Abnormal Total Cholesterol Levels Research Articles

Synthesis of novel hydrazide Schiff bases with anti-diabetic and anti-hyperlipidemic effects: in-vitro, in-vivo and in-silico approaches

The increasing global incidence of non-insulin-dependent diabetes mellitus (NIDDM) necessitates innovative therapeutic solutions. This study focuses on the design, synthesis and biological evaluation of Schiff base derivatives from 2-bromo-2-(2-chlorophenyl) acetic acid, particularly hydrazone compounds 4a and 4b. Both in-vitro and in-vivo assays demonstrate these derivatives’ strong antidiabetic and anti-hyperlipidemic properties. In a 15-d experiment, we administered 4a and 4b at doses of 2.5 and 5 mg/kg body weight, which effectively improved symptoms of alloxan-induced diabetes in mice. These symptoms included weight loss, increased water consumption and high blood glucose levels. The compounds also normalized abnormal levels of total cholesterol (TC), triacylglycerol (TG) and low-density lipoprotein cholesterol (LDL-C), while raising the levels of high-density lipoprotein cholesterol (HDLC). Computational analysis showed that these compounds effectively inhibited the α-glucosidase enzyme by interacting with key catalytic residues, specifically Asp214 and Asp349. These computational results were confirmed through in-vitro tests, where 4a and 4b showed strong α-glucosidase inhibitory activity, with IC50 values of 0.70 ± 0.11 and 10.29 ± 0.30 µM, respectively. These compounds were more effective than the standard drug, acarbose, which had an IC50 value of 873.34 ± 1.67 µM. Mechanistic studies further indicated competitive inhibition, reinforcing the therapeutic potential of 4a and 4b for NIDDM treatment. Communicated by Ramaswamy H. Sarma

Association between total cholesterol and all-cause mortality in geriatric patients with hip fractures: A prospective cohort study with 339 patients.

Total cholesterol (TC) levels represent the comprehensive level of human cholesterol metabolism, which is closely related to the nutritional status, metabolic level, disease development, and aging of the human body. Total cholesterol plays an important role in the maintenance of bodily functions, regulation of sexual function, immune regulation, and in the development of organisms. Abnormal TC levels are an important risk factor for cardiovascular disease (CVD), and TC is closely related to the development of many diseases, and is used as an important indicator of human blood lipid levels and overall health status. However, the relationship between serum TC levels and the prognosis of patients with hip fractures remains unclear. To evaluate the association between TC levels and all-cause mortality in patients with geriatric hip fractures. Elderly patients with hip fractures were screened between January 2015 and September 2019. Patient demographic and clinical characteristics were recorded. Linear multivariate Cox regression models were used to identify the association between TC levels and all-cause mortality. Analyses were performed using Empower Stats and R software. Three hundred and thirty-nine patients were enrolled. The mean follow-up period was 34.18 months. There were 99 (29.20%) cases of all-cause mortality. Total cholesterol levels after hip fracture were linearly associated with all-cause mortality in the elderly. Linear multivariate Cox regression models showed that TC levels were associated with mortality (hazard ratio (HR) = 0.67; 95% confidence interval (95% CI): 0.53-0.85; p = 0.001 after adjusting for confounding factors). Each 1 mmol/L increase in TC levels was associated with a 33% reduction in morbidity and mortality. Compared with the low-TC group, mortality was significantly lower in the middle-TC group (HR = 0.58; 95% CI: 0.35-0.94; p = 0.027) and high-TC group (HR = 0.45; 95% CI: 0.27-0.75; p = 0.002). Total cholesterol levels were associated with mortality in geriatric hip fracture patients and could be considered a protective factor for all-cause mortality.

Prevalence of hypercholesterolaemia in outpatient children aged 9-11 years.

The purpose of this study was to evaluate the importance of universal screening for dyslipidemia in children aged 9-11 years. An observational, descriptive, cross-sectional study was conducted from July 2021 to June 2022. A total of 532 children (279 girls and 253 boys) aged 9-11 years were enroled, and non-fasting blood samples were obtained to measure total cholesterol (TC) levels in the blood. The mean serum TC was 136.4±28.1mg/dl. Thirty-two children (6%) of the screened participants had abnormal TC levels; those were tested subsequently by fasting serum TC, and 19 children were confirmed as dyslipidemic (3.5%). The prevalence of borderline blood cholesterol levels (TC between 170 and 199mg/dl) was 2.6% CI 95% (2.2-3.2), and the prevalence of hypercholesterolaemia (TC ≥200mg/dl) was 0.9% CI 95% (0.5-1.4). A positive correlation was found between body mass index and blood cholesterol level. (r = 0.55, P =0.002). Universal non-fasting TC screening in children aged 9-11 years old is effective in detecting hypercholesterolaemia. Since the authors found that the positive family history as the sole basis for selective examination in children is insufficient.

25-Hydroxyvitamin D and metabolic-related laboratory values in women with schizophrenia and hyperprolactinemia

Schizophrenia is a severe mental disorder with various medical comorbidities and early mortality. Hyperprolactinemia is common in women and its impact on sexual function, galactorrhea and amenorrhea is well known. This paper evaluates the risk of 25-hydroxy vitamin D deficiency and other metabolic related laboratory abnormalities in women with schizophrenia having hyperprolactinemia (N = 43). The mean prolactin level in these women was 88.5 ± 56.0 ng/mL. We found that 100% of women were overweight of which 74% (32/43) of the women were obese, 56% (23/41) had abnormal total cholesterol levels and 30% (13/43) had high fasting blood glucose. Vitamin D levels were considered deficient or inadequate in 37% of women. We did not see significant correlations of prolactin with laboratory measures, however all female patients had elevated and high prolactin levels, leading to low variability in a small sample, which may have precluded seeing any direct relationships. Recognizing prolactin related side effects and understanding the role of other health measures seen in women with antipsychotic induced hyperprolactinemia in our female patients are critical steps toward better personalization of their care and recovery.

Analysis of Dietary Supplement Use and Influencing Factors in the Mongolian Population.

Objective Dietary supplements (DS) may improve micronutrient deficiencies, but the unique eating habits and cultural customs of the Chinese Mongolian population affect their choice of DS. Therefore, this study adopted a cross-sectional method to explore the current status of DS use and to assess the influencing factors in the Mongolian population in Inner Mongolia, China. Methods We used a multistage random cluster sampling method to select 1,434 Mongolian people aged ≥ 18 years in Hohhot and Xilinhot, Inner Mongolia. Data regarding general patient characteristics and DS use through questionnaire surveys were obtained, and the blood plasma was collected for biochemical index detection. The binary logistic regression and decision tree algorithm were used to predict the factors influencing DS use among the Mongolian population. Results Among 1,434 participants that completed the baseline survey, the usage rate of DS was 18.83%, and more women than men used DS (P = 0.017). Higher use of DS was reported among individuals aged ≤ 34 years, but this difference is not statistically significant (P = 0.052). Usage rate was higher among those living in urban areas (P < 0.001), those with higher education (P < 0.001), those engaged in mental work (P < 0.001), and nonsmokers (P = 0.019). The biochemical test results showed that the proportion of people with abnormal total cholesterol levels using DS was lower (P = 0.003), but that of those with abnormal triglyceride levels using DS was higher (P = 0.001), compared with the proportion of those with normal levels in each case. The most commonly used supplement was calcium (58.15%). Education level was the main factor affecting DS intake. The results of the binary logistic regression model and decision tree model both showed that region, educational level, and abnormal triglyceride levels were significant factors influencing DS intake among Mongolians. Conclusion Findings from this study indicate that DS intake is uncommon in the Mongolian population. In addition, sex, region, education level, and triglyceride levels may influence DS use.

Perbedaan Asupan Energi, Zat Gizi Makro dan Serat Berdasarkan Kadar Kolesterol Total pada Dewasa Muda Vegetarian di Indonesia Vegetarian Society Jakarta

Background: Vegetarians are people who live from consuming plant-based (or plant-based) products with or without milk and eggs, but over all avoid eating meat, poultry and marine animals.. According to Household Health Survey (SKRT) cited Budiarti, in 2004 prevalence of hypercholesterolemia in Indonesia in the age range 25-65 years of 11.2%. One way to prevent elevated levels of cholesterol in the blood is to change the diet to become a vegetarian. Objective: To purpose the difference between energy intake, macro nutrients (protein, fat, and carbohydrates), fiber, based on total cholesterol levels in young vegetarian adults in Indonesia Vegetarian Society Jakarta. Methods: Cross sectional study design, independent Bed T-Test test if normal distribution data and Mann Whitney if the data is not normally distributed. Determination of the sample was done by means of different test of two mean and obtained sample of 70 people. Results: The results of the statistical test obtained p-value for energy intake, protein intake, fat intake, carbohydrate intake based on total cholesterol level with normal and abnormal category showed significant difference (p-value ≤ 0,05), and mean fiber intake showed no significant difference (p-value &gt; 0,05). Conclusions: There are differences in energy, protein, fat, carbohydrate intake based on normal and abnormal total cholesterol levels, and fiber intake are expressed as no difference. There is a need for nutritional counseling and routine monitoring of total cholesterol in young vegetarian adults in IVS Jakarta.

Assessment of the hyperlipidemia risk for residents exposed to potential emitted metals in the vicinity of a petrochemical complex.

Hyperlipidemia, which is associated with certain environmental factors, is a risk factor for cardiovascular disease. Heavy metals are important pollutants from industrial emissions. However, the relationship between the exposure to heavy metals and the occurrence of hyperlipidemia is limited. This study aimed to investigate the association between serum metal levels and the risk of hyperlipidemia in adults living near a petrochemical complex. Our study subjects were 959 residents aged above 35years in 11 townships near the largest petrochemical complex in central Taiwan. The serum levels of chromium, arsenic, and mercury in the study subjects were measured. The basic characteristics of the study subjects were collected via a questionnaire survey, and the levels of blood lipid biomarkers were analyzed by health examination. The definition of hyperlipidemia was defined in the provided guidelines. Adjusted generalized linear and logistic regression models were applied to evaluate the associations between petrochemical-related metal exposure and hyperlipidemia. The study subjects had chromium, arsenic, and mercury serum levels of 3.24±3.45, 3.45±4.66, and 1.24±1.08 (μg/L), respectively, and close proximity of the study subjects to the petrochemical complex was significantly associated with increased serum metal levels. The results showed that the total cholesterol levels were significantly associated with the increased serum chromium, arsenic, and mercury levels. And, the LDL-C levels were significantly associated with the increased serum mercury levels. In addition, the increased serum arsenic and mercury levels of the study subjects were significantly associated with higher odds ratios for abnormal total cholesterol levels and the risk of hyperlipidemia. Residing in close proximity to a petrochemical complex and high arsenic and mercury exposure were associated with elevated blood lipid levels and an increased risk of hyperlipidemia among the residential population in the vicinity of the petrochemical industry.

Physical Health Status of Emergency Care Providers in South Africa

Background: Emergency care providers (ECPs) have a physically, mentally, and emotionally demanding profession. Therefore, they are predisposed to cardiovascular and other non-communicable disease risk factors. Objectives: The objective of the study was to determine the physical health status of ECPs in the North West province of South Africa through a selected anthropometric and other health parameter test battery. Methods: Ninety-one ECPs (64 males, 27 females) took part in the study voluntarily for health screening tests including body mass index (BMI), lean body mass (LBM), resting heart rate (RHR), blood pressure (BP), skinfold measurement, waist circumference (WC), waist-to-hip ratio (WHR), fasting blood glucose (FBG), and total cholesterol (TC). The collected data were subjected to statistical analysis using the Statistical Package for Social Sciences (SPSS) version 25 (IBM). Results: The participants demonstrated a mean BMI of 28.2 ± 5.5 kg/m2, body fat of 26 ± 7.6 %, and LBM of 58.6 ± 10 kg. Significant differences were seen in height (170.5 ± 6.2 vs. 160.7 ± 5.3 cm), BF% (22.5 ± 5.3 vs. 34.2 ± 6.2 %), and LBM (62.3 ± 8 vs. 49.2 ± 8.2 kg) between males and females (P ≤ 0.05). Mean systolic BP was 122 ± 15 mmHg, and diastolic BP was 81 ± 10 mmHg. Mean WC was 90.8 ± 11.4 cm. Other health parameters included mean FBG of 5.1 ± 2.4 mmol/L and mean TC of 4.9 ± 0.7 mmol/L. Significant differences were seen in WHR (0.88 ± 0.04 vs. 0.79 ± 0.06) between males and females (P ≤ 0.05). Conclusions: A significant number of ECPs presented with cardiovascular and other NCD risk factors such as hypertension, obesity, high WC, elevated FBG, and abnormal levels of TC. This can be attributed to the nature of their occupation such as working irregular shifts leading to sleep deprivation, being exposed to psychological trauma, poor nutrition during shifts, and/or lack of exercise. Stress management is an important part of these workers’ rehabilitation program. A well-formulated employee wellness program is required to set remedial measures in place.

Prevalence and associations of behavioural risk factors with blood lipids profile in Lebanese adults: findings from WHO STEPwise NCD cross-sectional survey

ObjectiveTo examine associations of behavioural risk factors, namely cigarette smoking, physical activity, dietary intakes and alcohol consumption, with blood lipids profile.Design and participantsData drawn from a cross-sectional study involving participants...

The Effect of Nephelium longata L Honeyconsumption on Decreasing of Cholesterol Level for Hypercholesterolemia Patient at Medical Clinic of Farras Husada of Sowan Lor, Kedung, Jepara

Cholesterol is actually not a disease, but rather the result of the body’s metabolism of fat that we makan.Kolesterol would be detrimental to the cause of deadly diseases such as coronary heart disease, stroke, hypertension, and diabetes when the amount exceeds normal limits.Riskesdas in 2013,obtained measurements of cholesterol levels in the population aged >15 years who have an abnormal total cholesterol levels by 35.9%, men 30%, women 39.6%.City at 39.5% and the country side at 32,1%. This study aims to examine the effect of Honey Consumption on decreasing Cholesterol Levels in Patients Hypercholesterolemia in Polyclinics of Farras Husada of Sowan Lor Kedung of Jepara. This study used quasi-experimental study. By making the total cholesterol level checked first before being given the honeyNephelium longata Lthen check back in total cholesterol levels after 14 days are given honey. With the draft pre-test and post-test nonequivalent control grup. This study showed that the cholesterol before it is given in the intervention group amounted to 233.94. Average cholesterol levels after given. With 200.65 P value 0.000 <0.05. This means that cholesterol-lowering There is a difference before and after. As for the control group, the average cholesterol level before it amounted to 287.20. Average cholesterol levels after at 252.40. Premises P value 0.001 <0.05. This means that there are differences decrease cholesterol levels before and after the control group.Conclusion:There was a significant effect of honey Nephelium longata L consumption to decrease cholesterol levels in the intervention group and there is effect on cholesterol lowering in the control group.

Differences by Sex in Cardiovascular Comorbid Conditions Among Older Adults (Aged 50-64 or ≥65 Years) Receiving Care for Human Immunodeficiency Virus.

Differences by sex in cardiovascular comorbid conditions among human immunodeficiency virus (HIV)-infected persons aged 50-64 years have been understudied; even fewer data are available for persons aged ≥65 years. We used matched interview and medical record abstraction data from the 2009-2012 data cycles of the Medical Monitoring Project, a nationally representative sample of HIV-infected adults in care. We included men and women aged 50-64 and ≥65 years at time of interview. We calculated weighted prevalence estimates and used logistic regression to compute adjusted prevalence differences and 95% confidence intervals (CIs) assessing sex differences in various characteristics and cardiovascular comorbid conditions. Comorbid conditions included overweight/obesity (body mass index ≥25), abnormal total cholesterol level (defined as ≥200 mg/dL), diagnosed diabetes mellitus, or diagnosed hypertension. Of 7436 participants, 89.5% were aged 50-64 years and 10.4% aged ≥65 years, 75.1% were men, 40.4% (95% CI, 33.5%-47.2%) were non-Hispanic black, 72.0% (70.4%-73.6%) had HIV infection diagnosed ≥10 years earlier. After adjustment for sociodemographic and behavioral factors, women aged 50-64 years were more likely than men to be obese (adjusted prevalence difference, 8.4; 95% CI, 4.4-12.3), have hypertension (3.9; .1-7.6), or have high total cholesterol levels (9.9; 6.2-13.6). Women aged ≥65 years had higher prevalences of diabetes mellitus and high total cholesterol levels than men. Cardiovascular comorbid conditions were prevalent among older HIV-infected persons in care; disparities existed by sex. Closer monitoring and risk-reduction strategies for cardiovascular comorbid conditions are warranted for older HIV-infected persons, especially older women.

Performance of gender- and age-specific cut-points versus NCEP pediatric cutpoints in dyslipidemia screening among Chinese children

Background and aimsConsiderable attention is given nowadays to the presence of cardiovascular diseases risk factors in children. The current blood lipid classification system for Chinese children was based on the United States National Cholesterol Education Program (NCEP) cutpoints, which did not take the age, gender and race differences into consideration. This study aimed to develop gender- and age-specific lipid cutpoints for dyslipidemia screening in Chinese children and compare the ability of new cutpoints and NCEP pediatric cutpoints to predict obesity and unfavorable blood pressure (BP) levels. MethodsData were obtained from a nationwide multicenter cross-sectional study: The China Child and Adolescent Cardiovascular Health Study, comprising 12,875 Chinese children aged 6–18 years. We calculated cutpoints for abnormal levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) that were linked to Chinese adult abnormal lipid thresholds using the General Additive Model for Location Scale and Shape method. ResultsBorderline-high and high cutpoints (TC, LDL-C and TG) as well as low cutpoints (HDL-C) were developed to classify the abnormal blood lipid levels in Chinese children. Better performance for prediction of obesity, elevated BP, and hypertension were found with the proposed cutpoints in comparison with the NCEP pediatric cutpoints (AUC for obesity: 0.612 vs. 0.597, p = 0.017; AUC for elevated BP: 0.529 vs. 0.521, p = 0.017; AUC for hypertension: 0.536 vs. 0.527, p = 0.016). ConclusionsThe gender- and age-specific cutpoints should improve the accuracy of dyslipidemia screening in China and be more reasonable in practice.

Canavalia ensiformis Protein Extract Effect Toward Serum Lipid Profile of Hypercholesterolemic Sprague Dawley Rat

Riskesdas 2013 showed the prevalence of abnormal total cholesterol levels in Indonesia is 35.9%, low HDL cholesterol is 22.9%, high LDL cholesterol is 15.9%, and high triglyceride is 11.9%. This study aimed to prove the effect of jack bean protein extract toward serum lipid profile of a hypercholesterolemic rat. This was a true experimental study conducted in September 2016 with post-only control group design. Twenty four male Sprague Dawley rats were randomly classified into 4 different groups; control negative group (C-), control positive group (C+), first experimental group (X1) which was given jack bean extract 4g/200g of body weight of the rat per day, and second experimental group (X2) which was given jack bean extracts 6g/200g of body weight of the rat per day. Treatment for 2 weeks showed a significant effect. Total cholesterol, LDL cholesterol, and triglycerides levels of groups with protein jack bean extract administration were lower than the positive control group (p &lt;0.05). Increasing doses of jack bean extracts was linear with serum lipid profile improvement of Sprague Dawley Rat. These result indicated the positive effect of jack bean protein extract toward serum lipid profile of hypercholesterolemic Sprague Dawley Rat.

Clinical significance of analysis of the level of blood fat, CRP and hemorheological indicators in the diagnosis of elder coronary heart disease.

ObjectiveTo investigate the levels of blood fat, C-reactive protein (CRP) and hemorheological indicators in the elder patients with coronary heart disease (CHD), so as to provide evidence for prospective study and treatment of elder CHD.MethodsWe collected the clinical data of 127 elder CHD patients who admitted to this hospital between July 2016 and December 2017 to detect the levels of blood fat, CRP and hemorheological indicators.ResultsIn elder CHD patients, levels of the total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterin (LDL-C) were significantly higher than the normal reference, and comparison with the control group also showed significant increases (p < 0.01); average levels of the high-density lipoprotein cholesterin (HDL-C), phospholipid (PL), lipoprotein a [LP (a)] and free fatty acid were in the range of normal reference. Abnormal levels of TC, TG, LDL-C and HDL-C were identified in 59.06%, 58.27%, 51.18% and 18.11% of the elder CHD patients, most of which were concomitant with obesity or hypertension, and levels of these indicators were significantly higher than those in the control group with statistically significant differences (p < 0.01). Comparisons of the age, gender distribution, hypotension, exercise and sleep showed that differences had no statistical significance (p > 0.05). In comparison with the control group, the levels of CRP, the whole blood viscosities at high and low shears, plasma viscosity, hematocrit value, aggregation index and rigidity index of red blood cells (RBC) were all higher than those in the control group, and the differences had statistical significance (p < 0.01). However, the erythrocyte sedimentation rate (ESR), deformity index of RBC, blood flow rates in the bilateral middle cerebral arteries (MCA), anterior cerebral arteries (ACA), terminal internal carotid artery (TICA), posterior cerebral arteries (PCA), vertebral arteries (VA) and basilar artery (BA) were significantly lower than those in the control group, and the differences had statistical significance (p < 0.05 or 0.01).ConclusionIn elder CHD patients, anomaly is mainly seen in levels of TC, TG and LDL-C with concentrated, adhesive and aggregating blood.

Parameters of Metabolic Syndrome in Obese Children and Adolescents.

Abstract Background: Obesity is the most common chronic metabolic disease in children and adolescents. It has reached epidemic ranges and is a significant global problem. Objective: This study aimed to investigate the possible metabolic disturbances in children and adolescents with obesity and severe obesity. Subjects and methods: This cross-sectional study included 158 (82 boys, 76 girls) obese children and adolescents between ages of 0 and 17years (10.43 ± 3.11 years). The obesity was defined according to the sex- and age-specific growth charts proposed by the Centers for Disease Control and Prevention as BMI ≥ 95th percentile. Severe obesity was classified as 120% of the 95th percentile for age and sex. Study participants underwent medical assessment and analysis of: ALT, AST, fasting serum triglycerides, total serum cholesterol, fasting plasma glucose and plasma glucose from oral glucose tolerance test. Results: The majority of study participants were severely obese (69.92%). The highest distribution of abnormal biochemical results was seen in elevated ALT (53.91%) followed by elevated triglycerides (34.75%). The prevalence of abnormal total cholesterol level was significantly higher (p=0.04) in the group of obese children compared to the severely obese children. The levels of total cholesterol were also statistically higher in the group of adolescents compared to preadolescents (p=0.02). An important number of obese patients (2.5%) and even higher number of severely obese patients (5.26%) had carbohydrate intolerance. Conclusion: There was a significant elevation of ALT, total serum cholesterol and triglycerides in all study participants. High serum lipids and high hepatic enzymes (as introduction in non-alcoholic fatty liver disease) are alarming. Strikingly, there was carbohydrate intolerance in an important number of patients. Treatment and education of patients and parents is mandatory. Preventive measures in the society concerning childhood obesity are necessary.

The "bad" cholesterol can predict abnormal apolipoprotein B levels in a large unselected outpatient cohort.

BackgroundThe significant association between total cholesterol (TC), non-high-density lipoprotein cholesterol (non-HDL), and low-density lipoprotein cholesterol (LDL) has been shown to be associated with Apolipoprotein B (Apo B). The objective of this study was to assess whether abnormal levels of TC, non-HDL and LDL can be used as predictors of abnormal serum Apo B levels.ResultsTC (r = 0.752), non-HDL (r = 0.799), and LDL(r = 0.817) were significantly positively correlated with Apo B. Areas under the curve of TC, non-HDL, and LDL for predicting abnormal Apo B (>1.10 g/L) were 0.906, 0.918, and 0.928, respectively. The optimal thresholds of prediction of abnormal Apo B were 5.13 mmol/L for TC, 4.23 mmol/L for non-HDL, and 3.34 mmol/L for LDL. At these optimal thresholds of TC, non-HDL and LDL, less than 1.13%, 1.67%, and 0.62% of tests with abnormal Apo B results would have been missed, but approximately 69.4%, 79.7%, and 73.2% of the performed Apo B tests could have been eliminated, respectively.ConclusionsApo B levels of unselected outpatients need be not tested (especially when LDL < 3.34 mmol/L, non-HDL < 4.23 mmol/L, and/or TC < 5.13 mmol/L). It will result in 69% reduction in number of ordered Apo B tests. LDL was significantly better than the TC and non-HDL for predicting abnormal Apo B indicating that Apo B needn't tested when LDL level is normal.MethodsWe retrospectively analyzed results of TC, HDL, LDL, and Apo B in a large cohort of unselected outpatients (n = 5486) in Shuyang People's Hospital, Shuyang, China. Non-HDL was calculated by deducting HDL from TC. Correlations between TC, non-HDL, LDL, and Apo B were analyzed by using Spearman's rho approach. Receiver operating characteristics curve analysis was used to evaluate the predictive value of TC, non-HDL, and LDL for abnormal Apo B.

Epidemic features of dyslipidemia among Uygur, Kazakh and Han ethnic groups in Urumqi

Objective: To analyze the epidemic features of dyslipidemia among 39 980 Uygur, Kazak and Han ethnic groups in Urumqi, and to explore the methods of prevention and treatment on dyslipidemia. Methods: The differences of blood total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) of health examination population with different ethnics, genders, and ages were compared, from 2012 to 2014 in the First Affiliated Hospital of Xinjiang Medical University. Results: Among the Uygur, Kazak and Han ethnic groups, the positive rate was respectively 35.0%, 37.0%, 30.3% in TC; 34.5%, 30.1% and 32.0% in TG; 24.9%, 18.3%, and 18.2% in HDL-C; 30.1%, 31.6% and 23.3% in LDL-C. In the same ethnic group, the abnormality rate of blood lipid in the female was lower than that of the male (P<0.001). The blood lipid abnormality rate increased significantly in those with 30-39 years, and reached the highest value in the 50-59 years group, then it decreased in those aged over 60 years (P<0.001). Conclusion: The lipid abnormality rate of the Uygur and Kazak residents was higher than that of the Han nationality, and the abnormal levels of TC and LDL-C were particularly evident in Urumqi.

Association of immune recovery with hyperlipidaemia and apolipoprotein gene polymorphisms following highly active antiretroviral therapy in a cohort of Chinese HIV patients

ObjectiveTo examine the associations between CD4 recovery, dyslipidaemia and apolipoprotein (APO) gene single nucleotide polymorphisms (SNPs) following highly active antiretroviral therapy (HAART).DesignRetrospective observational cohort study.SettingA major HIV care clinic in...

Evaluation of Lipid Metabolism and Nutritional Status in Male Goalball Players.

Lipid disorders, obesity and overweight are considered one of the most important modifiable cardiovascular risk factors. Population surveys carried out in Poland have demonstrated a tendency for lipid disorders to occur in 70% and overweight and obesity in more than half of Poles. No such studies have been conducted in groups of people with vision impairment so far. Yet, regular involvement of visually impaired people in sports is likely to reduce cardiovascular risk. Therefore, the authors attempted to evaluate the lipid profile and nutritional status of male goalball players. Thirty two blind or visually impaired male goalball players aged 20 to 45 years participated in the study during which somatic variables (BH, BM, WC, VFR, BMI) and the lipid profile (TC, LDL, HDL, TG) were evaluated. Overweight was found in 40.6% of athletes, with obesity being at the level of 9.3%. A high correlation was found between visceral fat and the BMI (r=0.7; p<0.001), as well as between visceral fat and WC (r=0.8; p<0.001). Abnormal total cholesterol levels were recorded for LDL (22% of study participants), HDL (17%) and triglycerides (13%). Lower levels of individual components of lipid profiles (and higher levels for HDL) were found in athletes with a normal BMI. A correlation was found between the BMI and TG (r=0.4, p<0.01), WC and TG (r=0.4, p<0.01), VFR and LDL ( r=0.4, p<0.05) and TG (r=0.5, p<0.001). The percentage of overweight and obese subjects with vision impairment was lower compared to the general population of men in Poland, with a more beneficial lipid profile. Regular physical activity of the study participants is likely to have a positive effect on their health.

Comparison of Clinical Findings of Positive-and Negative-Patients in Treadmill Test for Adults with Cardiovascular Events

This study was retrospectively designed to investigate differences in physiological variables between positive- and negative-patients in treadmill test for the diagnosis of patients with cardiovascular events and to confirm clinical usefulness of treadmill test. Total leukocyte and neutrophil counts, neutrophils/lymphocytes ratio and mean corpuscular volume were significantly higher, whereas platelet counts were lower in the positive group than in the negative group. Triglyceride and alkaline phosphatase concentrations were significantly higher in the positive group than in the negative group. The patients with abnormal levels of total cholesterol, high density lipoprotein cholesterol were higher in the positive group than in the negative group, but is reverse in hyperglycemia. High sensitivity C-reactive protein, erythrocyte sedimentation rate, lactic dehydrogenase, brain natriuretic peptide, creatinekinase-MB and troponine-I levels in the positive group were significantly greater than those of the negative group. P-, QRS- and T-axis in the EKG were higher whereas PR interval was shorter in the positive group than in the negative group. Most of cardinal symptoms were chest pain (57%) in the both groups. In final diagnosis angina pectoris (53% vs. 37%) and acute myocardial infarction (MI) (10% vs. 3%) were higher in the positive group than in the negative group. Cases of coronary artery angiography (CAG) and medication in the positive group were more than those of the negative group. Cases of normal CAG finding and observation in positive group were more than those of negative group. These data suggest that treadmill testpositive group had higher inflammation, myocardial injury, prevalence of angina pectoris and MI and that treadmill test has clinical usefulness. Also if adults have abnormal range of above mentioned clinical variables, treadmill test is recommended. However, treadmill test is not unique and the best tool for diagnosis of coronary artery disease because the patients with negative finding also had percutaneous coronary intervention and medications.