In the present report, an environmentally benign, cost-effective, and green route method was adapted to synthesize hematite (α-Fe2O3) nanocrystals (NCs) using Magnifera Indica leaf extract (MILE). Crystal structure characterization of Magnifera Indica leaf extract-mediated hematite nanocrystals [MILE@α-Fe2O3 NCs] showed rhombohedral crystallinity with space group R3¯c as confirmed through the Rietveld refinement method. Microstructural characterization carried out using a transmission electron microscope (TEM) confirmed the nano-dimensional formation of MILE@ α-Fe2O3 NCs with an average size of 3.7 nm as derived from the Gaussian distribution of particle analysis. The optical spectrum shows an absorption peak at 264 nm and another broad hump centered at 383 nm. MILE@α-Fe2O3 NCs exhibit superparamagnetic behavior and also intact reusability ability or recoverable efficiency after being used due to magnetically separation ability. The anticancerous activity of MILE@α-Fe2O3 NCs was carried out against MDA-MB 231 cell lines and it was found that cell viability follows a concentration-dependent manner with a low value of IC50 = 34.70 µg/mL.
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