Absence Of Aortic Regurgitation Research Articles

Aortic Regurgitation Is Common in Ankylosing Spondylitis: Time for Routine Echocardiography Evaluation?

ObjectivesThe aim of this study was to assess the prevalence of aortic regurgitation and any relation to disease activity and specific human leukocyte antigen (HLA)-B27 subtypes in patients with ankylosing spondylitis. MethodsTransthoracic echocardiography was performed in 187 patients (105 men), mean age (SD) 50 (13) years, and mean disease duration 24 (13) years, and was related to demographic, clinical, radiographic, electrocardiographic, and laboratory data. ResultsAortic regurgitation was found in 34 patients (18%; 95% confidence interval [CI], 12%-24%): mild in 24, moderate in 9, and severe in one. The prevalence was significantly higher than expected from population data. Conduction system abnormalities were documented in 25 patients (13%; 95% CI, 8%-18%), and significantly more likely in the presence of aortic regurgitation (P = .005), which was related to increasing age and longstanding disease, and increased from ∼20% in the 50s to 55% in the 70s. It was also independently associated with disease duration, with higher modified Stoke Ankylosing Spondylitis Spine Score, and with a history of anterior uveitis. HLA-B27 was present in similar proportions in the presence vs absence of aortic regurgitation. For comparison, clinically significant coronary artery disease was present in 9 patients (5%; 95% CI, 2%-8%). ConclusionPatients with ankylosing spondylitis frequently have cardiac abnormalities, but they more often consist of disease-related aortic regurgitation or conduction system abnormalities than manifestations of atherosclerotic heart disease. Because aortic regurgitation or conduction abnormalities might cause insidious symptoms not easily interpreted as of cardiac origin, we suggest that both electrocardiography and echocardiography evaluation should be part of the routine management of patients with ankylosing spondylitis.

Balloon valvuloplasty for congenital aortic stenosis: Multi-center safety and efficacy outcome assessment.

To describe contemporary outcomes of balloon aortic valvuloplasty (BAVP) performed in 22 US centers. BAVP constitutes first-line therapy for congenital aortic stenosis (cAS) in many centers. We used prospectively-collected data from two active, multi-institutional, pediatric cardiac catheterization registries. Acute procedural success was defined, for purposes of this review, as a residual peak systolic gradient≤35 mm Hg and no more than mild aortic regurgitation (AR) for patients with isolated cAS. For patients with mixed aortic valve disease, a residual peak systolic gradient≤35 mm Hg without worsening of AR was considered successful outcome. In 373 patients with a median age of 8 months (1 day to 40 years of age) peak systolic gradient had a median of 59 [50, 71] mm Hg pre-BAVP and 22 [15, 30] mm Hg post-BAVP (P<0.001). Procedural success was achieved in 160 patients (71%). The factors independently associated with procedural success were: first time intervention (OR=2.0 (1.0, 4.0) P=0.04), not-prostaglandin dependent, (OR=3.5 (1.5, 8.1); P=0.003), and isolated cAS (absence of AR) (OR=2.1 (1.1-3.9); P=0.03). Twenty percent of patients experienced adverse events, half of which were of high severity. There was no procedural mortality. Neonatal status was the only factor associated with increased risk of high severity adverse events (OR 3.7; 95% CI 1.5-9.0). In the current era, BAVP results in procedural success (gradient reduction with minimal increase in AR) in 71% of patients treated at US centers where BAVP is considered first-line therapy relative to surgery.

Transcatheter closure of ruptured sinus of Valsalva aneurysm into the right ventricle with an Amplatzer Vascular Plug II

We report a case of a 52-year-old female patient with perforated sinus of Valsalva (SVA) aneurysm presenting with severe left-to-right shunt from the aorta into the right ventricle. Aneuryms of the aortic sinus, better known as SVA are rare. Until interventional devices were introduced, the only treatment option for ruptured SVA aneurysms was surgery. The case was discussed in the heart team and decision was made to implant an Amplatzer Vascular Plug (AVP) II. Initially, closing attempts using AVP 16 mm and 14 mm devices were performed. Presumably as a consequence of inadequate sizing, the discs were not well formed in the connecting tunnel, leaving a severe rest shunt after both procedures. Finally, after implantation of a 12 mm AVP-device, only a minimal rest shunt remained detectable. Absence of aortic regurgitation was confirmed by transesophageal echocardiography, and the occluder was released. Mean pulmonary artery pressure immediately decreased from 39 to 15 mm Hg. Medication with aspirin (100 mg qid) and clopidogrel (75 mg qid) was initiated. Follow-up examinations at 4 weeks and 3 months confirmed the minimal rest shunt and a continuous decrease of systolic pulmonary artery pressure to 35 mm Hg, as assessed with transthoracal echocardiography. In conclusion, in cases of SVA rupture, closure with an AVP II represents an alternative to surgical treatment and other devices used for transcatheter treatment of SVA. © 2014 Wiley Periodicals, Inc.

Calcified subaortic left ventricular aneurysm causing right pulmonary artery obstruction in a child

A 14-year old asymptomatic boy was diagnosed as having a large calcified subaortic left ventricular aneurysm that was found to obstruct flow across the right pulmonary artery during systole. Surgical patch closure of the neck of the aneurysm resulted in relief of obstruction. The case is reported for its rarity, massive calcification, absence of aortic regurgitation and dynamic compression of the right pulmonary artery.

Aneurysms of sinus of Valsalva eroding into the interventricular septum: etiopathology and surgical considerations

To evaluate and discuss etiopathology, clinical manifestations and surgical outcome of a rare subset of unruptured aneurysm of the sinus of Valsalva which erodes into the interventricular septum. Between 1989 and 1995, seven cases of unruptured aneurysm of the sinus of Valsalva eroding into the interventricular septum underwent surgical correction at the King Edward VII Memorial Hospital, Bombay. The origin of all these aneurysms was from the right coronary sinus. The mean age of presentation was 31 years. All patients were male. Calcification of the aneurysm was seen in three. Three patients presented without aortic regurgitation; all had complete heart block. Four patients presented with aortic regurgitation and in addition, two had complete heart block. Preoperative left ventricular function was poor in patients with aortic regurgitation (Ejection fraction range; 30-42%), when compared to those without aortic regurgitation (Ejection fraction range; 48-52%). Of those without aortic regurgitation at initial presentation, one patient developed progressive aortic regurgitation after 3 years requiring surgery. While two other patients were operated at earliest for closure of aneurysm, even in the absence of aortic regurgitation. All those with aortic regurgitation required surgery for aortic valve replacement and closure of aneurysm. Aneurysm was closed by direct suturing of the ostium in two patients and by patch closure in five patients. Permanent pacemaker was implanted in five patients. There was no operative death. Patients who underwent aortic valve replacement required postoperative ionotropic support. Two patients, who underwent surgery in absence of aortic regurgitation, remain free of aortic regurgitation at the end of 36 and 42 months of follow-up. One of the patients with calcific aneurysmal sac underwent successful re-replacement of the aortic valve for paravalvar leak after a 2 year interval. Unruptured aneurysm of the sinus of Valsalva eroding into the interventricular septum should be operated at the earliest, which makes surgery simple and prevents development of complications such as aortic regurgitation and heart block.

Noninvasive Predictors of Systemic Embolism in Mitral Stenosis: An Echocardiographic and Clinical Study of 500 Patients

Few predictors of systemic embolism in patients with mitral stenosis have been identified by noninvasive methods. This study used the most powerful noninvasive diagnostic tool, transthoracic echocardiography, as well as other noninvasive clinical information to look for predictors. Five hundred consecutive patients with a mitral valve area of 2 cm2 or less were studied. They were divided into two groups: group 1 consisted of 143 patients with a history of systemic embolism and group 2 consisted of 357 patients with no history of systemic embolism. Using a stepwise logistic regression on a random subsample of 400 patients, 4 independent predictors were found: the presence of atrial fibrillation (p = 0.003, relative risk [RR] = 2.3, 95% CI = 1.3, 4.2), the absence of significant tricuspid regurgitation (p = 0.008, RR = 2.5, 95% CI = 1.3, 4.9), the absence of aortic regurgitation (p = 0.022, RR = 2.2, 95% CI = 1.1, 4.2), and the presence of left atrial smoky echoes (p = 0.039, RR = 1.7, 95% CI = 1.1, 3.0). When the above model, together with significant interaction terms, was applied to the remaining 100 patients, both the Hosmer-Lemeshow and Brown goodness-of-fit statistics were not significant (p = 0.888 and p = 0.248, respectively), indicating that the fit was adequate and the model was validated. Thus, important noninvasive predictors of systemic embolism in patients with mitral stenosis can easily be obtained. Subgroups of patients with high risk of systemic embolism can be identified. This may refine our therapeutic strategies to prevent the catastrophe of systemic embolism.

Comparison of transthoracic and transesophageal echocardiography for assessment of left-sided valvular regurgitation

To compare transthoracic and transesophageal echocardiography in the clinical assessment of left-sided valvular regurgitation, 118 patients who underwent both transesophageal and transthoracic echocardiographic studies within a 24-hour period were included in this study. Presence or absence of aortic regurgitation was identified concordantly by both techniques in 93 patients (79%). Complete agreement between both techniques was found in 88 patients (75%). Presence or absence of mitral regurgitation was identified concordantly by both techniques in 89 patients (75%). Complete agreement in grade was found in only 74 patients (63%). Twentynine patients (25%) had mitral regurgitation detected by transesophageal echocardiography, but not by transthoracic echocardiography. Four of these patients (14%) had significant (2 to 3+) mitral regurgitation. Differences between transesophageal and transthoracic echocardiography do not appear to be clinically important in patients with aortic regurgitation. In mitral regurgitation, significant differences exist between these 2 techniques, with transesophageal echocardiography being much more sensitive.

Correlation of prevalence and severity of aortic regurgitation detected by pulsed Doppler echocardiography with the murmur of aortic regurgitation in elderly patients in a long-term health care facility

The sensitivity and specificity of pulsed Doppler echocardiography for the diagnosis of aortic regurgitation (AR) were 96 and 96%, respectively. 1 They were 73 and 92%, respectively, for auscultation in 106 patients in whom the presence or absence of AR was demonstrated by supravalvular aortography. 1 We performed a blinded prospective study to determine the prevalence and severity of AR detected by pulsed Doppler echocardiography correlated with the diastolic murmur of AR in unselected elderly patients in a long-term health care facility.

Evaluation of aortic valve prolapse in ventricular septal defect.

Angiographic criteria for the recognition of aortic valve prolapse in isolated ventricular septal defect were based on the degree of aortic cusp deformity and the presence or absence of aortic regurgitation. Ninety eight consecutive patients with isolated perimembranous or infundibular ventricular septal defects who were catheterised and had aortography performed were reviewed. They included five with postoperative ventricular septal defects and three with additional mild right ventricular outflow tract obstruction. Eighteen were found to have aortic valve prolapse. Although eight of the 18 were noted to have aortic regurgitation angiographically, only three had an early diastolic murmur. Only eight of the 18 patients had cross sectional echocardiographic findings suggestive of prolapse. All of these had at least moderate prolapse angiographically. Cross sectional echocardiography was found to be insensitive in diagnosing mild degrees of aortic valve prolapse. A trend towards a decreasing left to right shunt was noted as the degree of aortic valve prolapse increased. Spontaneous decrease in the size of a ventricular septal defect may be due to unrecognised aortic valve prolapse without clinical evidence of aortic regurgitation.

Echocardiographic identification of an aortic valve ring abscess

A valve ring abscess was diagnosed in four patients with a prosthetic aortic valve by identifying an echo-free space on two-dimensional echocardiography. Three of the patients presented with severe aortic regurgitation and congestive heart failure after an episode of endocarditis, but two of them did not have evidence of active endocarditis. The fourth patient had endocarditis, but no evidence of aortic regurgitation or heart failure. All four patients required valve replacement. Similar findings in all 11 previously reported cases suggest that a valve ring abscess can be diagnosed by two-dimensional echocardiography. It may be found without clinical evidence of endocarditis, in the absence of aortic regurgitation, without echocardiographically identifiable vegetations or during resolution of endocarditis.

Diagnosis of acute aortic dissection by M-mode and cross-sectional echocardiography: a five-year experience.

During a five-year period, 26 cases of acute thoracic aortic dissection were studied by M-mode and cross-sectional echocardiography prior to cardiac catheterization and aortography. The diagnosis could be made non-invasively in 20 patients. Important information concerning the extent of the dissection, and the presence or absence of aortic regurgitation or a pericardial effusion could be obtained. Negative examinations were largely confined to cases where the distal thoracic aorta alone was involved. In a further 30 cases admitted to the coronary care unit during this period in which echocardiography was performed to rule out aortic dissection, two false-positive examinations led to aortography which demonstrated aortic dilatation and aortic regurgitation only. In the remaining 28 cases, echocardiographic examination was negative and none of these patients subsequently evidenced aortic dissection. Echocardiography using both M-mode and cross-sectional techniques is a rapid and highly effective method of making an early diagnosis of thoracic aortic dissection. Cross-sectional echocardiography is complementary to the M-mode technique, enhancing diagnostic accuracy by improving structural recognition in a condition where the normal anatomy is often severely distorted.

Detection and Measurement of Experimentally Produced Aortic Regurgitation by Means of Indicator-Dilution Curves Recorded from the Left Ventricle

In dogs studied without thoracotomy the detection of immediately appearing indicator in the left ventricle following its injection approximately 1 cm downstream from the aortic valve can be used as a reliable index of the presence or absence of aortic regurgitation. With this type of injection and under the conditions of these experiments, the ratio of the area encompassed by the immediately appearing portion of the dilution curve recorded from the left ventricle to the area encompassed by the primary portion of the curve recorded at the femoral artery bears a close positive correlation (correlation coefficient: 0.9) to the severity of aortic regurgitation as estimated by back perfusion of the valve at necropsy. Within limitations, the position of the tip of the sampling catheter in the left ventricle in dogs with aortic regurgitation is not an important determinant of the amount of immediately appearing indicator detected in this chamber. Furthermore, although the amount of indicator detected in the left ventricle following injections of very short duration is time-dependent, if the duration of the injection is extended to cover the full systolic or diastolic phase of one heartbeat or continues over one or more heartbeats, the exact timing of this injection in relation to the cardiac cycle is not an important determinant of this variable. It is concluded that under these conditions the positive correlation established between the amount of immediately appearing dye detected in the left ventricle (expressed as the regurgitant fraction) and the severity of aortic regurgitation determined by back perfusion at necropsy can be used as a valid means of estimating the severity of aoritic regurgitation in dogs. The applicability of this indicator-dilution method to the study of clinical aortic reguragitation merits further study.