This study observes the 2-D flow of a Maxwell hybrid nanofluid flow on a permeable stretching surface containing Cu and CuO nanoparticles and gyrotactic microorganisms. The thermal convective and zero-mass flux constraints are adopted by incorporating a hot working fluid with a heat transfer coefficient and zero mass flow at the permeable sheet’s surface to investigate the heat transfer rate. This study is designed to present a comparative analysis of the nanofluid (Cu–water) as well as hybrid nanofluid (Cu–CuO/water) flows on a stretching sheet. Examining activation energy in water-based hybrid nanofluid flow offers important insights into the kinetics of chemical reactions, which in turn helps to optimize the features of the nanofluid and build more effective systems that use nanofluids for a variety of applications. The problem formulated initially is converted to dimension-free notation using appropriate variables for finding the numerical solution by incorporating the bvp4c MATLAB function. From the obtained results, it is found that the higher magnetic and porosity factors have declined the velocity profiles. Also, in the absence of porous media and magnetic field effects, the velocity distribution is highly affected when compared with the existence of these effects. It is observed that the velocity profiles of both nanofluids are dominant for Newtonian fluid in comparison to non-Newtonian fluid. Also, the thermal profiles of both nanofluids are dominant for non-Newtonian fluid in comparison to Newtonian fluid. The friction force of hybrid nanofluid is significantly influenced by the magnetic factor, porosity factor, and volume fractions of the solid nanoparticles when compared to nanofluid.
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