Objective: To study the clinical outcomes of complete mesocolic excision (CME) for right-sided colon cancer using 3D (three-dimensional) laparoscopy compared to 2D (two-dimensional) laparoscopy. Methods: From January 2022 to December 2023, 58 patients with right-sided colon cancer treated at the Affiliated Hospital of Hebei Engineering University were randomly divided into a 3D laparoscopy group (observation group) and a 2D laparoscopy group (control group), with 29 patients in each group. Intraoperative blood loss, postoperative time to first flatulence, length of hospital stay, and incidence of complications in both groups were recorded. Results: There was a statistically significant difference in intraoperative blood loss between the two groups (P < 0.05). There was no statistically significant difference in the time to first flatulence between the groups (P > 0.05). However, there was a statistically significant difference in the length of hospital stay (P < 0.05) and the incidence of complications (P < 0.05) between the two groups. Conclusion: 3D laparoscopy for CME can reduce intraoperative blood loss, shorten hospital stay, and decrease postoperative complications, showing significant clinical advantages over traditional 2D laparoscopy.