Background. Sleep-disordered breathing (SDB) is a growing public health problem, and non-invasive treatments may be a valid option. The objective of this randomized controlled trial was to assess the effects of a 12-week exercise program and a lifestyle app on SDB severity, physical health (anthropometry, body composition, physical fitness), and health-related quality of life (HRQoL) in 18–50 years old adults with mild-to-moderate SDB.Methods. One-hundred-ninety-two participants (age 37.4±6.3years, BMI 33.3±4.2kg·m−2, 52.6% males) with mild-to-moderate SDB (apnea-hypopnea index [AHI] ≥5<30.0, objective snore ≥10%) were randomized into: Exercise (three times/week, 60 min), app, and control groups. The assessments included a three-night self-applied polysomnography, anthropometryt, body composition, physical fitness, and HRQoL. Repeated ANOVA, Wilcoxon signed-rank and Kruskal-Wallis test were used to evaluate the changes.Results. Time effect was observed in AHI (F=6.290, p=0.014), neck circumference (F=5.253, p=0.024), hand dynamometry (F=7.102, p=0.009), and 6-minute walking test (F=8.340, p=0.005). Group x time interactions were observed in weight (F=9.318, p=<0.001), BMI (F=9.302, p=<0.001), body fat percentage (F=4.756, p=0.01), body fat mass (F=5.916, p=0.004), and skeletal muscle mass (F=9.380, p=<0.001). Intragroup changes were observed in physical functioning, vitality, and general health in both the exercise and app groups, in addition to role limitations due to physical health in the exercise group.Conclusions. The 12-week exercise program reduced AHI and increased skeletal muscle mass, physical fitness, and HRQoL in four domains. The lifestyle app program reduced weight, BMI, neck circumference, body fat, visceral adiposity and skeletal muscle mass while increased three HRQoL domains in participants with mild-to-moderate SDB.
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