The current condition is still limited to analytical chemistry teaching materials that are integrated with research results, only using Analytical Chemistry textbooks as teaching materials or in the form of e-books. This is one of the causes of the lack of student interest in participating in the teaching and learning process. The purpose of this research is to produce innovative teaching materials in analytical chemistry based on research results, aiming to enhance students' interest in learning.This research is the initial stage as a basis for developing analytical chemistry e-modules integrated with research results. The development model used is ADDIE which consists of five stages, namely Analysis, Design, Development, Implementation and Evaluation. This research is limited to the needs analysis stage which includes RPS analysis, analysis of problems and needs of lecturers and problems and needs of students. Data collection instruments used interviews and questionnaires. The subjects of this study consisted of 6 Analytical Chemistry lecturers and 59 students from Riau Province, Riau Islands, North Sumatra, and West Java. The research results of this preliminary analysis include RPS analysis where there are 10 topics of study material and based on the needs questionnaire the topic of quantitative analysis is the topic with the highest percentage to be developed into an e-module. Then also obtained the results that there are still some shortcomings with the teaching materials used today, so that 98% of lecturers and students stated that they need the development of teaching materials, especially those that are digital-based and can be integrated with research results which are evidence of the implementation of analytical chemistry learning theory.

Sustainable Development Goals (SDGs) need to be implemented to create environmentally friendly chemistry learning. This can be done in an acid-base titration experiment using natural indicators of butterfly pea flowers. This research aims to produce a practicum guide for acid-base titrations using natural indicators of butterfly pea flowers that are valid and practicum. The research design uses the ADDIE research design, namely Analysis, Design, Development, Implementation, and Evaluation. The research results showed that butterfly pea flowers can be used as a natural indicator for acid-base titrations with color changes from pink (acidic condition) to blue (basic condition). The resulting learning media is a practicum guide which has a validity of 92% (very valid) and a practicality level of 88.75% (very practical). This data was analyzed using qualitative and quantitative analysis. The practicum guide developed is valid and practical to use as a practicum learning media in schools.

Cervical cancer is a life-threatening disease. The use of synthetic drugs for its treatment can have serious adverse effects on the body. Therefore, it is necessary to search for natural drugs that are safe for the body. One of the secondary metabolites contained in plants is essential oils (EO), EO are known to have activity as anti-cervical cancer. Genus Citrus is known for containing EO compounds, one of the species of the genus is Citrus×lemon (L) Osbeck. The purpose of this study is to identify the chemical components of the EO isolated from the leaves of C×limon and to evaluate its cytotoxic activity against cervical cancer. EO was isolated from C×limon leaves collected in Padang City, Indonesia using the hydrodistillation method. EO was then analyzed by GC-MS. To determine its cytotoxicity, BSLT was conducted, followed by molecular docking and MTT assays. The experiment yielded a yellow liquid with a density of 0,8684 g/mL and a yield of 0,181%. GC-MS analysis of the EO identified 56 chemical components, with the main compounds are (-)-β-pinene (7.32%), (-)-limonene (28.40%), geranial (5.54%), caryophyllene (5.22%). The EO showed high toxicity against Artemia salina L larvae, with an LC50 value of 3,697 µg/mL. Through molecular docking, it is known the (-)-limonene, geranial, (-)β-pinene and caryophyllene compounds as the main compounds in of EO are known to bind to form complexes with cervical cancer proteins (HPV18E6). MTT assay showed weak cytotoxic activity of EO against HeLa cells, with an IC50 of 218.9 µg/mL.

This research aims to obtain chemistry learning media based on joyful learning with the snakes and ladders game on stoichiometric material that is suitable for use to improve student learning outcomes based on the validity, practicality and effectiveness of the game. The research method used is the research development (R&D) method with the 4D model by Tigharajan which consists of 4 main stages, define, design, develop and disseminate. However, the development of Joyful Learing-based Chemistry Learning Media with the Snakes and Ladders game has only reached the development stage. The research was carried out at Surabaya State University and SMA Negeri 1 Menganti Gresik. Test the game media using the One Group Pretest-Posttest Design system. Validity is obtained from the assessment of the stoichiometric snake and ladder game media by the validator. Practicality is obtained from the results of observing student activities, observing the implementation of learning activities, and student response questionnaires. Effectiveness is obtained from student learning outcomes. The results of the research show that chemistry learning media based on joyful learning with the snakes and ladders game on stoichiometric material is suitable for improving student learning outcomes with a feasibility score of ≥ 4 in the feasible to very feasible category. The practicality of chemistry learning media based on joyful learning with the snakes and ladders game on stoichiometric material to improve student learning outcomes is said to be suitable for use in terms of the results of observations of student activities which obtained a percentage of 96.81%, the results of observations of learning implementation obtained a percentage of 93.98%, and Student responses obtained a percentage of 91.52%. Then, the effectiveness of chemistry learning media based on joyful learning with the snakes and ladders game on stoichiometry material to improve student learning outcomes which was developed in terms of pretest and posttest scores was declared effective. This is shown by the N-gain score of all students being in the medium to high category and meeting the KKM value, with an average N-gain value of 0.79 with high criteria. This shows that the stoichiometric snakes and ladders game is declared suitable for use as a chemistry learning medium based on joyful learning on stoichiometric material to improve student learning outcomes.

This study aims to produce an Environmental-Based Chemistry Practicum Assessment Instrument for Reaction Rate Material for Class XI MA / SMA. The development model used in this research is the development model according to Borg and Gall (in Sugiyono, 2011) which consists of 4 stages: Potential and Problems, Gathering Information, Product Design, and Design Validation. The development in this study refers to the product produced in the form of an assessment instrument. which is measured until the validity of the expert where the validity aspects are based on the results of the experts' assessment validation questionnaire. The aspects assessed in the product of the environmental-based practicum performance instrument assessment instrument are the feasibility of instructions, content feasibility and language feasibility. The assessment instrument in this content aspect is arranged sequentially according to the practicum procedure. Based on the results of validation by validators, the linguistic aspect obtained a score with a percentage of 93%, then the linguistic aspect is divided into several assessment criteria, including the use of language in accordance with EYD, clarity of instructions and directions and the language used is straightforward and easy to understand Based on the results of validation by validators, the linguistic aspect obtained a score with a percentage of 91%. The validity level of the chemistry practicum performance assessment instrument measured practicum performance in the form of scores 1-4. Determination of the validity of the practicum performance assessment instrument is done by calculating the score given by the validator and analyzing the validator's suggestions and input on the instrument product assessment questionnaire sheet in the form of a check list. The results concluded that the student practicum performance assessment instrument was feasible to use.

This study aims to find the presence of microplastics in Shellfish through the literature review method of several studies conducted. The increase in plastic pollution in water systems since the 1950s has become a significant problem worldwide due to the slow decomposition rate. Microplastics, mainly primary and secondary, can accumulate in marine organisms such as Shellfish and enter the food chain, which is a concern for humans. Shellfish, especially M. galloprovincialis, can be used as bioindicators and bioremediation tools to tackle microplastic pollution. Microplastics are a severe problem in the world's oceans, especially in marginal and densely populated coastal areas. Marine organisms like Shellfish contain microplastics, which can cause physical damage and disrupt the immune system. Mytilus edulis clams and Crassostrea gigas oysters are the most consumed species with significant microplastic content. Research has also shown the presence of microplastics in Mytilus chilensis in the Gulf of Ushuaia, South America, with fibers and fragments being the most common types. Microplastics are also found in wild mussels in Tunisia, with the estimated annual dietary intake of microplastics by Tunisians through wild mussel consumption amounting to 4.2 particles per capita per year. Mussels of the genus Mytilus were proposed as guardian organisms to monitor microplastic pollution.