Year
Publisher
Journal
Institution
1
Institution Country
Publication Type
Field Of Study
Topics
Open Access
Language
Filter 1
Year
Publisher
Journal
Institution
1
Institution Country
Publication Type
Field Of Study
Topics
Open Access
Language
Filter 1
Export
Sort by: Relevance
Can industry 5.0 technologies overcome supply chain disruptions?—a perspective study on pandemics, war, and climate change issues

AbstractIndustry 5.0 (I5.0) is the next industrial revolution that will leverage human intervention in collaboration with intelligent, logical, and smart machines to attain even more user-preferred and resource-efficient manufacturing and supply chain solutions. The main aim of this article is to study I5.0 technologies in supply chains when these are affected by disruptive phenomena such as those created by wars, climate change or pandemics. A systematic literature review methodology was conducted to understand the present knowledge connected with this theme. This study summarises 194 research articles from the period 2009 to 2022 to understand the present knowledge connected with this theme. The research findings show a significant gap related to the adoption of I5.0 technologies to prevent or overcome supply chain disruptions. 194 articles, including journal and review articles, were identified in the literature. The study provides a novel and insightful concept related to I5.0 within the context of supply chain disruptions. The potential applications of I5.0 and Industry 4.0 are elaborately discussed in three areas, namely: (1) disruptions in supply chains due to pandemics; (2) disruptions in supply chains due to war; and (3) disruptions in supply chains due to climate change. Finally, this study highlights research implications and proposes future research avenues that will contribute to further exploring the adoption of I5.0 technologies to prevent, manage and overcome disruptions in supply chains.

Read full abstract
Open Access
Exploring the asymmetric effect of fiscal decentralization on economic growth and environmental quality: evidence from India.

In recent years, environmental issues have become controversial, and policymakers are discovering new predictors of carbon emissions. Some economists/researchers have advocated for fiscal decentralization to improve the quality of the environment by offering more financial authority to provincial/local and sub-national governments. Therefore, this work aims to inspect the effect of fiscal decentralization on economic growth and environmental quality in India by taking data from 1996 to 2021. This work applies both ARDL and NARDL econometric models for empirical examination. The findings of this study suggest that expenditure decentralization has asymmetric long-term and short-term consequences on economic growth, and carbon emission in India. The result of the asymmetric ARDL model also indicates that positive and negative shock in expenditure decentralization contrarily affects economic growth and carbon emission. Moreover, the positive and negative shock in revenue decentralization helps in reducing carbon emissions both in the long run and short run in India. These outcomes are useful for policy analysis from the Indian economic policy perspective. The study also laid out potential outcomes that may benefit India's local governments and central government in resolving the issues of economic growth and environmental degradation.

Read full abstract
Open Access
Immunometabolic actions of trabectedin and lurbinectedin on human macrophages: Relevance for their antitumor activity

Abstract In recent years, the central role of cell bioenergetics in regulating immune cell function and fate has been recognized, giving rise to the interest in immunometabolism, an area of research focused on the interaction between metabolic regulation and immune function. Thus, early metabolic changes associated with the polarization of macrophages into pro-inflammatory or pro-resolving cells under different stimuli have been characterized. Tumor-associated macrophages are among the most abundant cells in the tumor microenvironment; however, it exists an unmet need to study the effect of chemotherapeutics on macrophage immunometabolism. Here, we use a systems biology approach that integrates transcriptomics and metabolomics to unveil the immunometabolic effects of trabectedin (TRB) and lurbinectedin (LUR), two DNA-binding agents with proven antitumor activity. Our results show that TRB and LUR activate human macrophages toward a pro-inflammatory phenotype by inducing a specific metabolic rewiring program that includes ROS production, changes in the mitochondrial inner membrane potential, increased pentose phosphate pathway, lactate release, TCA cycle, serine and methylglyoxal pathways in human macrophages. Glutamine, aspartate, histidine, and proline intracellular levels are also decreased, whereas oxygen consumption is reduced. The observed immunometabolic changes could explain additional antitumor activities of these compounds and open new avenues to design therapeutic interventions that specifically target the immunometabolic landscape in the treatment of cancer.

Read full abstract
Open Access
Dynamics between Power Consumption and Economic Growth at Aggregated and Disaggregated (Sectoral) Level Using the Frequency Domain Causality

We investigated the Granger causal relationship between the consumption of power both at the aggregate and sectoral level and economic growth in India using the frequency domain approach, which would help policy makers seek the efficient allocation of electricity via proper policy initiatives at different frequencies. We find that at the aggregate level, unidirectional causality runs from the total power consumption to economic growth, starting from the second up to the seventh quarter. In the sectoral context, the results are different. Since there is no causality between industrial power consumption and economic growth; therefore, an energy conservation policy can thus be implemented for the industrial sector. Moreover, since a bidirectional causality exists after 15 quarters for the commercial sector, a short-term policy but not an energy conservation policy could also be initiated for this sector. In the industrial and agricultural sectors, a promotional policy should be initiated because a unidirectional causality exists from sectoral power consumption to economic growth. Therefore, different and sector-specific policies would be more appropriate than a single policy for all power sectors in India in order to orient the efficient utilisation of power towards better economic development.

Read full abstract
Open Access
Linking empowering leadership and job attitudes: the role of psychological empowerment

PurposeThe purpose of this study is to explore the impact of empowering leadership (EL) on work attitudes [job satisfaction (JS) and organizational commitment (OCOM)]. The effects of EL on these work attitudes were also analysed in terms of the mediating effects of psychological empowerment (PE).Design/methodology/approachA survey research methodology was adopted where responses were collected on relevant measures of the constructs from 431 middle-level executives from 12 Indian organizations.FindingsResults implied that EL enhanced the levels of JS and OCOM of employees. The results further indicated that EL was positively related to PE at the workplace. The findings also revealed that PE was positively related to these positive work attitudes. Moreover, strong indirect effects of EL were observed on these work attitudes through PE, implying that PE partially mediated the impact of between EL on JS and OCOM.Originality/valueThe findings of this study affirm the efficacy of EL and PE in predicting positive work attitudes in a different cultural milieu than the West –the Indian work context. Especially, by establishing a strong positive relationship between empowerment and JS, it contributes to the existing literature underlining inconsistent findings with regard to this relationship.

Read full abstract