3D Facial Images Research Articles

Sources of variation in the 3dMDface and Vectra H1 3D facial imaging systems

As technology advances and collaborations grow, our ability to finely quantify and explore morphological variation in 3D structures can enable important discoveries and insights into clinical, evolutionary, and genetic questions. However, it is critical to explore and understand the relative contribution of potential sources of error to the structures under study. In this study, we isolated the level of error in 3D facial images attributable to four sources, using the 3dMDface and Vectra H1 camera systems. When the two camera systems are used separately to image human participants, this analysis finds an upper bound of error potentially introduced by the use of the 3dMDface or Vectra H1 camera systems, in conjunction with the MeshMonk registration toolbox, at 0.44 mm and 0.40 mm, respectively. For studies using both camera systems, this upper bound increases to 0.85 mm, on average, and there are systematic differences in the representation of the eyelids, nostrils, and mouth by the two camera systems. Our results highlight the need for careful assessment of potential sources of error in 3D images, both in terms of magnitude and position, especially when dealing with very small measurements or performing many tests.

Accuracy and Precision of Three-dimensional Imaging System of Children’s Facial Soft Tissue

The purpose of this study was to evaluate the accuracy and precision of the three-dimensional (3D) imaging system of children’s facial soft tissue by comparing linear measurements. The subjects of the study were 15 children between the ages of 7 and 12. Twenty-three landmarks were pointed on the face of each subject and 16 linear measurements were directly obtained 2 times using an electronic caliper. Two sets of 3D facial images were made by the 3D scanner. The same 16 measurements were obtained on each 3D image. In the accuracy test, the total average difference was 0.9 mm. The precision of 3D photogrammetry was almost equivalent to that of direct measurement. Thus, 3D photogrammetry by the 3D scanner in children had sufficient accuracy and precision to be used in clinical setting. However, the 3D imaging system requires the subject’s compliance for exact images. If the clinicians provide specific instructions to children while obtaining 3D images, the 3D device is useful for investigating children’s facial growth and development. Also the device can be a valuable tool for evaluating the results of orthodontic and orthopedic treatments.

Single image-based head pose estimation with spherical parametrization and 3D morphing

Head pose estimation plays a vital role in various applications, e.g., driver-assistance systems, human-computer interaction, virtual reality technology, and so on. We propose a novel geometry-based method for accurately estimating the head pose from a single 2D face image at a very low computational cost. Specifically, the rectangular coordinates of only four non-coplanar feature points from a predefined 3D facial model as well as the corresponding ones automatically/manually extracted from a 2D face image are first normalized to exclude the effect of external factors (i.e., scale factor and translation parameters). Then, the four normalized 3D feature points are represented in spherical coordinates with reference to the uniquely determined sphere by themselves. Due to the spherical parametrization, the coordinates of feature points can then be morphed along all the three directions in the rectangular coordinates effectively. Finally, the rotation matrix indicating the head pose is obtained by minimizing the Euclidean distance between the normalized 2D feature points and the 2D re-projections of the morphed 3D feature points. Comprehensive experimental results over two popular datasets, i.e., Pointing’04 and Biwi Kinect, demonstrate that the proposed method can estimate head poses with higher accuracy and lower run time than state-of-the-art geometry-based methods. Even compared with start-of-the-art learning-based methods or geometry-based methods with additional depth information, our method still produces comparable performance.

2D-human face recognition using SIFT and SURF descriptors of face’s feature regions

Face recognition is the process of identifying people through facial images. It has become vital for security and surveillance applications and required everywhere including institutions, organizations, offices, and social places. There are a number of challenges faced in face recognition which includes face pose, age, gender, illumination, and other variable condition. Another challenge is that the database size for these applications is usually small. So, training and recognition become difficult. Face recognition methods can be divided into two major categories, appearance-based method and feature-based method. In this paper, the authors have presented the feature-based method for 2D face images. speeded up robust features (SURF) and scale-invariant feature transform (SIFT) are used for feature extraction. Five public datasets, namely Yale2B, Face 94, M2VTS, ORL, and FERET, are used for experimental work. Various combinations of SIFT and SURF features with two classification techniques, namely decision tree and random forest, have experimented in this work. A maximum recognition accuracy of 99.7% has been reported by the authors with a combination of SIFT (64-components) and SURF (32-components).

A Comparison of 3D Facial Features in a Population from Zimbabwe and United States.

Objectives The purpose of this study was to determine the differences in three-dimensional (3D) facial features in a population from Zimbabwe and the United States. In addition, this study seeks to establish an average facial template of each population allowing clinicians to treat patients according to their cultural esthetic perceptions. Materials and Methods Three hundred one subjects from Zimbabwe and the United States were carefully selected and recruited for the study. Each subject presented with a normal facial profile, no asymmetries, and normal body mass index. The 3D images were captured using the 3dMD cameras. All images were further separated into male and female groups of the respective populations and imported to a dedicated software for analysis. Statistical Analysis The 3D facial images were constructed using Rapidform 6 software to recreate a composite facial average for each group representing a male and female average 3D face of Zimbabwean (Zim) and United States origin. Results The linear measurements showed that the maximum average distance between the Zim-M and Zim-F was 1.24 mm and the minimum distance between the African American (AA)-M and AA-F was 0.24 mm. This was the absolute distance. When the signed linear measurements were taken into consideration, the maximum average distance between Zim-F and AA-M was 1.22 mm and the least average distance between the Zim-M and AA-M was 0.22 mm. The absolute color histograms showed greatest similarity between the Zim-M and AA-M at 58% and the Zim-F had a 25 and 27% similarity with the AA-F and Zim-M, respectively. Conclusion The Zim-F showed the most variable features with a broader face, prominent forehead, and retruded alar base compared with their male counterparts and the Zim-M showed a wider prominent malar/zygomatic region, and prominent lateral supraorbital regions. There was a high similarity of 58% between the Zim-M and the AA-M, with the Zim-M showing a more protrusive superciliary arches, and a lateral zygomatic region tapering to the root of the nose.

Deep Facial Diagnosis: Deep Transfer Learning From Face Recognition to Facial Diagnosis

The relationship between face and disease has been discussed from thousands years ago, which leads to the occurrence of facial diagnosis. The objective here is to explore the possibility of identifying diseases from uncontrolled 2D face images by deep learning techniques. In this paper, we propose using deep transfer learning from face recognition to perform the computer-aided facial diagnosis on various diseases. In the experiments, we perform the computer-aided facial diagnosis on single (beta-thalassemia) and multiple diseases (beta-thalassemia, hyperthyroidism, Down syndrome, and leprosy) with a relatively small dataset. The overall top-1 accuracy by deep transfer learning from face recognition can reach over 90% which outperforms the performance of both traditional machine learning methods and clinicians in the experiments. In practical, collecting disease-specific face images is complex, expensive and time consuming, and imposes ethical limitations due to personal data treatment. Therefore, the datasets of facial diagnosis related researches are private and generally small comparing with the ones of other machine learning application areas. The success of deep transfer learning applications in the facial diagnosis with a small dataset could provide a low-cost and noninvasive way for disease screening and detection.

Craniofacial Asymmetry from One to Three Years of Age: A Prospective Cohort Study with 3D Imaging.

Deformational plagiocephaly (DP) is considered a risk factor for facial asymmetry. This cohort-based, prospective, follow-up study used three-dimensional (3D) stereophotogrammetry to assess the development of facial asymmetry in a normal birth cohort and to investigate the impact of DP on facial asymmetry for the age range of one to three years. The study sample consisted of 75 children: 35 girls (47%) and 40 (53%) boys recruited from Oulu University Hospital. A total of 23 (31%) subjects had a history of DP in infancy. 3D facial images were obtained at the mean (SD) age of 1.01 (0.04) year old at T1 and 3.02 (0.14) years old at T2. To determine facial asymmetry, both landmark-based and surface-based facial symmetry methods were used. As measured with the surface-based methods, upper facial symmetry improved from T1 to T2 (p < 0.05). As measured with the landmark-based methods, facial symmetry improved on the upper and lower jaw from T1 to T2 (p < 0.05). The asymmetric effect of DP on the upper parts of the face tends to correct spontaneously during growth. Results indicate that previous DP does not seem to transfer to facial or occlusal asymmetry at the age of three years old.

Assessing the influence of chin prominence on perceived facial aesthetics among three groups of observers

To assess the influence of chin prominence on facial aesthetics with 3D images, to investigate the cognitive boundaries of chin prominence among orthodontists, general dentists and laypeople and compare the variance of their cognitive data, in order to provide quantitative reference for selection of clinical treatment. A 3D facial image was obtained by 3dMD. The soft tissue pogonion point was altered in 2 mm increments from -10 to 10 mm with Geomagic Wrap 2015, in order to represent retrusion and protrusion of the chin. These images were rated by orthodontists, general dentists and laypeople with VAS scores. Multivariate mixed linear regression was used to analyze the influence of gender, age and chin prominence on VAS scores, and whether there were differences among different groups with SAS 9.4 software package. ANOVA was also applied for comparison of each prominence. This study was composed of 243 subjects, including 90 orthodontists, 101 general dentists and 52 laypeople. Chin prominence had significant effect on VAS scores. VAS scores decreased by 0.8910 for each unit increase in chin retrusion and decreased by 1.0958 for each unit increase in chin protrusion（P<0.01）. Desire for treatment started when chin retrusion exceeded 6 mm in orthodontist group and layperson group, 4 mm in general dentist group, and chin protrusion reached 6 mm in all groups（VAS scores <5）. There was no significant difference in the scores among orthodontists, general dentists and laypeople with the variance of chin prominence, and there was no significant difference in gender and age. Chin prominence had significant effect on facial aesthetics. Soft tissue pogonion point located on the zero meridian was considered as the most attractive. Treatment needs increased significantly when chin protrusion reached 6 mm or chin retrusion exceeded 6 mm. There was no significant difference in the assessment among orthodontists, general dentists and laypeople.

Multilevel principal components analysis of three-dimensional facial growth in adolescents

Background and objectivesThe study of age-related facial shape changes across different populations and sexes requires new multivariate tools to disentangle different sources of variations present in 3D facial images. Here we wish to use a multivariate technique called multilevel principal components analysis (mPCA) to study three-dimensional facial growth in adolescents. MethodsThese facial shapes were captured for Welsh and Finnish subjects (both male and female) at multiple ages from 12 to 17 years old (i.e., repeated-measures data). 1000 “dense” 3D points were defined regularly for each shape by using a deformable template via “meshmonk” software. A three-level model was used here, namely: level 1 (sex/ethnicity); level 2, all “subject” variations excluding sex, ethnicity, and age; and level 3, age. The technicalities underpinning the mPCA method are presented in Appendices. ResultsEigenvalues via mPCA predicted that: level 1 (ethnicity/sex) contained 7.9% of variation; level 2 contained 71.5%; and level 3 (age) contained 20.6%. The results for the eigenvalues via mPCA followed a similar pattern to those results of single-level PCA. Results for modes of variation made sense, where effects due to ethnicity, sex, and age were reflected in modes at appropriate levels of the model. Standardised scores at level 1 via mPCA showed much stronger differentiation between sex and ethnicity groups than results of single-level PCA. Results for standardised scores from both single-level PCA and mPCA at level 3 indicated that females had different average “trajectories” with respect to these scores than males, which suggests that facial shape matures in different ways for males and females. No strong evidence of differences in growth patterns between Finnish and Welsh subjects was observed. ConclusionsmPCA results agree with existing research relating to the general process of facial changes in adolescents with respect to age quoted in the literature. They support previous evidence that suggests that males demonstrate larger changes and for a longer period of time compared to females, especially in the lower third of the face. These calculations are therefore an excellent initial test that multivariate multilevel methods such as mPCA can be used to describe such age-related changes for “dense” 3D point data.

HETEROGENEITY OF AGING IN HUMAN POPULATIONS

Recently by analyzing the 3D facial images, we generated the first comprehensive mapping of the aging human facial phenome. We constructed a robust age predictor and found that on average people of the same chronological age differ by +/-6 years in facial age, with the deviations increasing after age 40. Using this predictor we identified slow- and fast-agers that are significantly supported by health indicators. We further profiled blood cell mRNA and lncRNA expression by RNA-seq of this cohort and computationally predict their regulatory networks and their contributions to the variation in aging rate among different individuals, and those that are modifiable by their lifestyles. By extending the study to a large Northern Chinese cohort of 10,000 people we can now use deep learning AI approaches to precisely estimate aging status based on 3D facial images and their associations with individuals’ health and medical history.

Computer-aided superimposition via reconstructing and matching 3D faces to 3D skulls for forensic craniofacial identifications

Identification of human remains via craniofacial superimposition (CS) is one of the prominent research areas in the forensic sciences. CS makes use of imaging techniques to identify an unknown skull by matching it with the available face photographs of missing individuals. Life-size enlargement of the face image and orientating the skull to correspond to the posture seen in the face photograph are the two main problems that affect identification accuracy with both the conventional and the computer-aided methods. Unlike the existing techniques, this research proposes a 3D skull–3D face model superimposition (3D–3D) approach to address the above two issues. The proposed method commences by reconstructing the 3D face model from a given 2D face image using the mean simplified generic elastic model, followed by registering the face model to a 3D skull along the jaw line using the analytical curvature B-spline (AC B-spline). The accuracy index of the registration is then evaluated to suggest the degree to which the face image corresponds to a skull. The superimpositions of positive and negative cases were conducted on a set of 3D skulls versus a set of 2D face images. The accuracy indices of the registration results suggest that the AC B-spline is more robust in 3D–3D superimposition compared to the other existing methods. The full experimental results have demonstrated the potential of the proposed method as an assistive tool to the forensic scientists for craniofacial identifications.

Simultaneous multi-descent regression and feature learning for facial landmarking in depth images

Face alignment (or facial landmarking) is an important task in many face-related applications, ranging from registration, tracking, and animation to higher-level classification problems such as face, expression, or attribute recognition. While several solutions have been presented in the literature for this task so far, reliably locating salient facial features across a wide range of posses still remains challenging. To address this issue, we propose in this paper a novel method for automatic facial landmark localization in 3D face data designed specifically to address appearance variability caused by significant pose variations. Our method builds on recent cascaded regression-based methods to facial landmarking and uses a gating mechanism to incorporate multiple linear cascaded regression models each trained for a limited range of poses into a single powerful landmarking model capable of processing arbitrary-posed input data. We develop two distinct approaches around the proposed gating mechanism: (1) the first uses a gated multiple ridge descent mechanism in conjunction with established (hand-crafted) histogram of gradients features for face alignment and achieves state-of-the-art landmarking performance across a wide range of facial poses and (2) the second simultaneously learns multiple-descent directions as well as binary features that are optimal for the alignment tasks and in addition to competitive landmarking results also ensures extremely rapid processing. We evaluate both approaches in rigorous experiments on several popular datasets of 3D face images, i.e., the FRGCv2 and Bosphorus 3D face datasets and image collections F and G from the University of Notre Dame. The results of our evaluation show that both approaches compare favorably to the state-of-the-art, while exhibiting considerable robustness to pose variations.

Contribution of shape and surface reflectance information to kinship detection in 3D face images.

Previous research has established that humans are able to detect kinship among strangers from facial images alone. The current study investigated what facial information is used for making those kinship judgments, specifically the contribution of face shape and surface reflectance information (e.g., skin texture, tone, eye and eyebrow color). Using 3D facial images, 195 participants were asked to judge the relatedness of 100 child pairs, half of which were related and half of which were unrelated. Participants were randomly assigned to judge one of three stimulus versions: face images with both surface reflectance and shape information present (reflectance and shape version), face images with shape information removed but surface reflectance present (reflectance version), or face images with surface reflectance information removed but shape present (shape version). Using binomial logistic mixed models, we found that participants were able to detect relatedness at levels above chance for all three stimulus versions. Overall, both individual shape and surface reflectance information contribute to kinship detection, and both cues are optimally combined when presented together. Preprint, preregistration, code, and data are available on the Open Science Framework (osf.io/7ftxd).

3D pedestrian tracking and frontal face image capture based on head point detection

This paper proposes a method to track pedestrians in crowded scenes and capture the close-up frontal face images of a person of interest (POI) for recognition. Pedestrians are tracked via 3D positions of the head points (the highest point of a person) using 2 static overhead cameras. Head points are located and tracked based on the geometric and color cues in the scene. Possible head areas in a frame acquired from one of the overhead cameras are determined based on projective geometry. Head areas belonging to a person are clustered. Without creating a full disparity map of the scene, the 3D position of a pedestrian is obtained by utilizing the disparity along the line segment that passes through his/her head top. The 3D head position is then tracked using common assumptions on motion velocity. If the tracking is not accurate enough, the color distribution of a head top is integrated as a complementary method. With the 3D head point information, a set of pan-tilt-zoom (PTZ) cameras are scheduled to capture the frontal face images of POI. A most suitable PTZ camera is selected by evaluating the capture quality of each PTZ camera and its current state. The approach is tested using a publicly available visual surveillance simulation test bed. The experiments show that the 3D tracking errors are around 4 cm and high quality frontal face images are captured.

Age-invariant face recognition using gender specific 3D aging modeling

The age-invariant face recognition (AIFR) is a relatively new area of research in the face recognition domain which has recently gained substantial attention due to its great potential and importance in real-world applications. However, the AIFR is still in the process of emergence and development, offering a large room for further investigation and accuracy improvement. The key challenges in the AIFR are considerable changes of appearance of facial skin (wrinkles, jaw lines), facial shape, and skin tone in combination with the variations of pose and illumination. These challenges impose limitations on the current AIFR systems and complicate the recognition task for identity verification especially for temporal variation. In order to address this problem, we need a temporally invariant face verification system that would be robust vis-a-vis several factors, such as aging (shape, texture), pose, and illumination. In this study, we present a 3D gender-specific aging model that is robust to aging and pose variations and provides a better recognition performance than the conventional state-of-the-art AIFR systems. The gender-specific age modeling is performed in a 3D domain from 2D facial images of various datasets, such as PCSO, BROWNS, Celebrities, Private, and FG-NET. The evaluation of the proposed approach is performed on FG-NET (the most referred database in the AIFR studies) and MORPH-Album2 (the largest aging database) by using the VGG face CNN descriptor for matching. In addition, we also test the effects of linear discriminant analysis (LDA) and principal component analysis (PCA) subspaces learning in our face verification experiments. The proposed AIFR system is evaluated both on the pose corrected and background composited age-simulated images. The experimental results demonstrate that the proposed system provides state-of-the-art performance on FG-NET (83.89% of rank-1, 43.24% of TAR) and comparable performance to the state-of-the-art on MORPH-Album2 (75.27% of rank-1, 96.93% of TAR).

A Novel to Identify Multiple faces by tracking 2D Face Images over 3D Plane

Nowadays, face recognition is very much effective way of counter security threats in various aspects of human life. Though, other means of defending security attacks exists but they have their own drawbacks and overheads. Human face can be recognized from 2D face images or from 3D geometry of human faces. Although very popular, 2D face recognition algorithms are constrained by various factors like change in illumination, varying facial expressions, make-up on the face and orientation of the head. On the other hand face recognition based on 3D geometry of the faces has been shown to have more correctness than 2D face recognition. The only technological drawback however is that the 3D cameras are much less common than 2D based cameras. Therefore the work propose a novel facial expression recognition in real-time by tracking 2D face over a 3D plane. We use multiple 2D planes projected on each-other such that a 2D facial feature point is projected over all the planes, selecting the closest points over the plane and finally creating a contour enclosing the projected feature point over multiple planes, thereby creating a 3D tracking plane with 2D feature point. We use Cambridge landmark markers [4, 5] for facial tracking with multiple Homomorphic projection [5] for creating the 3D feature points. This technique has been proven better in terms of accuracy improvement.

3D facial expression modeling based on facial landmarks in single image

Facial expression modeling is important for many applications such as human emotional analysis and facial animation. Generally, facial expression modeling from single 2D facial image is difficult. Different head poses and scales of facial data in images affect the accuracy of the modeling results. We propose a new 3D facial expression modeling method which is based on facial landmarks from single image. Using the facial landmarks, expression modeling can be processed in Kendall shape space. The Kendall shape space is mathematic space, the facial expression modeling process in Kendall shape space can be regarded as a geodesic path search between different faces. The modeling result is more accurate. The 3D facial expression modeling result is convenient to obtain from 2D facial image with different head poses. In experiments, we show the 3D facial expression modeling performance by our method, which include expression editing and evaluation in public facial database: JAFFE, LFW, Helen and RAF-DB.

An algorithm for learning shape and appearance models without annotations.

This paper presents a framework for automatically learning shape and appearance models for medical (and certain other) images. The algorithm was developed with the aim of eventually enabling distributed privacy-preserving analysis of brain image data, such that shared information (shape and appearance basis functions) may be passed across sites, whereas latent variables that encode individual images remain secure within each site. These latent variables are proposed as features for privacy-preserving data mining applications. The approach is demonstrated qualitatively on the KDEF dataset of 2D face images, showing that it can align images that traditionally require shape and appearance models trained using manually annotated data (manually defined landmarks etc.). It is applied to the MNIST dataset of handwritten digits to show its potential for machine learning applications, particularly when training data is limited. The model is able to handle "missing data", which allows it to be cross-validated according to how well it can predict left-out voxels. The suitability of the derived features for classifying individuals into patient groups was assessed by applying it to a dataset of over 1900 segmented T1-weighted MR images, which included images from the COBRE and ABIDE datasets.

MeshMonk: Open-source large-scale intensive 3D phenotyping

Dense surface registration, commonly used in computer science, could aid the biological sciences in accurate and comprehensive quantification of biological phenotypes. However, few toolboxes exist that are openly available, non-expert friendly, and validated in a way relevant to biologists. Here, we report a customizable toolbox for reproducible high-throughput dense phenotyping of 3D images, specifically geared towards biological use. Given a target image, a template is first oriented, repositioned, and scaled to the target during a scaled rigid registration step, then transformed further to fit the specific shape of the target using a non-rigid transformation. As validation, we use n = 41 3D facial images to demonstrate that the MeshMonk registration is accurate, with 1.26 mm average error, across 19 landmarks, between placements from manual observers and using the MeshMonk toolbox. We also report no variation in landmark position or centroid size significantly attributable to landmarking method used. Though validated using 19 landmarks, the MeshMonk toolbox produces a dense mesh of vertices across the entire surface, thus facilitating more comprehensive investigations of 3D shape variation. This expansion opens up exciting avenues of study in assessing biological shapes to better understand their phenotypic variation, genetic and developmental underpinnings, and evolutionary history.

Linking the Expression of Facial Shape and BMI via the Hippo Signaling Pathway

Obesity rates have more than tripled in children and adolescents in recent years. While many studies have examined the relationship between obesity and chronic illnesses, the impact of obesity on craniofacial form is less understood. Research in this area has suggested that obesity and facial form are risk factors for illnesses such as sleep apnea, but a mechanism that links these risk factors has been elusive. In order to explore a potential mechanism for linking risk for obesity and craniofacial abnormalities, this study examines variation within the Hippo signaling pathway. The Hippo signaling pathway plays an important role in organ size and tissue growth, as well as regulating craniofacial morphogenesis and adipocyte formation. For this study, we investigate the potential relationship between facial shape and BMI as a function of genetic variation within the Hippo signaling pathway.A sample of n=482 individuals with an age range of 3 to 16 years was targeted for the study. 3D facial images were captured using a 3dMD stereophotogrammetric camera and 34 coordinate landmarks were placed along the eyes, nose, mouth, and lower jaw for each face. Landmark data was registered via Generalized Procrustes Analysis (GPA) and then allometrically scaled to control for shape variation as a function of age. These allometric residuals were submitted to Principal Components Analysis (PCA), Canonical Variate Analysis (CVA) and linear regression within the software package MorphoJ in order to identify patterns of facial variation associated with BMI. These phenotypes were then tested for association with 23 single nucleotide polymorphisms (SNPs) in seven genes involved in Hippo signaling.The phenotypic results from the PCA, CVA, and the linear regressions between facial shape and high BMI/percentile BMI are characterized by having the eyes and chin shifted inferiorly, along with the nose being smaller in comparison to the normal weight category. This association between facial shape and obesity is significant at p&lt;0.001. Principal component 1 (PC1) and PC2 also illustrated the above phenotypic features and both PCs were significantly different based on weight status (p&lt;0.001). Genetic association testing indicated that shape variation along PC2 was significantly associated after Bonferroni correction with two SNPs in TEAD3 (p=0.002). Additionally, suggestive evidence for an association between phenotypic variation along PC1 and three SNPs located in RUNX2 was also identified (p=0.007).These results indicate that BMI and facial form are linked, and that genetic variation in TEAD3 (and possibly RUNX2) in the Hippo signaling pathway may be important for this relationship. Based on these results, further examination of the Hippo signaling pathway in both obesity and craniofacial form is warranted.Support or Funding InformationNIDCR: U01‐DE020078, R01‐DE016148, and R01‐DE027023This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.