Abstract Submission Deadline Research Articles

Natural History of Tumor Thrombus: A Single-Centre Retrospective Study

Introduction: Venous thromboembolism (VTE) encompasses a spectrum of disorders involving thrombosis in the venous circulation, namely deep vein thrombosis (DVT) and pulmonary embolism (PE). The incidence of thrombosis is significantly elevated in patients with malignancy due to a hypercoagulable state. In addition to the elevated risk of thrombus formation in patients with malignancy, certain tumours have a predilection for intravascular extension, termed tumour thrombus. The presence of tumour thrombus considerably worsens prognosis, alters staging, and can influence the treatment options for these patients. While tumour thrombus can have have a significant impact on patients, the clinical course and optimal management of tumour thrombus remains unknown. We aim to describe the natural history of tumour thrombus and compare outcomes in those treated with or without anticoagulation at our centre. Methods: We performed a retrospective, observational review of patients over 16 years of age with tumour thrombus at a single-centre between January 2008 and December 2017. Patients with documented tumour thrombus on computed tomography (CT), magnetic resonance imaging (MRI), or ultrasound (US) were included in this study. Patients already on anticoagulation were excluded. Data were collected through medical record review including baseline characteristics, treatment history, complications and clinical outcomes. Overall survival and VTE recurrence rates between those treated with or without anticoagulation were demonstrated using Kaplan-Meier survival curves and Log-rank test. Cox-proportional hazards models were used to estimate the hazard ratio for tumor thrombosis with and without adjustment for patient characteristics including comorbidities, treatment, acuity, and location. Results: A total of 153 patients were identified to meet inclusion criteria over the study period. The majority of patients were male (65.4%) with an mean age of 65.7. The most common malignancies associated with tumour thrombus were renal cell carcinoma (34.6%) and hepatocellular carcinoma (28.8%), with 125 patients (82.5%) having stage III or IV malignancies. The most common locations of tumour thrombus were the portal vein (37.5%), renal vein (32.9%) and inferior vena cava (26.3%). Forty-one patients (26.8%) were treated with anticoagulation. Of the entire study population, 18 patients (11.8%) developed VTE within a 6 month study period after being diagnosed with tumour thrombus. Of those that developed VTE following a diagnosis of tumour thrombus, 11 were on anticoagulation (61%) and 7 were not (39%). Five patients receiving anticoagulation experienced major bleeding. Mortality was 42.5% at 6 months with no significant difference in survival between those treated with or without anticoagulation (Figure 1; p = 0.42). Proportion hazards models were not completed at the abstract submission deadline; full study results will be presented at the ASH meeting. Conclusion: In our study, we show that there is no significant difference in survival between patients with tumour thrombus treated with or without anticoagulation. While there is no clear evidence that anticoagulation improves outcomes across all patients with tumour thrombus, further studies are needed to identify subgroups of patients who may benefit from anticoagulation given their increased risk of VTE. Figure 1 Disclosures Keating: Sanofi: Membership on an entity's Board of Directors or advisory committees; Celgene: Membership on an entity's Board of Directors or advisory committees; Novartis: Honoraria; Seattle Genetics: Consultancy; Janssen: Membership on an entity's Board of Directors or advisory committees; Shire: Membership on an entity's Board of Directors or advisory committees; Hoffman La Roche: Membership on an entity's Board of Directors or advisory committees.

Editorial

Announcement for the 20th Asian Bioethics Conference (ABC20) to be held on 22-25 Nov, 2019 at Dhaka, Bangladesh by Prof. Shamima Lasker, Secretary General, Bangladesh Bioethics Society .The conference will be organized by Bangladesh Bioethics Society (BBS) in cooperation with DGHS, Ministry of Health and Family Welfare, People’s Republic of Bangladesh and in conjunction with ABA and Eubios Ethics Institute, Thailand, New Zeeland and Japan. It will provide opportunity for all scholars around the world to present their research work, maximize networking opportunities, and learn about the latest information and methodologies on bioethics.
 Abstract Submission will be open from 1st March, 2019. Abstract Submission Deadline: August 15, 2019. Please send your abstract to Prof MA Shakoor at: shakoor.abc2019@gmail.com and rafe.dr@gmail.com and cc to splasker04@yahoo.com for your all communication.
 Come and join us in Dhaka the old Moghul city!

Abstract 1010: Establishing lobular-like and interlobular-like fibroblast cell lines from human breast reduction mammoplasties

Abstract Introduction: The importance of epithelial-stromal interactions for tissue homeostasis and maintenance is well documented. We have recently provided evidence that two distinct fibroblast lineages in the human breast stroma, lobular and interlobular, respectively, can be prospectively isolated and stably propagated in serial-passage subculture. The aim of the present study was to generate immortalized and stable cell lines derived from lobular and interlobular fibroblasts with preserved lineage identity and functionality. The availability of such cell lines will allow for an as of yet unprecedented detailed characterization of mammary fibroblast lineages including their specific interactions with normal and malignant breast epithelium. Results: Lobular- and interlobular-derived fibroblast cell strains in passage 8 were immortalized by retroviral introduction of human telomerase reverse transcriptase (hTERT) followed by neomycin selection. At abstract submission deadline, lobular and interlobular hTERT expressing fibroblasts had reached passage 56 corresponding to 60 and 100 population doublings, respectively, while mock-transfected controls had seized proliferating in passage 21. Lineage restriction of immortalized cells was maintained as lobular fibroblasts express higher levels of CD105 than interlobular fibroblasts. Also, lobular fibroblasts are able to undergo adipogenic and osteogenic differentiation upon relevant induction in culture, but fail to generate bone in an in vivo ectopic bone formation model, thus functionally distinguishing lobular fibroblasts from bone marrow-derived mesenchymal/skeletal stem cells. Upon co-culture with primary breast luminal progenitors, lobular fibroblasts support epithelial growth and branching morphogenesis, including correct apical-basal polarization. Conclusion: Lobular and interlobular fibroblasts have been successfully immortalized while preserving both lineage restriction and functional characteristics of their primary counterparts. With 80% of breast cancers arising in lobular epithelium, these established fibroblast models may prove instrumental to unravel such focal susceptibility to breast cancer development. Citation Format: Mikkel Morsing, Abbas Jafari, Moustapha Kassem, Ole William Petersen, Lone Rønnov-Jessen. Establishing lobular-like and interlobular-like fibroblast cell lines from human breast reduction mammoplasties [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1010.

From Abstract to Publication in a Peer-Reviewed Journal: Evaluation of the 63rd Annual Meeting of the German Society of Neurosurgery.

The presentation and academic discussion of the latest scientific research is the central purpose of meetings like the annual meeting of the German Society of Neurosurgery (DGNC). The aim of this study was to investigate the publication rate of all oral and poster abstracts of the DGNC meeting 2012 held in Leipzig, Germany, in peer-reviewed journals and to identify factors that are associated with a higher publication rate. We reviewed all accepted oral and poster presentations of the meeting. Then a search in PubMed was performed to determine the publication rate within 3 years after the abstract submission deadline. We used the information to identify factors associated with a higher publication rate. The publication rate in a peer-reviewed journal was 40.4% for all presented abstracts. Overall, 41.5% of all poster presentations and 40.1% of all oral presentations were published within 3 years. Abstracts presenting prospective studies or university research had a statistically higher chance of publication. The average journal impact factor for all published abstracts was 2.99, and 81 different journals were chosen for publication. Overall, 40.4% of all presented abstracts at the 2012 DGNC were published in a peer-reviewed journal indexed in PubMed, which reflects the high scientific standard of this meeting. Prospective studies and studies presented by authors from universities had a higher chance of being published.

PEI 2010: CUA NEWS Save the date!

Allow me to brag a little about the next CUA Annual Meeting. CUA’s 65th Annual Meeting will be held in beautiful Charlottetown, PEI. The local organizing committee and I are pretty excited that PEI is hosting this CUA meeting for the first time! We’re proud to state that PEI is the birthplace of Canada—over 140 years ago, in 1864 to be exact, elected officials met in PEI to discuss the idea of creating a country. This historic event was the catalyst to the founding of Canada. Come and explore this wonderful and historically rich part of Canada! If you haven’t attended a CUA Annual Meeting yet, make this your first! If you’ve already attended meetings in the past, be sure to save the date for next year’s meeting—June 27–30, 2010. Many of us are planning our family holidays in PEI to coincide with the meeting. Our scientific program promises to be intellectually stimulating and enriching. The program, chaired by Dr. Ricardo Rendon, will feature state-of-the-art lectures from key opinion leaders in urology, Educational Fora addressing a wide spectrum of the most compelling issues and controversies in urology, and an abstract-driven session showcasing the most cutting-edge research being done in Canada today. Michael Mulligan and Ian Reid, along with the rest of the local organizing committee, have been working hard to make sure the social program is exciting and exhilarating. In a nutshell, the CUA’s agenda is as follows: The Scientific Program will begin Sunday morning. Sunday night is the Welcome reception—an opportunity to meet up with old friends and make dinner plans. Take this evening to settle into our gorgeous headquarter hotel, the Delta Prince Edward, and prepare for the two full days of science ahead. On Monday, after the sessions, unwind at the CUA Fun Night. Here, you’ll feel right at home as you experience true Maritime hospitality with friends and colleagues. On Tuesday evening, join us for the traditional President’s Banquet. The CUA 2010 abstract submission deadline for oral, poster and video presentations is January 15, 2010. The online submission site will be operational in late fall 2009 at www.cuameeting.org. For any questions concerning abstract submissions, please contact the Scientific Program office atgro.auc@tcartsba. If you have any questions about the meeting or about the CUA, feel free to contact me. I hope to see you there!

Westward bound for the next CUA Annual Meeting!

First and foremost, I would like to thank CUA members, Executives and Past-President Dr. Sender Herschorn for entrusting me with the position of CUA President. I have big shoes to fill and am ready to serve members! This year our Annual Meeting was held in Montreal – the meeting was a success, with strong scientific content and a robust social program! Next year, I am honoured to host the 67th Annual CUA Meeting in Banff, Alberta. On June 24–26, 2012, please join us at the Fairmont Banff Springs Hotel for what will be the complete “package” of a meeting. The local organizing co-chairs Dr. Marty Duffy and Dr. Howard Evans throw a party like nobody else! Dr. Jay Lee and Dr. Trevor Schuler will put together a superb scientific meeting that will match the spectacular ambience of Banff National Park. Our special guest speakers will include dynamic experts in urology and other fields, such as Drs. CK Yeung, Mark Moyad, Jerry Jordan, Tony Zietman, Mark Soloway and Richard Satava. Please block off the week, bring your family and make it a vacation that you will never forget! We look forward to seeing all of you in Banff in June 2012. Abstract Submission Deadline: Friday, January 13, 2012

Special Issue of Accounting Forum: Social and environmental accounting and reporting in emerging and less developed countries

Submission Deadline: February 1, 2011 Research on social and environmental accounting in emerging and less developed countries is scarce as most of the literature in that area has concentrated on Western developed countries. The socio-economic realities of emerging and less developed countries are different as are corporate motivations for undertaking social and environmental accounting. Some of the emerging countries, more commonly known as BRICs (Brazil, Russia, India and China), have seen significant economic growth in recent times. Such growth will inevitably have social and environmental effects. Advocates of corporate social responsibility (CSR) and its reporting argue that business organisations as ‘engines of economic growth’ should be held responsible and accountable for the related social and environmental consequences which could be significant in these countries. Research on social and environmental accounting is also scarce in some of the former eastern European countries which went through significant political changes and introduced strong economic reforms. The BRICs, eastern European and other less developed smaller ex colonial countries are confrontedwith massive problems that include those related to the effects of climate change, poverty, human rights violations, child labour, corruption and social exploitations. Some of these issues are more contentious in this context. It can be argued that some of these tensions can be illuminated via complete and transparent social and environmental disclosures which then can be used to hold organisations to account. The purpose of this special issue is to provide a forum to explore social and environmental accounting and reporting from the under researched context of emerging and less developed countries. Appropriate topics include:

Scientific Programme - Abstract Submission deadline - Friday 21st August. Proffered papers will be allocated to the scientific sessions

Scientific Programme - Abstract Submission deadline - Friday 21st August. Proffered papers will be allocated to the scientific sessions

Call for Papers Verification and Computational Logic Special Issue of Theory and Practice of Logic Programming

Submission deadline: January 10, 2002The past decade has seen dramatic growth in the application of model checking techniques to the validation and verification of correctness properties of hardware, and more recently software systems. One of the methods is to model a hardware or software system as a finite, labelled transition system which is then exhaustively explored to decide whether a given temporal specification holds. Recently, there has been increasing interest in applying logic programming techniques to model checking in particular and verification in general. For example, table-based logic programming can be used as an efficient means of performing explicit model checking. Other research has successfully exploited set-based logic program analysis, constraint logic programming, and logic program transformation techniques.The aim of this special issue is to attract high-quality research papers on the interplay between verification techniques (e.g. model checking, reduction and abstraction) and logic programming techniques (e.g. constraints, abstract interpretation, program transformation).

12th ICA sets abstract submission deadline

12th ICA sets abstract submission deadline