3D Phase Research Articles

Ligand-Mediated Surface Reaction for Achieving Pure 2D Phase Passivation in High-Efficiency Perovskite Solar Cells.

The surface passivation with the heterostructure of the 2D/3D stack has been widely used for boosting the efficiency of n-i-p perovskite solar cells (PSCs). However, the disordered quantum well width distribution of 2D perovskites leads to energy landscape inhomogeneity and crystalline instability, which limits the further development of n-i-p PSCs. Here, a versatile approach, ligand-mediated surface passivation, was developed to produce a phase-pure 2D perovskite passivation layer with a homogeneous energy landscape by dual-ligand codeposition. The preferential adsorption of 3,6-dimethyl-carbazole-9-ethylammonium iodide with a large molecular size and lower adsorption energy could regulate the surface reaction between the m-fluorophenylethylammonium iodide and perovskite surface, resulting in a 2D perovskite with a narrow quantum well distribution and a uniform surface potential distribution. Beyond this, the preservation of the surface-confined 2D passivation layer retained a higher electric field at the interface of perovskite and the hole transport layer. As a result, the champion device reached an efficiency of 25.86% for the 0.05 cm2 device and 25.08% for the 1 cm2 device, with enhanced operational stability (T90 > 1000 h) and much better thermal stability. Our work provides deeper insights into efficient and stable 2D passivation for PSCs.

Real-Time Structural Dynamics at the 3D/2D Perovskite Interface in CsPbBr3/PEA2PbBr4 Nano-heterostructures.

Three-dimensional (3D) and two-dimensional (2D) perovskite hybrid systems, known for their exceptional optoelectronic properties and stability, are revolutionizing optoelectronic materials research. However, fundamental physics of the 3D/2D interfaces and their dynamics remain poorly understood. We use fluorescence microspectroscopy to study the photoluminescence (PL) properties of 3D/2D nano-heterostructures of CsPbBr3/PEA2PbBr4 formed by postgrowth self-assembly. The in situ PL spectra uncover the presence of new structural phases, quasi-2D PEA2Csn-1PbnBr3n+1 layers of varying n, at the 3D/2D interface and demonstrate their reversible restructuring under light excitation at room temperature. The restructuring is a result of layer-by-layer cation diffusion at the epitaxial interfaces, manifested as reversible spectral shifts occurring on a time scale of seconds. Such dynamics ultimately leads to optimized distribution of the quasi-2D phases in the system for efficient energy transfer from the 2D to the 3D phases. Our findings provide new insights into controlling energy flow in 3D/2D perovskites for next-generation optoelectronic devices.

3D Printing-Induced Phase Transition in Ferroelectric Porous Polymer Coatings for Stable Zinc Anodes.

The abundant availability of zinc and its environmentally friendly properties have increasingly drawn attention to the potential of aqueous zinc-ion batteries (AZIBs). However, their development is hindered by the formation of zinc dendrites and severe side reactions during charge/discharge cycles. In this work, a novel strategy is introduced to address these challenges by constructing a ferroelectric porous PVDF-HFP protective layer (PH-ZF) on the zinc anode surface using 3D printing technology. This approach not only simplifies the fabrication process but also achieves a high content of β-phase PVDF-HFP without the need for post-treatment. The ferroelectric porous polymer layer effectively regulates ion concentration distribution on the zinc anode surface, promoting uniform Zn2+ deposition. As a result, symmetric batteries exhibit cycle lifetimes of 1200 and 2000 h at current densities of 0.5 and 1.0 mA cm-2, respectively. Furthermore, full batteries with MnO2 cathodes maintained a discharge specific capacity of ≈88.3 mA g-1 after 1000 cycles at a current density of 1.0 A g-1, in contrast to bare zinc electrodes, which retain only 51 mAh g-1 under the same conditions. This method offers a promising approach for enhancing zinc anode protection and advancing ZIB performance.

High-speed three-dimensional random access scanning with a linear SLM

High-speed volumetric imaging is crucial for observing fast and distributed processes such as neuronal activity. Multiphoton microscopy helps to mitigate scattering effects inside tissue, but the standard raster scanning approach limits achievable volume rates. Random access point scanning can lead to a considerable speed-up by sampling only pre-selected locations, but existing techniques based on acousto-optic deflectors are still limited to a point rate of up to . This limits the number of parallel targets at the high acquisition rates necessary, for example, in voltage imaging or imaging of fast synaptic events. Here, we introduce SPARCLS, a method for 3D random access point scanning at up to 340 kHz using a single 1D phase modulator. We show the potential of this method by imaging synaptic events with fluorescent glutamate sensors in mammalian organotypic slices as well as in zebrafish larvae.

Dynamic three dimensional environment for efficient and large scale generation of smooth muscle cells from hiPSCs

BackgroundChronic ischemic limb disease often leads to amputation, which remains a significant clinical problem. Smooth-muscle cells (SMCs) are crucially involved in the development and progression of many cardiovascular diseases, but studies with primary human SMCs have been limited by a lack of availability. Here, we evaluated the efficiency of two novel protocols for differentiating human induced-pluripotent stem cells (hiPSCs) into SMCs and assessed their potency for the treatment of ischemic limb disease.MethodshiPSCs were differentiated into SMCs via a conventional two-dimensional (2D) protocol that was conducted entirely with cell monolayers, or via two protocols that consisted of an initial five-day three-dimensional (3D) spheroid phase followed by a six-day 2D monolayer phase (3D + 2D differentiation). The 3D phases were conducted in shaker flasks on an orbital shaker (the 3D + 2D shaker protocol) or in a PBS bioreactor (the 3D + 2D bioreactor protocol). Differentiation efficiency was evaluated via the expression of SMC markers (smooth-muscle actin [SMA], smooth muscle protein 22 [SM22], and Calponin-1), and the biological activity of the differentiated hiPSC-SMCs was evaluated via in-vitro assessments of migration (scratch assay), contraction in response to the treatment with a prostaglandin H2 analog (U46619), and tube formation on Geltrex, as well as in-vivo measurements of perfusion (fluorescence angiography) and vessel density in the limbs of mice that were treated with hiPSC-SMCs after experimentally induced hind-limb ischemia (HLI).ResultsBoth 3D + 2D protocols yielded > 5.6 × 107 hiPSC-SMCs/differentiation, which was ~ nine-fold more than that produced via 2D differentiation, and flow cytometry analyses confirmed that > 98% of the 3D + 2D-differentiated hiPSC-SMCs expressed SMA, > 81% expressed SM22, and > 89% expressed Calponin-1. hiPSC-SMCs obtained via the 3D + 2D shaker protocol also displayed typical SMC-like migratory, contraction, and tube-formation activity in-vitro and significantly improved measurements of perfusion, vessel density, and SMA-positive arterial density in the ischemic limb of mouse HLI model.ConclusionsOur dynamic 3D + 2D protocols produced an exceptionally high yield of hiPSC-SMCs. Transplantation of these hiPSC-SMCs results in significantly improved recovery of ischemic limb after ischemic injury in mice.

Development of a Wollaston phase grating polarized interferometer for simultaneous generation of interferograms

Wollaston phase-grating interferometer is introduced to measure of the optical phase across various samples. The system employs a Wollaston prism to create two angularly separated beams and with orthogonal linear polarizations. Working as a quasi-common-path interferometer, one of these beams serves as a reference while the other acts as the sample. Circular polarization states are induced in each beam using a quarter-wave plate. Both beams are directed onto a 4-f imaging system, within which a 2D phase grating is positioned at the Fourier plane. This 2D grating enables the superposition of the two beams, generating a polarized interferogram. The characteristics of the diffractive elements cause the grating to produce replicas of interference patterns, which are centered around the diffraction orders of the 2D phase grating itself. Due to the presence of interference patterns with inherent π phase shifts, this configuration reduces the number of polarizers needed to implement phase shifting methods. It is shown that by using two polarizers it is possible to generate four phase shifts. A polarizer oriented at 0° covers two of the replicas and another polarizer oriented at π/4 covers the remaining interferograms. This configuration introduces phase shifts of ξ1 = 0, ξ2 = π/2, ξ3 = π and ξ4 = 3π/2. Results obtained for static and dynamic samples are presented, as well as the corresponding statistics on the repeatability of the configuration.

Reliability of 4D Flow MRI for Investigation of Fetal Cardiovascular Hemodynamics in the Third Trimester.

Purpose To provide reference values for four-dimensional (4D) flow MRI in healthy fetuses and evaluate reliability of fetal 4D flow MRI hemodynamics in third trimester fetuses with normal cardiovascular development or suspected coarctation of the aorta (CoA). Materials and Methods Pregnant patients with healthy fetuses or fetuses with echocardiographic concern for CoA were prospectively recruited between May 2021 and October 2023. Doppler US-gated fetal 4D flow MRI was performed at 3 T. Repeated 4D flow (time permitting) and two-dimensional (2D) phase contrast (PC) MRI data were acquired. Net flow was quantified, and the reliability of 4D flow measurement was evaluated by using precision across adjacent measurement planes, internal consistency based on conservation of mass, comparison of net flow from 4D flow MRI versus 2D PC MRI, and repeatability of 4D flow from separate acquisitions. Results Data were obtained in 34 pregnant participants (mean maternal age, 33 years ± 5 [SD]; mean gestational age, 35 weeks ± 2; n = 22 healthy fetuses and 12 fetuses with suspected CoA). Precision was high across all vascular segments (mean within-subject coefficient of variation = 7%). For mass conservation, there was an average difference of 19% ± 12 between ductus arteriosus plus isthmus flow versus descending aorta flow (r = 0.76). Net flow measured with 4D flow MRI correlated with that measured with 2D PC MRI (r = 0.51) but was underestimated relative to 2D PC MRI by approximately 34%. Hemodynamic parameters quantified from repeated 4D flow acquisitions had good agreement, with an intraclass correlation coefficient of 0.94 between test and retest data. Conclusion Hemodynamic measurements derived from fetal 4D flow MRI were reliable, showing good internal consistency, precision, and repeatability; however, as expected, 4D flow MRI underestimated absolute blood flow relative to 2D PC MRI. Keywords: Fetal MRI, Cardiac, Aorta, Hemodynamics/Flow Dynamics, Pulmonary Arteries Supplemental material is available for this article. © RSNA, 2024.

Density Functional Theory Investigation of 2D Phase Separated Graphene/Hexagonal Boron Nitride Monolayers; Band Gap, Band Edge Positions, and Photo Activity

Density Functional Theory Investigation of 2D Phase Separated Graphene/Hexagonal Boron Nitride Monolayers; Band Gap, Band Edge Positions, and Photo Activity

Soliton Solutions and Chaotic Dynamics of the Ion-Acoustic Plasma Governed by a (3+1)-Dimensional Generalized Korteweg–de Vries–Zakharov–Kuznetsov Equation

This study explores the novel dynamics of the (3+1)-dimensional generalized Korteweg–de Vries–Zakharov–Kuznetsov (KdV-ZK) equation. A Galilean transformation is employed to derive the associated system of equations. Perturbing this system allows us to investigate the presence and characteristics of chaotic behavior, including return maps, fractal dimension, power spectrum, recurrence plots, and strange attractors, supported by 2D and time-dependent phase portraits. A sensitivity analysis is demonstrated to show how the system behaves when there are small changes in initial values. Finally, the planar dynamical system method is used to derive anti-kink, dark soliton, and kink soliton solutions, advancing our understanding of the range of solutions admitted by the model.

Improved Three-Dimensional Reconstructions in Electron Ptychography through Defocus Series Measurements.

A detailed analysis of ptychography for three-dimensional (3D) phase reconstructions of thick specimens is performed. We introduce multi-focus ptychography, which incorporates a 4D-STEM defocus series to enhance the quality of 3D reconstructions along the beam direction through a higher overdetermination ratio. This method is compared with established multi-slice ptychography techniques, such as conventional ptychography, regularized ptychography, and multi-mode ptychography. Additionally, we contrast multi-focus ptychography with an alternative method that uses virtual optical sectioning through a reconstructed scattering matrix (S-matrix), which offers more precise 3D structure information compared to conventional ptychography. Our findings from multiple 3D reconstructions based on simulated and experimental data demonstrate that multi-focus ptychography surpasses other techniques, particularly in accurately reconstructing the surfaces and interface regions of thick specimens.

A-Site Engineering with Thiophene-Based Ammonium for High-Efficiency 2D/3D Tin Halide Perovskite Solar Cells.

Tin halide perovskites are the most promising candidate materials for lead-free perovskite solar cells (PSCs) thanks to their low toxicity and ideal band gap energies. The introduction of 2D/3D mixed perovskite phases in tin-based PSCs (TPSCs) has proven to be the most effective approach to improving device efficiency and stability. However, a 2D perovskite phase normally shows relatively low carrier mobility, which will be unfavorable for carrier transfer in the devices. In this work, we used a thiophene-based cation 2-(thiophen-3-yl)ethan-1-aminium (3-TEA) as a spacer to form a novel 2D perovskite phase in TPSCs, which shows the most promising effect on the performance enhancement in comparison with other cations like 2-(thiophen-2-yl)ethan-1-aminium (2-TEA) and benzene-based 2-phenylethan-1-aminium (PEA). Theoretical calculations reveal that 3-TEA enables the most compact crystal packing of [SnI6]4- octahedral layers, resulting in the lowest hole effective mass and formation energy in the 2D phase. This effect significantly enhances device efficiency and stability by facilitating more efficient carrier transfer within the 2D phase. These findings indicate that thiophene-based 2D perovskites are well-suited for high-performance TPSCs.

A‐Site Engineering with Thiophene‐Based Ammonium for High‐Efficiency 2D/3D Tin Halide Perovskite Solar Cells

AbstractTin halide perovskites are the most promising candidate materials for lead‐free perovskite solar cells (PSCs) thanks to their low toxicity and ideal band gap energies. The introduction of 2D/3D mixed perovskite phases in tin‐based PSCs (TPSCs) has proven to be the most effective approach to improving device efficiency and stability. However, a 2D perovskite phase normally shows relatively low carrier mobility, which will be unfavorable for carrier transfer in the devices. In this work, we used a thiophene‐based cation 2‐(thiophen‐3‐yl)ethan‐1‐aminium (3‐TEA) as a spacer to form a novel 2D perovskite phase in TPSCs, which shows the most promising effect on the performance enhancement in comparison with other cations like 2‐(thiophen‐2‐yl)ethan‐1‐aminium (2‐TEA) and benzene‐based 2‐phenylethan‐1‐aminium (PEA). Theoretical calculations reveal that 3‐TEA enables the most compact crystal packing of [SnI6]4− octahedral layers, resulting in the lowest hole effective mass and formation energy in the 2D phase. This effect significantly enhances device efficiency and stability by facilitating more efficient carrier transfer within the 2D phase. These findings indicate that thiophene‐based 2D perovskites are well‐suited for high‐performance TPSCs.

Hydrogen‐Driven Phase Differentiation in BN Nucleation on Diamond

AbstractBoron nitride has attracted scientific interest in recent years due to its potential use in electronics, both as hexagonal (hBN) and cubic (cBN) phases. While both are successfully realized through chemical vapor deposition, the heteroepitaxial growth of cBN on another iconic semiconductor, diamond is plagued with mixed‐phase formation. Employing first‐principles computations and a nanoreactor approach, the BN phase preferences are explored on diamond (001) controlled—as it is discovered—by the hydrogen gas concentration. In a limited‐hydrogen environment, the initial BN‐island expands along the diamond surface, forming a 3D metastable cubic phase that grows in the direction normal to the basal plane through kinetically‐limited nucleation, thus overcoming the thermodynamic preference toward the hBN phase. Comparatively, the amorphous phase is favored in the absence of hydrogen, while the hexagonal phase dominates at its high levels, elucidating numerous experimental observations. A obtained kinetic phase diagram connects the phase with hydrogen chemical potential to facilitate targeted phase selection. The results suggest that gas‐mediated nucleation kinetics provide feasible control for the precise synthesis. It also offers valuable guidance for the controllable synthesis of desired BN phases and advances research toward potential BN electronics.

Abstract 4143256: Non-invasive, Radiation-free, Non-contrast Myocardial Volume Oxygen Consumption Quantification Using Free-breathing MR Blood Oximetry

Background: Myocardial oxygen consumption (MVO 2 ) is a central marker in measuring cardiac energetics. Current methods to quantify MVO 2 are inaccessible due to the requirement of invasive procedures or PET agents that require onsite cyclotrons. Hypothesis A free-breathing, non-ECG-gated, motion-resolved Cardiac MR blood oximetry technique can noninvasively quantify MVO 2 in standard clinical MRI scanners without using ionizing radiation and contrast agents. Method: The developed free-breathing CMR imaging technique was prescribed in a 3T clinical scanner to the mid left ventricle (LV) and the cross-section of the coronary sinus(CS) slices of the heart to obtain the corresponding blood oxygenation (SbO 2 ) and the hematocrit (Hct) in heart chambers. 2D phase contrast CMR was performed in the CS to quantify the myocardial blood flow (MBF). The MVO 2 was quantified with Fick’s law (MVO 2 =arterio-venous oxygen difference x MBF). We examined the developed method in healthy pigs (N=7) under rest and adenosine stress and validated it against invasive blood sampling. In addition, we tested the method’s clinical feasibility in healthy human volunteers (N=4). Results: Comparable blood oxygenation levels (SbO 2 ) and MVO 2 were measured and compared between the non-invasive CMR and invasive ground truth (Fig. 1). Significantly increased coronary sinus SbO 2 is observed in both methods during adenosine infusion. It is accompanied by decreased MVO 2 and rate pressure product (RPP) (Rest: CMR=10.2±2.7ml/min, Inv.=10.8±6.9 ml/min, RPP=7956.9±620.9 mmHg/min; Stress: CMR=5.3±1.9 ml/min, Inv=6.3±3.6 ml/min, RPP=5338.2±618.3 mmHg/min). In Fig. 2, the healthy human volunteers' MVO 2 estimations(14.1±6.7ml/min) shows no statistical difference compared to the previous invasive measurements(16.5±4.8 ml/min, Ganz, et al. circulation 1971). Conclusions: The proposed noninvasive CMR technique can quantify MVO 2 in standard MRI scanners without using a needle. It has the potential to provide an accessible, risk-free assessment of myocardial metabolism for patients with potential metabolism impairments.

Solid-State Replacement in the Polyhedra of Cu2+, Ni2+, and Co2+ upon Dehydration/Rehydration Processes Associated with a Color Change in Three Isomorphous Materials with 5,5'-Indigodisulfonate.

The significance of thermochromic materials in a wide range of applications makes their research and development highly desirable. Herein, three new thermochromic isomorphous supramolecular materials based on the 5,5'-indigodisulfonate ion of the indigo carmine dye, with formulas [Cu(H2O)6](C16H8N2O8S2)·2H2O (1), [Ni(H2O)6](C16H8N2O8S2)·2H2O (2), and [Co(H2O)6](C16H8N2O8S2)·2H2O (3), are reported. These materials exhibit thermochromic properties, with a color change from red-bronze to grayish-red after the first step of their dehydration process completed around 80 °C (conversion of 1 to [Cu(H2O)2(C16H8N2O8S2) (1')]), and then, this grayish-red color becomes lighter after the second step, which is completed around 230 °C (conversion of 1' to [Cu(C16H8N2O8S2)] (1d)). The 1, 1', and 1d phases have different crystal structures but similar tetragonal bipyramidal geometries around the copper ions. These dehydrated phases rehydrate by exposure to a higher humidity level. Solid-state UV-visible spectroscopy, thermogravimetric analysis, infrared spectroscopy, and X-ray powder diffraction analyses shed light on the structural and chemical changes accompanying the color change of 1, 2, and 3 to their partial dehydrated phases 1', 2', and 3', respectively. These transformations occur with the small modification of the charge transfer energy in the 5,5'-indigodisulfonate ions, indicating the potential of dye-based metall-organic materials for chromic properties.

Optical Brewster interfaces enabled object identification and 3D reconstruction

Efficient and accurate object identification and 3D reconstruction are crucial for processing image information in visual imaging. Here, we propose a novel scheme for all-optical 2D contour identification and 3D reconstruction based on optical Brewster interfaces. It is revealed that 2D amplitude and phase contours for high-contrast and low-contrast objects can be identified, which is attributed to the 1D and 2D light fields manipulated by the photonic spin Hall and the Brewster effects. The 3D model can be reconstructed by rotating or slicing the high-contrast objects and by inverting the thickness of the low-contrast objects. The study potentially opens up opportunities in applications such as intelligent driving and microscopic imaging.

Mixed-mode oscillations and chaos in a complex chemical reaction network involving heterogeneous catalysis.

The nonlinear dynamical behavior in a complex isothermal reaction network involving heterogeneous catalysis is studied. The method first determines the multiple steady states in the reaction network. This is followed by an analysis of bifurcation continuations to identify several kinds of bifurcations, including limit point, Bogdanov-Takens, generalized Hopf, period doubling, and generalized period doubling. Numerical simulations are performed around the period doubling and generalized period doubling bifurcations. Rich nonlinear behaviors are observed, including simple sustained oscillations, mixed-mode oscillations, non-mixed-mode chaotic oscillations, and mixed-mode chaotic oscillations. Concentration-time plots, 2D phase portraits, Poincaré maps, maximum Lyapunov exponents, frequency spectra, and cascade of bifurcations are reported. Period-doubling and period-adding routes leading to chaos are observed. Maximum Lyapunov exponents are positive for all the chaotic cases, but they are also positive for some non-chaotic orbits. This result diminishes the reliability of using maximum Lyapunov exponents as a tool for determining chaos in the network under study.

Partial crystallization in Pd-BMG systems: From understanding structure towards influencing functionality through temperature-time series

Small quantities of crystalline domains created in an amorphous matrix are seen as an active driver for enhanced properties in bulk metallic glasses (BMGs). We investigated partial crystallization and phase transformations through a series of isotherms at 370°C performed on amorphous Pd-based BMG samples with the nominal composition of Pd43Cu27Ni10P20 (Pd-BMG) and a density of 9.425 g/cm3. X-ray based methods such as X-ray diffraction (XRD) and phase enhanced micro-computed tomography (μ-CT) have been pushed to their limits for studying atomic structure and morphology, while time available before crystallization has additionally been investigated via differential scanning calorimetry (DSC), and are combined with optical microscopy (OM), scanning electron microscopy (SEM), and hardness measurements for their mechanical properties. We reveal that Pd-based BMG samples isothermally treated at 370 °C start to crystallize after 20 min and still undergo phase transformations and recrystallization even after being fully crystalline after 60 min of the isothermal treatment. Interestingly, 3D phase enhanced micro-computed tomography shows a clear separation of two domains of slightly different densities. We highlight X-ray tomographic scans, allowing the 3D spatial visualization of extremely low-density contrast in different material domains, thus providing a multi-scale physical description of the Pd-BMG system. Interesting is the fact, that the re-crystallization is not homogenous and the crystalline domains can reach large size of (100–200 μm) in an amorphous matrix.

3D distortion-free, reduced FOV diffusion-prepared gradient echo at 3 T.

To develop a 3D distortion-free reduced-FOV diffusion-prepared gradient-echo sequence and demonstrate its application in vivo for diffusion imaging of the spinal cord in healthy volunteers. A 3D multi-shot reduced-FOV diffusion-prepared gradient-echo acquisition is achieved using a slice-selective tip-down pulse in the phase-encoding direction in the diffusion preparation, combined with magnitude stabilizers, centric k-space encoding, and 2D phase navigators to correct for intershot phase errors. The accuracy of the ADC values obtained using the proposed approach was evaluated in a diffusion phantom and compared to the tabulated reference ADC values and to the ADC values obtained using a standard spin echo diffusion-weighted single-shot EPI sequence (DW-SS-EPI). Five healthy volunteers were scanned at 3 T using the proposed sequence, DW-SS-EPI, and a clinical diffusion-weighted multi-shot readout-segmented EPI sequence (RESOLVE) for cervical spinal cord imaging. Image quality, perceived SNR, and image distortion were assessed by two expert radiologists. ADC maps were calculated, and ADC values obtained with the proposed sequence were compared to those obtained using DW-SS-EPI and RESOLVE. Consistent ADC estimates were measured in the diffusion phantom with the proposed sequence and the conventional DW-SS-EPI sequence, and the ADC values were in close agreement with the reference values provided by the manufacturer of the phantom. In vivo, the proposed sequence demonstrated improved image quality, improved perceived SNR, and reduced perceived distortion compared to DW-SS-EPI, whereas all measures were comparable against RESOLVE. There were no significant differences in ADC values estimated in vivo for each of the sequences. 3D distortion-free diffusion-prepared imaging can be achieved using the proposed sequence.

Considerations on time resolution of neutron irradited single pixel 3D structures at fuences up to 1017 neq/cm2 using 120 GeV SPS pion beams

The proven radiation hardness of silicon 3D devices up to fluences of 1 × 1017 neq/cm2 makes them an excellent choice for next generation trackers, providing <10 μm position resolution at a high multiplicity environment. The anticipated pile-up increase at HL-LHC conditions and beyond, requires the addition of <50 ps per hit timing information to successfully resolve displaced and primary vertices. In this study, the timing performance, uniformity and efficiency of neutron and proton irradiated single pixel 3D devices is discussed. Fluences up to 1 × 1017 neq/cm2 in three different geometrical implementations are evaluated using 120 GeV SPS pion beams. A MIMOSA-26 type telescope is used to provide detailed tracking information with a ∼5 μm position resolution. Productions with single- and double-sided processes, yielding active thicknesses of 130 and 230 μm respectively, are examined with varied pixel sizes from 55 × 55 μm2 to 25 × 100 μm2 and a comparative study of field uniformity is presented with respect to electrode geometry. The question of electronics bandwidth is extensively addressed with respect to achievable time resolution, efficiency and collected charge, forming a 3D phase space to which an appropriate operating point can be selected depending on the application requirements.