ABSTRACT This study investigates the effect of time zone differences on service exports (total and nine categories—travel, transport, computer and information, construction, financial, insurance, government, other business services, and personal, cultural, and recreational services) from Kenya. Estimates from the Poisson Pseudo-Maximum Likelihood (PPML) estimator of the gravity model on bilateral service exports data from Kenya to 176 countries, for the period 2005–2019, show that the effects of time zone differences between Kenya and partner countries is positive and statistically significant in technology-sensitive service exports (computer and information) while negative for construction and government service exports. Further analysis shows that these results are robust when an alternative model is employed and overlapping workday hours are used. The authors also find that the effect of time zone differences on services is nonlinear and sensitive to regulations and physical infrastructure (particularly mobile subscriptions). Attracting investment in technology-sensitive sectors should be encouraged through appropriate policy, given the positive impact of time zone differences on their exports. Traders in these sectors can also create networks with foreign firms. Deregulating and developing information and communication infrastructure, to expand mobile subscriptions, should also be encouraged.

BACKGROUND The impact of frailty on postoperative outcomes in patients undergoing hepatectomy is still unclear. AIM To study the influence of frailty on postoperative outcomes, such as mortality, rate of complications, and length of hospitalization, following hepatectomy. METHODS PubMed, EMBASE, and Scopus databases were searched for observational studies with adult (≥ 18 years) patients after planned/elective hepatectomy. A random-effects model was used for all analyses, and the results are expressed as weighted mean difference (WMD), relative risk (RR), or hazards ratio (HR) with 95% confidence interval (CI). RESULTS Analysis of the 13 included studies showed a significant association of frailty with elevated risk of in-hospital mortality (RR = 2.76, 95%CI: 2.10-3.64), mortality at 30 d (RR = 4.60, 95%CI: 1.85-11.40), and mortality at 90 d (RR = 2.52, 95%CI: 1.70-3.75) in the postoperative period. Frail patients had a poorer long-term survival (HR = 2.89, 95%CI: 1.84-4.53) and higher incidence of “any” complications (RR = 1.69, 95%CI: 1.40-2.03) and major (grade III or higher on the Clavien-Dindo scale) complications (RR = 2.69, 95%CI: 1.85-3.92). Frailty was correlated with markedly lengthier hospital stay (WMD = 3.65, 95%CI: 1.45-5.85). CONCLUSION Frailty correlates with elevated risks of mortality, complications, and prolonged hospitalization, which need to be considered in surgical management. Further research is essential to formulate strategies for improved outcomes in this vulnerable cohort.

This editorial delves into Peng et al 's article, published in the World Journal of Gastrointestinal Surgery . Peng et al 's meta-analysis investigates the effectiveness of electrocautery-enhanced lumen-apposing metal stents (ECE-LAMS) in ultrasound-guided biliary drainage for alleviating malignant biliary obstruction. Examining 14 studies encompassing 620 participants, the research underscores a robust technical success rate of 96.7%, highlighting the efficacy of ECE-LAMS, particularly in challenging cases which have failed endoscopic retrograde cholangio pancreatography. A clinical success rate of 91.0% underscores its impact on symptom alleviation, while a reasonably tolerable adverse event rate of 17.5% is observed. However, the 7.3% re-intervention rate stresses the need for post-procedural monitoring. Subgroup analyses validate consistent outcomes, bolstering the applicability of ECE-LAMS. These findings advocate for the adoption of ECE-LAMS as an appropriate approach for biliary palliation, urging further exploration in real-world clinical contexts. They offer valuable insights for optimizing interventions targeting malignant biliary obstruction management.

Among minimally invasive surgical procedures, colorectal surgery is associated with a notably higher incidence of incisional hernia (IH), ranging from 1.7% to 24.3%. This complication poses a significant burden on the healthcare system annually, necessitating urgent attention from surgeons. In a study published in the World Journal of Gastrointestinal Surgery , Fan et al compared the incidence of IH among 1614 patients who underwent laparoscopic colorectal surgery with different extraction site locations and evaluated the risk factors associated with its occurrence. This editorial analyzes the current risk factors for IH after laparoscopic colorectal surgery, emphasizing the impact of obesity, surgical site infection, and the choice of incision location on its development. Furthermore, we summarize the currently available preventive measures for IH. Given the low surgical repair rate and high recurrence rate associated with IH, prevention deserves greater research and attention compared to treatment.

Chief executive officers (CEOs) can turn out to be the weakest link to an organization’s security and attackers know that if they successfully exploit or impersonate someone who has a high level of access like CEOs or chief finance officers (CFOs), they instantly gain great advantage. The problem comes when attacker manages to take control of email accounts of the CEOs and CFOs and sends an email to another staff in the organization, he/she is likely to take it seriously, act accordingly and quickly as possible, and may be wire cash to an account directed by the “CEO/CFO,” and/or get away with private or sensitive corporate information. Because of the nature of these attack methods, detection and protection are very difficult since the attackers take advantage of the human weakness which is the weakest link. The main aim of this study is to provide a solution to protect every surface of the organization. By developing a human firewall, working with the already existing technical solutions offers the solution to remaining problem of human weakness. This research developed a simulator to train the users with the latest trends the attackers are using making them do it right (flagging, reporting, not clicking suspicions links) and making email security part of their responsibility. This makes employee become human firewall. The results from the simulator are displayed in charts as number of employees who passed the test, number of employees who will click on the malicious links, number of employees who will download the dangerous attachments, number of employees who will reply to phishing emails, average awareness of the organization, and how individual employees performed. While organizations have made progress over the years, security is a never-ending process that requires improvement day by day. Since no one in the organization’s structure is immune including the top most in the cadre (i.e., CEO), complexity in understanding and awareness creation is more wanting than before. Integrating human firewall into existing security measures as the last line of defense in email communication against business email compromise frauds offers this solution because it has preventive as well as reactive measures both geared toward maximizing email security. A simulation of the attacks to analyze the user involvement to breaching the security followed by an evaluation simulation after integrating human firewall to the organization’s email security shows success level. The results from the test show the different success levels, that is, results from pre-assessment definitely show low success level since staff/employees have not been made aware/trained to profile or flag compared to when the employees/staff have gone through the training/awareness. Post-assessment indicates high success level because actions from employees turned into human firewall know how to take proper action, for example, flagging, not clicking malicious links. The organization should update its policies to accommodate and reinforce rules on the employees to ensure that the tool is used regularly and actions taken on user deemed a threat to the organizational email security.

ABSTRACT The COVID-19 pandemic presented myriad global challenges, placing unprecedented pressure on health services. Currently, there is limited qualitative research exploring the ‘felt’ impact of the pandemic on older adults’ health experiences and wider social life. Here, we report on the embodied experiences of older adults (65 and above), before, during and after the COVID-19 pandemic lockdowns in the UK, to chart the physical, social, and mental-health challenges. A figurational sociological lens was adopted to examine data from semi-structured interviews with 18 older adults, face-to-face or via telephone/video call. Notes from follow-up conversations were also recorded. Combined data were analysed thematically. Salient themes cohered around: physical activity engagement; health experiences; the role of family, friends, and community; and the role of modern technology. Our results highlight how older adults reported the felt benefits of increased PA during lockdowns, but also the negative impacts of treatment delays on experiences of hospital services. Participants also recounted how new social community connections were forged during lockdowns. Saliently, we identified a need to support older adults with modern technology so as to capture its potential to modernise, expand, and personalise healthcare within UK health services.

ABSTRACT This paper explores the experiences of a sport research team (n = 6) who attended a conference with and then interviewed relatives of athletes whose deaths were linked to traumatic brain injuries through playing sport. Afterwards the research team were interviewed to explore the effects of undertaking such emotionally demanding research. Several researcher team members (n = 3) also later conducted online interviews with bereaved relatives who had not attended the conference. These researchers were re-interviewed to explore how their online experience was different to conducting in-person interviews. Interviews with the research team took place with a colleague known to the researchers but not involved in data collection at the conference. Reflexive thematic analysis led to the development of five themes: (1) ‘Wow! I don’t know if we’re ready for this’, (2) the emotional struggle, (3) a vulnerable team, (4) learning how to take self-care, (5) less emotion but also less connection. Findings suggest that preparing for bereavement interviews is challenging, that the research team were collectively vulnerable, and that learning to take self-care was important. Online data collection was found to reduce researcher vulnerability but raised different challenges. Findings are discussed in relation to the challenges of preparing for sensitive interviews, the pros and cons associated with deeply connecting with participants, the importance of self-care and support for researchers, and the implications of conducting interviews online without having developed pre-established relationships with participants.

The pinoresinol-lariciresinol reductase (PLR), a crucial enzyme in the biosynthesis of lignans in plants, catalyzes a two-step reaction to produce lariciresinol and secoisolariciresinol. Lignans such as lariciresinol are the effective components of traditional Chinese medicine Radix Isatidis in exerting antiviral activity. In order to study the function of the key enzyme PLR in the biosynthesis of lariciresinol in Isatis indigotica, the original plant of Radix Isatidis, IiPLR2 was cloned from I. indigotica, with a full length of 954 bp, encoding 317 amino acids. Multiple sequence alignment showed that IiPLR2 contained a conserved nicotinamide adenine dinucleotide phosphate (NADPH)-binding motif. The phylogenetic tree showcased that IiPLR2 shared the same clade with AtPrR1 from Arabidopsis thaliana. The prokaryotic expression vector pET32a-IiPLR2 was constructed and then transformed into Escherichia coli BL21(DE3) competent cells for protein expression. The purified enzyme IiPLR2 could catalyze the conversion of pinoresinol to lariciresinol and the conversion of lariciresinol to secoisolariciresinol. The cloning, sequencing, and catalytic functional analysis of IiPLR2 in this study enrich the understanding of this kind of functional proteins in I. indigotica and supplement the biosynthesis pathways of lignans. Moreover, this study provides a functional module for further research on metabolic regulation and synthetic biology and lays a foundation for comprehensively revealing the relationship between the spatial structures and catalytic functions of such proteins.

ABSTRACT Amid the COVID-19 pandemic, while the world sought solutions, few scholars exploited the situation for personal gains through deceptive studies and manipulated data. This paper presents the extent of 400 retracted COVID-19 papers listed by the RetractionWatch database until the month of February 2024. The primary purpose of the research was to analyze journal quality and retractions trends. Evaluating the journal’s quality is vital for stakeholders, as it enables them to effectively address and prevent such incidents and their future repercussions. The present study found that one-fourth of publications were retracted within the first month of their publication, followed by an additional 6% within six months of publication. One third of the retractions originated from Q1 journals, with another significant portion coming from Q2 (29.8%). An analysis of the reasons for retractions indicates that a quarter of retractions were attributed to multiple causes, predominantly associated with publications in Q2 journals, while another quarter were linked to data issues, primarily observed in Q1 publications. Elsevier retracted 31% of papers, with the majority published as Q1, followed by Springer (11.5%), predominantly as Q2. The study also examined author contributions, revealing that 69.3% were male, with females (30.7%) mainly holding middle author positions.

Renal pelvic carcinoma is a common upper urothelial cancer. The lack of an ideal in vitro model seriously hinders the research progress in the treatment for this disease. This study established a pipeline for the culture of renal pelvic carcinoma organoids based on the tumor tissue samples derived from the patients and tested the organoids to chemotherapeutic drugs. The results of immunohistochemistry and fluorescence experiments confirmed that the renal pelvic carcinoma organoids obtained from culture presented obvious nuclear heteromorphism, which was consistent with the tissue samples from renal pelvic carcinoma patients. The tumor marker molecule CD44 and the cell proliferation marker molecule Ki67 were positive in the organoids, indicating that the organoids were enriched with tumor stem cells and had strong proliferative ability. The renal pelvic carcinoma organoids were highly sensitive to pirarubicin, which had obvious killing effects. In brief, this study successfully established an in vitro model of renal pelvic cancer organoids and tested the sensitivity of the model to chemotherapeutic drugs. The results provide a new laboratory model for the individualized diagnosis and treatment of epithelial carcinomas represented by renal pelvic carcinoma.