Global modulation studies with comprehensive numerical models contribute meaningfully to the refinement of very local interstellar spectra (VLISs) for cosmic rays. Modulation of positrons and anti-protons are investigated to establish how the ratio of their intensity, and with respect to electrons and protons, are changing with solar activity. This includes the polarity reversal of the solar magnetic field which creates a 22-year modulation cycle. Modeling illustrates how they are modulated over time and the particle drift they experience which is significant at lower kinetic energy. The VLIS for anti-protons has a peculiar spectral shape in contrast to protons so that the total modulation of anti-protons is awkwardly different to that for protons. We find that the proton-to-anti-proton ratio between 1–2 GeV may change by a factor of 1.5 over a solar cycle and that the intensity for anti-protons may decrease by a factor of ~2 at 100 MeV during this cycle. A composition is presented of VLIS for protons, deuteron, helium isotopes, electrons, and particularly for positrons and anti-protons. Gaining knowledge of their respective 11 and 22 year modulation is useful to interpret observations of low-energy anti-nuclei at the Earth as tests of dark matter annihilation.
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