This study proposes a direct synthesis-based two-degree-of-freedom (2-DOF) controller for various types of integrating processes with time delays. This 2-DOF controller includes a proportional-integral-derivative (PID) controller to enhance load disturbance rejection performance and a set-point filter to improve servo response performance. The main PID controller parameters are expressed as process model parameters and a single adjustment variable, while the set-point filter is composed of PID controller parameters with weighted factors. The adjustment variable is tuned to achieve an optimal balance between response performance and robustness, based on the maximum magnitude of the sensitivity function (Ms). Controller parameters for various Ms values and guidelines for setting these parameters are provided in a consistent formulaic form using a curve-fitting method. These parameter-setting formulas facilitate the accurate implementation of PID controllers with specified Ms values and allow the controller design to be extended to processes with larger dimensionless time delays for a given Ms value. Although a 2-DOF controller was proposed, the adjustment variable for setting the parameters of the main PID controller and the set-point filter was solely the desired time constant. The proposed method was applied to various integrating processes with time delays, and its performance was compared with existing methods reported in the literature, based on performance indices such as settling time, overshoot, integral of absolute error, total variation in input usage, and global performance index. Simulations were conducted using six examples of various integrating processes with time delays to verify the effectiveness and applicability of the proposed controller.