Absoluteness Research Articles

IoT-Based Automatic Hydro-Organic Smart Farming System in Greenhouse with Solar Panels for Khok Nong Na

In this research, we propose IoT-Based Automatic Hydro-Organic Smart Farming System (AHOSFS) in Greenhouse with Solar Panels for Khok Nong Na, design and development with Internet of Things and solar energy. Data is collected from sensors for the following factors that affect plant growth: humidity, temperature, light, pH, EC, air quality, water temperature, and water level. The Firebase cloud-based application was used to collect all the data, and it enables farmers to monitor and control the system using their smartphones. The results showed AHOSFS can mix water and nutrient solution, which measure pH of 6.61 and EC of 1.23, control water level and mix nutrient solution in appropriate quantities. Green oak can thrive at pH levels between 6.0 and 7.0, EC levels between 1.1 and 1.7, and humidity level between 75 and 85. The sensor measured temperature value between 18 and 25 °C, which was adequate for the growth of green oak. Sensor also measured water temperature between 25 and 28 °C. The comparative value of cultivation in a hydro-organic system deployed between AB solution, organic fertilizer Formula 1 and Formula 2 found that organic fertilizer formula 1 has an effective and approximate AB solution at 81.64%. The fertilizer formula 2 has AB solution at 89.72%, which was more secure at a comparable level.

Correlating the Ambient Conditions and Performance Indicators of the LoRaWAN via Surrogate Gaussian Process-Based Bidirectional LSTM Stacked Autoencoder

LoRa’s biggest advantage is its flexibility, which is the ability to increase or decrease data rate and range while decreasing or increasing sensitivity. Whenever propagation conditions change frequently, this function allows the spreading factor to be modified accordingly. Despite their efficiency and scalability, adaptive data rate algorithms ignore and fail to factor in the complex correlation between ambient weather parameters influencing the communication channel desig n. In this research, a Bayesian surrogate Gaussian pr ocess based bidirectional LSTM stacked autoencoder model (BSGP BLSTMSAE) is proposed to estimate the channel perfor-mance indicators such as received signal strength indicator (RSSI) and signal to noise ratio (SNR) and to determine the correlation between the ambient weather conditions and per-formance indicators for the LoRaWAN network. Bayesian op-timization algorithm has been used to optimize the hyper parameters of the developed model. A LoRaWAN experimental multivariate time series dataset has been used for the evalua-tion of the developed model, which upon testing and validation produces high accuracy in predicting the channel performance indicators and ambient conditions of the experimental Lo-RaWAN network. The mean absolu te error of the developed model was around 0.45. Thus, the proposed model can predict the link performance indicators and thereby assist in real time optimization of the transmission parameters to enhance the network performance in LoRaWAN based systems at different ambient conditions

An efficient symplectic stereo-modeling method for seismic inversion by using deep learning technique

AbstractThis paper proposes an efficient symplectic stereo-modeling (SSTEM) method for full waveform inversion (FWI) by using a deep learning technique. To solve the 2D acoustic equation, the SSTEM method uses a third-order optimal symplectic partitioned Runge–Kutta approach as a time-stepping method. An eighth-order stereo-modeling operator is used for spatial discretization. The SSTEM method is then expressed with a recurrent neural network (RNN). This is realized mainly because the time advancing format of the SSTEM method is similar to that of RNN, and they both use the information from the previous time step to obtain information from the current time step. With SSTEM as the forward modeling method, FWI is implemented using Tensorflow. The well-known adaptive moment estimation (Adam) optimizer and Nesterov adaptive moment estimation (Nadam) optimizer with mini-batch are used. The applicability of the developed code is also verified on GPUs. The numerical results show that the SSTEM method is more efficient and produces less numerical dispersion than the conventional finite-difference (FD) method when the same sampling rate in a wavelength is used. We compare several loss functions. The mean square (MSE) error and absolute (ABS) error loss functions are first tested. Another loss function that adds a physical differential operator to the original loss function is then considered. The FWI results show that this loss function has some improvements. Finally, we implement FWI on the complex Marmousi and SEG/EAGE models, and the inversion results demonstrate that the proposed method is suitable for seismic imaging in complex media.

Immuno-chromatic probe based lateral flow assay for point-of-care detection of Japanese encephalitis virus NS1 protein biomarker in clinical samples using a smartphone-based approach.

Lateral flow assays (LFAs) are one of the most economical, point-of-care (PoC) diagnostic assays that exploit the colorimetric properties of gold nanoparticles (AuNPs). Up to the best of our knowledge, no rapid antigen-based LFA exists for Japanese Encephalitis Virus (JEV) detection. Herein, we have reported a novel portable sandwich-type LFA for on-site detection of the non-structural 1 (NS1) secretory protein of JEV. In-house JEV NS1 antibodies (Abs) were generated and labelled with AuNPs as immunoprobes. A glass fibre membrane conjugate pad was soaked with AuNPs–Ab solution, while the JEV NS1 Ab and anti-rabbit IgG 2° Ab were coated as the test and control lines, respectively, on a nitrocellulose (NC) membrane. Different layers of the LFA were fabricated and various parameters were standardised for optimum colour intensity development. JEV negative serum samples spiked with JEV NS1 Ags (linear range – 1 pg ml−1 to 1 μg ml−1) were applied onto the sample pad and the intensity of the red colour developed on the test line increased with increasing concentration of Ag. The visual limit of detection (LOD) determined from the LFA was 10 pg ml−1, which corresponded to the LOD determined by the graphical data obtained from ImageJ software and the Colorimeter smartphone application. Furthermore, the colorimetric based immunosensor showed minimal non-specific detection of other closely related flaviviral NS1 Ags in the spiked serum, provided a rapid result within 10 min, showed storage stability up to a month at 4 °C, successfully detected the JEV NS1 protein in clinically infected pig serum samples, and hence, may be developed into a PoC screening diagnostic kit for JEV.

Non-Linear Energy Harvesting in RIS-Assisted URLLC Networks for Industry Automation

A reconfigurable intelligent surface (RIS)-assisted wireless communication system with non-linear energy harvesting (EH) and ultra-reliable low-latency constraints is considered for its possible applications in industrial automation. A distant data-center (DC) communicates with the multiple destination machines with the help of a full-duplex (FD) server machine (SM) and RIS. Assuming the deficiency of enough transmission power at the FD-SM, the SM is considered in the near vicinity of the destinations in the industry to forward the data received from the distant DC. The reception at SM is assisted by the RIS and a non-linear hybrid power-time splitting (PTS) based EH receiver architecture is adopted to extend the lifespan of SM, thus increasing network lifetime. The scheduling of multiple destinations is done by SM based on the considered selection criteria namely, random (RND) scheduling, absolute (ABS) channel-power-based (CPB) scheduling and normalized (NRM) CPB scheduling. The end-to-end performance of the considered FD RIS-assisted network is analyzed, and the expressions for the block error rate (BLER) for all scheduling schemes are derived. Moreover, the effects of number of RIS elements, packet size, channel uses on the system performance are analyzed for the considered ultra-reliable and low-latency communication (URLLC) network. The scheduling fairness of all the scheduling schemes is also analyzed to study the performance-fairness trade-off. The derived analytical results are verified through Monte-Carlo simulations.

ASSESSMENT OF KNEE JOINT POSITION SENSE IN PATIENTS WITH MULTIPLE SCLEROSIS

Purpose: Multiple sclerosis (MS) disrupts joint position sense (JPS). The aims were: - to assess the JPS of knee extensors, using three target angles in MS patients and in healthy; - to estimate the changes in reproducing the joint position by using absolute (AE), constant (CE) and variable error (VE) and the effect of sex on knee JPS acuity. Subjects and Methods: Twenty MS patients and twenty healthy were tested, by knee joint angle reproduction with three targets (20o, 60o, 75o), by passive and active mode, without visual and verbal feedback. JPS measurement was done using isokinetic dynamometry. Deviations from the targets were calculated as AE, VE and CE, which correspond to accuracy, precision and direction of the bias, respectively. Results: Increased values of AE and sex differences in JPS accuracy in MS individuals, as compared with healthy, were: - at targets 20o and 60o in females in passive mode in both legs; - at 60o in the involved leg in males (more pronounced as compared with females); and – at 75o in the less involved leg, in passive reproduction in women and active in men. The significantly increased negative CE indicates a more pronounced deficit in males with MS at 60o in the involved leg and at 75o in less involved leg. Increased VE in passive repositioning was also proved (p<0.05) in females with MS at 20o and 60o. Conclusion: These results suggest impaired proprioceptive performance and sex differences in MS individuals. The findings provide information to recommend appropriate strategies for the evaluation and treatment of proprioceptive deficits.

Variable Selection in the Chlamydia Pneumoniae Lung Infection Study

In this study, the data based on nucleic acid amplification tech niques (Polymerase chain reaction) consisting of 23 different transcript vari ables which are involved to investigate genetic mechanism regulating chlamy dial infection disease by measuring two different outcomes of muring C. pneumonia lung infection (disease expressed as lung weight increase and C. pneumonia load in the lung), have been analyzed. A model with fewer reduced transcript variables of interests at early infection stage has been obtained by using some of the traditional (stepwise regression, partial least squares regression (PLS)) and modern variable selection methods (least ab solute shrinkage and selection operator (LASSO), forward stagewise regres sion and least angle regression (LARS)). Through these variable selection methods, the variables of interest are selected to investigate the genetic mechanisms that determine the outcomes of chlamydial lung infection. The transcript variables Tim3, GATA3, Lacf, Arg2 (X4, X5, X8 and X13) are being detected as the main variables of interest to study the C. pneumonia disease (lung weight increase) or C. pneumonia lung load outcomes. Models including these key variables may provide possible answers to the problem of molecular mechanisms of chlamydial pathogenesis.

The Effect of Application of Combined Bovine-Derived Anorganic Bone Graft and Hemostatic Plant Extract on Bone Regeneration.

To evaluate the effect of bovine-derived anorganic bone graft (ABB) in combination with hemostatic plant extract (ABS) on bone regeneration. Three bone defects were created via an extraoral approach on the mandibles of nine domestic pigs. The first defects were filled with ABS solution (0.3 mL/defect) in a transporting agent of ABB (0.3 cc/defect), whereas the second defects were filled with ABS (0.3 mL/defect) in microcapsules for controlled drug release, combined with ABB (0.3 cc/defect) again. The third defects were left empty. After a 10-week healing period and the sacrification, undecalcified sections were prepared for histomorphometric analysis. The mean total area of hard tissue was 29.54% ± 3.2% in the control group, 59.78% ± 5.4% in the conventional group, and 63.67% ± 4.2% in the microsphere group (P < .001). The mean area of newly formed bone was 29.54% ± 3.2% in the control group, 34.79% ± 3.9% in the conventional group, and 37.95% ± 5.3% in the microsphere group (P = .003). The mean residual graft area was 24.99% ± 2.4% in the conventional group and 25.71% ± 4.4% in the microsphere group (P = .730). The combined usage of ABS and ABB in both ways increased bone regeneration statistically. However, there was no significant difference between the two methods for ABS delivery systems in terms of new bone regeneration.

On the Relation between the Astronomical and Visual Photometric Systems in Specifying the Brightness of the Night Sky for Mesopically Adapted Observers

ABSTRACT Due to the typical ambient light levels in inhabited places and light pollution of the night sky, most naked-eye astronomical observations are performed nowadays under mesopic conditions. The luminance (cd/m2) associated with the brightness of the night sky specified in the astronomical logarithmic scale of magnitudes per square arcsecond (mag/arcsec2) is strongly dependent on the spectrum of the sky, because the spectral sensitivity of the human visual system is not coincident with the standard photometric bands used in astronomy. The conversion between these two families of photometric systems was previously analyzed for observers presumed to be either fully photopically or scotopically adapted. In this work, we deduce the transformation equations between the astronomical and visual photometric systems for specifying and reporting the sky brightness in the mesopic range, within the framework of the MES-2 system for visual performance-based mesopic photometry. It is shown that the dependence of the conversion factors on the correlated color temperature of the night sky reaches a minimum spread for adaptation luminances of 0.5–1.0 cd/m2. The sky luminances corresponding to 22.0 mag/arcsec2 in the Johnson-Cousins V band (the assumed brightness of a natural night sky devoid of light pollution) span, for 1.0 cd/m2 adaptation, a relatively small range of ~195–215 μcd/m2 in the absolute (AB) magnitude system and ~210–225 μcd/m2 in the Vega-referenced one.

Corticomuscular Coherence and Motor Control Adaptations after Isometric Maximal Strength Training.

Strength training (ST) induces corticomuscular adaptations leading to enhanced strength. ST alters the agonist and antagonist muscle activations, which changes the motor control, i.e., force production stability and accuracy. This study evaluated the alteration of corticomuscular communication and motor control through the quantification of corticomuscular coherence (CMC) and absolute (AE) and variable error (VE) of the force production throughout a 3 week Maximal Strength Training (MST) intervention specifically designed to strengthen ankle plantarflexion (PF). Evaluation sessions with electroencephalography, electromyography, and torque recordings were conducted pre-training, 1 week after the training initiation, then post-training. Training effect was evaluated over the maximal voluntary isometric contractions (MVIC), the submaximal torque production, AE and VE, muscle activation, and CMC changes during submaximal contractions at 20% of the initial and daily MVIC. MVIC increased significantly throughout the training completion. For submaximal contractions, agonist muscle activation decreased over time only for the initial torque level while antagonist muscle activation, AE, and VE decreased over time for each torque level. CMC remained unaltered by the MST. Our results revealed that neurophysiological adaptations are noticeable as soon as 1 week post-training. However, CMC remained unaltered by MST, suggesting that central motor adaptations may take longer to be translated into CMC alteration.

The Growth and Yields of Shallot (Allium Wakegi Araki) CV. lembah palu Growing under Hydroponic Substrate Systems

The study was carried out used a Randomized Block Design (RBD) with AB Mix concentration treatments consisting of six levels of concentrations, namely: Concentration of AB Mix solution 3 mL/L water (K1), Concentration of AB Mix solution 5 mL/L water (K2), Concentration of AB solution Mix 7 ml/l water (K3), Concentration of AB solution Mix 9 mL/L water (K4), Concentration of AB solution Mix 11 mL/L water (K5) and Concentration of AB Mix solution of 13 mL/L water (K6). The results showed that use of various concentrations of AB Mix solution did not affect the diameter of bulbs, fresh weight and dry weight of leaves of shallot but significantly affected fresh bulb weight, bulb dry weight, fresh weight roots, and root dry weights. In conclusion, the concentration of AB Mix of 7 mL/L of water gave the highest yield of fresh bulb weight of 17.63 g and dry weight of plant bulb 3.95 g.

The moderating impact of maturation on acute neuromuscular and psycho-physiological responses to simulated soccer activity in academy soccer players

Resource constraints complicate load monitoring practices in some academies, which is problematic based on load-injury associations surrounding periods of rapid non-linear growth. Limited research has explored relationships between maturation and perceived psycho-physiological response to activity and associated neuromuscular performance changes. This study aimed to quantify neuromuscular and psycho-physiological responses to standardised activity and analyse whether dose-responses were moderated by maturation. Fifty-seven male soccer players (age: 14.1 ± 0.9 years; stature: 165 ± 10 cm; body mass, 57 ± 9 kg; percentage of predicted adult height 92.7 ± 5%) from two Elite Player Performance Plan (EPPP) academies completed the youth soccer-specific aerobic fitness test (Y-SAFT60). Countermovement jump (CMJ), reactive strength index (RSI), absolute (ABS) and relative leg stiffness (REL) were measured pre–post the Y-SAFT60 with playerload (PL), heart rate (HR), total distance (TDist) and differential ratings of perceived exertion (dRPE) used as markers of load and intensity. A moderation model was employed to analyse interactions of maturation as a continuous variable. Analysis indicated no significant interaction (p <0.05) between maturation and neuromuscular performance but RPE-Technical demonstrated significant interactions (p = 0.01). Slope analysis indicated four variables (PL, RSI, ABS and REL) that demonstrated significance at various stages of maturation, most notably aligning with peak height velocity (∼87–96% PAH). Tentatively, we propose that maturational developments in the neuromuscular system offer some mechanistic explanation to the varied dose-responses observed. It is therefore important that maturation is habitually considered within prescription of training programmes and that further empirical studies are completed to determine maturity specific dose-responses.

In-situ and simultaneous evaluation of optical absorption and deposition for phthalocyanine layer-by-layer thin films using an optical waveguide sensor utilizing surface plasmon resonance

A novel optical waveguide sensor utilizing surface plasmon resonance (SPR) that enables the measurement of optical absorption and the thickness of a thin film was proposed. A BK-7 glass slide was used as a waveguide core, and an Ag/Au film of 5 mm width and transparent polymethyl methacrylate-co-methacrylic acid (PMMA-co-PMAA) were consecutively deposited to develop the sensor. The PMMA-co-PMAA film was used to control the SPR wavelength. This sensor allows us to measure the optical absorption and thickness of the deposited film using the evanescent wave from the waveguide and the SPR phenomena, respectively. In order to demonstrate this, a layer-by-layer deposit of a film of water-soluble phthalocyanine dye (Alcian blue, pyridine variant, AB) and polystyrenesulfonate was observed. Additionally, adsorptions from a mixed solution of AB and polydiallyldimethylammonium chloride were observed.

Medidas de erros durante jogos de dardos virtual e real em pacientes com Acidente Vascular Cerebral: implicações para reabilitação neurológica

Objetivo: Realizar uma análise comparativa de medidas de erros após o treino com jogos de dardos virtual e real. Metodologia: Participaram do estudo 15 pacientes com Acidente Vascular Cerebral (AVC) (10 homens) e 12 indivíduos saudáveis (7 homens). O jogo virtual utilizado foi o Kinect Sports do Xbox 360 Kinect®. Os participantes realizaram 15 tentativas em cada jogo. Foram calculados os erros absoluto (EA), constante (EC) e variável (EV). Os dados foram analisados pela ANOVA. Resultados: Quanto ao EA observou-se diferença significativa entre os pacientes e saudáveis no jogo virtual (p=0,003) e no jogo real (p= 0,0001). Também houve diferença do EA entre os jogos virtual e real para os pacientes (p= 0,0001). No EC não foi encontrada diferença significativa entre pacientes e saudáveis no jogo virtual (p=0,355) e no jogo real (p= 0,544). Também não houve diferença do EC entre os jogos virtual e real para os pacientes (p= 0,452). Pela análise do EV não foi verificada diferença significativa entre pacientes e saudáveis no jogo virtual (p=0,406), mas houve no jogo real (p= 0,0001). Não houve diferença significativa do EV entre os jogos virtual e real para os pacientes (p= 0,579). Conclusão: Os resultados encontrados indicaram que os pacientes tiveram menor precisão, maior consistência de erros e menor variabilidade do desempenho. O jogo virtual proporcionou melhores resultados para os pacientes em comparação ao jogo real, o que pode ser de significativa importância para o planejamento da reabilitação motora dos pacientes com AVC.

Joint position error after neck protraction-retraction movements in healthy office workers: a cross-sectional study.

Since the upper cervical spine (UCS) has been regarded to be distinct from the lower cervical spine (LCS), joint position error (JPE) needs to be tested separately for both regions. The purpose of this study was to investigate the JPE after cervical protraction/retraction movements, involving opposite movements of extension and flexion for the UCS and LCS. These movements are frequently performed during office work. Cervical JPEs were tracked in thirty healthy office workers while performing four tests of cervical pro-retraction movements with variations in vision and movement direction, and assessed using the Kinect head tracker (Microsoft Corp), placed in front of each participant. The JPE was expressed in constant (CE), absolute (AE) and variable errors (VE). Multilevel linear models evaluated main and interaction effects of vision, movement direction, cervical region and sex. Slightly larger JPEs have been found in the UCS. Vision showed no effect on any outcome variable. No effect exceeded typical measurement errors reported for the Kinect head tracker. This study showed, that JPEs after pro-retraction movements of the head and neck may differ for UCS and LCS. The differences were small and not beyond measurement error reported for the Kinect.

Diammonium tetraborate dihydrate as hydrolytic by-product of ammonia borane in aqueous alkaline conditions

Ammonia borane NH3BH3 is able to generate H2 by catalytic hydrolysis at ambient conditions. Such a potential has been much studied but the hydrolysis by-products, i.e. ammonium borates, have been little studied. As such we undertook a systematic work aiming at getting a sound understanding of the borates forming by hydrolysis. Contrary to what is commonly believed, NH3BH3 (10 M) in aqueous alkaline (pH = 8) solution is not completely stable. Spontaneous hydrolysis takes place, resulting in the formation of by-products and precipitation of borate crystals. This means that long-term storage of concentrated AB solution is not possible. The borate crystals were analyzed with the help of various techniques and was identified as being diammonium tetraborate dihydrate (NH4)2B4O5(OH)4⋅2H2O (263.39 g mol−1). The crystal structure was solved and found to be monoclinic with a space group P21. The borate is an analog of borax Na2B4O5(OH)4⋅8H2O. These results, among others, are reported in details hereafter and they are discussed in order to bring elements of response to the questions concerning storage of aqueous NH3BH3 and recyclability of such a borate.

Magnitude to luminance conversions and visual brightness of the night sky

ABSTRACT The visual brightness of the night sky is not a single-valued function of its brightness in other photometric bands, because the transformations between photometric systems depend on the spectral power distribution of the skyglow. We analyse the transformation between the night sky brightness in the Johnson–Cousins V band (mV, measured in magnitudes per square arcsecond, mpsas) and its visual luminance (L, in SI units cd m−2) for observers with photopic and scotopic adaptation, in terms of the spectral power distribution of the incident light. We calculate the zero-point luminances for a set of skyglow spectra recorded at different places in the world, including strongly light-polluted locations and sites with nearly pristine natural dark skies. The photopic skyglow luminance corresponding to mV=0.00 mpsas is found to vary in the range 1.11–1.34 × 105 cd m−2 if mV is reported in the absolute (AB) magnitude scale, and in the range 1.18–1.43 × 105 cd m−2 if a Vega scale for mV is used instead. The photopic luminance for mV=22.0 mpsas is correspondingly comprised between 176 and 213 μcd m−2 (AB), or 187 and 227 μcd m−2 (Vega). These constants tend to decrease for increasing correlated colour temperature (CCT). The photopic zero-point luminances are generally higher than the ones expected for blackbody radiation of comparable CCT. The scotopic-to-photopic luminance (S/P) ratio for our spectral data set varies from 0.8 to 2.5. Under scotopic adaptation the dependence of the zero-point luminances with the CCT, and their values relative to blackbody radiation, is reversed with respect to photopic ones.

Processing of carbon fiber for 3D printed continuous composite structures

ABSTRACTThis article describes original carbon fiber impregnation procedure. The aim of this research is to determine carbon fiber impregnation process influence on mechanical properties of printed composite structures. 3D printing head and carbon fiber impregnation device were designed and produced. Three different polymer materials (PLA, PC, ABS) and solvent methylene chloride (DCM) were selected and solutions of different concentrations (2–10%) were prepared. 1 and 3K carbon fiber tow were impregnated with solutions (2–10%) and tensile tests of impregnated carbon fiber tow were performed. The correlation analysis revealed a strong relation between the tensile force of impregnated carbon fiber and mass of impregnated carbon fiber tow. For 3D printing 1 and 3K carbon fiber tow impregnated with 8 and 10% solutions were selected. Tensile tests were carried out to evaluate the mechanical properties of 3D printed composite structures. The obtained results revealed the dependency between the solution concentration and tensile strength, i.e. the higher the concentrations in carbon fiber impregnated with solution, the higher the tensile strength. This tendency is strong in PLA and PC impregnated 3K carbon fiber, however when the carbon fiber impregnated with ABS solution, the change in the results was not so significant. The obtained results can be used for the future development of different 3D printed composite structures.

Identifying insulin treatment responders with a composite measure: beyond Hba1c < 7% in patients with type 2 diabetes

Objectives: Many insulin-treated patients with type 2 diabetes (T2D) do not reach hemoglobin A1c (HbA1c) < 7%, but have clinically relevant HbA1c reductions. Using an integrated database (IDB) of 53 insulin lispro clinical trials and a real-world evidence (RWE) database of T2D patients initiating insulin therapy, an expanded HbA1c measure was used to identify responders to insulin therapy.Methods: Analysis included 4,908 patients (IDB) and 1,134 patients (RWE) with T2D treated with any insulin regimen with a baseline and ≥1 post-baseline HbA1c. Responders were defined as patients with endpoint HbA1c < 7% (cut point [CP]) and/or either ≥1% absolute (ABS) decrease, and/or ≥10% relative (REL) decrease in HbA1c from baseline. The percentage of responders with CP vs ABS and concordance between ABS and REL were calculated. As the ABS and REL measures were highly correlated (94%), the ABS measure was used to compare characteristics of responders and non-responders by age, diabetes duration, race/ethnicity, baseline HbA1c, and insulin regimen at 24 weeks.Results: In both databases, more responders were identified with ABS or REL (>62%) than CP (<41%). More ABS responders had a baseline HbA1c ≥ 9% and a shorter diabetes duration than non-responders. Basal insulin-treated patients in the IDB had 78.2% responders at 24 weeks, compared to 69.7% with basal/bolus or pre-mixed insulin (75.4%). Results were similar in the IDB and RWE.Conclusion: Composite HbA1c measures identified more patients with clinically meaningful responses to therapy than the broadly accepted HbA1c < 7% and may be useful in assessing clinical trials, clinical care, and quality measures.

Quando l'artista disconosce la propria opera d'arte: ricadute e implicazioni giuridiche

Installazioni da riattivare, opere realizzate con materiali che si degradano rapidamente, opere in continuo divenire: molte delle nuove forme di espressione dell'arte contemporanea hanno reso pi&amp;ugrave; complesso il rapporto tra l'artista e l'opera d'arte, chiamando l'artista ad un ricorrente intervento del suo momento creativo.Quali sono le ragioni di interesse dell'artista alla tutela dell'integrit&amp;agrave; dell'opera se l'opera &amp;egrave; soggetta a continue modifiche? Quali nuovi presupposti giuridici per la dichiarazione di disconoscimento da parte dell'artista dell'opera d'arte effimera e in divenire non correttamente riattivata o conservata? E, d'altra parte, quali sono i limiti del diritto del proprietario di tutelare l'identit&amp;agrave; e integrit&amp;agrave; dell'opera inizialmenteacquistata o di distruggere l'opera della quale voglia disfarsi? Il diritto reale di propriet&amp;agrave; attenua la peculiare caratteristica di assolutezza a fronte di una sopravvivenza pi&amp;ugrave; significativa dell'apporto creativo dell'artista?Tutela dell'integrit&amp;agrave;, garanzia di autenticit&amp;agrave;, diritto al disconoscimento e diritto di distruzione: si delinea una nuova relazione tra diritto d'autore e diritto di propriet&amp;agrave;.Deriva da tutto ci&amp;ograve; la necessit&amp;agrave; di ridefinire principi e criteri della tutela e della disciplina giuridica delle opere figurative contemporanee con adeguamento della nozione di tutela dell'integrit&amp;agrave;, di autenticit&amp;agrave;, di conservazione e di restauro delle stesse.