The appropriate alignment of the lower teeth is indicated by the Curve of Spee (COS), which can be observed in the sagittal profile view of human skulls. Graf Von Spee made the initial observation on this occlusal curvature. Through this systematic review and meta-analysis, we evaluated studies that looked at how COS affected masticatory activities. The databases PubMed-MEDLINE, Web of Science, Cochrane, and Scopus were all searched. A total of 12 documents were ultimately picked because they met the necessary inclusion and exclusion requirements. The data was then loaded into the RevMan 5 programme for meta-analysis after being chosen for information on the sample size, variables analyzed, and various aspects of the research. The Curve of Spee was found to have a noticeable impact on both the masticatory efficiency as well as dentofacial alignment in the 12 studies that we selected for the review and meta-analysis. In addition, other occlusal curvatures such as the Curve of Monson and the Curve of Wilson were found to be of vital importance on a similar level to the COS. The meta-analysis further revealed that seven of the included clinical trials had mentioned the noticeable impact on masticatory efficiency. This study focused on the significance of the COS on force distribution in the oral cavity as well as the necessity of COS corrections after receiving full orthodontic care. Following orthodontic treatment, the COS, along with other occlusal curves such as the Curve of Wilson and the Curve of Monson, is essential in removing strains from the condyle, as well as the maxilla and mandible, which enhances masticatory effectiveness and lessens the overall strain on a patient's oral cavity.