Aiming to address the wear and replacement inconvenience of concrete mixer liners, this study utilizes a laser cladding system to clad Fe60 alloy powder on the liner. It investigates the influence of different process parameters on the forming quality of the Fe60 alloy powder cladding layer. The optimal process parameters were obtained by weighted comprehensive evaluation, and single-layer multi-pass cladding experiments were carried out under the optimal process parameters to investigate the effects of a 30%, 40%, and 50% lap rate on the surface flatness and forming quality of the cladding layer. Using a metallographic microscope, a scanning electron microscope analysis of the macro morphology and microstructure of the cladding layer was conducted, a DPT-5 penetration flaw detector was used to observe the cracks on the surface of the multi-channel cladding, a microhardness tester and friction and wear experimental machine were used for the hardness of the cladding layer, and an abrasive wear resistance test was conducted. The results show that under the process parameters of a laser power of 900 W, powder feeding speed of 7 g/min, scanning speed of 600 mm/min, and 50% lap rate, the average microhardness of the fused cladding layer reaches 742 HV, which is 1.8 times higher than that of the liner plate, and the coefficient of friction is 0.57, which improves the liner plate’s wear resistance performance and service life.