A method for generation of intense secondary pulsed molecular beams and beams of radicals of high kinetic energy controllable by a powerful IR laser is described. A pressure shock (shock wave) is used as a source of secondary beams. The pressure shock is formed in interaction between an intense pulsed supersonic molecular beam (or flow) and a solid surface. The characteristics of the secondary beams were studied. Their intensities and the degree of gas cooling in them were shown to be comparable with the corresponding characteristics of the unperturbed primary beam. The acceleration of molecules in the secondary beam is achieved due to vibrational excitation of them by high-power IR laser pulse in the pressure shock and subsequent vibrational to translational (V–T) relaxation, which occurs when a gas expands through the orifice into a vacuum. Intense [⩾1020 molecules/(sr s)] beams of SF6 and CF3I molecules with kinetic energies approximately equal to 1.5 and 1.2 eV, respectively, were generated in the absence of carrier gases. The SF6 molecular beams with kinetic energies approximately from 2.5 to 2.7 eV with carrier gases H2, He and CH4 (SF6/carriergas=1/10) were obtained. The possibility of generation of intense beams of cold radicals by this method is demonstrated. The intense beams of cold and accelerated CF3 radicals were generated when the CF3I molecules in the shock were dissociated by high-power CO2 laser radiation. The spectral and energetic characteristics of acceleration of SF6 and CF3I molecules in the secondary beams were studied. The optimal conditions were found for obtaining high-energy molecules.