Acceleration Of Erythropoiesis Research Articles

Sports anaemia, regulation of erythropoietin biosynthesis during physical effort and EPO doping

Efficient transport of oxygen within the body is of particular importance for physical work performance, maximal aerobic power and resistance to fatigue, especially in endurance disciplines such as cycling, long...

Plasma High Density Lipoprotein in Anemic Cattle Infected with Theileria sergenti.

Changes in plasma concentration of lipid composition were analysed in cattle with anemia due to Theileria sergenti infection. Plasma levels of phospholipids, cholesterol, free cholesterol, high density lipoprotein cholesterol, and vitamin E decreased to 40-67% of the pre-infection levels, corresponding to the decrease of PCV due to the infection. However, no definite changes were detected in plasma level of triglyceride. By gradient centrifugation, it was confirmed that lipid components, other than triglyceride, occur in high density lipoprotein (HDL) and these decreases lowered the HDL value. There was no correlation between this phenomenon and liver function. As similar changes in lipid composition were also observed in phlebotomized calves, it was considered that this phenomenon might partially depend on the acceleration of erythropoiesis as a reaction to anemia caused by T. sergenti infection.

Accelerated erythropoiesis: the hidden benefit of autologous donation

The risks associated with the administration of blood products have increased efforts to avoid homologous transfusions. Preoperative autologous donation has received renewed interest as a method of decreasing homologous transfusion requirements. Autologous donations may also stimulate postoperative erythropoiesis. The purpose of this study is to evaluate the effect of an aggressive autologous donation program on postoperative erythropoiesis. Ten adult male baboons were divided into two groups. The autologous group (n = 5) donated an average of 2 units of blood per week for 5 weeks before operation. The control group (n = 5) had no preoperative treatment. All animals then underwent a laparotomy and exchange transfusion with hetastarch to a final hematocrit of 15 percent. The time required to recover to hematocrits of 20 percent (3.3 vs. 5.7 days, p less than 0.01), 25 percent (7.0 vs. 8.8 days, p less than 0.05), and 30 percent (11.1 vs. 17.7 days, p less than 0.01) was shorter in the autologous group. The autologous group had more intense reticulocytosis during the first 4 postoperative days (p less than 0.03). The data show that participation in an aggressive autologous donation program improves the erythropoietic response to anemia in the postoperative setting. This represents a hidden benefit of preoperative autologous donations and suggests that more aggressive donation schedules may be clinically beneficial. Recognition of that acceleration of erythropoiesis by autologous donation could further reduce the need for transfusion of homologous blood.

Granulopoiesis During Myleran-induced Suppression of Transplantable Hematopoietie Stem Cells

Abstract Granulopoiesis was studied in mice whose colony-forming units (CFU) had been suppressed to undetectable levels by Myleran. Measurements of the myelocyte-metamyelocyte transition rate and other parameters showed significant granulopoietic regeneration at a time when no CFU were demonstrable. This regeneration is attributed to the proliferation of intermediate granulopoietic stem cells, and the findings thus confirm the existence of such cells in an in vivo system. Acceleration of erythropoiesis in the Myleran-treated mice by large does of erythropoietin was without effect upon the concomitant granulopoietic regeneration, indicating that intermediate stem cells are not interchangeable and that the otherwise described competition for stem cells between the two systems must occur at the primitive CFU level.

The Effects of General Hypoxic Hypoxia and Renal Ischemia on Erythropoietin Production

AbstractThere is considerable evidence in literature concerning the stimulation of erythropoietin production in response to hypoxic hypoxia, as induced by exposure to simulated altitude (Stohlman and Brecher, 1957 and 1959; Jacobson et al., 1959; Gordon et al., 1959; Mirand et al., 1959). The increased erythropoietin in plasma is assumed to be responsible for the well-known acceleration of erythropoiesis under conditions of chronic and intermittent acute hypoxia. Some years ago, Grant (1951) and Terzioglu et al. (1955) demonstrated that the erythropoietic stimulation in chemoreceptor-denervated rabbits intermittently exposed to pressures of 400-410 mm Hg, for a total of 120-150 hours, was of a far greater magnitude than in the controls similarly treated. In order to investigate whether the greater erythropoietic response of the chemoreceptor-denervated animals was due to an increase in erythropoietin production, we undertook the present study where the plasma erythropoietic activity of the control and che...