Papaya skin (Carica papaya L.) has antibacterial activity against Staphylococcus aureus bacteria and Escherichia coli bacteria. This research aims to find out whether papaya peel extract can be formulated into solid soap. Solid soap preparations were made in 4 formulas with F0 (formula 0) as the base and the addition of papaya peel extract at Fl (formula 1) 3.5 g, FII (formula 2) 7 g, and FIII (formula 3) 10.5 g. The formulated solid soap preparation is subjected to physical evaluation including organoleptic, pH, foam height tests, water and free alkali content. The research results showed that all formulas met the requirements except for the water and free alkali content tests which did not meet the requirements because they still exceeded the maximum limit for free water & alkali content set by SNI 2016.

The use of the dye rhodamine B as a color additive in cosmetics has been prohibited by the Regulation of the Head of the Food and Drug Monitoring Agency (BPOM) Number: HK.00.05.42.1018 concerning Additional Ingredients in Cosmetics, because rhodamine B has carcinogenic properties if used long term in the body. In this research, 10 lipstick samples were used purposively obtained from the market in Bengkulu City. Lipstick samples were selected based on the criteria that they did not meet BPOM distribution requirements. Determination of rhodamine B levels was carried out using the UV-Visible Spectrophotometry method. The maximum wavelength used in the identification of Rhodamine B is 554 nm. The test results of ten lipsticks showed that nine lipsticks contained rhodamine B, in lipsticks with codes L2, L3, L4, L5, L6, L7, L8, L9 and L10 with a percentage of 0.0058%-0.0242%, and only one sample that was identified negative, L1 with an absorbance value of 0.364 with a percentage of 0%. In this study it can be concluded that there were 9 samples of 10 lipstick samples that were identified as containing Rhodamine B quantitatively.

Sungkai (Peronema canescens Jack) was used traditionally as a medicine to help relieve fever, malaria and flu. In general, people was used sungkai leaves in the form as infusion. This study was aimed to screening of secondary metabolite of Sungkai leaf infusion using the color reaction method. The sample in this study was sungkai leaf that obtained from Bengkulu city. The infusion was obtained by boiling 10 gram of sungkai leaf simplicia with 100 ml of distilled water for 15 minutes at 90 0C until a concentration of 10% (w/v) was obtained. Secondary metabolite screening was carried out using the color reaction method to identify alkaloids, flavonoids, saponins, tannins and steroids. Phytochemical screening using specific reagents with the test was repeated three times. The results were showed that sungkai leaves infusion was positive in alkaloid test as evidenced by the presence of white precipitate with Mayer reagent, brown precipitate with Wagner reagent, and orange precipitate with Dragendorff reagent. Positive results were also shown in flavonoid, saponin and tannin tests. While, negative result was seen in steroid test using Liebermann Burchard reagent. In this study it can be concluded that sungkai leaf infusion positively contains alkaloids, flavonoids, saponins and tannins.

Based on WHO data there are around 972 million people or 26.4% of people in the world who have hypertension, this number is likely to continue to increase by 29.2% in 2025. One of the steps that can reduce the prevalence of hypertension is by providing non-pharmacological therapy, one of which is the intake of bananas. Banana is a fruit that can prevent and control hypertension because it contains a lot of potassium minerals. This study aims to determine the characteristics of the test for microbial contamination and metal contamination of banana-based steamed cake. This research method uses experimental research methods. In this research, the formulation of banana-based steamed sponge cake can be used as an alternative snack for hypertension patients. The steamed sponge produced will be tested for microbial contamination and metal contamination. The analysis was carried out using the Saphiro Wilk test to see the distribution of the data, then continued with the ANOVA test for normally distributed data and the Kruskall Walis test for data that were not normally distributed. The results showed that ALT levels in formula 1 were 2,333.33 cfu/g, formula 2 was 8800 cfu/g, formula 3 was 1,566.66 cfu/g. The AKK levels in formulas 1, 2, 3 were <10 cfu/g and the Escherichia coli content in the three formulas was negative. The level of lead (Pb) in formula 1 is 0.1207 mg/kg, formula 2 is 0.1036 mg/kg, formula 3 is 0.1118 mg/kg. The level of copper (Cu) in formula 1 is 0.3243 mg/kg, formula 2 is 0.3059 mg/kg, formula 3 is 0.2897 mg/kg. The levels of zinc (Zn) in formula 1 are 1.6005 mg/kg, formula 2 is 4.6056 mg/kg, formula 3 is 3.6758 mg/kg and the arsenic content in the three formulas is negative. The conclusion in this study is that the content of microbial contamination and metal contamination of banana-based steamed sponge cake is in accordance with the SNI 01-3840 standard.

Information that has gone viral in the community is that there is an Indonesian plant that is used as a Covid-19 drug, namely sungkai leaves (Peronema Canescens Jack). This leaf is not well known by some Indonesian people, but its ancestors are often used as herbal therapy. Now Sungkai leaves are very popular. Even though scientific information about the effects of Sungkai leaves has not been found much. The mechanism of action in treating infections due to the corona virus is not yet known, but it is suspected that it can reduce the inflammatory effect. This study aims to examine the anti-inflammatory effect of extracts in Sungkai leaf (Peronema canescens) syrup formulations with different concentrations to obtain the right syrup formula if it does have anti-inflammatory potential. Potential as an anti-inflammatory was measured by its ability to reduce C-Reactive Protein (CRP) levels in the blood serum of male white rats after being induced by intraplantar carrageenan 1% on the right leg. This study used an experimental method with 18 male white rats and was divided into 5 groups, namely group 1 as normal control (only given 1% Na.CMC), group 2 as positive control I (given diclofenac Na), group 3 as positive comparator II (given dexamethasone), group 4 as the treatment group at dose I (given sungkai leaf extract at a dose of 400 mg/200 g BW every day), group 5 as the treatment group at dose II (given sungkai leaf extract at a dose of 600 mg/200 g BW every day). The results of measuring CRP levels in all groups of experimental animals qualitatively using the slide test method showed negative results (no increase in CRP levels).

Bukittinggi is a city in the province of West Sumatera with a population of 121,028 people. From this large population, it is predicted that the need for vaccines is very large. For this reason, the role of health service facilities in terms of handling vaccines is urgently needed, especially in terms of vaccine storage so that vaccine quality can be maintained. This research is a descriptive study using a checklist which aims to find out whether the storage of the covid-19 vaccine in Bukittinggi City complies with the standards for storing the covid-19 vaccine. From the research conducted, it can be concluded that the suitability of the requirements for facilities and infrastructure is categorized as very good for all Puskesmas in Bukittinggi City with a percentage range of 86.66% -93.33%. Sari, Mandiangin Health Center, Plus Mandiangin Health Center, Gulai Bancah Health Center and Tigo Baleh Health Center with a percentage range of 89.47% -84.21%. The Guguk Panjang Health Center is categorized as good with a percentage of 78.94%. Meanwhile, the suitability of vaccine management requirements is categorized as very good for all health centers in Bukittinggi City with a percentage range of 92.85% -100%.