Tooth agenesis, particularly the bilateral absence of maxillary lateral incisors, is a prevalent condition with notable aesthetic and functional implications. This anomaly, impacting approximately 62% of individuals with genetic predisposition, poses significant challenges in both orthodontics and prosthetic rehabilitation. The treatment of bilateral congenital lateral incisor agenesis is a multidisciplinary approach that requires a thorough clinical examination. Implant-based solutions face challenges due to narrow alveolar dimensions and adjacent root orientations. Successful implant placement often requires pre-treatment orthodontic space creation, ridge augmentation, and careful timing to accommodate continued alveolar growth. Advanced orthodontic techniques and precise implant placement protocols are critical for achieving optimal outcomes. This case report illustrates a time-sequenced interdisciplinary approach combining mesialization of canines with space opening and implant-supported rehabilitation. An interdisciplinary approach, leveraging advancements in orthodontics, implantology, and digital prosthetics, is essential for successful outcomes.
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