Antioxidant status in patients with chronic myeloid leukemia (CML) is significantly decreased in comparison with healthy individuals. Oxidative stress (OS) may be associated with the pathophysiology of CML and can influence on development of resistance to imatinib. The aim of our study was to investigate the effect of Aronia melanocarpa extract (A-lixir 400 PROTECT®) on OS in CML patients treated with imatinib. In this study a total of 40 CML patients treated with imatinib for longer than 1 month were included: twenty patients were treated with imatinib and A-Lixir 400 PROTECT® (treatment group) and twenty patients were treated only with imatinib (control group). OS parameters (d-ROM, PAT and OSI) were measured at the initial visit, and after 21 and 42 days of treatment. Adjuvant treatment with A-Lixir 400 PROTECT® could lead to attenuation of OS. d-ROM and OSI in this group of patients were significantly higher at initial visit when compared to values after 21 and 42 days of treatment (p<0.05). Total antioxidant capacity (PAT) was significantly higher after 21 and 42 days of treatment initiation in comparison with the pretreatment values. In the control group no significant differences were obtained between investigated parameters at any time of measurement. We can conclude that adjuvant treatment with A-Lixir 400 PROTECT® after 21 and 42 days lead to significant reduction of OS in patients with CML treated with imatinib. Keywords: Oxidative stress, d-ROM, PAT, OSI, chronic myeloid leukemia, imatinib, Aronia melanocarpa

Human dignity is a pivotal concept in contemporary ethical, political, and legal discourse. However, divergent and sometimes conflicting interpretations of human dignity contribute to confusion across various discussions. Given that all human beings possess inherent moral potential, each individual is endowed with universal dignity. The extent to which people develop their moral potential varies. Discussing an individual’s dignity, as in other medical specialties, cannot be separated from forensic medicine as a distinct medical discipline. In conclusion, the authors assert that establishing medical facts, or the truth ascertained through expert examination, serves justice by ensuring dignified treatment of the deceased, their family, and relatives. Keywords: dignity, ethics, forensic medicine, human remains