India ranks among the foremost global producers and consumers of cement, and the cement industry contributes significantly to carbon emissions. Alkali-activated materials have gained significant attention as a sustainable alternative to Portland cement, offering the potential to mitigate carbon dioxide emissions and promote effective recycling of waste materials. Fly ash (FA) and Ground granulated blast furnace slag (GGBS) are preferred raw materials for Alkali-activated concrete (AAC) owing to their effective repurposing of waste, widespread accessibility, advantageous chemical composition, and performance attributes. This review provides a comprehensive analysis of the current state-of-the-art on the durability aspects of fly ash/slag-based AAC. The paper explores the unique characteristics of FA/GGBS-based AAC, emphasizing their potential to enhance the durability of concrete structures. Insights into the material behaviour under various environmental exposures, including aggressive chemical environments and freeze–thaw cycles, are presented. Furthermore, the article addresses both the obstacles and prospects associated with implementing fly ash/slag-based AAC as a potential construction material suitable for large-scale infrastructure projects. This overview is designed to direct future research efforts and provide practitioners with insights into the potential of FA/GGBS-based AAC for ensuring the prolonged durability of concrete structures.