4-isopropyl Phenyl Research Articles

SYNTHESIS, BIOLOGICAL EVALUATION AND DOCKING STUDIES OF NEW 5-(4-ISOPROPYL PHENYL)-1,3,4- THIADIAZOL-2-AMINE DERIVATIVES

A straightforward synthetic pathway has been developed to prepare N-acylated derivatives of 5-(4-isopropyl phenyl)-1,3,4-thiadiazol-2-yl)amines 3(a-j) by reacting 5-(4-isopropyl phenyl)-1,3,4-thiadiazol-2-amine (2) with various symmetrical acid anhydrides in pyridine solvent under refluxing conditions with good yields. This study involves simple, easy, cheap, inexpensive, and benign processes. Molecular docking investigations were done using an auto dock and found that 3i, 3h, and 3a had good binding energies with PDB ID: 5JZX. The antibacterial efficacy of compounds 3(a-j) was investigated against S. aureus and E. coli. Among all the compounds 3c, 3h & 3j showed good strength towards gram-positive and compounds 3e, 3i & 3j showed good strength on gram-negative bacteria. Further antifungal activity is done against Candida albicans. Most of the prepared compounds 3(a-j) showed good activity against tested microorganisms.

Synthesis and Cytotoxic Test of Halogen-Substituted Chalcone Against MCF-7 Breast Cancer Cells

A series of chalcones was synthesized to be (E)-1-(4-chlorophenyl)-3-p-tolyprop-2-en-1-on (1), (E)-1-(4-chlorophenyl)-3-(4-tolyprophenyl) prop-2-en-1-on (2), (E)-1-(3-bromophenyl)-3-p-tolylprop-2-en-1-on (3), and (E)-1-(3-bromophenyl)-3-(4-isopropyl phenyl) prop-2-en-1-on (4) using irradiate microwave method with reaction time from 3, 6, and 8 min at 800 °C and 700 W. The compounds were characterized using TLC, UV-Vis, FTIR, 1H-NMR, and evaluated MCF-7 cancer cell cytotoxic test with Presto BlueTM. All compounds produced were in the form of yellow crystals. The results showed that compounds 2, 3, and 4 were potentially a Como prevention agent and inhibit cell proliferation with IC50 values of 37.24, 422.22, and 22.41 ppm, respectively. While compound 1 had IC50 1,484.75 and no cytotoxic effect. Further tests should be carried out for compounds 2, 3, and 4 against normal cells to measure the compound's safety for normal cells.

Enhanced corrosion inhibition of carbon steel in HCl solution by a newly synthesized hydrazone derivative: Mechanism exploration from electrochemical, XPS, and computational studies

The corrosion inhibition properties of a synthesized hydrazone derivative namely, 1-(4-isopropyl phenyl) -2- (2,4-dinitrophenyl) (HYD (iso)) on API 5L-X60 carbon steel (CS) in 1.0 M HCl solution were evaluated by chemical, electrochemical, X-ray photoelectron spectroscopy (XPS) and theoretical studies. The obtained results revealed that the tested compound acted as a good corrosion inhibitor with inhibition efficiency of 96.32% at a concentration of 5 × 10−3 M. The polarization technique indicated that the HYD (iso) belonged to mixed-type inhibitors, preventing simultaneously anodic and cathodic reactions. The binding between the HYD (iso)'s molecule and CS surface follows a Langmuir adsorption type model and its inhibition mechanism is assisted by physical and chemical interactions. Scanning electron microscope (SEM) and contact angle analyses were performed to examine the surface morphology of inhibited and uninhibited samples. Additionally, theoretical studies using Density Functional Theory (DFT) and molecular dynamics (MD) simulation were performed to explore the most reactive sites of the hydrazone molecule and its adsorption mechanism.

Improved thermal stability of graphite electrodes in lithium-ion batteries using 4-isopropyl phenyl diphenyl phosphate as an additive

To enhance the thermal stability of graphite electrodes for lithium-ion batteries, 4-isopropyl phenyl diphenyl phosphate (IPPP) was investigated as an additive in the electrolyte of 1.0 M LiPF6 in ethylene carbonate and diethyl carbonate (1:1 in weight). The electrochemical performance of Li/IPPP-electrolyte/C half cells was evaluated. The thermal behavior of LixC6 and LixC6-IPPP-electrolytes were examined using a C80 micro-calorimeter. Electrolytes with 5 and 10% IPPP improve the thermal stability of the graphite electrode in the tests. The electrochemical performance of Li/IPPP-electrolyte/C cells is not degraded by the addition of this amount of IPPP to the electrolyte.

New 1,2,3-triazole ligands through click reactions and their palladium and platinum complexes

The new ligands, 1-(4-isopropyl phenyl)-4-(2-pyridyl)-1,2,3-triazole, 1 and 1-(mesityl)-4-(2-pyridyl)-1,2,3-triazole, 2 were prepared by the reactions of the respective azides with 2-ethynylpyridine following the "click method". These ligands together with the reported ligands 1-(phenyl)-4-(2-pyridyl)-1,2,3-triazole, 3 and 1-(benzyl)-4-(2-pyridyl)-1,2,3-triazole, 4 were reacted with palladium and platinum precursors to give mononuclear cis-dichloropalladium and platinum complexes containing the triazole ligands. Structural characterisation of the free ligand 3 shows that the central N-N bond in the triazole ring has double bond character and hence is best described as an "azo-like" N-N double bond. The pyridine ring in 3 has an almost "anti" conformation with respect to the central triazole ring. The metal centers bind to the ligands through the pyridine N and a triazole N atom. The metal-N(triazole) distances are shorter than the metal-N(pyridine) distances. Cyclic voltammograms of the ligands show reduction processes that appear at extreme negative potentials. Coordination of metal centers induces huge anodic shifts of the reduction potentials due to sigma-polarisation by the metal centers. UV/Vis spectra of the ligands and complexes are also discussed. The properties of such chelating triazole ligands towards palladium and platinum centers is being compared and contrasted to the widely used 2,2'-bipyridine ligand.

Enhancing the safety of lithium ion batteries by 4-isopropyl phenyl diphenyl phosphate

To enhance the safety of lithium ion batteries, 4-isopropyl phenyl diphenyl phosphate (IPPP) was explored as an additive in 1.0 M LiPF 6/ethylene carbonate (EC) + diethyl carbonate (DEC) (1:1 wt.%). The electrochemical performances of LiCoO 2/IPPP electrolyte/C cells were tested. And then the LiCoO 2/IPPP electrolyte/C cells were disassembled and wrapped to detect the thermal behaviors using a C80 microcalorimeter. The results indicated that 5% and 10% IPPP content in the electrolyte can enhance the safety of lithium ion batteries. Furthermore, the electrochemical performances of LiCoO 2/IPPP electrolyte/C cells become slightly worse by using 5% and 10% IPPP content electrolyte. Therefore, 5–10% IPPP content in electrolyte can enhance the safety of lithium ion batteries with minimum sacrifice in electrochemical performance.

Enhancing the thermal stability of LiCoO 2 electrode by 4-isopropyl phenyl diphenyl phosphate in lithium ion batteries

To enhance the thermal stability of LiCoO 2 in lithium ion batteries, 4-isopropyl phenyl diphenyl phosphate (IPPP) was investigated as an additive in 1.0 M LiPF 6/EC + DEC (1:1 wt.%) electrolyte. The thermodynamics and kinetics parameters of the single LiCoO 2 and Li x CoO 2–IPPP-electrolyte are detected and calculated based on the C80 microcalorimeter data. The results indicated that IPPP can enhance the thermal stability of LiCoO 2 electrode in lithium ion battery more or less corresponding to the IPPP content in electrolyte. Furthermore, the electrochemical performances of LiCoO 2/IPPP-electrolyte/Li cells become slightly worse after using IPPP additive in the electrolyte. This alleviated trade-off between thermal stability and cell performance provides a possibility to formulate an electrolyte containing 5–10% of IPPP and enhance the LiCoO 2 electrode thermal stability with minimum sacrifice in performance.

4-Isopropyl Phenyl Diphenyl Phosphate as Flame-Retardant Additive for Lithium-Ion Battery Electrolyte

4-Isopropyl Phenyl Diphenyl Phosphate as Flame-Retardant Additive for Lithium-Ion Battery Electrolyte

SORPTION BEHAVIOR OF METOLACHLOR, ISOPROTURON, AND TERBUTHYLAZINE IN SOILS

The sorption-desorption of metolachlor [2-chloro-N-(ethyl-6-methyl phenyl)-N-(2-methoxy-1-methyl ethyl) acetamide], isoproturon [3-(4-isopropyl phenyl)-1,1-dimethyl urea] and terbuthylazine [N6-tert butyl-6-chloro-N4-ethyl- 1,3,5-triazine-2,4-diamine] herbicides was studied in two German soils at 1:10 soil to water ratio by batch method. Equilibrium of herbicides between soil and water (0.01 M CaCl2) was attained in 2 h. Sorption data fitted very well to Freundlich equation, represented by very high correlation coefficient (r2 > 0.934). Comparison of Freundlich K values indicated that sorption of all the three herbicides was most pronounced in soil having higher organic carbon content. Koc values were as expected nearly identical for each herbicide in the two soils. The Freundlich constant (1/n) was about 1 for metolachlor and less than 1 for terbuthylazine and isoproturon indicating a L-type of sorption isotherms. Desorption of all the three herbicides showed hysteresis. Nearly equal amounts of metolachlor, isoproturon and terbuthylazine were desorbed from both soils. There was a good correlation between Koc and solubility.

Study on the mineralization and degradation of isoproturon in three soils

Mineralization and degradation of 14C-ring-labelled isoproturon were investigated over 120 days under controlled laboratory conditions in three soils of eastern France chosen for their pH: a pelosol, a brown calcareous soil and a brown acid soil. Biological activity of the micro-flora was also measured by release of total CO 2. Common metabolites of isoproturon found in the three soils were N-(4-isopropyl phenyl)N'methylurea and N-(4-(2-hydroxyisopropylphenyl))-N'methylurea. Moreover N-(4-isopropylphenyl)urea was also found in brown acid soil. Other residues were detected; one in the pelosol and two in the brown acid soil. Analysis of non identified product of pelosol only revealed a polar affinity by presence of hydroxy fonction. One of the residues found in brown acid soil was characterised by GC/MS as 4,4′-diisopropylazobenzene.

Synthetic Juvenile Hormone Analogues Against Four Species of Stored Products Beetles

Juvenile hormone analogues (JHAs), JHA I (6,7’-epoxy3,7’-dimethyl-dec-2’-enyl 6-ethyl-3-pyridyl ether), JHA II (3’,7’-dimethyl-undec-2,6’-dienyl 6-ethyl-3-pyridyl ether), MV-678 (2-methoxy-9-[4-isopropyl phenyl]-2, 6-dimethylnonane), and R-20458 (4-ethylphenyl-6, 7’-epoxy-geranyl ether) in acetone solution were applied to insect diets at 10 ppm (v/v), and their effects on four species of stored products beetles observed. The larvae of the flour beetles, Tribolium confusum Jacquelin du Val, and Tribolium castaneum (Herbst), reared in media treated with JHAs I and II failed to pupate. At the end of the 6-week observation period, these larvae had not yet pupated. MV-678 and R-20458 produced ecdysial failures, lethal morphological abnormalities and larval/pupal and pupal/adult intermediates. Only a few apparently normal adult flour beetles emerged from these treatments. The lesser borer grain beetle, Rhizopertha dominica (Fabricus), completely failed to reproduce in a medium treated with JHA I. JHA II, MV-678 and R-20458 affected the reproduction of the two grain beetles, R. dominica and Sitophilus oryzae (L.), to varying extent, with MV-678 being the least potent JHA.

Activity of isoproturon on leaf cell membrane permeability

Disruption of leaf cell membranes was studied after the foliar application of isoproturon [N-(4-isopropyl phenyl)-N,N-dimethyl urea] through the parameters of electrolyte leakage and the quantity of efflux in ions. Differential activity of isoproturon, on leaf cell membranes ofSida acuta, cleome viscosa andAmaranthus viridis was observed. A high degree of correlation of resistance or susceptibility of a particular plant to the herbicide with appropriate change in electrolyte leakage and efflux of ions was observed.