The fundamental existence of any living organism necessitates the availability of pure and safe water. The ever-increasing population has led to extensive industrialization and urbanization, which have subsequently escalated micropollutants and water contamination. The environmental impact on various life forms poses a dire need for research in effective environmental management. Versatile technologies involving multiple approaches, including physiochemical and biological bioremediation strategies, draw insights from environmental biology. Metabolic annihilation mediated by microbes shows significant potential in the bioconversion of toxic micropollutants to tolerable limits. Environmentally friendly, cost-effective, and sustainable strategies are envisaged for efficient environmental protection. Phytoremediation technology, especially floating wetland treatments, facilitates micropollutant elimination, landscape management, ecosystem conservation, and aesthetic enhancement in diverse environments. The incorporation of nanomaterials in the bioremediation of toxic micropollutants augments novel and innovative strategies for water pollution abatement. This paper offers a novel strategy that combines nanomaterials to improve micropollutant degradation with bioremediation techniques, particularly the creative application of phytoremediation technologies like floating wetlands. Combining these techniques offers a novel viewpoint on long-term, affordable approaches to reducing water pollution. Additionally, the review proposes a forward-looking strategic framework that addresses the accumulation and refractory nature of micropollutants, which has not been thoroughly explored in previous literature.