We attempted to establish a method for estimating methane sulfonic acid methyl or ethyl ester in the dabigatran etexilate Mesylate in bulk and pharmaceutical dosage form. Dabigatran is an anticoagulant used in deep vein thrombosis and lung thrombosis. Methane sulfonic acid and ethyl sulfonic acid are DNA ethylating agents and genotoxic. These compounds can be estimated using the GC MS method using Helium as a carrier gas, and the compounds are estimated to be at 79 and 400 masses. The 60% methanol is used as diluent and blank. The method is validated as per the procedures of ICH, and all the validation parameters are within the acceptable limit of the impurities guidelines, as stated in the Q4 section. The different batches were analyzed using the same technique, and no impurities were found; hence, the batches were passed.

Recent approaches in regulatory perspectives for the registration of drugs in Southern states of India have been characterized by a focus on enhancing efficiency, transparency, and safety in the drug approval process. This involves the adoption of stringent regulatory frameworks aligned with international standards to ensure the quality, efficacy, and safety of pharmaceutical products. One significant development is the implementation of electronic submission systems for the registration of drugs, streamlining the application process and reducing administrative burdens for regulators and pharmaceutical companies. Additionally, there has been an emphasis on strengthening post-marketing surveillance mechanisms to monitor the safety and efficacy of drugs once they are in the market, enabling prompt identification and mitigation of potential risks or adverse reactions. Collaborative efforts between regulatory authorities, industry stakeholders, and healthcare professionals have also been encouraged to facilitate knowledge exchange and capacity building in regulatory compliance and pharmacovigilance. Overall, these recent approaches reflect a concerted effort to uphold public health standards and ensure access to safe and effective medications for the population of Southern states in India.

This study examines the neurological and neuropathological conditions, and clinical, imaging, and demographic traits linked to prosopagnosia. Out of 475 potential cases, 327 met criteria for probable or definite prosopagnosia. One patient had Niemann-Pick type C and another had a forkhead box G1 gene mutation; ten patients (80% male) had developmental prosopagnosia. Of 317 with acquired prosopagnosia, 228 had degenerative causes, primarily primary prosopagnosia syndrome, Alzheimer's disease dementia, posterior cortical atrophy, and semantic dementia. Non-degenerative cases often involved ischemic and hemorrhagic infarcts. Transient non-degenerative prosopagnosia, linked to hypoxic encephalopathy and migraines, improved over time. Degenerative prosopagnosia patients often showed temporal lobe involvement on PET scans, while non-degenerative patients had right temporal and occipital lobe lesions on MRI. Pathological findings included Alzheimer's, Lewy body disease, and frontotemporal lobar degeneration. Facial recognition loss spans various neurological illnesses.

Brain tumors are evaluated, characterized, and monitored using diagnostic imaging. However, because these tumors are so diverse, there are still several difficulties in each group. This might involve differences in the biology of the cancer that are linked to varying intensities of cellular invasion, proliferation, and necrosis, all of which have distinct imaging appearances. Due to these changes, tumor evaluation, including segmentation, surveillance, and molecular characterizations, has become more complex. Even though various rule-based techniques have been put into practice to relate to tumor appearance and size, these techniques naturally reduce the vast quantity of tumor imaging data to a small number of variables. Due to their efficacy in resolving image-based problems, approaches in artificial intelligence, machine learning, and deep learning have found increased use in computer vision tasks, such as tumor imaging. This section aims to provide an overview of some of these developments in tumor imaging.

The aim is to develop and evaluate capsules with various excipient compositions that satisfy the reference product's specifications to achieve an in-vitro correlation with the reference product after that. Pregabalin I.R. capsules were formulated using Corn starch, Dibasic calcium phosphate, Lactose anhydrous, and Avicel pH 102(Microcrystalline cellulose). After compatibility studies for the capsule blend were completed, the Drug was determined to be compatible with all excipients used in various formulations. After the blend was put into capsules, several metrics were examined, including average weight, disintegration, and assay. The formulation containing D.C.P. disintegrates at a faster rate than other formulations. It was discovered that the percentage of drug release in the F7 invitro dissolving profile was equal to that of the innovator product. Finally, it was concluded that the F7 formulation is better and similar to the innovator product.

The aim of this research work is to evaluate In – Silico Antifungal Drugs, in this work Molinspiration is used to provide predictive tools for essential molecular properties, such as lipophilicity, aqueous solubility and pKa, which are critical in drug discovery and cheminformatics. It operates based on a comprehensive database of chemical structures and employs algorithms to calculate these properties. Molinspiration is a renowned software and informatics company that plays a pivotal role in the pharmaceutical and biotechnology industries. With a primary focus on providing cutting-edge cheminformatics tools and software solutions, Molinspiration has significantly contributed to the field of drug discovery and medicinal chemistry. Molinspiration's software is an indispensable resource for the pharmaceutical and biotechnology sectors.

This paper uses spectrometric as well as chromatographic techniques to investigate the antioxidant properties of extracts from vine seeds (Vitis vinifera L.). For the study, ten vine varieties from the years 2015, 2016, along with 2017 were chosen. Four essentially distinct spectrophotometric methods were used to measure the antioxidant activity, whereas the Folin-Ciocalteu procedures were used to determine the level of total polyphenolic compounds. The composition of fourteen antioxidants was investigated in 2015. The study's findings indicate that grape seeds have a high level of antioxidant components, with variations in content between types and years. Grape seed extracts have potential applications in nutraceuticals, health supplements, as well as food product preservation.

Despite significant advancements in cancer therapy, traditional treatments like radiation, chemotherapy, and surgery often fall short, underscoring the need for innovative approaches like activated cell therapy. Chimeric antigen receptor T cells (CAR-T cells) represent a pioneering form of this therapy, targeting cancer with modified T lymphocytes. While CAR-T cell therapy has shown high effectiveness in hematological malignancies, its success in solid tumors has been limited due to challenges such as proliferation, stability, trafficking, and tumor environment navigation. Overcoming these hurdles is crucial for enhancing the therapy's efficacy against solid tumors. The success rate of CAR-T cell therapy can reach up to 90% in leukemia patients, illustrating its potential. However, its application is still nascent, with much to learn about its long-term effectiveness and safety. This study provides an in-depth review of CAR-T cell therapy’s accomplishments and limitations in cancer treatment and explores the potential of combining CAR-T cell therapy with other treatments.

The study aimed to produce and assess cidofovir microspheres using the emulsion solvent diffusion method. Microspheres loaded with ethyl cellulose and HPMC were prepared. FTIR analysis confirmed stability with no drug-polymer interaction, and compatibility investigations ensured formulation compatibility. SEM determined particle size, with yields ranging from 84.44% to 87.62% and drug content from 64.8% to 97.2%. Particle sizes ranged from 20 µm to 210 µm, with drug loading capacities of 55.6% to 96.8% and entrapment efficiencies of 55.5% to 89.1%. Swellability studies showed a range of 0.6 to 1.6 seconds. Formulation CM8 exhibited optimal dissolution in vitro at 62.87%. Drug dissolution data were fitted to various models, with R2 values ranging from 0.937 to 0.061. Up to 45 minutes of drug release was observed. Overall, cidofovir-loaded HPMC and ethyl cellulose microspheres showed favorable release properties under optimal conditions.

To investigate the efficacy and safety of Azilsartan 40 mg and Olmesartan 40 mg in patients with stage I systemic hypertension undergoing cardiac OPD at a tertiary care facility. A 6-month open-label comparison study was undertaken in the Department of Cardiology at Acsr Government Medical College and Hospital. All patients visiting the cardiac outpatient clinic at Acsr Government Medical College who have stage I systemic hypertension of any sex, aged 20-65, with blood pressures >140/90 mmHg, or glucose intolerance. Diagnoses for essential hypertension were made, and patients were randomised to receive either group 1 (40 mg of Azilsartan) or group 2 (40 mg of Olmesartan) after the initial screening. The individuals receiving care were instructed to come back for a fourth, eighth, twelveth, as well as twenty-fourth weeks. Both groups showed a statistically significant drop in systolic blood pressure (P value < 0.0000001). Both medicines regulated blood pressure in similar ways. However, the Azilsartan group had a lower mean SBP and DBP than the Olmesartan group. Both medicines were well tolerated, and no severe side effects were observed throughout the research.