4-fluorobenzoic Acid Research Articles

Synthesis and Characterization of Highly Fluorinated Hydrophobic Rare-Earth Metal-Organic Frameworks (MOFs).

Tuning a material's hydrophobicity is desirable in several industrial applications, such as hydrocarbon storage, separation, selective CO2 capture, oil spill cleanup, and water purification. The introduction of fluorine into rare-earth (RE) metal-organic frameworks (MOFs) can make them hydrophobic. In this work, the linker bis(trifluoromethyl)terephthalic acid (TTA) was used to make highly fluorinated MOFs. The reaction of the TTA and RE3+ (RE: Y, Gd, or Eu) ions resulted in the primitive cubic structure (pcu) exhibiting RE dimer nodes (RE-TTA-pcu). The crystal structure of the RE-TTA-pcu was obtained. The use of the 2-fluorobenzoic acid in the synthesis resulted in fluorinated hexaclusters in the face-centered cubic (fcu) framework (RE-TTA-fcu), analogous to the UiO-66 MOF. The RE-TTA-fcu has fluorine on the linker as well as in the cluster. The MOFs were characterized by powder X-ray diffraction, X-ray photoelectron spectroscopy, thermogravimetric analysis, and contact angle measurements.

Electrolyte matching design for carboxylic acid-based organic K-storage anode

Carboxylic acid-based organic anodes are emerging as sustainable alternatives to traditional inorganic materials for potassium-ion batteries (PIBs), owing to their potential to improve both sustainability and K-storage performance. Herein, a readily available 4-fluorobenzoic acid (4FA) supported on ordered mesoporous carbon (4FA/CMK3) is proposed as a novel K-storage anode material. Importantly, we extensively investigated the compatibility of various electrolytes with the 4FA/CMK3 anode, focusing on electrolytes with tunable solvation structures to optimize electrode/electrolyte interfacial electrochemistry. A significantly decreased amount of free solvent in the optimized ether-based electrolytes compared to conventional ester-based electrolytes provides excellent compatibility with the modified 4FA/CMK3 anode, which promotes the formation of salt anion-derived interfacial phases, thereby improving K-storage performance. As a result, the optimized 4FA/CMK3||KFSI/DME storage system delivered a reversible capacity of 164 mAh/g with Coulombic efficiency above 99.8 % after 500 cycles at high current density of 200 mA/g. These excellent electrochemical properties are attributed to the synergistic effects of 4FA modification and electrolyte solvation structure modulation, which collectively mitigate the dissolution issues of organic actives and improve the cycling life of PIBs. This work presents a novel vision for designing PIBs with high energy density and long cycle life based on carboxylic acid-based organic electrodes.

Gas adsorption and fluorescence studies of Cd2+ and Zn2+ metal organic frameworks based on the same fluorinated ligand

Two new metal organic frameworks (MOFs) were synthesized by solvent-thermal synthesis with fluorinated 4,4′-(pyridine-3, 5-diyl) bis (3-fluorobenzoic acid) ligands (L1), namely {[Cd(L1)H2O]·DMF}n (MOF 1) and {[Zn(L1)]·3H2O}n (MOF 2). Single crystal X-ray diffraction analysis shows that MOF 1 is a two-dimensional structure with binuclear unit of [Cd2(COO)4N2O2]. MOF 2 displays a three-dimensional structure based on binuclear unit of Zn2(COO)2. The PXRD determination demonstrates the purity of the synthesized MOF 1 and MOF 2 samples, while the TGA shows the thermal stability of the structures. The gas adsorption studies show that MOF 1 and MOF 2 exhibit good gas adsorption characteristics, and MOF 2 has high selectivity for C2H2/CH4. Moreover, both MOF 1 and MOF 2 can selectively and sensitively detect Fe3+ in water.

Fluorination modification enhanced the water resistance of Universitetet i Oslo-67 for multiple volatile organic compounds adsorption under high humidity conditions: Mechanism study

The construction of metal–organic frameworks (MOFs) with highly efficient capture for volatile organic compounds (VOCs) adsorption under humid conditions is a significant yet formidable task. Herein, series of fluorinated UiO-67 modified with trifluoroacetic acid (TFA) and 4-fluorobenzoic acid were successfully synthesized for VOCs adsorption under high humidity conditions. Experiments results showed that UiO-67 modified with 4-fluorobenzoic acid (67-F) presented excellent adsorption capacity of 345 mg/g for toluene adsorption and exhibited great water resistance (10.0 vol% H2O, 374 mg/g toluene adsorption capacity). Characterization results indicated that the introduction of 4-fluorobenzoic acid induced the competitive coordination between 4-fluorobenzoic acid and 4,4-biphenyl dicarboxylic acid (BPDC) with Zr4+, causing the formation of abundant defects to provide extra adsorption sites. Meanwhile, the benzene ring in 4-fluorobenzoic acid enhanced the π-π conjugation, causing the further promotion of VOCs adsorption capacity. More importantly, the water resistance mechanism was investigated and elucidated that the introduction of F decreased the surface energy of 67-F and its affinity with water. Meanwhile, the metal complex induced by the fluorinated modification produced an electron-dense pore environment, which greatly improved its chemical and water stability. This work provided a strategy for preparing an adsorbent with high water resistance for real-world VOCs adsorption at high humidity conditions.

Synthesis and Evaluation of Antiphlogistic Activity of Some New 4-Fluorophenyltriazolothiadiazines

The reaction between 4-fluorobenzoic acid hydrazide (1) and carbon disulfide in the existence of alcoholic potassium hydroxide yielded N?-(4-fluoro-benzoyl)-hydrazinecarbodithioic acid (2). Subsequently, product 2 on reaction with an aqueous solution of hydrazine hydrate led to the formation of compound 3. The condensation of compound 3 with various substituted ?-bromoacetophenones in ethanol furnished the targeted triazolothiadiazines, bearing a 4-fluorophenyl moiety (4a-l). Subsequently, a comprehensive evaluation of the antiphlogistic potential of the synthesized molecules 4a-l was conducted. This assessment was completed using albino Wistar rats that had their paws swollen with carrageenan. Compounds 4l and 4b demonstrated significant (P < 0.01) antiphlogistic activity. Furthermore, compounds 4d, 4f, and 4k exhibited noteworthy antiphlogistic effects (P < 0.05), comparable to the standard drug indomethacin. This study sheds light on the antiphlogistic properties of these compounds and holds promise for further research in this area. . KEYWORDS :Antiphlogistic, Anti-inflammatory, 4-Fluorophenyl, Triazole, Thiadiazine.

Revealing Solid–Liquid Equilibrium Behavior of 4-Fluorobenzoic Acid in 12 Pure Solvents from 283.15 to 323.15 K by Experiments and Molecular Simulations

Revealing Solid–Liquid Equilibrium Behavior of 4-Fluorobenzoic Acid in 12 Pure Solvents from 283.15 to 323.15 K by Experiments and Molecular Simulations

Synthetic Transformation of 4-fluorobenzoic Acid to 4-fluorobenzohydrazide Schiff Bases and 1,3,4-Oxadiazole Analogs having DPPH Radical Scavenging Potential

Aims: Synthesis of 4-fluorobenzohydrazide Schiff bases and 1,3,4-oxadiazole analogs has a DPPH radical scavenging potential. Background: Synthetic antioxidants are widely used because they are effective and cheaper than natural antioxidants. Based on the literature survey, this present study is mainly focused on the study of the free radical scavenging activity of the Schiff base and oxadiazole motifs. Methods: In this research work, Schiff’s base (4a-4g) and 1,3,4-oxadiazole (5a-5g) derivatives based on 4-fluorobenzoic acid were synthesized through multistep reactions. Initially, 4-fluorobenzoic acid was esterified in the presence of sulphuric acid (H2SO4) in ethanol solvent, and then it was reacted with an excess of hydrazine hydrate to obtain the desired 4-fluorobenzohydrazide. Various aromatic aldehydes were reacted with 4-fluorobenzo hydrazide in the presence of a catalytic amount of acetic acid to obtain the desired hydrazones. Finally, different substituted hydrazones were cyclized in the presence of iodine and potassium carbonate in DMSO to obtain substituted 1,3,4-oxadiazoles. The progress of all reactions was checked using thin-layer chromatography. The compounds were recrystallized from ethanol with good yield. The synthesized compounds were characterized with the help of EI-MS and 1H-NMR spectroscopy. Results: The synthesized Schiff bases (4a-4g) and oxadiazole derivatives (5a-5g) of 4-fluorobenzoic acid demonstrated good free radical scavenging activity. Among the series, Compound 4f (IC50 = 25.57 ± 7.41 μM), showed comparable activity when compared with the standard Vitamin C (IC50 = 19.39 ± 12.57 μM). Similarly Compound 4a (IC50 = 40.90 ± 1.92 μM), 4b (IC50 = 34.77 ± 1.03 μM), 4c (IC50 = 90.2 ± 2.90 μM), 4e (IC50 = 78.62 ± 9.64 μM), 4g (IC50 = 80.65 ± 1.80 μM), 5a (IC50 = 52.67 ± 4.98 μM) and 5f (IC50 = 89.45 ± 9.11 μM) showed moderate antioxidant activity. Furthermore compounds, 4d (IC50 = 102.55 ± 10.4 μM), 5b (IC50 = 123.76 ± 12.34 μM), 5d (IC50 = 701.62 ± 1.06 μM), and 5e (IC50 = 102.87 ± 7.98 μM) displayed less significant anti-oxidant potential, while compounds 5c and 5g were found inactive. Conclusion: Schiff’s base (4a-4g) and substituted 1,3,4-oxadiazole (5a-5g) derivatives based on 4- fluorobenzoic acid scaffolds were synthesized using standard pathways. All compounds were structurally characterized through EI-MS and 1H-NMR spectroscopy and evaluated for their in vitro DPPH free radical scavenging activity. In-vitro study reveals that the newly prepared derivatives of 4-fluorobenzoic acid have potent antioxidant potential. Whereas compound 5c and 5g were found inactive, this study has recognized a series of potential molecules as antioxidant agents and is useful in the field of medicinal chemistry.

Endophytic fungal species Nigrospora oryzae and Alternaria alternata exhibit antimicrobial activity against gram-positive and gram-negative multi-drug resistant clinical bacterial isolates

BackgroundThe emergence of multidrug-resistant pathogens and the lack of new antimicrobial drugs is a major public health concern that needs urgent and innovative solutions. Endophytic fungi living in unique niches such as in endosymbiosis with plants are increasingly drawing attention as alternative sources of novel and chemically diverse compounds with unique mechanisms of action.MethodsIn the present study, ten endophytic fungi isolated from the medicinal plant, Sclerocarya birrea were screened for bioactivity against a panel of indicator bacteria. Three bioactive endophytic fungi (strains P02PL2, P02MS1, and P02MS2A) were selected and identified through ITS-rDNA sequencing. The whole broth extracts of the three selected isolates were further screened against contemporary drug-resistant bacterial pathogens. This was followed by partial purification by solid phase extraction and GC–MS analysis of bioactive fractions.ResultsThe bioactive endophytic fungi were identified as Alternaria alternata species (strains P02PL2 and P02MS1) and Nigrospora oryzae (strain P02MS2A). The whole broth extracts from N. oryzae P02MS2A exhibited a MIC of one μg/mL and 16 μg/mL against gram-negative, MDR Pseudomonas 5625574 and gram-positive MRSA 25775 clinical isolates, respectively. After partial purification and GC–MS analysis of whole broth extract from A. alternaria PO2MS1, 2-fluorobenzoic acid heptadecyl was putatively identified as the active compound in fraction C of this extract. This compound was also putatively identified in fraction E of A. alternata P02PL2, fraction B of A. alternata P02MS1 and fraction B of N. oryzae P02MS2A, and interestingly, all these fractions retained activity against the two MDR clinical isolates.ConclusionThe putative identification of 2-fluorobenzoic acid heptadecyl compound showing a broad-spectrum of activity, more especially against gram-negative MDR contemporary pathogens is highly encouraging in the initiative at developing novel drugs to combat multi-drug resistance.

Carbon 14 synthesis of glycine transporter 1 inhibitor Iclepertin (BI 425809) and its major metabolites.

Carbon 14 labeled Iclepertin (BI 425809, 1) and its major metabolites were needed for ADME and several other studies necessary for the advancement of this drug candidate in clinical trials. Iclepertin is composed of two main chemical blocks, (R)-5-(methylsulfonyl)-2-([1,1,1-trifluoropropan-2-yl]oxy)benzoic acid (2), and 3-[(1R,5R)-3-azabicyclo[3.1.0]hexan-5-yl]-5-(trifluoromethyl)isoxazole (3) linked to each other via an amide bond. In the first synthesis of carbon 14 labeled 1, 2-fluorobenzoic acid, carboxyl-14 C was converted to [14 C]-2 in three steps and then coupled to 3 to provide [14 C]-1a in 45% overall yield. In the second synthesis, [14 C]-3 was prepared in six radioactive steps and coupled to the acid 2 to furnish [14 C]-1b in 20% overall yield. Both synthetic routes provided [14 C]-1a and [14 C]-1b with specific activities higher than 53 mCi/mmol and radiochemical, chemical, and enantiomeric purities above 98%. Two major metabolites of 1, BI 761036 and BI 758790, were also prepared labeled with carbon 14 using intermediates already available from the synthesis of [14 C]-1.

Structure-Activity Relationships of Flupirtine Analogues for the Liver Esterase-mediated Cleavage of the 4-Fluorobenzylamine Moiety and its possible Relevance to Liver Toxicity.

Flupirtine and retigabine were essential drugs to combat pain and epilepsy. However, the Kv7 potassium channel openers are fraught with hepatotoxicity and tissue discoloration, respectively, limiting their therapeutic value. Both adverse events are likely due to reactive metabolites arising from oxidative metabolism. Designing safer analogues lacking the structural elements leading to described side effects is an active area of current research. One of the main metabolites of flupirtine is the biologically inactive 4-fluorohippuric acid. Hitherto unexplained, the proposed metabolic pathway leading to the formation of 4-fluorohippuric acid from flupirtine is verified here. Through the use of eighteen flupirtine analogues, mechanistic details of this pathway could be elucidated. A possible connection with the in vitro hepatotoxicity of the flupirtine analogues and the levels of 4-fluorobenzoic acid formed in enzyme incubations was examined by correlation analysis. These findings provide important information for the design of new flupirtine analogues as potential drug candidates.

Chemical composition and antifungal activity of Morinda Citrifolia fruit extract

Noni (Morinda citrifolia) fruit is a well-known plant used as a traditional medicine for preventing some diseases because of its abundance in chemical compounds. This research aimed to determine the phytochemical concentration, chemical composition, and antifungal activity of M. citrifolia fruit extract. M. citrifolia fruit was extracted with methanol and then distilled water for the partition extract. Subsequently, the extract was fractionated using various nonpolar to polar solutions, such as; chloroform, ethyl acetate, water, 2-propanol, and methanol fractions. Each fraction was evaporated until the dry extract was released. Additionally, the photochemical concentration of the M. citrifolia fruit extract was quantitatively determined using a UV-visible spectrophotometer. The chemical composition of the M. citrifolia fruit extract of each fraction was identified using gas chromatography-mass spectrometry (GC-MS). Then, the antifungal activity of M.citrifolia fruit extract against C. albicans and C. krusei was determined using the disc diffusion method. The results showed that the phytochemical concentration of the M. citrifolia fruit extract was 1970.25 ppm flavonoids, 35.61 ppm tannins, and 148.62 ppm steroids. 2-Fluorobenzoic acid, eucalyptol, 2-chloroaniline-5-sulfonic acid, hexa-decamethyl octasiloxane, and tetra-propyl stannane were found to be the major components of M. citrifolia fruit extract. According to the research, M. citrifolia fruit extract showed antifungal activity against C. albicans and C. krusei in all tested fractions. The maximum inhibition zone of C. albicans was 14.0 ± 1.00 mm in the 2-propanol fraction, while that of C. krusei was 11.7 ± 0.58 mm in the methanol fraction.

Photopolymerization-Driven Macroscopic Mechanical Motions of a Composite Film Containing a Vinyl Coordination Polymer.

We report a unique vinyl coordination polymer (CP), [Zn(4-Fb)2(tkpvb)] n (1, 4-HFb = 4-fluorobenzoic acid, tkpvb = 1,2,4,5-tetrakis(4-pyridylvinyl)benzene) that undergoes a rare photopolymerization reaction to form a two-dimensional CP integrated with a one-dimensional linear organic polymer. Upon light irradiation at different wavelengths, 1 exhibits an unprecedented phenomenon of photoinduced nonlinear lattice expansion. 1 can be uniformly dispersed in polyvinyl alcohol (PVA) to form the composite film of 1-PVA. When this film is exposed to UV light, internal minute stresses within crystallites are released by lattice expansion, resulting in a variety of photopolymerization-driven macroscopic mechanical motions. The findings provide new insights into the conversion of small lattice expansions of CPs into macroscopic mechanical motions based on photopolymerization reactions, which can promote the development of CPs-based smart photoactuators in the burgeoning field of microrobotics.

Design, synthesis and biological activity of novel oxadiazole containing monoacylglycerols as potential bioactive lipids

A series of novel 1,3,4-oxadiazole based 1-monoacylglycerol derivatives were synthesized and evaluated for their antimicrobial and anticancer activity. Eight different substituted benzoic acids were utilized for the synthesis of new fatty acids incorporating the 1,3,4-oxadiazole scaffold. These fatty acids were further employed for the preparation of 1-monoacylglycerols (10a-10 h) in an eight step synthetic route. The synthesized 1-monoacylglycerols were characterized by NMR, IR and MS spectral data and screened for their in vitro antimicrobial activity against selected bacterial and fungal strains. The best results were obtained for 3,4-dimethoxybenzoic acid (10c), benzoic acid (10a) and 4-methoxybenzoic acid (10b) derivatives with a noticeable zone of inhibition on all the tested organisms. In the in vitro cytotoxicity assay against B16-F10, DU145, Hep G2 and CHO-K1 cell lines, the 2,3,4-trimethoxybenzoic acid (10d) and 4-fluorobenzoic acid derivative (10e) showed a broad spectrum of cytotoxicity. Based on the preliminary screening it can be suggested that these novel lipidic oxadiazole derivatives could act as promising antitumor agents with some degree of therapeutic effect and further studies can help in designing potential analogs.

Unexpected Factors Affecting the Kinetics of Guest Molecule Release from Investigation of Binary Chemical Systems Trapped in a Single Void of Mesoporous Silica Particles.

In this work, we present results for loading of well-defined binary systems (cocrystal, solid solution) and untreated materials (physical mixtures) into the voids of MCM-41 mesoporous silica particles employing three different filling methods. The applied techniques belong to the group of "wet methods" (diffusion supported loading - DiSupLo) and "solvent-free methods" (mechanical ball-mill loading - MeLo, thermal solvent free - TSF). As probes for testing the guest1-guest2 interactions inside the MCM-41 pores we employed the benzoic acid (BA), perfluorobenzoic acid (PFBA), and 4-fluorobenzoic acid (4-FBA). The guests intermolecular contacts and phase changes were monitored employing magic angle spinning (MAS) NMR Spectroscopy techniques and powder X-ray diffraction (PXRD). Since mesoporous silica materials are commonly used in drug delivery system research, special attention has been paid to factors affecting guest release kinetics. It has been proven that not only the content and composition of binary systems, but also the loading technique have a strong impact on the rate of guests release. Innovative methods of visualizing differences in release kinetics are presented.

A highly stable chain-based EuIII metal-organic framework as a turn-on and blue-shift luminescent sensor for dipicolinic acid.

The development of a rapid and selective method for the identification of dipicolinic acid (DPA), a specific biomarker in Bacillus anthracis spores, is of great importance for the avoidance of anthrax infection. Herein, a chain-based EuIII metal-organic framework with the formula {[Eu3(BTDB)3(μ3-OH)3(H2O)]·solvents}n (JXUST-38, H2BTDB = (benzo[c][1,2,5]thiadiazole-4,7-diyl)dibenzoic acid) was obtained using 2-fluorobenzoic acid as the pH regulator. JXUST-38 exhibits good chemical and thermal stability and can specifically recognize DPA in N,N-dimethylformamide solution through luminescence enhancement and blue-shift effects with a detection limit of 0.05 μM. Furthermore, the significant luminescence enhancement and blue shift under UV lamps are obviously observable by the naked eye. The luminescence sensing mechanism is attributed to absorbance-induced enhancement between JXUST-38 and DPA. Test paper and mixed-matrix membrane based on JXUST-38 are designed for DPA detection. In addition, the feasibility of using JXUST-38 in biosensing is discussed in detail.

Reticular chemistry for the rational design of mechanically robust mesoporous merged-net metal-organic frameworks

Reticular chemistry for the rational design of mechanically robust mesoporous merged-net metal-organic frameworks

Synthesis, characterization and Hirshfeld surface analysis of 2-aminobenzothiazol with 4-fluorobenzoic acid co-crystal

The co-crystal of 2-aminobenzothiazol with 4-fluorobenzoic acid were synthesized and characterized by elemental analyses, spectral studies (FT-IR, NMR, HRMS) and single-crystal X-ray diffraction analysis. This compound co-crystallizes in the monoclinic space group P21/c (no. 14), a = 11.7869(14) Å, b = 4.0326(5) Å, c = 27.625(3) Å, β = 92.731(10)°, V = 1311.6(3) Å3, Z = 4, T = 293(2) K, μ(CuKα) = 2.345 mm-1, Dcalc = 1.470 g/cm3, 3568 reflections measured (7.508° ≤ 2Θ ≤ 134.202°), 2280 unique (Rint = 0.0262, Rsigma = 0.0413) which were used in all calculations. The final R1 was 0.0446 (I > 2σ(I)) and wR2 was 0.1274 (all data). The crystal structure is stabilized by elaborate system of N–H···O and O-H···O hydrogen bonds to form supramolecular structures. Furthermore, the 3D Hirshfeld surfaces and the associated 2D fingerprint plots have been analyzed for molecular interactions.

Solubility and dissolution rate of progesterone cocrystals using 4-fluorobenzoic acid and 2-hydroxy-6-naphthoic acid as coformers

The objective of our study was to improve the solubility and consequently enhance the oral bioavailability of progesterone, an endogenous steroid with poor water solubility, by synthesizing cocrystals. Progesterone cocrystals with pharmaceutically acceptable conformers, namely, 4-fluorobenzoic acid and 2-hydroxy-6-naphthoic acid, in a stoichiometric ratio of 1:4 and 1:2, respectively, were synthesized using solution crystallization technology. The cocrystals were characterized using single-crystal X-ray diffraction, powder X-ray diffraction, Fourier-transform infrared spectroscopy, differential scanning calorimetry, and thermogravimetry. Results from the solubility and dissolution experiments indicated that the solubility of both progesterone cocrystals in water and dissolution rate in 0.1 M HCl solution (pH = 1) could enhance the aqueous solubility of progesterone 1.93 and 1.12 times, respectively. Therefore, the formulation of pharmaceutical cocrystals is a potentially viable and effective approach to improve the solubility of active pharmaceutical ingredients that are poorly water soluble.

Efficient Synthesis of Fluorinated Derivatives from Isolated 24-Ethyl cholest-5-en-3β-ol: Characterization, Quantum Chemical Calculations by DFT and Molecular Docking

The current work focuses on the synthesis, characterization and docking study of two new fluorine containing steroidal esters, viz. 1a (3-β-(4-fluoro benzoyloxy)stigmast-5-en) and 1b (3-β-(2-fluoro benzoyloxy)stigmast-5-en). Synthesis of compounds 1a and 1b was done by conjugating β-sitosterol (1) with 4-fluorobenzoic acid and 2-fluorobenzoic acid, respectively using high yielding Steglich esterification method and their structures were identified using 1H NMR, FT-IR and UV spectroscopy as well as mass spectrometry. Docking studies of compounds 1, 1a and 1b assisted in evaluating the inhibitory effect of these steroids against the 2ITO a lung cancer protein. The ΔG values (binding energy) of all the compounds revealed that synthetic derivatives 1a (with binding energy –9.6 Kcal/mol) and 1b (with binding energy –9.5 Kcal/mol) are more potent than the parent molecule, compound 1 (with binding energy –7.5 Kcal/mol). A comparative atoms in molecules (AIM) studies predicted greater stability of compound 1b over 1a. High value of β0 of 1a (4.1 × 10–30 esu) suggested that they may be used as NLO materials.

Synthesis and structural characterization of lanthanide metal complexes by 2-fluorobenzoic acid with 2,2′:6′,2″-terpyridine, and their fluorescence properties

Three new lanthanide complexes were synthesized by conventional solution synthesis at room temperature with the formula of [Ln(2-FBA)2(terpy)(NO3)(H2O)]·(terpy)·H2O(Ln=Dy(1)), [Ln(2-FBA)3terpy]2·2(2-FHBA)·2H2O(Ln=Pr(2),Tb(3)), (2-FBA=2-fuorobenzoate, terpy=2,2′:6′,2″-terpyridine). The complexes were characterized by elemental analysis, X-ray single crystal diffraction and infrared spectroscopy. The coordination number of complexes 1–3 is 9, showing a muffin geometry. Complex 1 is mononuclear, crystallized in the monoclinic system and space group P21/c . Complexes 2 and 3 are binuclear molecules of isomorphous, and their adjacent structural units form 1D chain and 2D sheets structure through C-H···F hydrogen bonding and π-π stacking interactions. In addition, the solid state fluorescence spectra of complexes 1 and 3 were measured. The test shows that complex 3 emits strong green light. The thermal decomposition mechanism of the complexes was studied by synchronous thermal analyzer infrared spectroscopy TG-DSC/FTIR and the 3D stacked plots of the escape gases were analyzed.