Academic Journal Network Publishing Database Research Articles

Risk factors for the recurrence of pelvic organ prolapse: a meta-analysis

Female pelvic organ prolapse (POP) is a common condition, which has a high recurrence rate after reconstructive surgery, and the risk factors for POP recurrence are unclear. The aim of this study was to perform a meta-analysis to determine risk factors for POP recurrence. A thorough search of PubMed, Medline, EMBASE, Cochrane Central Register of Controlled Trials, and China Academic Journal Network Publishing Database was conducted for relevant publications until 29 October 2022, without language restrictions. A total of 29 studies involving 6597 patients were included, and the recurrence rate of POP after surgery was 37.7%. Significant OR and CI were found for levator avulsion (OR: 2.46, 95% CI: 1.80–3.36), preoperative stage ≥ III (OR: 1.87, 95% CI: 1.53–2.27), hiatal area on Valsalva manoeuvre (OR: 1.08, 95% CI: 1.03–1.12) and previous pelvic floor surgery (OR: 1.60, 95% CI: 1.07–2.39). Levator avulsion, preoperative stage ≥ III, hiatal area on Valsalva manoeuvre and previous pelvic floor surgery are significant risk factors for POP recurrence. IMPACT STATEMENT What is already known on this subject? It has been reported that genetic factors, parity, obesity, birth-induced injury during delivery, etc. are risk factors for POP development and recurrence after operation. What do the results of this study add? There are few literatures about the risk factors of POP recurrence at present. Our research has increased the information regarding risk factors for POP recurrence. What are the implications of these findings for clinical practice and/or further research? Our study provides an overview of the risk factors affecting POP recurrence and their contribution (OR, CI) to POP recurrence, which provides valuable evidence-based basis for clinical decision-making in POP treatment and prevention of POP recurrence.

Meta-analysis of the associations of IMPDH and UGT1A9 polymorphisms with rejection in kidney transplant recipients taking mycophenolic acid.

To investigate the associations of IMPDH and UGT1A9 polymorphisms with rejection in kidney transplant recipients taking mycophenolic acid (MPA). PubMed, Web of Science, Embase, Cochrane Library, Wanfang Data, and the China Academic Journal Network Publishing Database were systematically searched for studies investigating the associations of IMPDH1, IMPDH2, and UGT1A9 polymorphisms with rejection in kidney transplant recipients taking MPA. Associations were evaluated by pooled odds ratios (ORs) and effect sizes (ESs) with 95% confidence intervals (CIs). Twelve studies were included in the analysis, including a total of 2342 kidney transplant recipients. The results showed that compared with the TC + CC variant genotypes, the TT genotype of IMPDH2 3757T > C was significantly associated with a higher risk of rejection (ES = 1.60, 95% CI = 1.07-2.40, P = 0.021), while there was no significant association of the IMPDH2 3757T > C polymorphism with acute rejection within 1year in kidney transplant recipients (OR = 1.49, 95% CI = 0.79-2.80, P = 0.217; ES = 1.44, 95% CI = 0.88-2.36, P = 0.142). The GG genotypes of IMPDH1 125G > A and IMPDH1 106G > A were significantly associated with a higher risk of rejection (ES = 1.91, 95% CI = 1.11-3.28, P = 0.019) and acute rejection within 1year (ES = 2.12, 95% CI = 1.45-3.10, P < 0.001) than the variant genotypes GA + AA. The TT genotype of UGT1A9 275T > A showed a decreased risk of rejection compared with the variant genotypes TA + AA (ES = 0.44, 95% CI = 0.23-0.84, P = 0.013). IMPDH1, IMPDH2, and UGT1A9 polymorphisms were associated with rejection in kidney transplant recipients, and the genetic backgrounds of patients should be considered when using MPA.

Bibliometric Study on the Highly Cited Papers and Correlation Between Citation Frequency and Download Frequency in Chinese Medicine Journals

The purpose of this paper is to retrieve and study the highly cited papers as well as the correlation between the citation frequency and the download frequency of the 20 traditional Chinese medicine journals in China, in order to provide the guidance for improving the influence and academic quality of these journals. Bibliometric analyses were conducted on 1103 papers of 20 traditional Chinese medicine journals from 2011 to 2020 by retrieving for the China Academic Journal Network Publishing Database (CAJD) in China National Knowledge Infrastructure (CNKI). SPSS 17.0 software was used to analyze the correlation between the citation frequency and the download frequency via conducting regression fitting and establishing the mathematical models. The results showed that the total citations of the 1103 papers were 93051 times and the average citations were 84.36 times per paper. The total downloads of the 1103 papers were 2058442 times, and the average downloads were 1866.22 times per paper. China Journal of Chinese Materia Medica ranked first according to the number of papers, total citations and total downloads. The citations of Journal of Chinese Medicinal Materials ranked first based on the number of citations per paper. One of Li’s paper had been cited the most (983 times). There were 629 (57.03%) papers whose first author was from universities. The scopes of the first authors were distributed in 29 regions and 2 special administrative regions (Macao, Hong Kong) in China. The authors from Beijing published 283 (25.66%) papers, ranking number one. The number of papers supported by funds was 882 (79.96%). The research results of correlation showed that the citation frequency and the download frequency of the highly cited papers had a highly positive correlation from both journal and paper level for whether the sample data of journals was normally distributed or nonnormally distributed. The correlation coefficients of the 20 journals at journal level and that at paper level were 0.9765 and 0.6677, respectively. The correlation was better at journal level than that at paper level, while the optimal regression fitting was all cubic polynomial. Among the 1103 papers, there were 684 (62.01%) research papers and 419 (37.99%) review papers. The main citation period of the top 15 papers was from the 2nd year to the 6th year after publication, accounting for 78.39%. Papers on clinical therapeutics research, papers on the pharmacological effects and its mechanism of traditional Chinese medicine, and papers on traditional Chinese medicine and natural medicine were the main source of the highly cited papers of the traditional Chinese medicine journals. Editors of the journals should focus on the above-mentioned research areas to select manuscripts for exploiting the excellent sources extensively, while paying attention to review papers, focusing on national major or key projects, paying attention to network spreading, stabilizing authors with quality services, in order to improve the influence and the academic quality of journals.

Exploring the research themes and their relationships of LIS in China from 2013 to 2018 using co-word analysis

This study aims to examine the research themes and their relationships of library and information science (LIS) in mainland China during the period of 2013–2018. Data were collected from the China Academic Journal Network Publishing Database (CAJD) and co-word analysis method was employed to measure correlation among the extracted key words. Seventeen theme-clusters, network characteristics (centre and density), clustering strategy diagram, and correlation network are revealed through cluster analysis, multidimensional scaling (MDS), and social network analysis. The results show that in recent years research on LIS in China, several important research themes like Electronic Government, Reading Promotion, and Social Media have emerged with high relevance, which can be considered as concentrated, mature and well-developed. Some research topics such as Ontology, Big data, and Cloud Computing have developed on a considerable scale, while others remain isolated and undeveloped like Knowledge Sharing and Virtual Community. In addition, the current research has also identified a few of emerging research topics with great potential for development like Mobile Library, Subject Services, and User Experience. The study is beneficial to understand the overall picture of research themes and their relationships of LIS in China in recent years to provide support for follow-up research.

The efficacy and safety of Banxia-Houpo-Tang for chronic pharyngitis: A protocol for systematic review and meta analysis.

Background:Chronic pharyngitis is a common disease with a dry throat, sore throat, pharyngeal itching, dry cough, and difficulty in swallowing, bringing inconvenience to patients’ daily life. Banxia-Houpo-Tang (BHT) has proven to be effective in the treatment of chronic pharyngitis, yet its real extent is not well understood. To prove this point, we will perform a protocol for a systematic review and meta-analysis of BHT for chronic pharyngitis.Methods/design:We will search for electronic databases both English and Chinese from inception to December 2019. Two experienced researchers select the qualified articles from: The Cochrane Library, EBM Reviews, OVID, Web of Science, PubMed, Chinese National Knowledge Infrastructure (CNKI), China Academic Journal Network Publishing Database (CAJD), China Biomedical Literature database (CBM), VIP Database for Chinese Technical Periodicals (VIP). Journal Integration Platform and WAN FANG Database. We select the appropriate searching language. The primary outcome was remission rate, and the secondary outcomes include clinical symptoms, clinical examination, adverse event. Data extraction and quality assessment will be conducted by 2 experienced researchers independently. Data analysis and the risk of bias assessment will be determined by RevMan 5.3 software.Results:Based on the current proofs, we will get the exact evidence about the safety and effectiveness of BHT in the treatment of chronic pharyngitis.Conclusion:Our study is the first meta-analysis to evaluate the efficacy and safety of BHT in the treatment of chronic pharyngitis, and it will provide evidence for alternative treatment for the management of chronic pharyngitis.OSF Registration number:DOI 10.17605/OSF.IO/QNF6X

Mapping disciplinary differences of knowledge production and collaboration networks in China

ABSTRACT The knowledge economy – defined here as production and services based on knowledge intensive activities – is widely recognized to have accelerated knowledge production and spillovers through a deepening of collaborative networks that can extend over extensive geographical distances. However, limited by data availability, the geography of China’s knowledge production and collaborative networks, segmented by different disciplines, has been little studied in economic geography or innovation studies. This paper draws on data on academic publications that were extracted from the China Academic Journal Network Publishing Database (CAJD) in order to construct knowledge production and collaboration networks for different disciplines in China. The results depict a series of maps that show that: (1) the ‘hard’ sciences (natural sciences and engineering) outperform much more than the ‘soft’ sciences (humanities and social sciences) both in article number and collaboration strength; and (2) large metropolises have overwhelming advantages in the terms of both paper production and the collaboration strength for all disciplines, despite varying among different disciplines. These uneven geographical patterns can be partially attributed to a high concentration of scientific resources in a few large cities, which was inherited from the Maoist period.

Trends and Reflections

Christianity in China has achieved a rapid growth in population since the 1980s. This article mainly reviews empirical studies on Christianity from 2000 to the present. Drawing on statistics from the China Academic Journal Network Publishing Database (cajd), this article begins with an analysis of the trends in both quantity and research interests of large-scale empirical studies. Categories of churches are defined and applied to the analysis of various topics related to Christianity in China and to academic questions addressed by Chinese scholars. The article also discusses theoretical frameworks used to explain the dynamics behind the revival of Christianity and studies of the social functions of Christian churches. In addition, the article reviews investigations of Christianity in social life in contemporary China, studies of religious boundaries and civil society, the causal relationship between Christianity and economic development, its functions in urbanization, and other related subjects. It ends with discussions of Christianity’s global dimension, its identity as a global religion, and its relation to the emergence of a global China.

Repeat abortion and determinants of Chinese women: A systematic review and meta-analysis

Background Repeat abortion is a public health problem globally and has adverse impacts on women's reproductive health. Risk factors associated with repeat abortion have been well-established in many studies; however, studies documenting the prevalence of repeat abortions and associated risk factors in China are hard to access, due to the language barrier, as they are mostly published in Chinese. Meanwhile, the two-child policy in China may increase the risk of repeat abortions among women in China, hence, the need to review and document existing evidence on repeat abortions in China. Methods For this systematic review, we searched through six electronic databases, including PubMed, EMBASE, Cochrane Library, China Academic Journal Network Publishing Database, China Science Period Database, and China Biology Medicine disc. The focus of the review was on original studies, with no restrictions on language or publication date. The last search was run on May 5, 2017. The studies, which presented data on repeat abortion and related risk factors of women in mainland China were selected for the review. Two reviewers reviewed all the articles and extracted relevant data from the selected full-text studies. Meta-analyses were performed using RevMan 5.3 and the odds ratios with 95% confidence intervals were calculated in fixed or random effects models based on the results of the Q test. The publication bias was quantitatively evaluated by Egger's linear regression analysis using Stata 13.0. A narrative approach was used to analyze exposures; for which a meta-analysis was not possible. We used descriptive statistics to assess whether the percentage of repeat abortion varied significantly among women in different groups of each exposure. Results Of 3015 records initially identified, 29 studies met our inclusion criteria, representing 36,879 individuals from China. Of 36,879 individuals in 28 cross-sectional studies, 43.0% (15854) had a repeat abortion. Of 48 exposures identified, 25 were significantly associated with repeat abortions of Chinese women. Meta-analyses indicated that women who were older (≥ 20 years, OR: 2.08, 95% CI: 1.72–2.50), multiparous (≥ 1 child, 4.99, 2.18–11.43), migrant (1.62, 1.34–1.96), unemployed (2.20, 1.65–2.93), tobacco/alcohol users (2.35, 1.66–3.32), with early sexual debut ( Conclusions Chinese women with a repeat abortion account for a large percentage of the total sample of women in the included studies. Despite significant heterogeneity of some risk factors, there is evidence that repeat abortions of women are associated with individual, sexual-partner's, and parental risk factors. More targeted strategies should be developed to reduce the high-risks of repeat abortions of women.

Study of Literatures for the Impact on PM2.5 Purification by Architectural Design under Haze Conditions

This paper focuses on literatures reviewing with key words of architectural and PM2.5 based on the China Academic Journal Network Publishing Database (CKNI) and Elsevier SD database. Statistical analysis on the searched 184 related literatures show the following results. (1) 20.6% of the all targeted literatures showed that PM2.5 concentration was one of the important impact parameters of indoor & outside air quality. (2) 16.3% of the literatures illustrated that the architecture designing contributed significantly to indoor and outdoor fine particulate pollution by controlling particle generation and diffusion. It can be concluded that the three-dimensional architectural design, the total layout of the building designing strategy and the architectural space design based on green building-oriented architectural designing concept will be the future focused research and the frontier question.

Single nucleotide polymorphisms of IL-13 and CD14 genes in allergic rhinitis: a meta-analysis.

The aim of this study was to conduct a meta-analysis for single nucleotide polymorphisms (SNPs) in interleukin-13 (IL-13) and cluster of differentiation 14 (CD14) genes and the risk for allergic rhinitis (AR). We screened studies identified through seven databases including Pubmed, Medline, Web of Science, Embase, China Biology Medicine disc, Wanfang, and China Academic Journal Network Publishing Database. The odds ratios (ORs) and 95% confidence intervals (CIs) were determined to assess the association under allelic, dominant and recessive models. Twelve studies with a total of 8547 participants (3223 cases and 5324 controls) investigated IL-13 SNP rs20541, five studies combining 4580 participants (1411 cases and 3169 controls) examined IL-13 SNP rs1800925, and nine studies with 2301 participants (1174 cases and 1127 controls) assessed CD14 SNP rs2569190. We found that the A allele of IL-13 SNP rs20541 was associated with an increased risk of AR (OR 1.19, 95% CI 1.11-1.28, P < 0.001). Stratifying studies by ethnic group produced significant results in Asians (OR 1.21, 95% CI 1.11-1.32, P < 0.001), but not in Caucasians (OR 1.14, 95% CI 1.00-1.30, P = 0.051). No association of IL-13 SNP rs1800925 and CD14 SNP rs2569190 with AR risk was found in either Asians or Caucasians (P > 0.05). Our findings suggest that IL-13 SNP rs20541 is significantly associated with AR risk in Asians but not in Caucasians. However, the accumulating evidence does not support an association of IL-13 SNP rs1800925 and CD14 SNP rs2569190 with AR risk.

Topical application of corticosteroids to tracheal tubes to prevent postoperative sore throat in adults undergoing tracheal intubation: a systematic review and meta-analysis.

Postoperative sore throat negatively affects patient satisfaction and recovery. Numerous randomised trials have tested the efficacy of corticosteroids applied to tracheal tubes to prevent postoperative sore throat. We searched PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, Wanfang Database, and the China Academic Journal Network Publishing Database from inception to 7 December 2017. We included randomised controlled trials that assessed the efficacy and safety of corticosteroids applied to tracheal tubes, compared either with non-analgesic controls and analgesic agents, in adults undergoing elective surgery under general anaesthesia. We pooled the data using a random-effects model and assessed the risk of random error by applying trial sequential analysis. Our primary outcomes were postoperative sore throat 24 h after surgery/extubation, and adverse events. The evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria. We included 20 randomised controlled trials involving 2200 patients. Compared with non-analgesic controls, corticosteroids applied to tracheal tubes were associated with a reduced incidence of postoperative sore throat, risk ratio (95%CI) 0.39 (0.32-0.49) (18 trials, 1506 patients). Two randomised trials reported no adverse events. Compared with lidocaine, corticosteroids applied to tracheal tubes were associated with reduced incidence of postoperative sore throat, risk ratio (95%CI) 0.42 (0.35-0.51) (nine trials, 706 patients). Trial sequential analyses suggested the presence of firm evidence that corticosteroids applied to tracheal tubes were superior both to non-analgesic controls and lidocaine, in preventing postoperative sore throat. Evidence for postoperative sore throat for both comparisons was assessed as high quality. Only two trials sought adverse events; none were recorded.

Research status of the effect mechanism on catgut-point embedding therapy

This paper aims to review the research status of the effect mechanism of catgut-embedding therapy. The literature was retrieved from China Academic Journal Network Publishing Database with the keywords as "catgut-point embedding" "embedding", dated from the database establishment to December 2015. Totally, over 5 000 papers had been collected. It was summarized that TCM effect mechanism of catgut-point embedding therapy includes the effects of needle retaining and embedding, harmonizing yin and yang, balancing zangfu organs, promoting meridian qi, regulating qi and blood, tonifying for the deficiency and reducing for the excess, strengthening the antipathogenic qi and eliminating pathogens. From the point of view of western medicine, the effect mechanism of catgut-embedding therapy refers to recovering nerve function, regulating neural reflex, increasing human immunity, improving local circulation, inhibiting the release of inflammatory factors, reducing apoptosis, regulating cellular factor and improving body metabolism. It was found that the effects of catgut-embedding therapy were not only related to the effects induced by common acupuncture, but also to the persistent treatment through prolonged stimulation duration, especially in the treatment of chronic diseases with many systems involved. This therapy reduces or complements to the use of western medicine to certain extent. However, the longitude theoretic study on the catgut-embedding therapy is limited; the specific statement is less predominant and the clinical controlled trial is insufficient at present. Hence, further studies are requested.

The Rise of MOOCs: The Literature Review of Research Progress and Hot Spots of MOOCs Education in Mainland China

With the development of information technology, knowledge acquisition is not just limited to the traditional classroom. As a rising educational method, “Massive Open Online Courses (MOOCs)” has attracted extensive attention by educational circles. Taking 445 pieces of journal articles about educational study of MOOCs included in China Academic Journal Network Publishing database (CAJD) from 2013 to 2016 as samples, this study adopts bibliometric analysis method and visual knowledge network analysis tool CiteSpace to carry out in-depth exploration of aspects such as development status, developing trend, and hot subjects of educational study of MOOCs. The study discovers that the quantity of the articles about educational study of MOOCs presents a rising trend as a whole in the past four years. Highly cited articles mainly concentrate on pedagogy. A small part of articles focus on fields like library and information and computer science. The evolution course of study has experienced the process of “introduction-development-deepening” and its hot subjects include reflection on teaching practice, modern teaching means and existing problems and reform path. On this basis, the shortcomings of the existing researches are pointed out.

Research status, hotspots and trends for information behavior in China using bibliometric and co-word analysis

PurposeThe purpose of this paper is to analyze the research status and outputs of information behavior in China in order to reveal its in-depth research pattern and trends.Design/methodology/approachThe author collected literature during the past 29 years from China Academic Journal Network Publishing Database. Bibliometric analysis, including publication growth analysis, core authors and collaborative degree analysis, core journals analysis, and institutions distribution, was performed. The temporal visualization map of burst term was drawn, and the co-occurrence matrix of these keywords was analyzed by the hierarchical cluster analysis, strategic diagram, and social network analysis.FindingsThe earliest article on information behavior in China was published in 1987. And the number of articles has risen continually since then, which follows the logical growth law of literature. The collaborative degree of authors is on the rise in general. The distribution of these articles obeys the Bradford’s Law of Scattering. School of Information Management of Wuhan University remarkably ranks the top in most publications. In all, ten important research directions were identified, which are in the imbalanced development. And a newly appearing topic with great potential for further development, namely information seeking and information security, is identified.Originality/valueThis study provides important insights into the research status and trends on information behavior in China, which might provide a potential guide for the future research.

Prophylactic Corticosteroids for Prevention of Postextubation Stridor and Reintubation in Adults: A Systematic Review and Meta-analysis

Corticosteroid administration before elective extubation has been used to prevent postextubation stridor and reintubation. We updated a systematic review to identify which patients would benefit from prophylactic corticosteroid administration before elective extubation. We searched PubMed, EMBASE, the Wanfang Database, the China Academic Journal Network Publishing Database, and the Cochrane Central Register of Controlled Trials for eligible trials from inception through February 29, 2016. All randomized controlled trials were eligible if they examined the efficacy and safety of systemic corticosteroids given prior to elective extubation in mechanically ventilated adults. We pooled data using the DerSimonian and Laird random-effects model. We identified 11 trials involving 2,472 participants for analysis. Use of prophylactic corticosteroids was associated with a reduced incidence of postextubation airway events (risk ratio [RR], 0.43; 95%CI, 0.29-0.66) and reintubation (RR, 0.42; 95%CI, 0.25-0.71) compared with placebo or no treatment. This association was prominent in participants at high risk for the development of postextubation airway complications, defined using the cuff-leak test, with a reduced incidence of postextubation airway events (RR, 0.34; 95%CI, 0.24-0.48) and reintubation (RR, 0.35; 95%CI, 0.20-0.64). This association was not found in trials with unselected participants. Adverse events were rare. Administration of prophylactic corticosteroids before elective extubation was associated with significant reductions in the incidence of postextubation airway events and reintubation, with few adverse events. It is reasonable to select patients at high risk for airway obstruction who may benefit from prophylactic corticosteroids.

Investigating disciplinary differences in the relationships between citations and downloads

Several studies have examined the relationships between citation and download data. Some have also analyzed disciplinary differences in the relationships by comparing a few subject areas or a few journals. To gain a deeper understanding of the disciplinary differences, we carried out a comprehensive study investigating the issue in five disciplines of science, engineering, medicine, social sciences, and humanities. We used a systematic method to select fields and journals ensuring a very broad spectrum and balanced representation of various academic fields. A total of 69 fields and 150 journals were included. We collected citation and download data for these journals from China Academic Journal Network Publishing Database, the largest Chinese academic journal database in the world. We manually filtered out non-research papers such as book reviews and editorials. We analyzed the relationships both at the journal and the paper level. The study found that social sciences and humanities are different from science, engineering, and medicine and that the pattern of differences are consistent across all measures studied. Social sciences and humanities have higher correlations between citations and downloads, higher correlations between downloads per paper and Journal Impact Factor, and higher download-to-citation ratios. The disciplinary differences mean that the accuracy or utility of download data in measuring the impact are higher in social sciences and humanities and that download data in those disciplines reflect or measure a broader impact, much more than the impact in citing authors.

Research Progress on the Subject Service of Domestic Libraries and its Significance on Medical Scientific Research Management

Taking the papers in core journals of 'CNKI’ academic journal network publishing database as data sources, the paper conducts statistical analysis on papers about subject services by the end of 2014, including analysis on publishing years, periodical distribution, author distribution, subject distribution and so on. The paper summarizes current situation and characteristics of the research of domestic subject service so as to provide some references for hospital libraries and thinks over its significance on medical scientific research management. Key words: Subject service; Literature metrological analysis; Hospital library; Medical scientific research management

Relationship between the thyroid autoimmunity and the risk of preterm birth in pregnant women: a meta-analysis

To evaluate the relationship between thyroid autoimmunity and the risk of preterm birth. Literature search was done among PubMed, Embase, Wanfang Medical Database, China Academic Journal Network Publishing Database and China Biology Medicine disc from Jan. 1(st) 1980 to July 31(st), 2015. (1) Literature were extracted according to inclusion and exclusion standards, and the quality of the extracted literature were evaluated by Newcastle-Ottawa Scale (NOS). (2) Meta-analysis was performed by RevMan 5 software formulated by using the Cochrane library databases. Various heterogeneity of the research was inspected firstly. According to the results of the inspection a certain effect model was selected (including fixed effects model, the random effects model) to be utilized in merger analysis. In this study pregnant women with both thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin (TG-Ab) positive were defined as thyroid antibody positive pregnant women. Pregnant women with only TPO-Ab positive were defined as TPO-Ab positive pregnant women. Then the relationship of antibody positive and the risk of a preterm birth was analyzed respectively. (1) Ten cohort studies were enrolled, of which NOS scale score were 7 or higher. All the studies are of medium quality and above. A total of 1 322 cases of preterm birth occurred among 19 910 pregnant women. (2) Positive thyroid autoantibodies did not increase the risk of preterm birth in euthyroid pregnant women (OR=1.41, 95%CI: 0.83-2.40, P=0.200) or in pregnant women with hypothyroidism (OR=0.68, 95% CI: 0.32-1.44, P=0.310) . Positive TPO-Ab in euthyroid pregnant women increase the risk of preterm birth significantly (OR=2.08, 95%CI: 1.09-3.97, P=0.030), but positive TPO-Ab in pregnant women with hypothyroidism did not increase the risk of preterm birth significantly (OR=1.21, 95%CI: 0.65-2.24, P=0.550). Positive TPO-Ab is an independent risk factor of preterm birth in euthyroid pregnant women.

Meta-analysis of aetiology and the severity of acute pancreatitis about Chinese clinical trials

Objective To investigate the characteristics of common causes of acute pancreatitis (AP) in China and to evaluate the association of the aetiology with the severity of disease. Methods The relevant literature was searched from the China National Knowledge Infrastructure (CNKI) database (1989.1-2015.3), WANFANG database (1999.1-2015.3), VIP database (1994.1-2015.3), and China Academic Journal Network Publishing Database (CAJD). To collect related literature about aetiology and the severity of acute pancreatitis, Meta analysis was performed for gallstone, alcohol, hyperlipidemia and other AP from the aspects of the severity of disease in the literature which reaches the criteria. Results The Meta analysis included 24 clinical articles which were accordance with the criteria, totally 17359 patients, including 8673 cases of biliary AP [6690 cases of mild acute pancreatitis (MAP), 1983 cases of acute necrotizing pancreatitis (ANP)], 1408 cases of alcoholic AP (1022 cases of MAP, 386 cases of ANP), 1753 cases of hyperlipidemia AP (1107 cases of MAP, 646 cases of ANP), and 5525 cases of other aetiology (4179 cases of MAP, 1346 cases of ANP). The Meta analysis showed that among the common causes which was developed to AP, there was significant difference between biliary AP and alcohol AP (OR=0.65, 95% CI: 0.45~0.93, P 0.05). Conclusions There is difference in the severity of AP caused by different reasons in China. There is more likely that hyperlipidemia AP and alcohol AP easily developed into ANP than biliary AP. However, further investigation and large-scale clinical trials will be needed to confirm this conclusion. Key words: Pancreatitis/ET; Meta-analysis

Short and long-term outcomes of placental transfusion in very low birth weight infants: a meta analysis

Objective To investigate the risks and benefits of interventions promoting placental transfusion (PT) at delivery [delayed cord clamping (DCC) or umbilical cord milking (UCM)] compared with early cord clamping (ECC) on outcomes among very low birth weight infants (VLBWI). Methods A systematic search was conducted of PubMed, EMBASE, ClinicalTrials.gov, China Academic Journal Network Publishing Database and Wanfang Medical Databases (January 1965 to July 2014) for randomized controlled trial (RCT) articles relating to PT strategies (DCC and UCM) in VLBWI. The Cochrane Handbook 5.1.0 was used to evaluate the methodological quality and RevMan 5.3 software from Cochrane Collaboration was used for meta-analysis. The fixed effect or random effect model was adopted according to the result of heterogeneity. Results We identified 14 eligible studies describing a total of 659 neonates with an average birth weight 0.05): 5-minute Apgar scores (MD=0.01, 95%CI: -0.21-0.22), admission temperature (MD=0.13, 95%CI: -0.15 to 0.41), peak serum bilirubin levels (MD=0.59, 95%CI: -0.13 to 1.31), initial reported hematocrit (MD=3.48, 95%CI: -0.46 to 7.43), mortality before discharge (OR=0.63, 95%CI: 0.31-1.25), Bell's stage 2 or greater necrotizing enterocolitis (OR=0.62, 95%CI: 0.29-1.33), rates of transfusion due to anemia (OR=0.63, 95%CI: 0.35-1.15) and oxygen therapy at 36 weeks of corrected age (OR=0.79, 95%CI: 0.46-1.34). Conclusions It is suggested that enhanced PT (both DCC and UCM) at birth is safe and provide better neonatal outcomes than ECC for those VLBWI, most notably reduces the overall IVH occurrence and lower the incidence of sepsis. The optimal umbilical cord clamping practice and UCM among VLBWI infants remains uncertain and long-term neurodevelopmental outcomes are warranted. Key words: Infant, very low birth weight; Blood transfusion; Placental circulation; Umbilical cord; Ligation; Constriction; Meta-analysis