China to assess the health risks associated with trace metals (TMs) pollutants in the facility and the surrounding soil. Deterministic risk assessment indicated that cobalt, cadmium, antimony, manganese, arsenic, plumbum, and mercury (Co, Cd, Sb, Mn, As, Pb, and Hg) necessitated further evaluation through probabilistic risk assessment to assess potential health risks to residents. The 95% quantile concentrations of other TMs were found to be within acceptable health risk limits. For the probabilistic risk assessment, exposure parameters such as body weight, respiration rate, and exposure duration were collected using a questionnaire. This targeted assessment of the residential microenvironment revealed it as the site of the highest carcinogenic (CR) and non-carcinogenic risks (NCR), with values ranging from 2.84×10-5 to 6.7×10-5 and 1.59 to 5.57, respectively. The primary contaminants posing the greatest health risks in residential and industrial areas have been identified as As, Pb, and Mn. The probabilistic health risk model, which focuses on microenvironmental factors, yields more precise results and offers a valuable tool for managing soil health risks.

Refined Cumulative Risk Assessment of Pb, Cd, and as in TCM Decoction Based on Bioavailability through In Vitro Digestion/MDCK Cells.

In this study, the oral bioavailability of Pb, Cd, and As in three types of traditional Chinese medicines (TCMs) and TCM decoctions were investigated through in vitro PBET digestion/MDKC cell model. Furthermore, a novel cumulative risk assessment model associated with co-exposure of heavy metal(loid)s in TCM and TCM decoction based on bioavailability was developed using hazard index (HI) for rapid screening and target organ toxicity dose modification of the HI (TTD) method for precise assessment. The results revealed that the bioavailability of Pb, Cd, and As in three types of TCM and TCM decoction was 5.32-72.49% and 4.98-51.97%, respectively. After rapid screening of the co-exposure health risks of heavy metal(loid)s by the HI method, cumulative risk assessment results acquired by TTD method based on total metal contents in TCMs indicated that potential health risks associated with the co-exposure of Pb, Cd, and As in Pheretima aspergillum (E. Perrier) and Oldenlandia diffusa (Willd.) Roxb were of concern. However, considering both the factors of decoction and bioavailability, TTD-adjusted HI outcomes for TCMs in this study were <1, indicating acceptable health risks. Collectively, our innovation on cumulative risk assessment of TCM and TCM decoction provides a novel strategy with the main purpose of improving population health.

Evaluating the protective capacity of soil heavy metals regulation limits on human health: A critical analysis concerning risk assessment - Importance of localization

Heavy metal pollution of agricultural soil is a major global concern, prompting the establishment of maximum allowable limits (MALs) to ensure food safety and protect human health. This study collected and compared MALs for six heavy metals (As, Cd, Hg, Pb, Zn, and Cu) in agricultural soils from representative countries and organizations (EU and WHO/FAO). The research evaluated the critical health risks and efficacy of these MALs under the hypothetical scenario of metals concentrations reaching the maximum allowable level. Safe thresholds for heavy metals were then derived based on maximum acceptable health risk levels. The comparative analysis revealed significant variations in the specific limit values and terms of MALs across countries and organizations, even for the same metal. This suggests that there is no consensus among countries and organizations regarding the level of metal-related health risks. Furthermore, the risk analysis of metal concentrations reaching the maximum level accentuated heightened risks associated with As, suggesting that the current risk of soil As exposure was underestimated, particularly for children. However, soil Cu, Cd, and Zn limits generally resulted in low health risks, implying that the current limits may overestimate their hazard. Overall, the results highlight that the current MALs for soil heavy metals may not fully safeguard human health. There is a critical need to optimize current soil MALs based on localized risks and the actual impact of these metals on human health. It is suggested to appropriately lower the limits of metals (such as As) whose impact on health risks is underestimated, and cautiously increase the limits of metals (such as Cu, Cd, and Zn) that currently pose minor health risks. This approach aims to reduce both over and insufficient protection problems of soil heavy metal MALs, emphasizing the importance of considering the locality in setting these limits.

Comprehensive identification and risk assessment of regulated and emerging mycotoxins in infant foods and related raw materials and risk management advice: A case study of an infant food company in China

This study evaluated muti-mycotoxins in 199 samples including processed infant foods and raw materials collected randomly from an infant food company and assessed their role in dietary exposure in infants and young children via probabilistic risk assessment. Approximately 79.6 % (74/93) of the processed infant foods and 65.1 % (69/106) of the raw materials were contaminated by mycotoxins, with a mean occurrence level of 3.66–321.8 µg/kg. Deoxynivalenol (DON) and tenuazonic acid (TeA) were the more prevalent mycotoxins detected, based on their higher frequencies and levels across samples. Co-occurrence of more than two mycotoxins was detected in 61.3 % (57/93) of the processed infant foods and 53.8 % (57/106) of the raw materials. Wheat flour and derived products (e.g., infant noodles and infant biscuits) were contaminated with higher contamination levels and a greater variety of mycotoxins than other samples (e.g., infant cereal and rice grains). The estimated daily exposure to OTA, DON, ZEN, and TEN was lower than the corresponding reference health-based guidance values, indicating acceptable health risks. However, the estimated dietary exposure to alternariol monomethyl ether (AME), alternariol (AOH), and tenuazonic acid (TeA) exceeded the corresponding thresholds of toxicological concern values, indicating potential dietary intake risks. Among the various samples, cereals and cereal-based infant foods emerged as the primary contributors to mycotoxin exposure. Further research is advised to address the uncertainties surrounding the toxicity associated with emerging Alternaria mycotoxins and to conduct cumulative risk assessments concerning multiple mycotoxin exposure in infants and young children.

Pesticide Residues in Greenhouse Leafy Vegetables in Cold Seasons and Dietary Exposure Assessment for Consumers in Liaoning Province, Northeast China

Excessive pesticide application in greenhouses leads to elevated levels of pesticide residues, especially in cold seasons, thereby posing a potential dietary exposure risk to the residents’ health. This study aimed to investigate 65 pesticides in 469 leafy vegetable samples collected from greenhouses in Liaoning province between October 2018 and May 2020. Overall, the pesticide levels in 96.4% (452/469) of the samples were below the MRLs established by the Codex Alimentarius Commission. The detection rate of 65 pesticides ranged from 0.2% to 11.9%. Multiple pesticide contamination was common, with dimethomorph being the most recurrent contaminant. The dietary risk assessment study revealed obvious differences in chronic and acute exposure risk values. The chronic risk quotients (RQcs) for leafy vegetable samples were 0.001%–3.993%, indicating an acceptable public health risk for the residents. As two leafy vegetables highly consumed in cold seasons in northeast China, the acute risk quotients (RQas) of Chinese cabbage samples were significantly lower than 100%; however, pakchoi samples exhibited RQa values ranging from 0.159% to 580.529%, showing an unacceptable acute dietary risk. This highlights that, compared to the chronic dietary risks, the potential acute dietary risks induced by the pesticides are higher in greenhouse-grown leafy vegetables during cold seasons.

A novel bioaccessibility-based probabilistic risks assessment of potentially toxic elements (PTEs) in earthworm.

Introduction: Early risk assessment studies usually based on total heavy metal (loid) contents, inevitably leading to an overestimation of the health risks. In addition, inputs are represented as single-point estimates in deterministic models, leading to underestimation or overestimation of the health risks. Methods: To overcome these barriers, a novel probabilistic risk assessment strategy based on the combinational use of bioaccessibility and Monte Carlo simulation was developed to assess heavy metal (loid) associated health risks of earthworms in this study. To obtain a realistic and robust probabilistic risk assessment, heavy metal (loid) exposure duration and frequency were determined using our questionnaire data. Results: As a result, the mean gastrointestinal bioaccessibility was in the order: Cd > As > Cu > Hg. The mean hazard index (HI) values for investigated metal (loid)s were 0.65 and 0.59 for male and female, respectively, demonstrating an acceptable health risk in an average community. However, the 90th percentile of HI values was 1.87 and 1.65 for male and female, respectively. And the total non-cancer risks of heavy metal (loid) exposure exceeded the acceptable threshold for 19.9% and 17.8% of male and female, respectively. In addition, the total cancer risk (TCR) value through co-exposure to As and Cd suggested that the carcinogenic risks may be of concern for average exposure population. Sensitivity analyses revealed that the exposure frequency and bioaccessible As concentration were the dominant contributors to the total risk variance, which provided meaningful implications for environmental management. Conclusion: Altogether, the refined strategy based on bioaccessibility and Monte Carlo simulation is the first of its kind, such effort attempts to scientifically guide the rational clinic use of TCM and the improvement of population-health.

ENVIRONMENTAL RISKS FOR PUBLIC HEALTH AS A SIGNIFICANT CRITERION FOR CREATING FUNCTIONAL ZONES IN A CITY WITHIN URBAN DEVELOPMENT

Background. This study focuses on a vital issue concerning the necessity to consider public health when making decisions on urban development.&#x0D; Purpose. Test approaches to using available data on environmental public health risks when creating functional zones in a large industrial center.&#x0D; Materials and Methods. Aerogenic health risks associated with ambient air pollution were assessed by calculating dispersion of emissions from 2500 industrial sources and 4000 traffic network sections as well as by using environmental monitoring data.&#x0D; Results. We established that 1889 land spots of 3619 functional zones with standardized air quality were fully or partially located in areas with unacceptable public health risks. These land spots included 905 residential areas and 984 spots with recreational potential.&#x0D; Conclusion. Obviously, an inconsistency between actual health hazards for city population and a functional purpose of a zone requires immediate action. Either a functional purpose should be changed, or certain air protection activities should be implemented to make ambient air quality conform to the existing standards and to guarantee acceptable health risks levels. Either option requires environmental and economic substantiation. Any decision on changes in a specific situation in each specific functional zone should be made separately considering hazards, their sources and reasons for their occurrence. These decisions should rely on economic estimates and technical capabilities necessary for implementation of planned activities. People’s life and health should always remain the top priority. The study describes an algorithm for considering environmental factors when functional zones are created within urban development.

Effective reducing the mobility and health risk of mercury in soil under thiol-modified biochar amendment

Soil mercury contamination poses health risks. However, effective immobilization techniques are lacking with challenges including low efficiency, limited long-term stability, susceptibility to multi-medium interference, and difficulty in controlling health risks. This study confirmed the feasibility of thiol-modified biochar, and elucidated the underlying mechanisms. Within 32 days of treatment, the leachable mercury decreased from 184.7 μg/L to below the hazardous waste threshold (100 μg/L, HJ/T299–2007, China). After 198 days of treatment, the soil achieved a safe ecological state with a mercury immobilization rate of 79.8–98.2% and a 50% reduction in available methylmercury. Thiol-modified biochar facilitated the conversion of active mercury species (exchangeable, carbonate, and oxide) into stable forms (organic and residual) through complexation and precipitation (e.g., HgS). Soil quality improvements were observed, including enhanced cation exchange capacity, available nitrogen, and total organic carbon. Thiol-modified biochar exhibits long-term effectiveness. After one and two years of treatment, the leachable mercury remained within acceptable health risk limit (hazard quotient < 1) for adults and children, respectively. After three years, the leachable mercury met the Level III groundwater quality standard (< 1 μg/L, GB 14848–2017, China). This study demonstrates an effective strategy for long-term diminishing mercury mobility and health risks in soil.

Generalizable consistency of soil quality standards for pesticides: Modeling perspectives

Soil quality standards for pesticides play a crucial role in protecting plants and preventing potential health hazards to humans. Here we discuss modeling approaches to define pesticide soil quality standards from two effect endpoints, which ensures consistency throughout the entire pesticide life cycle from application to human exposure assessment. Given that pesticides are applied in a pulse-like emission pattern and their soil concentrations change over time, both a ceiling legal limit and an average legal limit for pesticide soil quality standards should apply to the initial pesticide application practice and the potential human health effect. The timing intervals for pesticide application and the dissipation half-life in the soil can be used to quantify the relationship between the ceiling and average legal limits. By analyzing primary exposure pathways related to soil contamination, the average legal limit can be linked to theoretical human health risks, which requires a comprehensive evaluation for an adequate safety margin, including human interactions with soil, exposure assessment of soil pesticides, and allocation exposure assessment. To establish acceptable human health risks, the average legal limit can be determined, and the ceiling legal limit can be estimated based on the quantitative relationship between the ceiling and average legal limits. Additionally, we discuss situation-specific factors, including climate-pattern and behavior-pattern factors, to define pesticide soil quality standards to further complete the modeling framework. We hope insights presented in this paper will assist regulatory agencies worldwide in defining pesticide soil quality standards that meet their specific regulatory needs throughout the entire pesticide life cycle.

Setbacks for gas stations in a world with regionally varying emissions factors and acceptable health risks

MotivationGas stations chronically release gasoline vapor to the environment that contains the carcinogen benzene. However, there is no method for estimating setbacks for a gas station depending on an acceptable excess cancer risk due to the benzene emissions, sales volume, benzene content of the emissions, and inhalation dose, without performing an air dispersion simulation for each scenario.MethodsWe developed a new modeling framework, in which only one air dispersion simulation is performed for a reference gas station. Then, a new scaling law is used to estimate cancer risks and setbacks for different gas station characteristics and exposure scenarios.ResultsOur new scaling law allows estimating cancer risk vs. distance as a function of an acceptable excess cancer risk, total benzene emission rate, and frequency of exposure. Setbacks can also be determined from this scaling law or graphically from a design chart. Calculated setbacks differ only slightly from those determined from air dispersion simulations. Different emission control technologies substantially affect calculated setbacks.ConclusionsWe developed a framework that allows policy makers to examine easily how setbacks depend on regulatable measures such as emission control and acceptable cancer risk as well as on exposure characteristics. The framework also allows incorporating a safety factor to account for increased emissions. While this study was conducted in the context of US gas stations, our framework can be applied world-wide.

Health risk assessment of dietary cadmium intake in children aged 2-17years in East China.

Food is the main way for people to be exposed to heavy metal cadmium (Cd), and Cd pollution will affect human health. In this paper, exposure and health risk assessment of dietary Cd intake were conducted in children aged 2, 3, 4, 5, 6-8, 9-11, 12-14 and 15-17years in East China. The results showed that the total exposure of dietary Cd intake in children exceeded the standard limits. The total exposure of all age groups were 1.11 × 10-3, 1.15 × 10-3, 9.67 × 10-4, 8.75 × 10-4, 9.18 × 10-4, 7.75 × 10-4, 8.24 × 10-4, 7.11 × 10-4mgkg-1d-1, respectively, and the highest was the children aged 3years. The hazard quotients of children aged 2 and 3years were 1.11 and 1.15, respectively, at an unacceptable health risk level. The hazard quotients of dietary Cd intake in children of other ages were less than 1, at an acceptable health risk level. Staple foods were the most significant contributor to the dietary Cd intake in children, and the contribution ratio of non-carcinogenic risk of dietary Cd intake in all age groups were more than 35%, the proportion of non-carcinogenic risk in children aged 6-8 and 9-11years were as high as 50%. This study provides scientific basis for the health of children in East China.

Health risk study of cadmium, chromium, lead and arsenic in reservoir water of Changzhou, China

Accurately assessing the health risks of human exposure to heavy metals via water is of great importance for performing targeted health risk prevention measures. To better understand the concentration characteristics and potential harm to human health of cadmium, chromium, lead and arsenic in the main drinking water-type reservoirs of Changzhou city, we collected samples from the Haidi Reservoir, Dongjin Reservoir, Xinfushan Reservoir, Maodong Reservoir and Xiangyang Reservoir of Changzhou in the summer of 2019. The results showed that the daily average comprehensive exposure level of metals was much lower than the provisional tolerated daily intake (PTDI), i.e., Cd: 1 µg kg−1 d−1; Cr: 3 µg kg−1 d−1; Pb: 3.57 µg kg−1 d−1; and As: 2.14 µg kg−1 d−1. The comprehensive non-carcinogenic risk levels of four metals under water-drinking exposure and water-skin exposure routes ranged from 4.68E − 3 to 1.69E − 1, and the carcinogenic risk ranged from 2.09E − 5 to 7.30E − 5, which were all at acceptable risk levels. Although lead and chromium were present at acceptable health risk levels, they still represented the main pollutants of potential health risk in the local water environment from a non-carcinogenic or carcinogenic perspective, and they should be listed as the primary targets for water environmental risk management.

Innovative accumulative risk assessment strategy of co-exposure of As and Pb in medical earthworms based on in vivo-in vitro correlation

Recent studies on risks assessment of heavy metal(loid) are usually based on their total concentrations. Nevertheless, such an analysis does not assess their real amounts absorbed by human body. To scientifically assess the health risks, in this study medical earthworms were analyzed for relative bioavailability (RBA) of arsenic (As) and lead (Pb) using a multiple gavage mouse model with liver, kidneys, brain, and leg bones as biomarkers for the first time. Metal(loid) bioaccessibility was determined using in vitro physiologically based extraction (PBET) assay. We are the first to develop a novel accumulative health risk assessment strategy by combinational analyzing bioavailability of heavy metal(loid) levels to calculate target organ toxicity dose (TTD) modification of the HI and total cancer risk (TCR), which has capacity to evaluate the health risks of co-exposure of Pb and As in medical earthworms. As a result, As-RBA ranged from 7.2% to 45.1%, and Pb-RBA ranged from 16.1% to 49.8%. Additionally, As and Pb bioaccessibility varied from 6.7% to 48.3% and 7.8% to 52.5%, respectively. Moreover, strong in vivo-in vitro correlations (IVIVCs) were observed between metal-RBA and bioaccessibility, indicating the robustness of the in vitro PBET assay to predict metal-RBA in medical earthworms. The refined accumulative assessment strategy revealed that when adjusted by heavy metal(loid) bioavailability, the TTD modification of HI method typically exhibited an acceptable health risk caused by the co-exposure of Pb and As for cardiovascular, hematological, neurological, and renal system. The TCR levels associated with exposure to Pb and As due to the ingestion of medical earthworms were also acceptable after adjustment by bioavailability. Collectively, our innovation on accumulative risk assessment based on in vivo-in vitro correlation provides a novel approach engaging in assessing the risks due to co-exposure of As and Pb in medical earthworms.

Antibiotic residues of drinking-water and its human exposure risk assessment in rural Eastern China

Trace levels of antibiotics were frequently found in drinking-water, leading a growing concern that drinking-water is an important exposure source to antibiotics in humans. In this study, we investigated antibiotics in tap water and well water in two rural residential areas in Eastern China to assess the related human health exposure risks in drinking-water. Twenty-seven antibiotics were analyzed using ultra performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry (UPLC-MS/MS). The average daily dose (ADD) and the health risk quotient (HRQ) for exposure to antibiotics in humans were evaluated using 10000 times of Monte Carlo simulations. Ten antibiotics were detected in drinking-water samples, with the maximum concentrations of antibiotic mixture of 8.29 ng/L in tap water and 2.95 ng/L in well water, respectively. Macrolides and sulfonamides were the predominant contaminants and showed the seasonality. Azithromycin had the highest detection frequencies (79.71-100%), followed by roxithromycin (25.71-100%) and erythromycin (21.43-86.96%). The estimated ADD and HRQ for human exposure to antibiotic mixture through drinking-water was less than 0.01 μg/kg/day and 0.01, respectively, which varied over sites, water types, seasons and sex. Ingestion route was more important than dermal contact route (10−6 to 10−4 μg/kg/day magnitude vs. 10−11 to 10−8 μg/kg/day magnitude). Macrolides also contributed mainly to health exposure risks to antibiotics through drinking-water, whose HRQ accounted for 46% to 67% of the total HRQs. Although the individual antibiotic and their combined effects contributed to acceptable health risks for human, the long-term exposure patterns to low-dose antibiotics in drinking-water should not be ignored.

Pollution Characteristics of Organochlorine Pesticides in Water and Sediments of Huixian Karst Wetland in Guilin

Karst wetland plays an important role in the ecological environment; however, due to the existence of karst pipeline, pollutants can threaten the underground environment through the highly developed karst pipeline. Therefore, understanding the pollution characteristics of the karst surface environment is the premise of pollution ecological risk assessment and prevention. In this study, 24 organochlorine pesticides (OCPs) were analyzed to study the concentration, composition, source, and risk of OCPs in water and surface sediments in the Huixian Wetland of Guilin. The results showed that:the concentration of OCPs in water ranged from 3.17 ng·L-1 to 92.50 ng·L-1, and the concentration of OCPs in sediment ranged from 1.16 ng·g-1 to 219.52 ng·g-1, showing the main pollution characteristics of HCHs and DDTs. The concentration of OCPs in water was higher in the wet season than that in the dry season. The concentration of OCPs in sediments was higher in the dry season than that in the wet season. The isomer ratios revealed that OCPs in the study area were mainly derived from long-term degradation residues, and some sites had new input of lindane. Based on Monte Carlo simulation, the human health risk assessment of the study area showed that the 95% quantile carcinogenic risk of OCPs in water was greater than 1×10-6, with potential but acceptable health risk. The non-carcinogenic risk was lower than 1, which indicated that the level of OCPs residues in the water in the study area was not enough to cause non-carcinogenic risk to the human body.

Potentially toxic elements in the soils of Campi Flegrei (south Italy) and the immediate surroundings: Spatial distribution, origin and probabilistic human health risk

Campi Flegrei is an active volcanic field in south Italy where the potentially toxic elements (PTEs) are of growing concern because the intensive anthropogenic and volcanic activities might pose adverse human health effects. In this article, 394 topsoils (0–15 cm) are collected for instrumental analysis of the <2 mm fraction. The geochemical maps indicate that higher concentrations of Pb, Zn, Cd, Cr, Hg, Ni and Sb are related to the urban area, but greater levels of As, Tl, Co, Cu, Se and V are observed in the other parts. A robust principal component analysis detected: (1) the Pb–Zn–Hg–Cd–Sb–Cr–Ni association that probably highlights anthropogenic activities such as heavy traffic load and fossil fuel combustion in the urbanized area; (2) the Al–Fe–Mn–Ti–Tl–V–Co–As–U–Th association that mostly reveals the contribution of pyroclastic deposits; and (3) the Na–K–B association that feasibly indicates the weathering degree. The probabilistic health risk modeling for the children under 6 years old shows negligible Pb and Zn non-carcinogenic risk and unexpected Pb carcinogenic risk for exposure through soil ingestion. However, for the inhalation pathway, the children aged <1 year old have the highest chance (90%) of acceptable (i.e. between 1E-6 and 1E-4) Pb carcinogenic health risk. This should not be overlooked because Naples is under high environmental pressure and previous studies reported the increased Pb and Zn quantities in soil over a 26-year timespan. Overall, the results of geostatistical interpolation, compositional data analysis and probabilistic health risk modeling potentially uncover the link between soil geochemistry and human health.

Bioaerosols emission characteristics from wastewater treatment aeration tanks and associated health risk exposure assessment during autumn and winter

Aeration tanks from activated sludge wastewater treatment plants (WWTPs) can release a large amount of bioaerosols that can pose health risks. However, risk characterization of bioaerosols emissions form wastewater treatment plants is currently not systematically carried out and still in its infancy. Therefore, this study investigated emission characteristic of two indicator model bioaerosols Staphylococcus aureus and Escherichia coli, emitted from aeration tanks of a municipal WWTP. Monte Carlo simulation was then used to quantitatively assess microbial risk posed by different aeration modes under optimistic and conservative estimates. Further to this, two different exposure scenarios were considered during 3 days sampling campaign in autumn and winter. Results showed that the bioaerosol concentration from microporous aeration tank (20–262 CFU m−3) was one order of magnitude lower than rotating disc aeration tank. Average aerosolization rate was 7.5 times higher with mechanical aeration mode. Health risks of exposed populations were 0.4 and 9.6 times higher in winter than in autumn for E. coli and S. aureus bioaerosol, respectively. Health risks of staff members were 10 times higher than academic visitors. Interesting results were observed for academic visitors without personal protective equipment (PPE) respectively exposed to S. aureus and E. coli bioaerosol in autumn and winter: while the derived infection risk met the United States Environmental Protection Agency (U.S. EPA) benchmark under optimistic estimation, the disease risk burden was over the World Health Organization (WHO) benchmark under conservative estimation. These revealed that only satisfying one of the two benchmarks didn't mean absolute acceptable health risk. This study could facilitate the development of better understanding of bioaerosol quantitative assessment of risk characterizations and corresponding appropriate risk control strategies for wastewater utilities.

Addressing the Governance of Harmful Algal Bloom Impacts: A Case Study of the Scallop Fishery in the Eastern French Coasts of the English Channel

Harmful Algal Blooms (HAB) are phenomena that result from alterations to ecosystems. Due to their potential toxicity, the level of danger depends on the species concerned, their frequency and intensity. They can cause impacts on biodiversity and on the anthropic activities that take place in maritime and coastal areas. Primary industries such as shellfish fisheries are mainly affected. To deal with this issue, the French administration has built a governance system based on two pillars. The first relies on a water quality monitoring system that assesses the risks of HAB contamination of coastal waters. The second is a regulatory system of production and commercial bans of seafood products from the impacted areas. This public action has two objectives. The first is human health-related and aims to protect consumers of seafood. The second is economic-based and aims to minimize the economic impacts associated with the commercial bans suffered by the businesses concerned. These two objectives may appear to be antagonistic. Using the case study of the French scallop fishery in the eastern Channel and based on an analysis of the commercial bans associated with HAB and associated potential economic impacts, this paper analyses the governance scheme dealing with HAB events in France. The authors highlight that this governance is not only a matter of applying administrative closures when toxicity thresholds are exceeded, but is a dynamic decision-making process involving experts and the Administration that attempts to balance acceptable health risks and economic impacts.