Fog droplets are very often used as a cleaning agent when air pollution can be dangerous for health conditions and ecosystem. This work presents a new system to optimize the cleaning properties of fog by tuning its microphysical parameters. For this purpose, a newly developed system, which is based on the electromagnetic echo effect (EMEE) sensor, is used to detect the most efficient interaction between fog and impurities, i.e., which fog droplets can be used to most effectively clean a certain type of pollutant from the air. Fog droplet spectra controlled by the nozzle pressure system can be used to effectively remove pollutants from the air. For this purpose, an automated system for aerosol generation can allow an accurate control over the fog microphysical parameters and the use of fluids with specific concentrations of pulverized chemical compounds. Fog droplet size distribution is controlled by the feeding gas pressure at the nozzle and chemical simulants. The experimental results showed that the microphysical parameters (MP) are directly related to the impurity of species used in the cleanup simulation process. The MP parameters of fog are liquid water content (LWC), droplet mean radius (Rm), droplet number concentration (Nd), and both aerosol type and mass concentration. In the lab testing, harmless simulants of CBRN (chemical, biological, radiological and nuclear) species were used. During the tests, fog droplet size distribution is controlled by the air pressure at the nozzle and simulants. It is concluded that an integrated fog generator system (IFGS) with EMEE sensor developed in the current work can be utilized broadly to control fog microphysical parameters, leading to an optimum aerosol/chemical species’ cleaning process.